Clinical trials: Cervix
Preterm Birth
Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature Birth
The aim of the study is to determine the effect of cerclage pessary on the incidence of spontaneous delivery between randomization (at 20-24+6 weeks) and 33+6 weeks in asymptomatic women with singleton pregnancies found at…
- Trial name
- NCT00735137
- Testing
- Vaginal pessary (CE0482, MED/CERT ISO 9003 / EN 46003)
- Where
- 24 sites in Austria, Brazil and 10 more
- Volunteers
- 2,109 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Cancer of Cervix
Neoadjuvant Chemotherapy Followed by Surgery Versus Concurrent Chemoradiation in Carcinoma of the Cervix
Carcinoma cervix is a common malignancy in women in developing countries including India. The standard treatment of locally advanced cervical cancer (Stages IB2 to IIIB)is concomitant chemoradiation (CT RT) using platinum based…
- Trial name
- NACTcervix (NCT00193739)
- Testing
- NACT, Radical abdominal hysterectomy (class III), BPLND & lower para aortic lymph node sampling, Inj.Cisplatin
- Where
- India
- Volunteers
- 635 people
- Sponsor
- Tata Memorial Hospital
Cancer of the Cervix, Cervical Intraepithelial Neoplasia
Compass - Randomised Controlled Trial of Primary HPV Testing for Cervical Screening in Australia
Compass is a randomised controlled trial of primary HPV testing for cervical cancer screening in Australia. A pilot study involving 5,000 women was carried out in 2013-2014.
- Trial name
- Compass (NCT02328872)
- Testing
- Molecular testing for HPV, Liquid Based Cytology
- Where
- Australia
- Volunteers
- 76,181 people, healthy volunteers welcome
- Sponsor
- VCS Foundation
Cervix Uteri Cancer
Clinical Response and Toxicity of Hypo-fractionated Chemoradiotherapy in Cervix Cancer
Uterine cervix cancer can be treated definitively with concurrent chemoradiation (external beam radiotherapy and chemotherapy) followed by high dose rate brachytherapy.
- Trial name
- NCT04831437
- Testing
- Hypofractionated EBRT, Standard EBRT
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Uterine Cervix Cancer
Clinical Trial of Molecular Biomarkers in Women With Uterine Cervix Cancer
This is a phase 0 clinical trial of molecular biomarkers in women with uterine cervix cancer. Women receive standard-of-care radiochemotherapy followed by brachytherapy.
- Trial name
- NCT05462951
- Testing
- Standard
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Denise Fabian
Cervical Neoplasia
Costa Rican Natural History Study of HPV and Cervical Neoplasia
A population-based study was initiated in Costa Rica in June 1993 to investigate the natural history of human papillomaviruses (HPV) and cervical neoplasia.
- Trial name
- NCT00342173
- Where
- Costa Rica
- Volunteers
- 11,545 people
- Sponsor
- National Cancer Institute (NCI)
Cervix Cancer, Endometrial Cancer
Prognostic and Diagnostic Added Value of Medical Imaging in Gynecological Cancer (PRODIGYN)
The goal of this observational study is to learn about the added diagnostic and prognostic value of advanced medical imaging procedures in cervical cancer, endometrial cancer and ovarian cancer.
- Conditions
- Cervix Cancer, Endometrial Cancer, Epithelial Ovarian Cancer
- Trial name
- PRODIGYN (NCT05855941)
- Testing
- FDG-PET/CT and FDG-PET/MRI
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Region Västerbotten
Cervical Shortening
Routine Activity and Preterm Delivery Risk in Women With a Short Cervix
The goal of this clinical trial is to evaluate the effect of routine activity versus rest on the risk of preterm delivery in pregnant women with a short cervix diagnosed between 24 and 34 weeks of gestation.
- Trial name
- NCT06884761
- Testing
- Maximal Rest
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Wolfson Medical Center
HPV Infection, HPV Integration
Effect of EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid on HPV DNA Integration
This interventional, single-center, open-label randomized clinical study evaluates the efficacy of an oral dietary supplement (Pervistop®) in women with persistent Human Papillomavirus (HPV) infection.
- Conditions
- HPV Infection, HPV Integration, HPV Disease, HPV Genital Infection
- Trial name
- NCT07697196
- Testing
- Epigallocatechin gallate (EGCG), Folic Acid (FA), Vitamin B12 (B12), and Hyaluronic Acid (HA)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS San Raffaele
Cervical Intraepithelial Neoplasia, Uterine Cervical Dysplasia
A Two-Stage Phase 2 Study Of A-007 Topical Gel in High-Grade Squamous Intraepithelial Lesions (HSIL)
A-007 is an investigational therapy which may be effective in the treatment of pre-cancerous cervical dysplasia (abnormal cell growth).
- Trial name
- TG-003 (NCT00596258)
- Testing
- A-007
- Where
- 5 sites in United States
- Volunteers
- 11 people
- Sponsor
- Tigris Pharmaceuticals
Infection, Precancerous Condition
Human Papillomavirus Vaccine Therapy in Treating Men With HIV-1 Infection
RATIONALE: Vaccines made from human papillomavirus may help the body build an effective immune response to kill HIV cells. PURPOSE: This phase II trial is studying the side effects and how well human papillomavirus vaccine…
- Trial name
- NCT00513526
- Testing
- Gardasil
- Where
- 8 sites in United States
- Volunteers
- 112 people
- Sponsor
- AIDS Malignancy Consortium
Preterm Birth
Study of Cervix and Inflammation in Preterm Birth Prediction
Preterm birth rate is 7.2% in Quebec, it's risen worldwide in the past decade and it's the leading cause of perinatal mortality and morbidity. Preterm birth is a major public health problem.
- Trial name
- COLIBRI (NCT01007513)
- Testing
- Transvaginal ultrasound, Vaginal secretion sampling
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
CIN, Cancer of Cervix
Histopathological Findings in Symptomatizing Patients After Supracervical Hysterectomy
Supracervical hysterectomy is widely common and had many complications either immediate or delayed. In these patients bleeding, infection, chronic pelvic pain are common.
- Conditions
- CIN, Cancer of Cervix, Cervicitis
- Trial name
- HSTH (NCT04809727)
- Testing
- Cervical biopsy
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Tanta University
Premature Birth
Comparing Double Dose of Vaginal Progesterone to no Treatment for Prevention of Preterm Birth in Twins and Short Cervix
Twin pregnancies are more likely to be delivered preterm than singleton pregnancies. Vaginal progesterone administration (200 mg Utrogestan) to asymptomatic women with a singleton pregnancy and sonographic short cervix reduced…
- Trial name
- NCT02329535
- Testing
- Micronized progesterone
- Where
- 2 sites in Israel
- Volunteers
- 15 people
- Sponsor
- HaEmek Medical Center, Israel
Cervix; Pregnancy
Sound Check-Correlation Between Transperineal and Digital Cervical Exam in 3rd Trimester Pregnancy
The primary purpose of this study is to compare the accuracy of the Butterfly iQ pocket ultrasound with the digital cervical examination in the third trimester cervix.
- Trial name
- NCT05260333
- Testing
- Butterfly iQ transperineal ultrasound exam
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Endometrial Carcinoma, Cervix Cancer
Dosimetric Analysis of Vaginal Cuff Brachytherapy in Endometrial Carcinoma
The purpose of this study is to investigate the effect of certain variables such as the fullness of the patients bladder and the position of the treatment applicator on the dose of radiation that other organs such as the bladder…
- Conditions
- Endometrial Carcinoma, Cervix Cancer, Carcinoma of the Uterus
- Trial name
- NCT00165126
- Testing
- Radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Dana-Farber Cancer Institute
Premature Ejaculation
A Safety and Tolerability Study of Administration of PSD502
A Phase I, Single-Centre, Double-Blind, Randomised, Placebo-Controlled, Parallel Group, Pharmacokinetic and Safety Study to Evaluate Systemic Exposure and Local Vaginal Exposure to Lidocaine and Prilocaine and the Metabolites 2,6…
- Trial name
- NCT01183208
- Testing
- Intervention A, Intervention B, Intervention C
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Plethora Solutions Ltd
Squamous Intraepithelial Lesions of the Cervix, Human Papilloma Virus Infection
Papilocare®: Effects on Regression of Histologically Confirmed Cervical Intraepithelial Lesions 1 and Tolerance
clinical trial comparing the regression rate after 12 months of histologically confirmed cervical intraepithelial lesions 1 in 2 parallel groups.
- Conditions
- Squamous Intraepithelial Lesions of the Cervix, Human Papilloma Virus Infection, Cervix Lesion
- Trial name
- PAPILOCARE (NCT04624568)
- Testing
- PAPILOCARE
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Cervical Cancer
Interleukin-12 in Treating Patients With Advanced or Recurrent Cancer of the Cervix
RATIONALE: Interleukin-12 may kill tumor cells by stopping blood flow to the tumor and by stimulating a person's white blood cells to kill cancer cells in the cervix.
- Trial name
- NCT00003017
- Testing
- recombinant interleukin-12
- Where
- 9 sites in United States
- Sponsor
- Eastern Cooperative Oncology Group
Neoplasms, Uterine Cervix, Cervical Cancer
Cross-sectional Study on Human Papillomavirus Type Distribution in Adult Women Diagnosed With Cervical Cancer
The current study will elucidate the human papillomavirus type distribution in a population of women diagnosed with cervical high grade pre-cancerous lesions and invasive cervical cancer in Sri Lanka.
- Trial name
- NCT01221987
- Testing
- Cervical sampling, Data collection
- Volunteers
- 40 people
- Sponsor
- GlaxoSmithKline