Clinical trials: Cervical Lesion
Oral Potentially Malignant Lesions, Oral Potentially Malignant Disorders
Feasibility and Validation of an Automated AI-Enabled Deep Ultraviolet (DUV) Cytology Platform for Point-of-Care Oral Cancer Triage
This research study evaluates an experimental, point-of-care tool that combines Deep Ultraviolet (DUV) light imaging with Artificial Intelligence (AI) to rapidly screen for oral cancer and pre-cancer (dysplasia).
- Conditions
- Oral Potentially Malignant Lesions, Oral Potentially Malignant Disorders, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Oral Cancer
- Trial name
- DEEP UV-M (NCT07842211)
- Testing
- Deep UV-M and AI Cytology Triage
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Anh Le
Intraepithelial Neoplasia, Intraepithelial Neoplasm, Cervical
HRME in the Screening of Cervical Cancer Precursor Lesions in Brazil (UH3 - Brazil)
STUDY PURPOSES: This study aims to evaluate a high resolution microendoscope (HRME): 1) To assess the sensitivity and specificity of the HRME device in the detection of cervical intraepithelial neoplasia grade 2 (CIN2) or…
- Conditions
- Intraepithelial Neoplasia, Intraepithelial Neoplasm, Cervical, Cervical Cancer, Neoplasm Cervix
- Trial name
- UH3 (NCT03195218)
- Testing
- HRME examination
- Where
- Brazil
- Volunteers
- 1,780 people, healthy volunteers welcome
- Sponsor
- Barretos Cancer Hospital
Evaluation of New Tissue Biomarkers for Cervical Cancer
Biomarkerscreening in Cervical Cancer and Its Preinvasive Lesions
The following trial is a multicenter and prospective research trial of the colposcopy unit of luebeck university and the national research center in Borstel, Germany.
- Trial name
- NCT02238990
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Luebeck
Cervical Lesion
Bioactive Glass Air-abrasion and Non-carious Cervical Lesions
Evaluating the clinical behavior of composite restorations in NCCLs when the surface is pre-conditioned using bioactive glass air-abrasion has not been reported in the dental literature.
- Trial name
- NCT04578717
- Testing
- Air-abrasion, Adhesive application - Etch&rinse, Adhesive application - Self-etch
- Where
- Syria
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Damascus University
Bruxism, Noncarious Cervical Lesions
Clinical Performance of a Glass Hybrid Restorative in NCCL's of Patients With Bruxism
This is a double blinded, split mouth, randomized clinical study that evaluated the performance of a glass hybrid restorative material in non-carious servical lesions in patients with bruxism.
- Trial name
- NCT03713827
- Testing
- tooth restoration
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Cervical Cancers, Vulvar Cancer
A Study of V503 (A Multivalent Human Papillomavirus [HPV] L1 Virus-Like Particle [VLP] Vaccine) in Preadolescents and Adolescents (V503-002)
This study will evaluate the immunogenicity and tolerability of V503 (a multivalent human papillomavirus [HPV] L1 virus-like particle [VLP] vaccine) in preadolescent and adolescent participants between 9 and 15 years old and…
- Conditions
- Cervical Cancers, Vulvar Cancer, Vaginal Cancer, Genital Lesions
- Trial name
- NCT00943722
- Testing
- V503
- Volunteers
- 3,074 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Comparison of Salivary Paxillin Levels in OPMLs and OSCC to Healthy Subjects
Evaluation of the Levels of Salivary Paxillin Oral Premalignant and Malignant Lesions
This investigation was carried out to analyze and compare the salivary paxillin levels between oral premalignant and malignant lesions (OPMLs), OSCC and the healthy controls in order to assess its potential role as a biomarker of…
- Trial name
- NCT06154551
- Testing
- Paxillin biomarker
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingival Recession
Two Surgical Approaches for Root Coverage of Teeth Presenting Gingival Recession and Non-carious Cervical Lesion
The aim of the present study is to compare the use of the xenogeneic graft (MC) plus coronary advanced flap (CAF) and the coronary advanced flap alone, both associated with the partial restoration of composite resin in the…
- Trial name
- NCT03341598
- Testing
- CAF, R, MC
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Oral Cancer, Diagnoses Disease
Exfoliated Cytology in Detection of Oral Premalignant and Malignant Lesions
Micronuclei have been used since 1937 as an indicator of genetic toxic exposure due to their association with chromosomal alterations.
- Trial name
- NCT04955197
- Testing
- exfoliated cytology
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
Advanced Colorectal Neoplasms, Throat Cancer
Fecal Screening Assay for Taiwanese Population
Fecal occult blood test (FOBT) is a convenient tool for the screening of asymptomatic gastrointestinal (GI) bleeding while 「guaiac-based fecal occult test (G-FOBT) 」 is increasingly replaced by the use of an 「immunochemical-based…
- Conditions
- Advanced Colorectal Neoplasms, Throat Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT01341197
- Testing
- Fecal immunochemical test, guaiac fecal occult-blood test, and Helicobacter pylori stool antigen test
- Where
- Taiwan
- Volunteers
- 3,172 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Human Papillomavirus Clearance at 12 Months
Cryotherapy for Human Papillomavirus Clearance in Biopsy-confirmed Cervical Low-grade Squamous Intraepithelial Lesions
Persistent human papillomavirus (HPV) infections is the single necessary cause of cervical cancer. Cervical cancer is still the major health problem in the developing countries.
- Trial name
- Cryotherapy (NCT00566579)
- Testing
- Cryotherapy
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Gingival Recession
Acellular Dermal Matrix Graft In Root Coverage of Gingival Recessions With Previously Restored Cervical Lesions
Patients with high standards of oral hygiene frequently search for buccal gingival recession (GR) treatment due to cervical wear, root sensitivity and compromising aesthetics.
- Trial name
- NCT03615092
- Testing
- Root coverage with extended flap technique and acelular dermal matrix
- Where
- Brazil
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Non-carious Cervical Lesions
Chlorhexidine as Coadjuvant in Dentin Adhesion of Noncarious Cervical Lesions
This study aims to evaluate the effect of chlorhexidine digluconate (CRX) application in etched dentin on the retention of noncarious cervical lesions restorations.
- Trial name
- NCT01947192
- Testing
- Treatment with chlorhexidine, Water pre-treatment
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Dentin Sensitivity, Hypersensitivity
A Clinical Trial to Compare Lasotronix Alone or in Combination With CPP-ACP to Treat DH
Dentin hypersensitivity (DH) is defined as sharp pain of a shorter duration arise from exposed dentin in response to several chemicals and thermal or tactile stimuli that cannot be ascribed to other dental defects".
- Conditions
- Dentin Sensitivity, Hypersensitivity, Cervical Lesion
- Trial name
- NCT06463938
- Testing
- Active comparator, Experimental group, Combination of laser and paste
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Gingival Recession, Tooth Abrasion
Mucoderm® Versus CTG in the Treatment of Multiple Gingival Recessions Associated With Non-carious Cervical Lesion.
The aim of the present study is to compare two different multidisciplinary protocols using two types of grafts, porcine acellular dermal matrix (Mucoderm®) versus connective tissue graft, both associated with modified coronally…
- Trial name
- NCT03594513
- Testing
- MCAF, PR, CTG
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Cervical Intraepithelial Neoplasia Grade 2/3, Cervical Lesion
Accurate Screening and Prevention of Cervical Lesions-- Development of Accurate Screening Methods for Cervical Lesions
The goal of this observational study is to compare the accuracy and sensitivity of High-throughput human papilloma virus(HPV) typing and integrated assays with routine screening protocols (Cobas HPV test combined with thinprep…
- Trial name
- NCT05851079
- Testing
- TCT test, Vaginoscopy, High throughput HPV typing and integration detection methods
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Head And Neck Cancer, Oropharynx Cancer
OraTest in Combination With Visual Examination and Visual Examination Alone
Primary Objectives: 1. To assess the ratio in sensitivities of OraTest® in combination with visual examination versus visual examination alone in the detection of serious pathology defined as severe dysplasia, CIS, or cancer of…
- Trial name
- NCT00537199
- Testing
- Visual Examination, OraTest
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Patient With Invasive Cervical Carcinoma, Patient With CIN Lesion
Evaluation of ELISA Assay on Human Papilloma Viruses (HPV) Infection Population
Cervical cancer the most frequent neoplasm and the fifth mortality rate of malignancies of the women in the world. It results in about 1,000 women in Taiwan and about 200,000 women worldwide dying of cervical cancer each year.
- Conditions
- Patient With Invasive Cervical Carcinoma, Patient With CIN Lesion, Patient With HPV Infected Patients Without Histopathologic Lesion, Normal Populations.
- Trial name
- NCT00673192
- Testing
- peripheral blood isolation
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Tooth Diseases
Clinical Evaluation of Three Different Universal Adhesives in Non-carious Cervical Lesions
The aim of this randomized, controlled prospective clinical trial is to evaluate and compare the performances of three different universal adhesives using a flowable universal composite resin in the restoration of non-caries…
- Trial name
- NCT03415412
- Testing
- Clearfil Univesal Bond, IBond Universal, G-Premio Bond
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Dental Caries
Evaluation of a New Bioactive Material Versus a Fluoride-Releasing Hybrid Restorative Material in Cervical Lesions
This study will be conducted to evaluate and compare the clinical performance of fluoride, calcium, and phosphate-releasing new bioactive material versus a fluoride-releasing hybrid restorative material in cervical lesions for…
- Trial name
- NCT05149209
- Testing
- cervical restoration
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University