Clinical trials: Cervical, active
Cervical Cancer, Gynecologic Cancer
Radiotherapy for Gynecologic Cancer With Up to 10 Active Metastatic Lesions
OLIGYNE-10 RT is an international registry of adults with gynecologic cancer and a limited number of active sites of cancer spread who receive radiotherapy (RT) to at least one metastatic lesion during routine care.
- Conditions
- Cervical Cancer, Gynecologic Cancer, Endometrial Cancer, Uterine Cancer
- Trial name
- OLIGYNE-10 RT (NCT07883798)
- Testing
- Routine-care metastasis-directed radiotherapy
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Affidea Nu-med Center of Oncological DIagnostics and Therapy
Cervical Intraepithelial Neoplasia Grade 3
Exploratory Study of the Efficacy of HAL-PDT in CIN 3
This is a prospective, multicenter, biomarker-guided Phase II study evaluating the efficacy and safety of hexaminolevulinate-mediated cervical photodynamic therapy (HAL-PDT) in women with cervical intraepithelial neoplasia grade…
- Trial name
- Lumiteg-I (NCT07891338)
- Testing
- Hexaminolevulinate (HAL)
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Tongji Hospital
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Nivolumab in Treating Patients With Persistent, Recurrent, or Metastatic Cervical Cancer
This phase II trial studies the side effects and how well nivolumab works in treating patients with cervical cancer that has grown, come back, or spread to other places in the body.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Recurrent Cervical Carcinoma, Stage IV Cervical Cancer AJCC v6 and v7
- Trial name
- NCT02257528
- Testing
- Laboratory Biomarker Analysis, Nivolumab
- Where
- 331 sites in United States
- Volunteers
- 26 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
This phase II MATCH screening and multi-sub-trial studies how well treatment that is directed by genetic testing works in patients with solid tumors, lymphomas, or multiple myelomas that may have spread from where it first…
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Bladder Carcinoma, Breast Carcinoma
- Trial name
- NCT02465060
- Testing
- Adavosertib, Afatinib, Afatinib Dimaleate
- Where
- 1,410 sites in United States, Guam and 1 more
- Volunteers
- 6,452 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Vaginal Adenocarcinoma, Advanced Vaginal Adenosquamous Carcinoma
Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers
This randomized phase III trial studies radiation therapy and cisplatin with triapine to see how well they work compared to the standard radiation therapy and cisplatin alone in treating patients with newly diagnosed stage IB2…
- Conditions
- Advanced Vaginal Adenocarcinoma, Advanced Vaginal Adenosquamous Carcinoma, Advanced Vaginal Squamous Cell Carcinoma, Cervical Adenocarcinoma
- Trial name
- NCT02466971
- Testing
- Brachytherapy, Cisplatin, External Beam Radiation Therapy
- Where
- 381 sites in United States, Canada and 1 more
- Volunteers
- 450 people
- Sponsor
- National Cancer Institute (NCI)
Cancer of the Cervix, Vulvar Cancer
Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers
This study expands on protocol (NCT01908504"PET adaptive RT") designed to evaluate the utility of adaptive PET-CT planning for radiation therapy (RT).
- Conditions
- Cancer of the Cervix, Vulvar Cancer, Esophageal Cancer, Anal Canal Cancer
- Trial name
- NCT03403465
- Testing
- FDG PET scan
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Duke University
Cervical Cancer
AK105 Combined With Anlotinib in Patients With Cervical Cancer
The purpose of this study is to evaluate the efficacy and safety of AK105 (anti-PD-1 mab) combined with Anlotinib Hydrochloride in the treatment of persistent, recurrent and metastatic cervical cancer.
- Trial name
- NCT05137171
- Testing
- AK105 and anlotinib
- Where
- 2 sites in China
- Volunteers
- 36 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Human Papillomavirus-Related Cervical Carcinoma
Single-Dose HPV Vaccination for the Prevention of Cervical Cancer in Young Adult Women in Costa Rica, The PRISMA ESCUDDO Trial
This phase IV trial tests whether a single dose of the human papillomavirus (HPV) vaccine works in preventing cervical cancer in young women in Costa Rica.
- Trial name
- PRISMA (NCT05237947)
- Testing
- Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed, Questionnaire Administration, Recombinant Human Papillomavirus Bivalent Vaccine
- Where
- Costa Rica
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Metastatic Solid Tumor, Recurrent Solid Tumor
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
The purpose of this study is to find out whether the study drug, LY4052031, is safe, tolerable and effective in participants with advanced, or metastatic solid tumors including urothelial cancer.
- Conditions
- Metastatic Solid Tumor, Recurrent Solid Tumor, Advanced Solid Tumor, Urinary Bladder Neoplasm
- Trial name
- NEXUS-01 (NCT06465069)
- Testing
- LY4052031, Pembrolizumab
- Where
- 39 sites in United States, Australia and 6 more
- Volunteers
- 460 people
- Sponsor
- Eli Lilly and Company
Locally Advanced Cervical Adenocarcinoma, Locally Advanced Cervical Adenosquamous Carcinoma
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
This phase III trial compares the addition of induction chemotherapy, with carboplatin, paclitaxel and pembrolizumab, to chemotherapy and radiation, with cisplatin and pembrolizumab followed by pembrolizumab maintenance for the…
- Conditions
- Locally Advanced Cervical Adenocarcinoma, Locally Advanced Cervical Adenosquamous Carcinoma, Locally Advanced Cervical Squamous Cell Carcinoma, Stage IIIA Cervical Cancer FIGO 2018
- Trial name
- NCT07061977
- Testing
- Biospecimen Collection, Brachytherapy, Carboplatin
- Where
- 344 sites in United States, Puerto Rico
- Volunteers
- 336 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer Screening, Human Papilloma Virus
Developing and Implementing HPV SCREENED
This study will assess the feasibility of implementing HPV self-sampling as a primary cervical cancer screening strategy for under-screened women in the emergency department (ED).
- Trial name
- NCT07657104
- Testing
- HPV Self-collection in the ED
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Cervical Carcinoma
A Community Based Intervention to Improve Cervical Cancer Screening Among Women in the Hispanic and East African Immigrant Community
This clinical trial studies whether a community based intervention improves cervical cancer screening (CCS) among women in the Hispanic and East African immigrant community.
- Trial name
- NCT07890402
- Testing
- HPV Self-Collection, Informational Intervention, Interview
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Advanced Solid Tumors
A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1311/BNT324 in subjects with advanced solid tumors.
- Trial name
- NCT05914116
- Testing
- DB-1311, Lopinavir and Ritonavir Tablets, itraconazole
- Where
- 107 sites in United States, Australia and 2 more
- Volunteers
- 862 people
- Sponsor
- DualityBio Inc.
Cervical Spondylitis
Reciprocal Inhibition vs PNF for Cervical Spondylitis
Cervical spondylitis is a common cause of chronic neck pain and limited function. Physiotherapists often use two manual techniques: Reciprocal Inhibition (RI) and Passive Proprioceptive Neuromuscular Facilitation (PNF)…
- Trial name
- RI-PNF-CS (NCT07637812)
- Testing
- Reciprocal Inhibition Technique, Passive PNF Stretching
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Faisalabad
Cervical Radiculopathy, Cervical Myelomalacia
Cervical Spinal Cord Signal Abnormalities in Patients With Cervical Radicular Pain
This prospective observational study aims to determine the prevalence of cervical spinal cord signal abnormalities, including myelomalacia, among adult patients presenting to a tertiary pain clinic with cervical radicular pain.
- Trial name
- CSCS (NCT07823426)
- Testing
- Clinical and Cervical MRI Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Ankara City Hospital Bilkent
Cervical Spinal Cord Injury
Effect of Rimonabant on Hand Function in Patients With Spinal Cord Injury
This is an one arm study to be conducted in spinal cord injury patients. The goal of this clinical trial is to learn if rimonabant improves hand motor and performance function in patients with cervical spinal cord injury.
- Trial name
- RIMOHANDOPEN (NCT07843108)
- Testing
- Rimonabant
- Where
- Spain
- Volunteers
- 8 people
- Sponsor
- Sinfatin S.L
Cervical Intraepithelial Neoplasia Grade 2 (CIN2)
RWS of PDT for CIN 2
This is a prospective, observational, multicenter real-world study designed to evaluate the effectiveness and safety of photodynamic therapy (PDT) in women with cervical intraepithelial neoplasia grade 2 (CIN2).
- Trial name
- Lumiteg-R (NCT07885566)
- Testing
- Hexaminolevulinate (HAL)
- Volunteers
- 1,000 people
- Sponsor
- Tongji Hospital
Cervical Stenosis, Cervical Spine
Evaluation of the Statistical Validity of Cervical Spine Measurements-Including Range of Motion, Strength, and Functional Test Results-for Return to Sport in Patients Who Have Undergone Surgery for Cervical Stenosis and/or Herniation.
Cervical stenosis is characterized by a narrowing of the spinal canal that exerts pressure on adjacent sensitive areas, potentially causing significant neck pain and cervicobrachial neuralgia accompanied by functional…
- Trial name
- RC REPRO (NCT07886112)
- Testing
- Questionnaires, Physical tests
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Spinal Cord Injury Cervical, Spinal Cord Injuries (SCI)
Transcutaneous Spinal Cord Stimulation for Blood Pressure Augmentation Immediately After Spinal Cord Injury
In the treatment of spinal cord injury (SCI) patients in the hyperacute setting, it is imperative to closely control mean arterial pressure (MAP) to ensure adequate spinal cord perfusion in the absence of properly functioning…
- Conditions
- Spinal Cord Injury Cervical, Spinal Cord Injuries (SCI), Spinal Cord Injury (SCI), Initial Encounter
- Trial name
- Stim for MAP (NCT07887373)
- Testing
- Spinal Cord Stimulation
- Volunteers
- 20 people
- Sponsor
- Markey Olson
Localized Prostate Carcinoma, Locally Advanced Cervical Carcinoma
Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers
This phase II trial studies how well time-restricted eating works in reducing side effects of radiation or chemoradiation side effects when compared to nutritional counseling among patients with prostate, cervical, and rectal…
- Conditions
- Localized Prostate Carcinoma, Locally Advanced Cervical Carcinoma, Locally Advanced Rectal Carcinoma, Malignant Solid Neoplasm
- Trial name
- NCT05722288
- Testing
- Biospecimen Collection, Informational Intervention, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- City of Hope Medical Center