Clinical trials: Cervical Dilation
Abortion, Second Trimester
24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E
This study aims to compare mifepristone and buccal misoprostol to mifepristone and vaginal misoprostol for cervical preparation for second trimester dilation and evacuation (D\&E).
- Trial name
- NCT03134183
- Testing
- Vaginal Misoprostol, Buccal Misoprostol
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Uterine Hemorrhage
Hysteroscopy and Misoprostol Project
To investigate if self-inserted vaginal misoprostol prior to outpatient hysteroscopy will lead to satisfactory cervical ripening, compared to placebo.
- Trial name
- NCT00363389
- Testing
- misoprostol and cervical ripening
- Where
- Norway
- Volunteers
- 86 people
- Sponsor
- Ullevaal University Hospital
Obstetrics, Labor
Clinical Evaluation of New Computerized Labor Monitoring System
The study is an open label feasibility study. The purpose of the study is to evaluate the ease of use of the Cervical ITR in terms of duration of attachment and number of detachments.
- Trial name
- CLM (NCT00496899)
- Where
- Israel
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Barnev Ltd
Cervical Dilation Prior to Dilation and Evacuation
Same-day Cervical Preparation Before Dilation and Evacuation
The purpose of this randomized trial is to compare same-day cervical preparation using Dilapan-S™ plus buccal misoprostol to overnight cervical preparation using Dilapan-S™ before D\&E at 16.0 to 20.0 weeks.
- Trial name
- NCT03002441
- Testing
- Same-Day Dilapan-S, Overnight Dilapan-S
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Greater New York
Esophageal Cancer
Clinical Efficacy and Safety of Endoscopic Dilatation With Eso-Filp in Benign Esophageal Strictures
Benign esophageal strictures are frequently seen in endoscopic practice and are caused by a variety of esophageal disorders, including peptic, radiotherapy-induced and caustic injuries, Schatzki ring, eosinophilic esophagitis…
- Trial name
- ESO-FLIP (NCT05725473)
- Testing
- Eso-Flip
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Clinico Humanitas
Cervix Uteri Dilation
Effectiveness and Safety Evaluation of Aqueduct 100-device
Evaluation of efficacy and safety of using Aqueduct -100 - Cervical Dilator Device, focusing on diagnostic or operative hysteroscopies.
- Trial name
- NCT02959567
- Testing
- Aqueduct 100 dilation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Aqueduct Medical Ltd
Pain Management, Cervical Preparation
Self-administered Lidocaine Gel for Pain-control During Cervical Preparation for Dilation and Evacuation
This study seeks to compare self-administered lidocaine gel for pain control during cervical preparation for dilation and evacuation (D\&E) to paracervical block.
- Trial name
- NCT02852434
- Testing
- Lidocaine Gel (2%), Lidocaine Paracervical Block (1%)
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cervical Dilation
Balloon Catheter for Cervical Ripening
Once admitted, women who will have a transcervical balloon catheter inserted for induction will be approached for participation in this study.
- Trial name
- 25148 (NCT02606643)
- Testing
- Slight traction, Foley Catheter to no traction
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- St. Louis University
Abortion, Second Trimester, Procedural Pain
Cervical Preparation for Same-Day Dilation & Evacuation
This is a noninferiority randomized control trial of two cervical preparation methods prior to same-day Dilation \& Evacuation (D\&E). Cervical preparation is a process that softens and dilates the cervix prior to a procedure.
- Conditions
- Abortion, Second Trimester, Procedural Pain, Procedural Complication
- Trial name
- NCT06799052
- Testing
- Transcervical single-balloon catheter, Synthetic osmotic dilators
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
First Trimester Pregnancy, Surgical Termination of Pregnancy
Misoprostol for Cervical Priming Prior to Vacuum Aspiration
Despite of the widespread use, and extensive studies, the optimal route of administration of misoprostol before surgical abortion remains to be defined.
- Trial name
- NCT01933360
- Testing
- Misoprostol sublingual, 1h, Misoprostol sublingual, 3h, Misoprostol vaginal, 1h
- Where
- Sweden
- Volunteers
- 184 people
- Sponsor
- Karolinska Institutet
Abortion, Induced
Dilapan-S / Dilasoft E-Registry in Induced Abortion
International Observational E-Registry on the use of osmotic dilators DILAPAN-S® / DILASOFT® for cervical priming prior to induced abortion.
- Trial name
- DSREGISTRYIA (NCT02318212)
- Testing
- Dilapan-S
- Volunteers
- 439 people
- Sponsor
- Medicem International CR s.r.o.
Cervical Ripening
Hysteroscopy After Pretreatment With Misoprostol and Estradiol Trial
The aim of this study is to investigate whether 1000 micrograms of self-administered vaginal misoprostol 12 hours before operative hysteroscopy results in effective preoperative cervical ripening after two weeks pretreatment with…
- Trial name
- NCT00572819
- Testing
- Misoprostol
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Ullevaal University Hospital
Cervical Ripening, Labor, Induced
A Randomized Study on Comparing the Efficacy of Foley Catheter and Extraamniotic Saline Infusion for Labor Induction
Our purpose was to compare the efficacy and safety of Foley catheter with oxytocin and extraamniotic saline infusion with oxytocin for induction of labor requiring cervical ripening.
- Trial name
- NCT00366951
- Testing
- Foley catheter only, Extraamniotic saline infusion
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rush University Medical Center
Contraception
Misoprostol With Intrauterine Device Insertion
The purpose of this study is to see if using misoprostol (a medication that softens the cervix) before placing an intrauterine device for contraception reduces pain in women who have never delivered a baby.
- Trial name
- NCT00613366
- Testing
- Misoprostol, Magnesium Oxide
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cervical Preparation Prior to Dilation and Evacuation
RCT of Cervical Ripening Double Ballon Catheter Prior to Dilation and Evacuation.
The purpose of this study is to determine whether the overnight use of an FDA-cleared CRDB catheter is superior to the use of overnight osmotic dilators as is standard of care cervical preparation for patients presenting for…
- Trial name
- CRDB RCT (NCT07200115)
- Testing
- Cervical Ripening Double Balloon (CRDB) Catheter, Osmotic Dilators
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Preterm Birth
Labor Characteristics and Maternal-Infant Outcomes in Preterm Primiparous Women
This retrospective observational study evaluates labor characteristics in primiparous women with spontaneous preterm birth at different gestational ages and examines their associations with maternal and neonatal outcomes.
- Trial name
- NCT07844499
- Testing
- Gestational Age at Delivery
- Where
- China
- Volunteers
- 436 people
- Sponsor
- Maternal and Child Health Hospital, Jiading District
Legally Induced Abortion Without Mention of Complication
Mifepristone Versus Osmotic Dilators in Conjunction With Misoprostol for Cervical Preparation Prior to D&E at 14-19 Weeks
Dilation and evacuation (D\&E) is a common surgical procedure in the U.S. Adequate pre-operative preparation of the uterine cervix is an important part of preventing complications of the procedure.
- Trial name
- NCT02679092
- Testing
- Misoprostol, Mifepristone, Hygroscopic cervical dilators
- Where
- United States
- Sponsor
- Stanford University
Abortion Early
Dry vs Wet Misoprostol for Cervical Dilation in First Trimester Abortion
This study aims to verify whether the moisture of 400 µg of misoprostol pre uterine evacuation increases the dilatation of uterine cervix compared to dry misoprostol
- Trial name
- MisoWet (NCT02522078)
- Testing
- dry misoprostol, wet misoprostol
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Induced Abortion, Abortion Techniques
Mifepristone Versus Misoprostol for Cervical Preparation Prior to Surgical Abortion Between 11 to 15 Weeks
Surgical abortion in the late first trimester and early second trimester is usually performed with the aid of a cervical preparing agent, which helps to open up the uterine cervix for the procedure.
- Conditions
- Induced Abortion, Abortion Techniques, Mifepristone, Misoprostol
- Trial name
- MIMI11-15 (NCT01636063)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Boston University
Cervix Uteri Dilation
Effectiveness and Safety Evaluation of Aqueduct -100 Device
The purpose of the present clinical investigation is to collect data regarding the safety and effectiveness of the Aqueduct 100 device.
- Trial name
- NCT02851953
- Testing
- Aqueduct-100
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- Aqueduct Medical Ltd