Clinical trials: Cervical Dystonia
Cervical Dystonia
Analysis of Three-dimensional Movements of the Head in Cervical Dystonia
This study addresses postures and range of motion in cervical dystonia (Spasmodic Torticollis). It uses 3D miniature and wireless motion captures sensors, and aims to increase the understanding of the biomechanics of the movement…
- Trial name
- STAC1 (NCT02069548)
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cervical Dystonia
Open-label Extension Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia
The aim of this study is to assess longer term safety and effectiveness of Dysport®.
- Trial name
- NCT00288509
- Testing
- Botulinum toxin type A
- Where
- 18 sites in United States, Russia
- Volunteers
- 108 people
- Sponsor
- Ipsen
Cervical Dystonia
Conversion to Dysport in CD
The first line of therapy for cervical dystonia patients is botulinum toxin injections, however injection parameter determination and optimization are challenging for physicians to do.
- Trial name
- NCT04270214
- Testing
- Dysport Injectable Product
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Western University, Canada
Cervical Dystonia
Extension Study of ABP-19000 to Evaluate Safety and Efficacy of Repeat Treatments of ABP-450 in Cervical Dystonia
This Open-label Extension trial will evaluate the safety and efficacy of ABP-450 for the treatment of cervical dystonia in adults.
- Trial name
- NCT04871451
- Testing
- ABP-450
- Where
- 20 sites in United States
- Volunteers
- 51 people
- Sponsor
- AEON Biopharma, Inc.
Cervical Dystonia
Keppra for Cervical Dystonia
The purpose of this study is to evaluate if there is an improved response in CD symptoms when Keppra is used as adjunctive therapy to Botox.
- Trial name
- Keppra (NCT00760318)
- Testing
- Keppra
- Volunteers
- 17 people
- Sponsor
- University of South Florida
Dystonia
The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias
Dystonia is a disorder characterized by excessive involuntary contraction of muscles with repetitive and patterned movements. The isolated dystonias are the most common type of dystonia and include Limb dystonias (like writer's…
- Trial name
- DCP (NCT01373424)
- Where
- 42 sites in United States, Australia and 5 more
- Volunteers
- 3,265 people
- Sponsor
- Emory University
Cervical Dystonia
A Multicenter Pilot Study of Pallidal Deep Brain Stimulation for Cervical Dystonia
The purposes of this study are: to determine if bilateral pallidal deep brain stimulation results in improvement in neck postures/movements; to determine if bilateral pallidal deep brain stimulation results in improvement in…
- Trial name
- NCT00132990
- Testing
- Deep brain stimulation
- Where
- 5 sites in Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Cervical Dystonia
Safety and Tolerability of Perampanel in Cervical Dystonia
Cervical dystonia (CD) is the most common focal dystonia. Currently there are no effective oral medications for the treatment of CD.
- Trial name
- SAFE-PER-CD (NCT02131467)
- Testing
- Perampanel
- Where
- 5 sites in United States, Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto
Cervical Dystonia
Plasticity in Cervical Dystonia
This study will identify changes that occur in the part of the brain that controls hand movements in patients with cervical (neck) dystonia.
- Trial name
- NCT00323765
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cervical Dystonia, Spasmodic Torticollis
Identification of Optimal Stimulation Site for Cervical Dystonia Symptoms: An Exploratory Study
The overall objective of this application is to therapeutically target the dysfunctional premotor-motor interaction in dystonia-and to provide a focused treatment of specific anatomical networks in order to reduce side effects…
- Trial name
- NCT01859247
- Testing
- rTMS
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of New Mexico
Cervical Dystonia
Assessment of Long-term Clinical Response to BoNT in Cervical Dystonia
The goal of this retrospective, international, multi-center chart abstraction is to learn about the long-term impact of product-specific immunogenicity-related factors in different botulinum neurotoxin type A formulations in…
- Trial name
- RELY-CD (NCT05884528)
- Testing
- CC BoNT/A, CF BoNT/A, CF to CC BoNT/A
- Where
- Germany
- Volunteers
- 270 people
- Sponsor
- Merz Therapeutics GmbH
Dystonia, Cervical Dystonia
Novel Stimulation Patterns for the Treatment of Dystonia
Deep brain stimulation (DBS) is an effective surgical therapy for select Dystonia patients who are refractory to medications or who have generalized symptoms (e.g.
- Trial name
- NCT02468843
- Testing
- Biphasic DBS stimulation, Unified Dystonia Rating Scale, Burke-Fahn- Marsden scale
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Dystonia, Generalized Primary Dystonia
Deep Brain Stimulation for Cervical Dystonia
This study will evaluate the effectiveness of deep brain stimulation (DBS) in treating primary generalized dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal…
- Trial name
- NCT00105430
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia, Focal
Motor and Non-motor Symptoms in Cervical Dystonia
In this monocenter, observational, non-interventional, prospective, open label study investigators will enrol 43 CD patients from the outpatient Movement Disorders Clinic of the Department of Human Neurosciences, Sapienza…
- Trial name
- Royal (NCT04560101)
- Testing
- botulinum toxin A
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- University of Roma La Sapienza
Isolated Cervical Dystonia, Complex Dystonia
Functional MRI and DTI in the Preoperative Assessment of Dystonia
The aim of this study is to evaluate the organization of the motor circuit in a group of patients suffering from dystonia compared with a group of healthy controls.
- Conditions
- Isolated Cervical Dystonia, Complex Dystonia, Spasticity
- Trial name
- IRMF-DIFF (NCT02877836)
- Testing
- magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Cervical Dystonia
Integration of the Cervical Proprioceptive Signals in Patients With Cervical Dystonia
The purpose of this study is to compare the cervical muscular force control , taking into account the proprioceptive signals, in patients with and without cervical dystonia.
- Trial name
- STAC2 (NCT02834871)
- Testing
- Electromyogram
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cervical Dystonia
Theta Burst Transcranial Focused Ultrasound as a Novel Treatment for Cervical Dystonia
This study is a single-blinded, randomized control study that aims to recruit 48 participants. Participants will be "randomized" into one of the study arms of the study: active stimulation to GPi, active stimulation to DN, or…
- Trial name
- NCT07690514
- Testing
- LIFUS - GPi Active, LIFUS - DN Active
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Robert Chen
Cervical Dystonia
A Phase 2 Study to Evaluate the Safety and Efficacy of ABP-450 in the Treatment of Cervical Dystonia
This Phase 2 trial will evaluate the safety and efficacy of ABP-450 for the treatment of cervical dystonia in adults. The study will enroll 60 patients across approximately 30 sites in the United States.
- Trial name
- NCT04849988
- Testing
- ABP-450
- Where
- 21 sites in United States
- Volunteers
- 61 people
- Sponsor
- AEON Biopharma, Inc.
Blepharospasm, Hemifacial Spasm
Post Marketing Surveillance Study of Dysport
The purpose of this study is to provide further information regarding the risks and benefits of Dysport in marketed indications.
- Conditions
- Blepharospasm, Hemifacial Spasm, Cervical Dystonia, Spasmodic Torticollis
- Trial name
- NCT00210431
- Where
- 36 sites in France, Germany and 1 more
- Volunteers
- 783 people
- Sponsor
- Ipsen
Cervical Dystonia
Insights Into Deep Brain Stimulation (DBS) for Cervical Dystonia
The purpose of this research study is to determine the physical brain changes in people with cervical dystonia after deep brain stimulation (DBS) surgery and as compared to healthy controls.
- Trial name
- NCT01671527
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Florida