Clinical trials: Cervical Cerclage
Cerclage, Cervical
ED90 of 3% Chloroprocaine for Cervical Cerclage
The aim of this study is to identify the dose of intrathecal (IT) chloroprocaine that provides effective anesthesia in 90% of patients undergoing elective cerclage placement (intraoperative analgesic supplementation not required).
- Trial name
- NCT03805438
- Testing
- Chloroprocaine Hcl 3% Inj
- Where
- 2 sites in United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Duke University
Twin Pregnancy With Antenatal Problem
Cerclage and Progesterone for Twin Pregnancies
Twin pregnancies face a high risk of complications, most notably preterm birth (delivery before 37 weeks), which is a major cause of infant death and illness globally.
- Trial name
- NCT07319715
- Testing
- McDonald Cervical Cerclage, Vaginal Progesterone Therapy (VPT)
- Where
- Egypt
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Benha University
Cervical Incompetence
Prolene Versus Ethibond for Cervical Cerclage
The purpose of the proposed study is to examine the relationship between cerclage suture material of Ethibond and Prolene and its effect on the vaginal microbiome in a prospective randomized control trial.
- Trial name
- PECC (NCT03311867)
- Testing
- Ethibond Suture, Prolene Suture
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Cerclage, Cervical, Cervical Insufficiency
Long-Term Patient-Reported Maternal Outcomes Following Abdominal Cerclage for the Prevention of Preterm Birth
This study aims to explore the maternal patient reported outcomes on pelvic pain sexual health anxiety and depression bladder discomfort foreign body sensation trust in the cerclage, and how these parameters affect the general…
- Trial name
- NCT06875401
- Testing
- Abdominal cerclage (open or laparoscopic)
- Where
- Denmark
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Preterm Birth, Twin Pregnancy With Antenatal Problem
Prophylactic Cerclage for Twin Pregnancy With Shortened Cervix
This randomized controlled trial is aimed to evaluate pregnancy and neonatal outcomes in twin pregnancies, in which a cervical cerclage is placed due to the shortening of the cervix with or without visible fetal membranes.
- Conditions
- Preterm Birth, Twin Pregnancy With Antenatal Problem, Cervical Shortening
- Trial name
- NCT05338164
- Testing
- cervical cerclage
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Preterm Birth
Efficacy Study of a Cervical Pessary Containing Progesterone for the Prevention of Preterm Delivery
Assess the efficacy of 2 Cervical Pessaries containing 6.3 g and 7.7 g micronized progesterone for the prevention of preterm delivery, established through spontaneous birth before gestation weeks 32 (31 weeks and 6 days) and 34…
- Trial name
- PCP002 (NCT02225353)
- Testing
- Progesterone Cervical Pessary 6.3 g, Progesterone 200 mg vaginal capsules, Progesterone Cervical Pessary 7.7 g
- Where
- 4 sites in Chile
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Cervical Insufficiency, Preterm Birth
Investigation Into the Microorganisms in Pregnant Women
Pregnant women with short cervical length (<25 mm) in second-trimester ultrasonographic assessment are at high risk for preterm birth, a major cause of perinatal mortality and morbidity worldwide.
- Trial name
- NCT04688866
- Testing
- Sequencing
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Preterm Labor, Cervical Incompetence
Cervical Cerclage for Singleton Pregnant on Vaginal Progesterone With Progressive Cervical Length Shortening
The aim of this study is to Determine whether cerclage with vaginal progesterone will: 1. Reduce the overall spontaneous preterm birth rate. 2. Prolong pregnancy latency. 3. Improve neonatal outcome.
- Trial name
- NCT03837288
- Testing
- Cerclage
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Preterm Birth, Twin Pregnancy, Antepartum Condition or Complication
Prophylactic Cervical Cerclage in Twin Pregnancies With Non-shortened Cervix
This randomized controlled trial is aimed to assess the protective value of prophylactic cervical cerclage against preterm birth in twin pregnancies with history of one or more preterm births without having cervical shortening in…
- Conditions
- Preterm Birth, Twin Pregnancy, Antepartum Condition or Complication, Cervical Cerclage
- Trial name
- NCT05334264
- Testing
- Cervical cerclage
- Where
- Egypt
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Zagazig University
High Risk Pregnancy, Incompetent Cervix
Amniotic Fluid Sludge in Cerclage Patients as an Indicator for Increased Risk of Preterm Delivery and Neonatal Outcome.
Amniotic Fluid "Sludge" Does Not Increase Risk of Preterm Delivery in Cerclage Patients.
- Conditions
- High Risk Pregnancy, Incompetent Cervix, Cerclage, Amniotic Fluid Sludge
- Trial name
- NCT00722085
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Center For Maternal Fetal Medicine
The Primary Outcome is Preterm Delivery Before 28 Weeks Gestational Age Compared to Women With One vs Two Cerclages Placed
Single Versus Double Suture Cervical Cerclage to Prevent Preterm Birth
Cerclage placement is known to be beneficial in prevention of preterm birth when placed inn a certain subset of patients. Clinically, the number of sutures can also vary by surgeon preference to one or two sutures in one…
- Trial name
- NCT04742647
- Testing
- Double cerclage, Single cerclage
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Pre-term Birth
fFN Clinical Evaluation in Asymptomatic Women at High Risk for Preterm Birth
This study is designed to determine if quantitative analysis of fetal Fibronectin (fFN) can be used to advance prediction of spontaneous preterm birth (sPTB).
- Trial name
- NCT01955148
- Where
- 16 sites in United States
- Volunteers
- 1,210 people, healthy volunteers welcome
- Sponsor
- Hologic, Inc.
Premature Birth
Cerclage On LOw Risk Singletons: Cervical Cerclage for Prevention of Spontaneous Preterm Birth in Low Risk Singleton Pregnancies With Short Cervix
The aim of this study is to evaluate the efficacy of cervical cerclage in prevention of spontaneous preterm birth in singleton pregnancies with a short transvaginal cervical length (<=25mm) and without prior spontaneous preterm…
- Trial name
- COLORS (NCT03251729)
- Testing
- Cervical cerclage, Vaginal progesterone
- Where
- 3 sites in United States, Italy
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Cervical Cerclage, Premature Birth
Perioperative Use of Atosiban for Ultrasound-indicated Cerclage to Reduce Spontaneous Preterm Birth(sPTB)
After ultrasound-indicated cerclage, some pregnant women still experience sPTB, and there is controversy regarding the use of tocolytic agents during the perioperative period to reduce the incidence of sPTB.
- Trial name
- sPTB (NCT06537778)
- Testing
- Atosiban, Normal saline
- Where
- 2 sites in China
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Chongqing Medical University
Preterm Birth, Obstetric Labor, Premature
Azithromycin to Improve Latency in Exam Indicated Cerclage Control Trial
Azithromycin is an antibiotic that is effective against bacteria that been associated with preterm birth (PTB). The purpose of this study is to evaluate if the addition of azithromycin prior to exam indicated cerclage prolongs…
- Conditions
- Preterm Birth, Obstetric Labor, Premature, Obstetric Labor Complications, Pregnancy Complications
- Trial name
- ALEC (NCT05132829)
- Testing
- Azithromycin 1 gram IV, Cefazolin and indomethacin
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Preterm Birth, Short Cervical Length
The Impact of Vaginal and IM Progestins on the Cervix
The purpose of this study is to analyze how the body handles and responds to progesterone treatment in parous and nulliparous women at risk of pre-term birth.
- Trial name
- NCT01954095
- Where
- 4 sites in United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Premature Birth
LATe Cerclage in High-risk Pregnancies (LATCH)
The goal of this clinical trial is to determine whether cervical cerclage reduces the risk of preterm birth in patients with a short transvaginal ultrasound (TVU) cervical length (CL) ≤25mm between 24 0/7-26 6/7 weeks.
- Trial name
- LATCH (NCT06036446)
- Testing
- Cervical cerclage, Vaginal Suppository Progesterone
- Where
- 2 sites in United States
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Cervical Insufficiency
Relation of the Area of Cerclage With Preterm Birth
This study is planned prospectively in pregnancies who applied to Etlik Zübeyde Hanım Women's Health Care, Training and Research Hospital which is a teritiary hospital with 15.000 births anually, between January 2022 and January…
- Trial name
- NCT05220839
- Testing
- Type of cerclage procedure Mc Donald
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Cervical Incompetence
Comparison of Anesthesia Type in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC)
The investigator aimed to compare the effect of anesthesia on overall postoperative outcomes including post-operative pain score and the fetal well-being (heart rate) in patients undergoing transabdominal cervico isthmic…
- Trial name
- NCT03636048
- Testing
- Bupivacaine Hcl 0.5% Inj, Propofol 10 milligram/ML
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2
Cerclage for Twins With Short Cervix
A prospective randomized control trial that will compare cervical cerclage plus vaginal progesterone to vaginal progesterone along in twin pregnancies complicate by a short cervix (</= 15.0mm) between 16w0d to 25w6d.
- Conditions
- Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2, Cervical Incompetence, Cervical Shortening
- Trial name
- NCT03077633
- Testing
- Cervical Cerclage placement, Vaginal Progesterone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pediatrix