Clinical trials: Cervical Cancer Radiation Complications
Chemotherapy, Treatment Compliance
Cervical Cancer Oligo States (Recurrence, Metastasis) Multicentre Outcomes Study.
Systemic chemotherapy with or without palliative radiation represents the current standard of care in patients with recurrent or metastatic cervix cancer.
- Conditions
- Chemotherapy, Treatment Compliance, Radiotherapy, Cervix Cancer
- Trial name
- Retro-COSMOS (NCT07400809)
- Testing
- Not applicable- observational study
- Where
- India
- Volunteers
- 350 people
- Sponsor
- Tata Memorial Hospital
Malignant Neoplasm, Malignant Neoplasm of Rectum
Dietary Fiber During Radiotherapy - a Placebo-controlled Randomized Trial
The investigators hypothesize that an increase in dietary fiber intake during radiation therapy may provide better long-term intestinal health for the cancer survivor.
- Conditions
- Malignant Neoplasm, Malignant Neoplasm of Rectum, Malignant Neoplasm of Anus, Malignant Neoplasm of Urinary Bladder
- Trial name
- FIDURA (NCT04534075)
- Where
- Sweden
- Volunteers
- 354 people
- Sponsor
- Sahlgrenska University Hospital
Cervical Cancer
Feasibility Study of the Xoft® Axxent® Electronic Brachytherapy System for the Treatment of Cervical Cancer
The purpose of this study is to evaluate the safety, performance and usability of the Xoft Axxent Electronic Brachytherapy System and Cervical Applicator as incorporated into the physician's current standard treatment practice…
- Trial name
- NCT01851772
- Testing
- Treatment with Electronic Brachytherapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Xoft, Inc.
Uterine Cancer, Cervical Cancer
Intensity Modulated Radiotherapy (IMRT) for the Pelvis Post-Hysterectomy
The goal of this clinical research study is to use CT scans to find any changes in position of the vagina and pelvic lymph node areas during the course of IMRT radiation therapy.
- Conditions
- Uterine Cancer, Cervical Cancer, Endometrial Cancer
- Trial name
- NCT00508703
- Testing
- Intensity Modulated Radiotherapy (IMRT), CT Scan
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer
Spatially Fractionated Radiation Therapy for Locally Advanced Cervical Cancer
This randomized clinical trial will evaluate whether adding spatially fractionated radiation therapy (SFRT) to definitive chemoradiotherapy improves outcomes in patients with locally advanced cervical cancer.
- Trial name
- SFRT-LACC (NCT07781475)
- Testing
- Spatially Fractionated Radiation Therapy, standard of care
- Where
- China
- Volunteers
- 126 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Astrocytoma, Brain Cancer
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S
This is a multi-center, open-label, dose escalation study to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and maximum tolerated dose (MTD) of QBS10072S in patients with advanced or metastatic cancers…
- Conditions
- Astrocytoma, Brain Cancer, Brain Metastases, Bladder Cancer
- Trial name
- NCT04430842
- Testing
- QBS10072S
- Where
- 2 sites in Australia
- Volunteers
- 15 people
- Sponsor
- Quadriga Biosciences, Inc.
Cervical Cancer
Magnetic Resonance Imaging (MRI) Brachytherapy Applicator Study
The goal of this clinical research study is to learn if computed tomography (CT) and magnetic resonance imaging (MRI) images can better help to plan internal radiation treatment.
- Trial name
- NCT01706705
- Testing
- Intracavitary Applicator Placement, Computed Tomography (CT), Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer, Radiotherapy
A Predictive Model for Early Metastasis in Cervical Cancer Patients After Radiotherapy
This study aims to help to screen out appropriate cases for consolidation therapy and more intensive follow up.
- Conditions
- Cervical Cancer, Radiotherapy, Distant Metastasis, Prognostic Model
- Trial name
- NCT06101966
- Testing
- external pelvic beam radiotherapy (EBRT) followed by individualized high-dose-rate intracavitary brachytherapy (HDR-ICBT)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Fujian Cancer Hospital
Healthy Volunteers, Pancreatic Ductal Adenocarcinoma
Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer or Other Solid Tumors
This is a Phase 1a, open label, single dose, extended study of safety and biokinetics of RAD301 in healthy human volunteers and individuals with PDAC or Other Solid Tumors
- Conditions
- Healthy Volunteers, Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer (NSCLC), Esophageal Squamous Cell Carcinoma
- Trial name
- RAD301 (NCT05799274)
- Testing
- RAD301 ([68Ga]-RAD301)
- Where
- 2 sites in United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Radiopharm Theranostics, Ltd
Esophageal Cancer
A Trial of Palliative Chemotherapy, Radiation and Immune Treatment for Oesophageal Cancer: PALEO Study
The purpose of this study is to investigate the effects of the addition of the stereotactic body radiotherapy and durvalumab to a well tolerated 2 week chemotherapy and radiation treatment regimen in people with esophageal cancer…
- Trial name
- PALEO (NCT06290505)
- Testing
- Durvalumab
- Where
- 9 sites in Australia, New Zealand
- Volunteers
- 54 people
- Sponsor
- Australasian Gastro-Intestinal Trials Group
Cervix Neoplasm
Low-Dose Taxotere® (Docetaxel) With Concurrent Radiotherapy For Localized, Inoperable Carcinoma Of The Uterine Cervix
The purpose of this study is to find out how effectively cervix cancer is controlled when radiation is combined with low-dose chemotherapy (Taxotere) .
- Trial name
- NCT00178269
- Testing
- docetaxel, Radiation Therapy
- Where
- United States
- Sponsor
- University of Rochester
Cervical Cancer, Female Sexual Dysfunction (FSD)
Biofeedback-Assisted Pelvic Floor Rehabilitation for Radiation-Induced Sexual Dysfunction in Cervical Cancer Survivors
This randomized controlled trial aims to evaluate the efficacy of biofeedback-assisted pelvic floor muscle training on radiation-induced sexual dysfunction in cervical cancer survivors following pelvic radiotherapy.
- Conditions
- Cervical Cancer, Female Sexual Dysfunction (FSD), Radiation Induced Pelvic Floor Muscle Dysfunction
- Trial name
- NCT07597083
- Testing
- Biofeedback-Assisted Pelvic Floor Muscle Rehabilitation, Conventional Pelvic Floor Muscle Training
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Cervical Cancer, Endometrial Cancer
CerviPrep for Applying Topical Gemcitabine to the Cervix in Treating Patients With Primary Endometrial, Cervical, or Ovarian Epithelial Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Cervical Cancer, Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT00610740
- Testing
- topical gemcitabine hydrochloride, therapeutic conventional surgery
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Uterine Cervical Neoplasms
Sexual Function, Coping and Dyadic Coping in Patients With Cervical Cancer
The studies currently available in the literature about sexual function and coping in cervical cancer are poor and heterogeneous, and their results are often conflicting; therefore, no definitive recommendations can be…
- Trial name
- SUCCEEDER (NCT06124040)
- Testing
- psychological assessment evaluation
- Where
- Italy
- Volunteers
- 154 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Head and Neck Cancer, Chronic Periodontitis
suPAR is a Potential Biomarker of in Chronic Periodontitis Through the Impact of Post-radiotherapy on HNCs Patients
This study aims to improve a soluble urokinase plasminogen activator receptor suPAR is a reliable biomarker of chronic periodontitis and may be replaced in patients with head and neck cancer post-radiotherapy (HNC post-RT).
- Conditions
- Head and Neck Cancer, Chronic Periodontitis, Radiotherapy; Complications
- Trial name
- HNCs (NCT06481059)
- Testing
- Head and Neck cancer post-radiotherapy
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Al-Maarif University College
Head and Neck Cancer, Oral Complications of Radiation Therapy
Radiation Therapy With or Without Chemotherapy in Reducing Mouth Dryness in Patients With Nasopharyngeal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Giving radiation therapy in different ways may cause less damage to normal tissue, prevent or lessen mouth dryness, and may help patients live more…
- Conditions
- Head and Neck Cancer, Oral Complications of Radiation Therapy, Radiation Toxicity
- Trial name
- NCT00057785
- Testing
- cisplatin, fluorouracil, Intensity modulated radiation therapy
- Where
- 17 sites in United States
- Volunteers
- 68 people
- Sponsor
- Radiation Therapy Oncology Group
Cervical Cancer
Intermediate Risk Cervical Cancer: Radical Surgery +/- Adjuvant Radiotherapy
The objective of the trial is to evaluate if adjuvant (chemo)radiation is associated with a disease-free survival benefit after radical surgery in patients with intermediate risk cervical cancer.
- Trial name
- CERVANTES (NCT04989647)
- Testing
- No adjuvant therapy, Adjuvant radiotherapy
- Where
- Czechia
- Volunteers
- 514 people
- Sponsor
- The Central and Eastern European Gynecologic Oncology Group
Cervical Cancers
Serplulimab With Chemoradiotherapy for Postoperative Cervical Cancer With Risk Factors
A Phase II Study of Serplulimab Plus Chemoradiotherapy as Adjuvant Treatment for Postoperative Cervical Cancer with Multiple Risk Factors
- Trial name
- NCT06727617
- Testing
- Serplulimab, Chemotherapy, radiotherapy
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Head and Neck Cancer, Radiation Therapy Complication
Surface Monitoring Technology to Remove The Mask - Stage 1
A pilot-stage device feasibility study investigating a mask-free motion-monitoring patient immobilisation system for use during radiation therapy treatment of head and neck cancer (HNC).
- Conditions
- Head and Neck Cancer, Radiation Therapy Complication, Anxiety
- Trial name
- SMART (NCT04266223)
- Testing
- Mask-free surface monitoring
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- University of Sydney
Cervical Cancer
Usefulness of FDG-PET for Advanced Cervical Cancer
The objective of this study is to determinate whether the adding of FDG-PET is helpful in the treatment of advanced cervical cancer with concurrent chemoradiation.
- Trial name
- NCT00146458
- Testing
- 18F-fluorodeoxyglucose positron emission tomography
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital