Clinical trials: Cervical Cancer Radiation Complications
Lung Cancer, Esophageal Cancer
A Multi Tumor, Open Phase I Clinical Study on the Progression of First-line Anti-tumor Therapy Using Cardonizumab Combined With Pulsed Low-dose Rate External Irradiation (PLDR)
At present, the treatment methods for recurrent cancers are very limited. The immune checkpoint inhibitors (ICBs) is a promising new directions for recurrent lung cancer/ esophageal cancer / cervical cancer, but the clinical…
- Conditions
- Lung Cancer, Esophageal Cancer, Cervical Cancer
- Trial name
- NCT06232083
- Testing
- PLDR+Cardunizumab
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
Uterine Cancer, Cervical Cancer
Effectiveness of an Individualized Symptom Education Program (ISEP)
The purpose of this study is to examine whether an Individualized Symptom Education Program (ISEP) is helpful to women to manage their symptoms when they are receiving radiation therapy for gynecological cancer.
- Conditions
- Uterine Cancer, Cervical Cancer, Vaginal Cancer, Vulvar Cancer
- Trial name
- NCT00275353
- Testing
- Individualized Symptom Education
- Where
- Canada
- Volunteers
- 144 people
- Sponsor
- University of Toronto
Esophageal Cancer, Gastric Cancer
The Effect of Nutritional Counseling for Cancer Patients
Background and aims: Cancer-related malnutrition is multifactorial and related to a bad prognosis. The aim of this study was to investigate the effect of intensive, individual dietary counseling of patients in radiotherapy and/or…
- Conditions
- Esophageal Cancer, Gastric Cancer, Uterine Cancer
- Trial name
- NCT01962272
- Testing
- Weekly nutritional counseling, Forticare®.
- Where
- Denmark
- Volunteers
- 61 people
- Sponsor
- University of Copenhagen
Cervical Cancer
Inactivated KAWAI Bacteria for Diarrhea Prevention During Pelvic Radiotherapy in Postoperative Cervical Cancer
This is a multicenter, randomized, double-blind, placebo-controlled study. The purpose of this study is to evaluate whether an oral probiotic supplement (KAWAI inactivated bacteria) can reduce the side effects (especially…
- Trial name
- NCT07900477
- Testing
- KAWAI powder
- Volunteers
- 100 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Melanoma, Medullary Thyroid Cancer
Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors
Phase I study to examine safety of the addition of concurrent tarlatamab with standard palliative and consolidative RT regimens , with a main cohort of N=20-24 patients with extracranial anatomic radiation sites.
- Conditions
- Melanoma, Medullary Thyroid Cancer, Sinonasal Undifferentiated Carcinoma, Esthesioneuroblastoma
- Trial name
- RABBIT (NCT06814496)
- Testing
- Tarlatamab, Concurrent Radiation Therapy, Sequential Radiation therapy
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Arizona
Recurrent Gynecologic Cancer, Recurrent Uterine Cancer
Reirradiation and Total Ablative Strategies for Recurrent Gynecologic Cancer
REGYNERA(dia)TION is an international, multicenter, ambispective observational patient registry of adults with recurrent gynecologic malignancies after prior radiotherapy who are treated or planned for reirradiation and/or total…
- Conditions
- Recurrent Gynecologic Cancer, Recurrent Uterine Cancer, Recurrent Cervical Cancer, Recurrent Vaginal Cancer
- Trial name
- Regynera-RT (NCT07667192)
- Testing
- Reirradiation, Total Ablative Strategy
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Affidea Nu-med Center of Oncological DIagnostics and Therapy
Cervical Cancer
An Exploratory Study of Using Magnetic Resonance Prognostic Imaging Markers for Radiotherapy In Patients With Cervix Cancer (EMPIRIC Study)
Patients with cervical cancer that has not spread to other parts of the body can be cured with radiotherapy. One of the reasons radiotherapy can fail is because there are areas within the tumour that have a poor oxygen supply…
- Trial name
- EMPIRIC (NCT05532930)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- East and North Hertfordshire NHS Trust
Uterine Cervical Neoplasms
A Pilot Study of Radiation-Immune Cell Combination Therapy in Cervical Cancer
Among the immune cell therapy, autologous adoptive immune cell therapy is a method to transfer the immune cells derived from peripheral white blood cells and expanded and stimulated with various cytokines and tumor specific…
- Trial name
- NCT01194609
- Testing
- Immune cell, Low dose radiation
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Korea Cancer Center Hospital
Cervical Cancer
Weekly IV Topotecan and Cisplatin With Radiation in Cervical Carcinoma
There will be approximately 14,000 new patients with invasive cervical cancer diagnosed in the United States in 2003 with about 4,000 deaths from this disease.
- Trial name
- NCT00257816
- Testing
- Topotecan, Cisplatin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, Irvine
Radiotherapy, Immunotherapy
NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy
The 1100 study is an open-label, Phase I, dose escalation and expansion prospective clinical study to assess the safety of intratumoral injection of NBTXR3 activated by radiotherapy in combination with anti-PD-1 therapy.
- Conditions
- Radiotherapy, Immunotherapy, Microsatellite Instability-High Solid Malignant Tumour, Metastasis From Malignant Tumor of Liver
- Trial name
- NCT03589339
- Testing
- NBTXR3, SABR, Nivolumab
- Where
- 13 sites in United States
- Volunteers
- 145 people
- Sponsor
- Nanobiotix
Cervix Cancer
CRP on Radiobiological and Clinical Studies on Viral-Induced Cancer's Response to Radiotherapy
The purpose of this trial is to study clinical effects of two/four high dose rate (HDR) brachytherapy applications and teletherapy with or without weekly cisplatin in cervix cancer.
- Trial name
- NCT00122772
- Testing
- Radiotherapy, Radiotherapy/Cisplatin
- Where
- 11 sites in Austria, Brazil and 9 more
- Volunteers
- 601 people
- Sponsor
- International Atomic Energy Agency
Cervix Cancer
Prediction of Clinical Response and Outcome in Uterine Cervix Cancer
Observational study based on the routine clinical treatment and diagnostic course, to correlate imaging features with outcome objectives.
- Trial name
- NCT01764217
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Maastricht Radiation Oncology
Cervical Cancer, Advanced Cancer
TSR-042 as Maintenance Therapy for Patients With High-risk Locally Advanced Cervical Cancer After Chemo-radiation
Patients with locally advanced cervical cancer (LACC) despite definitive chemo-radiotherapy, has a poor progression-free survival (PFS) and overall survival (OS).
- Trial name
- ATOMICC (NCT03833479)
- Testing
- No Further Treatment, TSR-042
- Where
- 29 sites in Spain, Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Grupo Español de Investigación en Cáncer de Ovario
Cervical Cancer
Cisplatin and Radiation Therapy With or Without Hyperthermia Therapy in Treating Patients With Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00085631
- Testing
- cisplatin, hyperthermia treatment, brachytherapy
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Mark Dewhirst
Cervical Adenocarcinoma, Cervical Adenosquamous Cell Carcinoma
Cisplatin and Radiation Therapy With or Without Tirapazamine in Treating Patients With Cervical Cancer
This randomized phase III trial is studying cisplatin, radiation therapy, and tirapazamine to see how well they work compared to cisplatin and radiation therapy in treating patients with cervical cancer.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Cell Carcinoma, Cervical Squamous Cell Carcinoma, Stage IB Cervical Cancer
- Trial name
- NCT00262821
- Testing
- cisplatin, tirapazamine
- Where
- 282 sites in United States, Canada
- Volunteers
- 402 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer
Prospective Evaluation of Intrafractional and Interfractional Cervical Motion During External Beam Radiation for Intact Cervical Cancer by the Calypso® 4D Localization System™
The purpose of this study is to find out how the cervix normally moves during radiation treatment. This study will also evaluate how cervical cancer shrinks during chemotherapy and radiation.
- Trial name
- NCT00907634
- Sponsor
- Emory University
Cervical Cancer
BrUOG 355: Nivolumab to Tailored Radiation Therapy With Concomitant Cisplatin in the Treatment of Patients With Cervical Cancer
This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of the investigational drug in combination with radiation to learn whether the drug(s) works in treating a specific…
- Trial name
- NCT03527264
- Testing
- Nivolumab induction, Cisplatin, Radiation
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Brown University
Cervical Cancer
Orcellex® Brush Versus Cervex-Brush® on Vault Smear Adequacy in Patients Treated With Radiotherapy for Cervical Cancer
Vaginal vault cytology is commonly used for follow-up surveillance in patients treated for cervical cancer. It is known that the smear inadequacy rate is high, especially in patients post-radiotherapy at 10%.
- Trial name
- NCT04461574
- Testing
- Orcellex Brush, Cervex Brush
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- Princess Margaret Hospital, Hong Kong
Esophagus Cancer, Esophagogastric Junction Cancer
Phase II/III Study Comparing Chemoradiotherapy With Radiotherapy in Elderly Patients With Esophageal or Esophagogastric Cancer - 3JECROG P-01
Ratiotherapy alone is the current standard treatment for elderly esophageal or esophagogastric cancer in China. And Little is known about chemoradiotherapy (CRT) in elderly patients.
- Conditions
- Esophagus Cancer, Esophagogastric Junction Cancer, Radiotherapy; Complications, Chemoradiation
- Trial name
- NCT02979691
- Testing
- SIB-IMRT, S-1
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Chinese Academy of Medical Sciences
Cervical Cancer, Stage IB Cervical Cancer
Proton Beam Radiation Therapy and Cisplatin in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer and Positive Lymph Nodes
RATIONALE: Specialized radiation therapy, such as proton beam radiotherapy, that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Conditions
- Cervical Cancer, Stage IB Cervical Cancer, Stage IIA Cervical Cancer, Stage IIB Cervical Cancer
- Trial name
- NCT01019278
- Testing
- proton beam radiation therapy, radiation therapy treatment planning/simulation, cisplatin
- Sponsor
- Abramson Cancer Center at Penn Medicine