Clinical trials: Cervical Cancer
Cervical Cancer, Hiv
Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South Africa: Part 2
The investigators will conduct the formative work that is necessary to develop a novel, multi-level intervention (inclusive of patient- and provider-level components), which will increase awareness of and modify the complex…
- Trial name
- NCT06182241
- Testing
- Retention in cervical cancer care intervention
- Where
- 3 sites in United States, South Africa
- Volunteers
- 62 people
- Sponsor
- Boston University Charles River Campus
Endometrial Cancer, Cervical Cancer (Early Detection)
Remote Robotic Surgery for Gynecologic Cancer: A Safety and Effectiveness Study
This investigator-initiated, multicenter, single-blind, randomized controlled clinical study is designed to evaluate the safety and effectiveness of the MP2000 thoracoabdominal endoscopic surgical system (Shenzhen Jingfeng…
- Trial name
- RRS-GYN-RCT (NCT07896720)
- Testing
- MP2000 Thoracoabdominal Endoscopic Surgical System
- Volunteers
- 92 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Cervical Intraepithelial Neoplasia, Uterine Cervical Neoplasms
Clinical Audit of Cervical Cytology Services in an Early Cancer Detection Unit
Cervical cancer is largely preventable when precancerous changes are detected and treated early. However, an effective screening program requires not only collecting a screening test, but also ensuring seamless continuity across…
- Conditions
- Cervical Intraepithelial Neoplasia, Uterine Cervical Neoplasms, Cervical Precancerous Lesions, Cervical Dysplasia
- Trial name
- NCT07897786
- Volunteers
- 500 people
- Sponsor
- Assiut University
Cervical Cancer Screening
Addressing Stigma in Screening and Diagnostic Delay for Cervical Cancer
This study aims to 1) implement a culturally and contextually rooted innovative multifoci, social marketing intervention involving societal focused media campaign elements to break down the barriers and facilitate timely and…
- Trial name
- NCT01287871
- Testing
- supportive care
- Where
- United States
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
This phase II MATCH screening and multi-sub-trial studies how well treatment that is directed by genetic testing works in patients with solid tumors, lymphomas, or multiple myelomas that may have spread from where it first…
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Bladder Carcinoma, Breast Carcinoma
- Trial name
- NCT02465060
- Testing
- Adavosertib, Afatinib, Afatinib Dimaleate
- Where
- 1,410 sites in United States, Guam and 1 more
- Volunteers
- 6,452 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Solid Tumor, Melanoma
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This is a proof-of-concept study designed to investigate HER3-DXd monotherapy in locally advanced unresectable or metastatic solid tumors.
- Conditions
- Advanced Solid Tumor, Melanoma, Head and Neck Cancer, Gastric Cancer
- Trial name
- NCT06172478
- Testing
- HER3-DXd
- Where
- 96 sites in United States, Australia and 14 more
- Volunteers
- 740 people
- Sponsor
- Daiichi Sankyo
Recurrent or Metastatic Solid Tumors
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
This study is designed to assess the efficacy and safety of ifinatamab deruxtecan (I-DXD) in the following tumor types: endometrial cancer (EC); head and neck squamous cell carcinoma (HNSCC); pancreatic ductal adenocarcinoma…
- Trial name
- NCT06330064
- Testing
- Ifinatamab deruxtecan
- Where
- 120 sites in United States, Argentina and 16 more
- Volunteers
- 680 people
- Sponsor
- Daiichi Sankyo
Locally Advanced Cervical Adenocarcinoma, Locally Advanced Cervical Adenosquamous Carcinoma
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
This phase III trial compares the addition of induction chemotherapy, with carboplatin, paclitaxel and pembrolizumab, to chemotherapy and radiation, with cisplatin and pembrolizumab followed by pembrolizumab maintenance for the…
- Conditions
- Locally Advanced Cervical Adenocarcinoma, Locally Advanced Cervical Adenosquamous Carcinoma, Locally Advanced Cervical Squamous Cell Carcinoma, Stage IIIA Cervical Cancer FIGO 2018
- Trial name
- NCT07061977
- Testing
- Biospecimen Collection, Brachytherapy, Carboplatin
- Where
- 345 sites in United States, Puerto Rico
- Volunteers
- 336 people
- Sponsor
- National Cancer Institute (NCI)
Ovary Cancer, Cervical Cancer
Feasibility of the "One-Finger Technique" for Identifying the Upper Left Ureter During Para-Aortic Lymphadenectomy
Para-aortic lymphadenectomy plays an important role in the surgical treatment of major gynecological malignancies (ovarian, endometrial, and cervical cancer).
- Conditions
- Ovary Cancer, Cervical Cancer, Endometrial Cancer
- Trial name
- NCT07895212
- Testing
- One-Finger Technique
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
HSIL, High Grade Squamous Intraepithelial Lesion, DNA Methylation
Predictive Biomarkers for Precision Management of Pre-cancerous Cervical Neoplasia
The goal of this observational study (retrospective cohort study) is to determine whether DNA methylation status in archived cervical cytology samples can predict regression, persistence, or progression of high-grade cervical…
- Conditions
- HSIL, High Grade Squamous Intraepithelial Lesion, DNA Methylation, CIN - Cervical Intraepithelial Neoplasia
- Trial name
- NCT07895641
- Testing
- DNA methylation
- Where
- Sweden
- Volunteers
- 199 people
- Sponsor
- Lund University
Cervical Cancer, HPV
Elimisha HPV (Human Papillomavirus)
This research study aims to develop a stigma-responsive educational intervention which includes simplified scripts that provide clear messages about HPV and video aimed at addressing fears and misperceptions from a peer…
- Conditions
- Cervical Cancer, HPV, HIV, Stigma
- Trial name
- NCT05736588
- Testing
- Elimisha HPV
- Where
- Kenya
- Volunteers
- 963 people, healthy volunteers welcome
- Sponsor
- Duke University
Cervical Cancer, Gynecologic Cancer
Radiotherapy for Gynecologic Cancer With Up to 10 Active Metastatic Lesions
OLIGYNE-10 RT is an international registry of adults with gynecologic cancer and a limited number of active sites of cancer spread who receive radiotherapy (RT) to at least one metastatic lesion during routine care.
- Conditions
- Cervical Cancer, Gynecologic Cancer, Endometrial Cancer, Uterine Cancer
- Trial name
- OLIGYNE-10 RT (NCT07883798)
- Testing
- Routine-care metastasis-directed radiotherapy
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Affidea Nu-med Center of Oncological DIagnostics and Therapy
Cervical Intraepithelial Neoplasia Grade 3
Exploratory Study of the Efficacy of HAL-PDT in CIN 3
This is a prospective, multicenter, biomarker-guided Phase II study evaluating the efficacy and safety of hexaminolevulinate-mediated cervical photodynamic therapy (HAL-PDT) in women with cervical intraepithelial neoplasia grade…
- Trial name
- Lumiteg-I (NCT07891338)
- Testing
- Hexaminolevulinate (HAL)
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Tongji Hospital
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Nivolumab in Treating Patients With Persistent, Recurrent, or Metastatic Cervical Cancer
This phase II trial studies the side effects and how well nivolumab works in treating patients with cervical cancer that has grown, come back, or spread to other places in the body.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Recurrent Cervical Carcinoma, Stage IV Cervical Cancer AJCC v6 and v7
- Trial name
- NCT02257528
- Testing
- Laboratory Biomarker Analysis, Nivolumab
- Where
- 331 sites in United States
- Volunteers
- 26 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Vaginal Adenocarcinoma, Advanced Vaginal Adenosquamous Carcinoma
Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers
This randomized phase III trial studies radiation therapy and cisplatin with triapine to see how well they work compared to the standard radiation therapy and cisplatin alone in treating patients with newly diagnosed stage IB2…
- Conditions
- Advanced Vaginal Adenocarcinoma, Advanced Vaginal Adenosquamous Carcinoma, Advanced Vaginal Squamous Cell Carcinoma, Cervical Adenocarcinoma
- Trial name
- NCT02466971
- Testing
- Brachytherapy, Cisplatin, External Beam Radiation Therapy
- Where
- 381 sites in United States, Canada and 1 more
- Volunteers
- 450 people
- Sponsor
- National Cancer Institute (NCI)
Cancer of the Cervix, Vulvar Cancer
Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers
This study expands on protocol (NCT01908504"PET adaptive RT") designed to evaluate the utility of adaptive PET-CT planning for radiation therapy (RT).
- Conditions
- Cancer of the Cervix, Vulvar Cancer, Esophageal Cancer, Anal Canal Cancer
- Trial name
- NCT03403465
- Testing
- FDG PET scan
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Duke University
Cervical Cancer
AK105 Combined With Anlotinib in Patients With Cervical Cancer
The purpose of this study is to evaluate the efficacy and safety of AK105 (anti-PD-1 mab) combined with Anlotinib Hydrochloride in the treatment of persistent, recurrent and metastatic cervical cancer.
- Trial name
- NCT05137171
- Testing
- AK105 and anlotinib
- Where
- 2 sites in China
- Volunteers
- 36 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Human Papillomavirus-Related Cervical Carcinoma
Single-Dose HPV Vaccination for the Prevention of Cervical Cancer in Young Adult Women in Costa Rica, The PRISMA ESCUDDO Trial
This phase IV trial tests whether a single dose of the human papillomavirus (HPV) vaccine works in preventing cervical cancer in young women in Costa Rica.
- Trial name
- PRISMA (NCT05237947)
- Testing
- Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed, Questionnaire Administration, Recombinant Human Papillomavirus Bivalent Vaccine
- Where
- Costa Rica
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Metastatic Solid Tumor, Recurrent Solid Tumor
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
The purpose of this study is to find out whether the study drug, LY4052031, is safe, tolerable and effective in participants with advanced, or metastatic solid tumors including urothelial cancer.
- Conditions
- Metastatic Solid Tumor, Recurrent Solid Tumor, Advanced Solid Tumor, Urinary Bladder Neoplasm
- Trial name
- NEXUS-01 (NCT06465069)
- Testing
- LY4052031, Pembrolizumab
- Where
- 39 sites in United States, Australia and 6 more
- Volunteers
- 460 people
- Sponsor
- Eli Lilly and Company
Cervical Cancer Screening, Human Papilloma Virus
Developing and Implementing HPV SCREENED
This study will assess the feasibility of implementing HPV self-sampling as a primary cervical cancer screening strategy for under-screened women in the emergency department (ED).
- Trial name
- NCT07657104
- Testing
- HPV Self-collection in the ED
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey