Clinical trials: Cervical Spine Disease
Cervical Spondylosis, Neck Pain
An Evaluation of Yoga Therapy for Cervical Spondylosis
Cervical spondylosis is a chronic degenerative condition, commonly affecting >40-year-old adults worldwide. Cervical spondylosis is an important cause of neck pain and low back pain, and seriously affects the physical health…
- Trial name
- NCT04113473
- Testing
- Yoga Therapy
- Where
- India
- Volunteers
- 62 people
- Sponsor
- NMP Medical Research Institute
Musculoskeletal Diseases
Sacroiliac Orthopedic Blocking and Cervical Spine Function
This study seeks to determine if the correction of a sacroiliac lesion can produce a functional change in cervical spine. Reduction of a sacroiliac joint lesion may alter cervical spine function.
- Trial name
- NCT00523822
- Testing
- Spinal Manipulative Therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Logan College of Chiropractic
Disc Herniation, Cervical Radiculopathy
Mobilization With Movement vs. Neural Mobilization on Nerve Root Function in Patients With Cervical Radiculopathy
This study will be conducted to compare the effect of sustained natural apophyseal glides (SNAGS) versus neural mobilization on clinical outcomes such as 1- nerve root function in the form of: (A) peak to peak amplitude; (B)…
- Conditions
- Disc Herniation, Cervical Radiculopathy, Cervical Radiculopathy at C5 Nerve Root, Cervical Radiculopathy at C6 Nerve Root
- Trial name
- NCT05803954
- Testing
- Sustained natural apophyseal glides (SNAGS), Neural mobilization, Traditional physical therapy
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Cairo University
Degenerative Disc Disease, Trauma (Including Fractures)
BIO4 Clinical Case Study: Cervical Spine
The goal of this study is to investigate the efficacy of BIO4 bone matrix in patients undergoing 1 or 2-level Anterior Cervical Discectomy and Fusion (ACDF) spine surgery.
- Conditions
- Degenerative Disc Disease, Trauma (Including Fractures), Spondylolisthesis
- Trial name
- NCT03077204
- Testing
- 1 or 2-Level ACDF utilizing BIO4 with Bio AVS Cervical Allograft (with graft window)., Aviator Anterior Cervical Plating System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Seton Healthcare Family
Intervertebral Disc Replacement, Degenerative Disc Disease
Activ C European Multicenter Study
Patients are candidates for single-level Artificial Disc Replacement between C3 and C7 who suffer from cervical symptomatic degenerative disc disease. A maximum of 200 cases will be enrolled into the study.
- Trial name
- NCT02492724
- Where
- 10 sites in Czechia, Finland and 3 more
- Volunteers
- 210 people
- Sponsor
- Aesculap AG
Ossification Posterior Longitudinal Ligament, Cervical Spondylotic Myelopathy
Comparison of IONM Between Remimazolam and Propofol
Inhalation anesthetics significantly can delay latency and reduce amplitude of cortical MEPs and SSEPs signals compared to intravenous anesthetics by acting on not only GABA (γ-aminobutyric acid) receptors but also NMDA…
- Trial name
- NCT04968054
- Testing
- Arm I (Propofol), Arm II (Remimazolam)
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Orthopedic Disorder of Spine, Neurologic Disorder
A fMRI Study of Compressive Spinal Cord
Cervical myelopathy (CM), a chronically compressive spinal cord lesion, is the most common cause of non-traumatic paraparesis/quadriparesis among the elderly.
- Trial name
- CSM Plasticity (NCT03504254)
- Testing
- MRI examination
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Degenerative Disc Disease (DDD), Instabilities
PMCF Study to Evaluate the VERTICALE® Cervical System in Spine Surgery According to Its Intended Use.
In accordance with the European Medical Device Regulation MDR 2017/745/EU, the legal manufacturers of medical devices are obliged to evaluate medical devices with regard to their clinical performance and safety.
- Conditions
- Degenerative Disc Disease (DDD), Instabilities, Trauma, Deformity
- Trial name
- NCT05489822
- Testing
- VERTICALE® Cervical System
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Silony Medical GmbH
Degenerated Cervical Spine, Spinal Diseases
Evaluation and Physical Therapy for Patients With Degenerated Cervical Spine
The specific aims are as follows: 1. To investigate the degree of impairment, such as range, proprioception, sensation, and electromyography (EMG) pattern of healthy, older subjects. 2.
- Trial name
- NCT00162890
- Testing
- Therapeutic exercise
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cervical Spondylosis
Effect of Cupping Therapy on Nitric Oxide Level in Patients With Cervical Spondylosis
this study will be conducted to investigate the effect of cupping therapy on the nitric oxide level in patients with cervical spondylosis
- Trial name
- CT (NCT06271525)
- Testing
- cupping therapy
- Volunteers
- 60 people
- Sponsor
- Shady Abdelsattar Refaat
Radiculopathy, Cervical, Myelopathy Cervical
Cervical Arthroplasty Cost Effectiveness Study (CACES)
To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD).
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Myelopathy, Compressive, Radiculopathy, Cervical Region
- Trial name
- CACES (NCT04623593)
- Testing
- ACDF, ACDA
- Where
- Netherlands
- Volunteers
- 198 people
- Sponsor
- Valérie Schuermans
Intervertebral Disc Herniation, Stiffness; Spine
Cervical Changes by 4h of Hyper-buoyancy Flotation and Followed by 15 Mins 1g Re-loading
Study with the aim to see the effect on a space ground anaologue, Hyperbuoyancy Floatation (HBF) on cervical column.
- Trial name
- NCT05296200
- Testing
- Hyperbuoyancy Floatation
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Universidad Autonoma de Madrid
Neck Pain
Investigation of the Relationship Between Neck Pain and Spinal Curvatures
Although it is known that the cervical, thoracic and lumbar regions of the spine are related with each other biomechanically, there are no studies examining the relationship between cervical pain and other regions of the spine.
- Trial name
- neck pain (NCT06884137)
- Volunteers
- 81 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Spondylosis, Spinal Stenosis
A Prospective Study of NuCel® in Cervical Spine Fusion
The study is intended to demonstrate that the NuCel® allograft is effective and safe in promoting bone growth and fusion rate when used in cervical fusion in patients with one, two or three-level diseases of the cervical spine.
- Conditions
- Spondylosis, Spinal Stenosis, Spondylolisthesis, Intervertebral Disc Disease
- Trial name
- NCT02381067
- Testing
- NuCel with Allograft Bone
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- NuTech Medical, Inc
Degenerative Disc Disease
ACDF Using Structural Allograft vs. Tritanium C
This is an observational, descriptive, prospective and retrospective data collection study. The purpose of this study is to observe radiographic outcomes of patients who will undergo anterior cervical discectomy and fusion (ACDF)…
- Trial name
- NCT04388332
- Testing
- Structural allograft, Tritanium C
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Mechanical Neck Pain, Neck Pain
Dry Needling for Mechanical Neck Pain
Mechanical neck pain is one of the most common musculoskeletal disorders among adults. It is characterized by pain and stiffness in the cervical region, often related to poor posture, repetitive movements, or prolonged sitting.
- Conditions
- Mechanical Neck Pain, Neck Pain, Musculoskeletal Disorders, Cervical Spine Dysfunction
- Trial name
- NCT07368517
- Testing
- Dry Needling with Exercise, Conventional Physiotherapy with Exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Deraya University
Intervertebral Disk Degeneration
An Assessment of P-15 Bone Putty in Anterior Cervical Fusion With Instrumentation
The aim of this trial is to evaluate if P-15 bone putty (investigational device) is not inferior in effectiveness and safety to local autologous bone (control device) when applied in instrumented anterior cervical discectomy and…
- Trial name
- NCT00310440
- Testing
- P-15 Synthetic osteoconductive bone substitute, Autologous bone
- Where
- 12 sites in United States, Canada
- Volunteers
- 319 people
- Sponsor
- CeraPedics, Inc
Lumbar Degenerative Disc Disease, Cervical Degenerative Disc Disease
Evaluation of the Prosthetic Disc Replacement
Until now, arthrodesis (intervertebral fusion) is the formal treatment for the lumbar and cervical degenerative disc disease : arthrodesis has been the standard surgical treatment for the patients when nonsurgical management has…
- Conditions
- Lumbar Degenerative Disc Disease, Cervical Degenerative Disc Disease, Kyphosis
- Trial name
- EVA (NCT00640029)
- Testing
- Arthrodesis, Arthroplasty (PRODISC-C® , PRODISC-L®, Mobi-C®, Mobidisc®, PrestigeLP®, A-Mav®, O-Mav®, DISCOCERV®)
- Where
- 2 sites in France
- Volunteers
- 301 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Degenerative Disc Disease, Grade 1 Spondylolisthesis
Retrospective Study With Patients Treated With STALIF® C or M and Ti or FLX Implants for 1 and 2 Levels
This is a Retrospective, Observational Multi-Center study, utilizing patients diagnosed with up to a Grade1 spondylolisthesis or retrolisthesis or symptomatic degenerative disc disease and treated with STALIF® C, or M, Ti and/or…
- Conditions
- Degenerative Disc Disease, Grade 1 Spondylolisthesis, Retrolisthesis, Symptomatic Cervical Disc Disease
- Trial name
- Stalif (NCT05610397)
- Testing
- STALIF®
- Volunteers
- 200 people
- Sponsor
- Centinel Spine
Cervical Disc Herniation, Cervical Foraminal Stenosis
Endoscopic Posterior Cervical Foraminotomy Versus Anterior Cervical Discectomy and Fusion for Cervical Radiculopathy
Cervical radiculopathy caused by cervical disc herniation or foraminal stenosis is a common condition that may result in upper limb pain, sensory disturbances, and motor deficits.
- Conditions
- Cervical Disc Herniation, Cervical Foraminal Stenosis, Cervical Radiculopathy
- Trial name
- ENDOFOR (NCT07894159)
- Testing
- Uniportal Endoscopic Posterior Cervical Foraminotomy, Anterior Cervical Discectomy and Fusion
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France