Clinical trials: Cervical Dilation
Abortion, Induced
Cervical Preparation Before Dilation and Evacuation
The purpose of this research study is to compare three different ways of opening a woman's cervix before her second-trimester surgical abortion.
- Trial name
- NCT01751087
- Testing
- Mifepristone, misoprostol, Osmotic dilators
- Where
- 7 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Pain
12 Versus 20 mL PCB for D&E Cervical Prep
More research is needed to investigate methods of pain control for cervical preparation for abortion procedures. Women report pain with paracervical block injection as well as with osmotic dilator placement.
- Trial name
- NCT03356145
- Testing
- 12 mL paracervical block, 20 mL paracervical block
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Stanford University
Legally Induced Abortion Without Mention of Complication
Pre-Operative Effects of Mifepristone on Dilation and Evacuation Services
This research study investigates the use of a drug, mifepristone, given before second trimester abortion. Mifepristone is a medication that is approved for medical abortion during the first trimester.
- Trial name
- POEM (NCT01862991)
- Testing
- Hygroscopic cervical dilators, Misoprostol, Intra-amniotic digoxin
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Stanford University
Cervical Priming
Efficacy and Safety Study of the Misoprostol Vaginal Priming Insert (MVPI) Prior to Hysteroscopy
A Phase II, multicenter, double-blind, randomized, placebo-controlled, dose-ranging, study to assess the efficacy and safety of the 100, 200, 400, 800, 1200 and 1600 mcg Misoprostol Vaginal Priming Insert (MVPI) for Women…
- Trial name
- NCT00925938
- Testing
- misoprostol
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Ferring Pharmaceuticals
Cervix; Pregnancy
Sound Check-Correlation Between Transperineal and Digital Cervical Exam in 3rd Trimester Pregnancy
The primary purpose of this study is to compare the accuracy of the Butterfly iQ pocket ultrasound with the digital cervical examination in the third trimester cervix.
- Trial name
- NCT05260333
- Testing
- Butterfly iQ transperineal ultrasound exam
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Pre-induction Dilation of Cervix
Induction of Labor in Women With Unfavorable Cervix: Dilapan Versus Foley Bulb
Women undergoing mechanical cervical ripening for labor induction will be randomized to Dilapan-S® versus Foley bulb. The investigators hypothesized that osmotic cervical dilators (Dilapan-S®) are as effective as Foley bulb…
- Trial name
- NCT02899689
- Testing
- Dilapan, Foley Catheter
- Where
- 2 sites in United States
- Volunteers
- 419 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Abortion, Induced
Value of Mifepristone in Cervical Preparation Prior to Dilation and Evacuation 19-24 Weeks
A common practice for preparation for surgical abortion after 19 weeks gestation is the placement of multiple sets of osmostic dilators 1-2 days prior to the procedure.
- Trial name
- NCT01615731
- Testing
- Mifepristone, Hygroscopic cervical dilators, Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Second Trimester Abortion
Laminaria Compared to Dilapan-S for Cervical Preparation Before Dilation and Evacuation at 18-24 Weeks of Gestation
Primary objective: To study the difference in dilation and evacuation (D\&E) procedure time following overnight cervical preparation with laminaria or Dilapan-S™.
- Trial name
- NCT02033083
- Testing
- Laminaria, Dilapan-S
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Greater New York
Abortion Late, Pain
Paracervical Block for Pain Control With Osmotic Dilator Placement
Cervical dilators are frequently used for preparation prior to second trimester surgical abortion. While their use decreases complications associated with surgical abortion, their placement is often uncomfortable for the patient.
- Trial name
- NCT02354092
- Testing
- Local anesthetic for tenaculum placement, Paracervical Block, Dilator Placement
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Abortion
Mifepristone Versus Laminaria Insertion for Cervical Preparation Prior to Surgical Abortion at 14-16 Weeks
Women who are requesting pregnancy termination at 14-16 weeks, who would normally have osmotic dilator insertion the day before their procedure, would be asked if they wanted to participate.
- Trial name
- SAMi (NCT00986921)
- Testing
- mifepristone 200 mg, osmotic dilator insertion
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston University
Procedural Pain, Buprenorphine
Addition of Buprenorphine to Paracervical Block for Pain Control During Osmotic Dilator Insertion
Cervical preparation with osmotic dilators is commonly used prior to dilation and evacuation (D\&E) procedures to decrease the risk of complications.
- Conditions
- Procedural Pain, Buprenorphine, Adjuvants, Anesthesia, Dilation and Evacuation
- Trial name
- ABCD&E (NCT04254081)
- Testing
- Buprenorphine 0.15 MG, Lidocaine 1% Injectable Solution
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of California, San Diego
Abortion, Second Trimester
24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E
This study aims to compare mifepristone and buccal misoprostol to mifepristone and vaginal misoprostol for cervical preparation for second trimester dilation and evacuation (D\&E).
- Trial name
- NCT03134183
- Testing
- Vaginal Misoprostol, Buccal Misoprostol
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Pain Management, Cervical Preparation
Self-administered Lidocaine Gel for Pain-control During Cervical Preparation for Dilation and Evacuation
This study seeks to compare self-administered lidocaine gel for pain control during cervical preparation for dilation and evacuation (D\&E) to paracervical block.
- Trial name
- NCT02852434
- Testing
- Lidocaine Gel (2%), Lidocaine Paracervical Block (1%)
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cervical Dilation
Balloon Catheter for Cervical Ripening
Once admitted, women who will have a transcervical balloon catheter inserted for induction will be approached for participation in this study.
- Trial name
- 25148 (NCT02606643)
- Testing
- Slight traction, Foley Catheter to no traction
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- St. Louis University
Contraception
Misoprostol With Intrauterine Device Insertion
The purpose of this study is to see if using misoprostol (a medication that softens the cervix) before placing an intrauterine device for contraception reduces pain in women who have never delivered a baby.
- Trial name
- NCT00613366
- Testing
- Misoprostol, Magnesium Oxide
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Induced Abortion, Abortion Techniques
Mifepristone Versus Misoprostol for Cervical Preparation Prior to Surgical Abortion Between 11 to 15 Weeks
Surgical abortion in the late first trimester and early second trimester is usually performed with the aid of a cervical preparing agent, which helps to open up the uterine cervix for the procedure.
- Conditions
- Induced Abortion, Abortion Techniques, Mifepristone, Misoprostol
- Trial name
- MIMI11-15 (NCT01636063)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Boston University
Cervical Dilation, Labor Pain
DilaCheck Cervical Dilation Measurement Trial
Trial to compare the interexaminer agreement between two cervical dilation examinations conducted by Labor and Delivery physicians when using standard methods versus DilaCheck device.
- Conditions
- Cervical Dilation, Labor Pain, Labor Fast, Labor; Irregular
- Trial name
- NCT03440723
- Testing
- DilaCheck, Cervical dilation examination
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Elm Tree Medical Inc.
Pain Management
Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Control During Cervical Dilator Placement Prior to Dilation and Evacuation
This study evaluates the use of Transcutaneous Electrical Nerve Stimulation (TENS) as a method of pain control during osmotic dilator insertion prior to dilation and evacuation.
- Trial name
- NCT03868787
- Testing
- TENS
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Ashley Turner, MD
Miscarriage in First Trimester
Misoprostol 400 µg Versus 200 µg for Cervical Ripening in 1st Trimester Miscarriage
Local current protocol for cervical ripening in 1st trimester miscarriage recommends 400 µg of misoprostol intravaginally 3 hours before uterine evacuation. This regime has been recommended by some international guidelines .
- Trial name
- MISO200 (NCT02957305)
- Testing
- Misoprostol 400mcg Tab, Misoprostol 200mcg Tab
- Where
- Brazil
- Volunteers
- 211 people
- Sponsor
- Hospital de Clinicas de Porto Alegre