Clinical trials: Cerebrovascular Disorders, open to volunteers
Ischemic Stroke
Post-Stroke Sensory Reweighting on Walking and Balance Outcomes
The primary objective of this proof-of-concept study is to longitudinally track the development of post-stroke sensory reweighting (PSR), identify associated structural neuroanatomical correlates, and investigate their…
- Trial name
- PSR (NCT06727097)
- Testing
- Posturography, Walking Speed, Instrumented 7M Timed UP and GO
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Cincinnati
Stroke, Aphasia
Language Processing and TMS
This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.
- Conditions
- Stroke, Aphasia, Language
- Trial name
- NCT05425615
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Stroke
R3THA Rehabilitation Feasibility and Usability Study
The purpose of this study is to assess how the Rehabilitation Technologies for Hand and Arm (R3THA) device can be used for rehabilitation of people with stroke.
- Trial name
- RETHA (NCT06854978)
- Testing
- RETHA
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kessler Foundation
Stroke
Effects of Trans-Auricular Vagal Stimulation on Neuromotor Recovery in Subacute Stroke During Technological and Traditional Training
This randomized pilot clinical study aims to investigate the effects of trans-auricular vagus nerve stimulation (tVNS) on neuromotor recovery in patients in the subacute phase after stroke.
- Trial name
- NCT07254390
- Testing
- Active trans-auricular vagus nerve stimulation (tVNS), Khymeia robotic upper limb rehabilitation, Traditional Rehabilitation
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Chronic Stroke
Motor Imagery Training for Upper Limb Functional Strength in Chronic Stroke Patients
Stroke is a leading cause of upper extremity deficits worldwide. Persistent upper extremity dysfunction affects many post stroke patients and is strongly associated with decreased activities of daily living and poor quality of…
- Trial name
- NCT06945185
- Testing
- Intervention Group A Conventional Physical Therapy, Intervention Group B Motor Imagery with Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Foundation University Islamabad
Ischemic Stroke, Cerebral Veinous Thrombosis
Thrombus Composition in Cerebral Infarctions: Study of Its Association With Plasma Biomarkers, Treatment Efficacy, Etiology and Prognosis.
This study focuses on thrombi collected during mechanical thrombectomy procedures, as well as on plasma biomarkers analyzed concomitantly.
- Trial name
- COMPOCLOT (NCT07384520)
- Volunteers
- 500 people
- Sponsor
- François Delvoye
SAH (Subarachnoid Hemorrhage), Headache
Transnasal Sphenopalatine Ganglion Block for Treatment of Acute Subarachnoid Hemorrhage Associated Headache
The study titled \"Transnasal sphenopalatine ganglion block for treatment of acute subarachnoid hemorrhage associated headache\" is a randomized controlled pilot study aimed at evaluating the efficacy of a transnasal…
- Trial name
- NCT06621329
- Testing
- Transnasal sphenopalatine ganglion block
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Davis
Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia
EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION ON NAMING IN APHASIC PATIENTS WITH ACUTE ISCHEMIC STROKE
The use of transcranial direct current stimulation (tDCS) for the management of deficits developed in stroke is a relatively new type of management option.
- Conditions
- Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia, Aphasia Following Cerebral Infarction, Aphasia, Acquired
- Trial name
- NCT07496645
- Testing
- Transcranial Direct Current Stimulation
- Where
- India
- Volunteers
- 28 people
- Sponsor
- Dr. Ram Manohar Lohia Hospital
Atrial Fibrillation (AF), Stroke
Elite AF IDE Trial (Elite AF)
The primary objective of this study is to establish the safety and effectiveness of the WATCHMAN Elite Left Atrial Appendage Closure (LAAC) Device for subjects with non-valvular atrial fibrillation who are eligible for…
- Trial name
- NCT07287436
- Testing
- WATCHMAN Elite LAAC Device
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Boston Scientific Corporation
Stroke
Exoskeleton for Balance
Many people who have experienced a stroke have deficits in their walking balance. The long-term goal of this research is to develop an exoskeleton that can effectively improve walking balance, thus improving functional mobility.
- Trial name
- NCT07356011
- Testing
- No Exoskeleton, Exoskeleton (zero impedance), Exoskeleton (low impedance)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Stroke, Acute Ischemic, Medium Vessel Occlusion
INTRA-ARTERIAL MeVO TREATMENT (IMP-ACT) Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
This domain will be conducted as part of ACT-GLOBAL platform trial and will have the nested domain name of IMP-ACT. Acute ischemic stroke (AIS) caused by intracranial arterial occlusion remains a major cause of disability and…
- Trial name
- IMP-ACT (NCT07906275)
- Testing
- Mechanical Endovascular Thrombectomy, Intravenous Thrombolysis, Tenecteplase/Alteplase- depending upon availability at each treating centre
- Where
- 4 sites in Canada
- Volunteers
- 800 people
- Sponsor
- University of Calgary
Atrial Fibrillation, Stroke
Impact of Steerable Delivery Sheaths on Successful Closure of LA A With AMULET
The novel Amplatzer steerable delivery sheath (Abbott Vascular) is found to be safe and effective in performing LAAO procedure. However, the procedural outcomes have not been compared with the traditional non-steerable fixed…
- Trial name
- NCT05464511
- Testing
- Left atrial appendage occlusion with the dual mechanism closure Amulet device using a novel steerable sheath.
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Temporal Perturbation, Virtual Lesion
Dynamic Causal Modeling of Neuromodulation of Action Speed Via Targeted TMS-EEG
Stroke is a major cause of long-term disability, with cognitive and motor deficits-especially action slowing and executive dysfunction-being strong predictors of poor recovery outcomes.
- Conditions
- Temporal Perturbation, Virtual Lesion, EEG, fNIRS
- Trial name
- NAS (NCT07468032)
- Testing
- Phase 1 functional MRI (fMRI), Phase 2 functional MRI (fMRI), Phase 3 functional MRI (fMRI)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Unruptured Intracranial Aneurysm
Assessment of the Clinical and Economic Impact of Sim&Size, a Simulation Software for Implantable Devices Used in the Treatment of Intracranial Aneurysms: A Prospective Multicenter Study.
In recent years, endovascular treatment of intracranial aneurysms has seen remarkable growth, now surpassing traditional surgical approaches in terms of frequency of use.
- Trial name
- ESSNAI (NCT07433075)
- Testing
- 3D simulation of placement of neurovascular implantable medical device, Manual planning of endovascular procedure
- Where
- 6 sites in France
- Volunteers
- 576 people
- Sponsor
- Sim&Cure
Stroke
Powering Up Stroke Rehabilitation Through HIIT
Objectives: To investigate the effects of high-intensity interval training (HIIT) on musculoskeletal fitness in chronic stroke survivors.
- Trial name
- NCT06554665
- Testing
- High-intensity Interval Training, Moderate-Intensity Continuous Training, Stretching
- Where
- Hong Kong
- Volunteers
- 66 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke, Stroke Acute
Individual vs Co-Treatment in Acute Stroke Rehabilitation and Evaluation
This is a single center, pragmatic, randomized trial comparing the effectiveness of two commonly used approaches (co-treatment and individual treatment) in acute care rehabilitation.
- Trial name
- ICARE (NCT07411534)
- Testing
- Co-treatment, Individual Treatment
- Where
- United States
- Volunteers
- 567 people
- Sponsor
- Vanderbilt University Medical Center
Arterial Ischemic Stroke
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also…
- Trial name
- DOP-MOBILIZE (NCT07232498)
- Testing
- Doppler-guided early mobilization
- Where
- 7 sites in Croatia, Portugal
- Volunteers
- 1,300 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Fabry Disease, Cardiovascular Diseases
the Role of cArdiac Inflammation, endoThelial Dysfunction, and FIbrosis in fabrY Disease
The overall objective of this study is to investigate Fabry-related cardiomyopathy and the use of native T1-mapping, coronary microvascular function, cardiac inflammation, and cardiac injury in an effort to improve the ability to…
- Trial name
- RATIFY (NCT06776419)
- Testing
- Cardiac Magnetic Ressonance Imaging, 82Rubidium-positron emission tomography and computer-tomography
- Where
- Denmark
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Caroline Michaela Kistorp
Cerebral Ischemia, PET / MR
Research on the Application of Sigma Radiopharmaceutical FBFP in Cerebral Stroke
This clinical research, aims to investigate the uptake of [18F]FBFP, a Sigma-1 receptor (Sig 1R) PET imaging agent, in stroke participants, compare differences with healthy controls, and evaluate its diagnostic efficacy…
- Trial name
- NCT07558577
- Testing
- PET/MR multimodality imaging
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Thrombus, Brain, Thrombosis
Thrombus Imaging and Treatment Analytics in Neurology
In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and…
- Trial name
- Titan (NCT05663281)
- Testing
- thrombus imaging appearance
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
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