Clinical trials: Cervical Cancer Radiation Complications
Quality of Life, Oral Mucositis
Efficacy of a Probiotic and Microbiological Analysis on Oral Complications in Patients With HNC
The study is a Clinical Trial and the main objective is to Evaluate the effects of probiotics on oral complications induced by antineoplastic therapies in patients with head and neck cancer, attended at the radiotherapy service…
- Conditions
- Quality of Life, Oral Mucositis, Dental Plaque, Periodontal Diseases
- Trial name
- HNC (NCT06122636)
- Testing
- The probiotic to be used in the intervention corresponds to PRODEFEN Plus manufactured by ITALFARMACO S.A. laboratory
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- University of Barcelona
Head and Neck Cancer, Oral Complications
Sargramostim to Prevent Mucositis in Patients Receiving Radiation Therapy for Laryngeal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as sargramostim may protect normal cells from the side effects of radiation therapy.
- Conditions
- Head and Neck Cancer, Oral Complications, Radiation Toxicity
- Trial name
- NCT00004256
- Testing
- sargramostim, quality-of-life assessment, radiation therapy
- Where
- United Kingdom
- Sponsor
- Royal Marsden NHS Foundation Trust
Cervical Cancer
Radiation Therapy or Chemoradiation, Interstitial Brachytherapy in Combination With Hyperthermia in Advanced Cervical Cancer
The combination of radiation therapy or chemoradiation with Interstitial brachytherapy for advanced cervical cancer (pN+, FIGO-Stage II B - IV A is standard of therapy.
- Trial name
- NCT03249519
- Testing
- Radiation, brachytherapy, Cisplatin
- Where
- Germany
- Volunteers
- 999 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cancer
Care of Cancer Patients With Bowel Injury Caused by Radiation Therapy to the Pelvis
RATIONALE: A step-by-step procedure may help health care practitioners diagnose and treat cancer patients with bowel injury symptoms caused by radiation therapy.
- Trial name
- NCT00737230
- Testing
- educational intervention, questionnaire administration, assessment of therapy complications
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Cervical Cancer
NeoAdjuvant Chemotherapy Followed by Radical Hysterectomy (OP) Versus Primary Chemo-RADiation in Cervical Cancer FIGO Stage IB2 and IIB
Randomized comparison of neoadjuvant chemotherapy followed by radical hysterectomy with pelvic ± para-aortic lymphonodectomy (LNE) versus primary cisplatin-based chemo-radiation in patients with cervical cancer FIGO IB2 and IIB.
- Trial name
- NACOPRAD (NCT02422563)
- Testing
- hysterectomy, Radiation, Cisplatin
- Volunteers
- 534 people
- Sponsor
- Charite University, Berlin, Germany
Head and Neck Neoplasms, Radiation Therapy Complication
Collection of Head Images During Radiotherapy
The primary objective of this observational study is to quantify the translation, rotation, and deformation of patient head positions of head and neck cancer patients over the course of a radiation therapy treatment for head and…
- Trial name
- CHIRP (NCT05218824)
- Where
- Australia
- Volunteers
- 32 people
- Sponsor
- University of Sydney
Cervical Cancer
Neoadjuvant Bevacizumab and Carboplatin Followed by Concurrent Bevacizumab, Carboplatin and Radiotherapy in the Primary Treatment of Cervix Cancer
This trial is designed to study the safety and efficacy of the combination of carboplatin, bevacizumab, and pelvic radiation therapy.
- Trial name
- NCT00600210
- Testing
- Bevacizumab, Carboplatin, Radiation Therapy
- Where
- United States
- Sponsor
- Leo W. Jenkins Cancer Center
Endometrial Cancer, Cervical Cancer
Sexual Rehabilitation Programme After Radiotherapy for Gynaecological Cancer
The aim of this randomized controlled trial is to demonstrate that a nurse-led sexual rehabilitation intervention significantly improves sexual recovery and functioning among gynaecological cancer (GC) patients treated with…
- Conditions
- Endometrial Cancer, Cervical Cancer, Vaginal Cancer, Gynecologic Cancer
- Trial name
- SPARC (NCT03611517)
- Testing
- Sexual rehabilitation programme
- Where
- 8 sites in Netherlands
- Volunteers
- 220 people
- Sponsor
- Leiden University Medical Center
Head and Neck Cancer
Combination Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, cisplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00352118
- Testing
- filgrastim, pegfilgrastim, cisplatin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Rectal Cancer, Cervical Cancer
Irradiation Modulates the Pharmacokinetics of Anticancer Drugs
Radiation therapy (RT) is used as an effective local treatment modality to inhibit cell proliferation, induce cell death and suppress tumor growth.
- Trial name
- NCT01755585
- Volunteers
- 40 people
- Sponsor
- Far Eastern Memorial Hospital
Esophageal Cancer
Defining the Radiotherapy Dose and Volume Parameters Affecting Postoperative Complications in Esophageal Cancer Patients
The purpose of this study is to identify features of the cumulative dose-volume histogram (DVH) for patients treated with trimodality therapy in oesophageal cancer and correlate these with postoperative complications.
- Trial name
- NCT02323776
- Testing
- Trimodality protocol
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht Radiation Oncology
Cervical Cancer
Cisplatin Based Chemoradiation v.s Radiotherapy for Cervical Cancer and With Clinically Defined Good Prognosis
This phase III study is designed to examine if low-risk, as defined by clinical and radiological parameters, stage IB-IIB cervical cancer patients treated by cisplatin-based chemoradiation, which is a recommended method by…
- Trial name
- NCT00846508
- Testing
- Cisplatin
- Where
- 2 sites in Taiwan
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cervical Cancer Radiation Complications, QoL
Recovery and Quality of Life in Cervical Cancer Patients Using Vaginal Dilators After Radiotherapy
The goal of this longitudinal observational study is to understand the trajectory of Quality of Life (QoL) recovery in women with cervical cancer who have received definitive radiation therapy.
- Trial name
- QoL (NCT07698795)
- Where
- Thailand
- Volunteers
- 67 people
- Sponsor
- Chulabhorn Cancer Center
Cervical Adenocarcinoma, Stage IB Cervical Cancer
Dose Optimization in 3D Pulsed Dose Rate Brachytherapy for Patients With Locally Advanced Cervical Cancer
This prospective phase II trial study aims to optimize the increase in dose to the target volume at high risk (85 to 90 Gy over 90% of its volume) and the intermediate target volume (60 Gy to 90 % of its volume) in 3D Pulsed Dose…
- Conditions
- Cervical Adenocarcinoma, Stage IB Cervical Cancer, Stage II Cervical Cancer, Stage III Cervical Cancer
- Trial name
- TRIDICOL (NCT02880007)
- Testing
- External Beam Radiation Therapy, PDR Brachytherapy, Cisplatin
- Where
- 9 sites in France
- Volunteers
- 48 people
- Sponsor
- Institut de Cancérologie de Lorraine
Head and Neck Cancer, Oral Complications
Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer
RATIONALE: Cevimeline may be effective in treating dry mouth that is caused by radiation therapy for head and neck cancer. It is not yet known if cevimeline is more effective than no therapy in treating dry mouth caused by…
- Conditions
- Head and Neck Cancer, Oral Complications, Radiation Toxicity
- Trial name
- NCT00017511
- Testing
- cevimeline hydrochloride
- Where
- 71 sites in United States
- Sponsor
- Daiichi Sankyo
Radiotherapy; Complications, Cardiotoxicity
Multimodal Assesment of Acute Cardiac Toxicity Induced by Thoracic Radiotherapy in Cancer Patients
The purpose of this study is to evaluate and compare the changes by two modalities: Imaging by Strain by Speckle Tracking and Magnetic Resonance versus soluble markers of cardiac dysfunction as early predictors of cardio-toxicity…
- Conditions
- Radiotherapy; Complications, Cardiotoxicity, Cancer, Lung Cancer
- Trial name
- NCT04896242
- Where
- Chile
- Volunteers
- 47 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Cervical Cancer
Extended-field Proton Therapy for Cervical Cancer
Severe lymphopenia is a common complication of extended-field radiotherapy in cervical cancer, significantly impacting immune function and clinical outcomes.
- Trial name
- NCT07298642
- Testing
- Proton extended field radiation therapy, Photon extended field radiation therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 44 people
- Sponsor
- National Taiwan University Hospital
Uterine Neoplasms, Genital Neoplasms, Female
RT for Cervical Adenocarcinoma/adenosquamous Carcinoma
The purpose of this study was to retrospectively analyze patients with cervical adenocarcinoma/adenosquamous carcinoma who had been admitted to our hospital.
- Trial name
- NCT06741046
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking Union Medical College Hospital
Cervical Cancer
Sexual Functioning in Cervical Cancer Survivors
Objectives: Primary Objectives: To assess the entire range of sexual functioning (desire, arousal, orgasmic capacity, dyspareunia, and sexual satisfaction) over the course of treatment and early follow-up in patients with local…
- Trial name
- NCT00522223
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer, Uterine Cervical Cancer
FDG Tumor Heterogeneity During Chemoradiation as a Predictor of Response in Patients With Cervical Cancer
In this study, 50 evaluable patients will undergo one FDG-PET study during their chemoradiation, in addition to the standard of care pretreatment and 3-month post-treatment clinical FDG-PET/CT or FDG-PET/MR scans.
- Conditions
- Cervical Cancer, Uterine Cervical Cancer, Uterine Cervical Neoplasms
- Trial name
- NCT02317302
- Testing
- FDG-PET/MR, FDG-PET/CT
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Washington University School of Medicine