Clinical trials: Cervical Neoplasms
Radiodermatitis; Acute, Radiotherapy Side Effect
The Use of Photobiomodulation in the Management of Radiodermatitis in Head and Neck Cancer Patients
It is estimated that there will be 670,000 new cases of cancer worldwide in 2020-2022 and it is known that the most commonly instituted treatments in cancer are chemotherapy, radiotherapy and surgery.
- Conditions
- Radiodermatitis; Acute, Radiotherapy Side Effect, Head and Neck Cancer
- Trial name
- NCT05557825
- Testing
- Photobiomodulation Therapy
- Where
- Brazil
- Volunteers
- 3 people
- Sponsor
- University of Nove de Julho
Thyroid Cancer, Papillary
Ultrasound-Guided Microwave Ablation Vs. Surgery for Low-Risk PapilaryThyroid Carcinoma
This study aims to investigate the efficacy and prognosis of ultrasound-guided and gene-based microwave ablation (MWA) versus surgical treatment in patients with low-risk papillary thyroid carcinoma (PTC).
- Trial name
- NCT06725576
- Testing
- Ablation
- Where
- China
- Volunteers
- 201 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Head and Neck Cancer, Precancerous/Nonmalignant Condition
Photodynamic Therapy With Porfimer Sodium in Treating Patients With Precancerous Lesions, Cancer, or Other Disease of the Aerodigestive Tract
RATIONALE: Photodynamic therapy uses a drug that becomes active when it is exposed to a certain kind of light. When the drug is active, precancerous cells and cancer cells are killed.
- Trial name
- NCT00453336
- Testing
- Porfimer Sodium, Photodynamic Therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Miami
Mucositis
Low-Level Laser Therapy for Prevention of Oral Mucositis
The overall purpose of this study is to examine the efficacy of prophylactic low-level laser therapy (LLLT) to reduce the incidence of oral mucositis and adverse events in patients receiving combined modality therapy consisting…
- Trial name
- NCT02723604
- Testing
- Low Level Laser Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Oral Nutritional Supplement
Administration of ONS Based on Purple Sweet Potato in Head and Neck Cancer Patients With Radiotherapy
The goal of this clinical trial is to compare the effect of local food-based oral nutritional supplements (ONS) containing immunonutrients (omega-3 and anthocyanins) on nutritional status and inflammatory response in head and…
- Trial name
- NCT05740878
- Testing
- immunonutrients oral nutritional supplements, standard oral nutritional supplements
- Where
- Indonesia
- Volunteers
- 58 people
- Sponsor
- University of Brawijaya
Cervical Cancer
HPV Testing In Polish POpulation-based Cervical Cancer Screening Program.
The HIPPO PROJECT is a randomized healthcare study nested in the OCCSP in Poland. This project will assess the performance of the new screening test (HR HPV test) before its implementation in Poland.
- Trial name
- HIPPOPROJECT (NCT04111835)
- Testing
- Offering an alternative cervical cancer screening method - hrHPV molecular testing.
- Where
- Poland
- Volunteers
- 33,000 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Head and Neck Cancer, Squamous Cell Carcinoma
Prognostic Immune Biomarkers in HNSCC
Evaluation of the prognostic potential of tumor-infiltrating lymphocytes and PD-L1 expression in non-metastatic squamous cell carcinoma of the head and neck
- Trial name
- NCT05941676
- Testing
- Tumour immunoprofile evaluation
- Where
- Czechia
- Volunteers
- 55 people
- Sponsor
- University Hospital Ostrava
Esophageal Cancer
NIR-Guided Sentinel Lymph-Node Mapping for Esophageal Cancer
This research study is a Phase I clinical trial. Phase I clinical trials test the feasibility and safety of an investigational technique or drug.
- Trial name
- NCT01808417
- Testing
- Near Infrared Imaging
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Dana-Farber Cancer Institute
Urothelial Carcinoma, Head and Neck Cancer
MAGE-A10ᶜ⁷⁹⁶T for Urothelial Cancer, Melanoma or Head and Neck Cancers
This Phase 1 study is designed as a cell dose escalation trial in HLA-A*02:01 and HLA-A*02:06 subjects with MAGE-A10 positive urothelial, melanoma or head and neck tumors.
- Conditions
- Urothelial Carcinoma, Head and Neck Cancer, Melanoma, Bladder Urothelial Carcinoma
- Trial name
- NCT02989064
- Testing
- Autologous genetically modified MAGE A10ᶜ⁷⁹⁶T cells
- Where
- 11 sites in United States, Canada and 1 more
- Volunteers
- 10 people
- Sponsor
- Adaptimmune
Cancer of Head and Neck
Single-arm Phase II Study of NDURE for Patients With HNC
This study will evaluate whether a new patient navigation intervention can decrease delays starting post-operative radiation therapy after surgery for white and African-American head and neck cancer patients.
- Trial name
- NDURE (NCT03821064)
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Esophageal Squamous Cell Carcinoma
PD-1 Inhibitor Combined With Radiotherapy for Elderly ESCC
Concurrent chemoradiotherapy is now considered to be the standard treatment modality for esophageal cancer patients who are medically unfit for surgery.
- Trial name
- NCT06186609
- Testing
- PD-1 inhibitor 200mg per three to four weeks, for one year
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Affiliated Hospital of Nantong University
Parotid Neoplasms
Application of 3D MR Neurogram for Intraparotid Facial Nerves Evaluation
Parotid neoplasm consists of a wide range of benign and malignant lesions, and parotidectomy has been the mainstay for management of these neoplasms.
- Trial name
- NCT05296109
- Testing
- Magnetic Resonance Imaging on 3T scanner (Magnetom Prisma, SIemens) with dedicated neurogram sequences (Constructive interference in steady state - CISS; Dual Echo Steady State - DESS)
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Head and Neck Cancer Squamous Cell Carcinoma
Immunotherapy and Nodal-Sparing Irradiation for T-Cell Induction and Unmasking of Tumor Antigenicity in the Microenvironment for Head and Neck Cancer
This is a non-comparative randomized Phase 2 study using the INITIUM regimen with or without elective nodal irradiation (ENI) delivered before surgery for resectable head and neck squamous cell carcinoma (HNSCC).
- Trial name
- INITIUM (NCT07773987)
- Testing
- Pembrolizumab, Radiotherapy, ENI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Cervical Cancer
A Study of Carilizumab Combined With Concurrent Chemoradiotherapy
This is a one-arm phase II clinical study. In patients with stage III-IVA cervical cancer with pelvic lymph nodes > 2cm, positive para-aortic lymph nodes, or lymph node metastases > 2, patients with positive PD-L1 expression (CPS…
- Trial name
- NCT05151549
- Testing
- Camrelizumab, Cisplatin or Carboplatin
- Volunteers
- 46 people
- Sponsor
- Hunan Cancer Hospital
Colorectal Cancer Metastatic, Squamous Cell Carcinoma of Head and Neck
A Phase 1b Study of WU-NK-101 in Combination With Cetuximab
This study is a Phase 1b open-label study designed to characterize the safety, tolerability, and preliminary anti-tumor activity of WU-NK-101 in combination with cetuximab in patients with advanced and/or metastatic CRC (Cohort…
- Trial name
- NCT05674526
- Testing
- WU-NK-101 - Dose Escalation, Cetuximab - Dose Escalation, WU-NK-101 - Cohort Expansion
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Allotera Therapeutics
Esophageal Squamous Cell Carcinoma (ESCC)
A Study of Tislelizumab (BGB-A317) Versus Chemotherapy as Second Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma
The purpose of this study was to evaluate the efficacy and safety of tislelizumab as second line treatment in participants with advanced unresectable/metastatic ESCC that had progressed during or after first line therapy.
- Trial name
- NCT03430843
- Testing
- Tislelizumab, Paclitaxel, Docetaxel
- Where
- 104 sites in United States, Belgium and 9 more
- Volunteers
- 512 people
- Sponsor
- BeiGene
Carcinoma, Squamous Cell, Cancer of the Head and Neck
Dose Escalation Study of Hyperbaric Oxygen With Radiation and Chemotherapy to Treat Squamous Cell Carcinoma of the Head and Neck
This research is being done because we do not know the best treatment for advanced Squamous Cell Carcinoma of the Head and Neck.
- Trial name
- HBO-XRT (NCT00474825)
- Testing
- Hyperbaric Oxygen Therapy, Hyperbaric Oxygen
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- National Baromedical Services
Cancer Cervix
Image Guided Brachytherapy in Locally Advanced Cancer Cervix
This is non comparative prospective interventional study with some areas for observational research to implement based image guided adaptive cervical cancer brachytherapy ( BT ) combined with Intensity Modulated Radiotherapy …
- Trial name
- NCT04767425
- Testing
- Brachytherapy
- Volunteers
- 50 people
- Sponsor
- Fatma Ahmed Abdelfatah Rikabe
Nasopharyngeal Carcinoma
A Phase II Clinical Trial of Chemotherapy With or Without Endostar® Continuous Intravenous Infusion in Refractory NPC
We define refractory nasopharyngeal carcinoma as the following: recurrence with radiation brain injury after radiotherapy, recurrence after the second or more courses of radiotherapy, standard treatment failure after recurrence…
- Trial name
- NCT02590133
- Testing
- Recombinant Human Endostatin Injection (Endostar), Fluorouracil (5-Fu), Nedaplatin
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Yun-fei Xia
Solid Tumors
Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of escalating doses of RMC-5552 monotherapy in adult participants with relapsed/refractory solid tumors…
- Trial name
- NCT04774952
- Testing
- RMC-5552
- Where
- 8 sites in United States
- Volunteers
- 58 people
- Sponsor
- Revolution Medicines, Inc.
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