Clinical trials: Cervix
Cervical Cancer
Bryostatin-1 Plus Cisplatin in Treating Patients With Recurrent or Advanced Cancer of the Cervix
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00005965
- Testing
- bryostatin 1, cisplatin
- Where
- 6 sites in United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cervical Cancer, Cervix Cancer
Adjuvant Chemotherapy in cfHPV-DNA Plasma Positive Patients: A Biomarker In Locally Advanced Cervical Cancer
This study hypothesizes that patients who persist with cell-free human papillomavirus deoxyribonucleic acid (cfHPV-DNA) plasma expression at the end of standard treatment, can derive the benefit of using adjuvant chemotherapy in…
- Conditions
- Cervical Cancer, Cervix Cancer, Cervix Neoplasm
- Trial name
- AddChemo (NCT05764044)
- Testing
- cisplatin, gemcitabine, Follow-up
- Where
- 26 sites in Brazil
- Volunteers
- 365 people
- Sponsor
- Hospital do Coracao
Preterm Birth, Twin Pregnancy With Antenatal Problem
Prophylactic Cerclage for Twin Pregnancy With Shortened Cervix
This randomized controlled trial is aimed to evaluate pregnancy and neonatal outcomes in twin pregnancies, in which a cervical cerclage is placed due to the shortening of the cervix with or without visible fetal membranes.
- Conditions
- Preterm Birth, Twin Pregnancy With Antenatal Problem, Cervical Shortening
- Trial name
- NCT05338164
- Testing
- cervical cerclage
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Carcinoma, Adenocarcinoma
Study of Nimotuzumab, Radiation Therapy and Cisplatin Versus Radiation Therapy and Cisplatin for Treatment of Stage IB e IVA UCC(CORUS)
The primary study objective will be to assess the efficacy of the combination of radiation therapy with nimotuzumab and cisplatin, as compared to the combination of radiation therapy plus cisplatin in the treatment of Uterine…
- Conditions
- Carcinoma, Adenocarcinoma, Uterine Cervix Adenosquamous Carcinoma
- Trial name
- NCT01301612
- Testing
- Nimotuzumab, Cisplatin, Brachytherapy
- Where
- 7 sites in Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Radiation
Intensity-modulated Radiotherapy Protocol in Cervix Cancer
Definitive treatment protocol for high-dose intensity-modulated radiotherapy (IMRT) with intracavitary radiotherapy in locally advanced cervical cancer: A phase II trial
- Trial name
- NCT02993653
- Testing
- High-dose Intensity-modulated radiotherapy
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul St. Mary's Hospital
Cervical Cancer
Surgery With or Without Chemotherapy in Treating Patients With Stage IB Cervical Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy drugs before surgery may shrink the tumor so that it can be removed during surgery.
- Trial name
- NCT00002536
- Testing
- cisplatin, vincristine sulfate, surgical procedure
- Where
- 41 sites in United States
- Sponsor
- Gynecologic Oncology Group
HPV Disease, Cervical Intraepithelial Neoplasia Grade I
HIFU vs Observation for LSIL of Cervix: A Randomized Controlled Trial
The majority of low-grade pre-invasive lesions of cervix (low-grade squamous intraepithelial lesions, LSIL).will regress spontaneously over 2 years and immediate treatment may not be necessary.
- Trial name
- HIFU Colpo (NCT07461064)
- Testing
- HIFU treatment
- Volunteers
- 180 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Induction of Labor Affected Fetus / Newborn
Sonographic Assessment for Prediction of Labor Induction Success
The study is conducted to assess several sonographic parameters for prediction of labor induction success. These parameters include cervical length, fetal head circumference, and fetal head to cervix angle.
- Trial name
- NCT03944187
- Testing
- Transvaginal sonography
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Cancer of the Cervix, Cervical Neoplasms
Integrated Dose Escalation for Advanced, Localized Gynecologic Cancer (The IDEAL - GYN Trial)
The purpose of this study is to determine the maximum tolerated dose of integrated boost radiation therapy when given with concurrent chemotherapy (cisplatin).
- Trial name
- IDEAL (NCT01627288)
- Testing
- Boost radiation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Malignant Tumor of Cervix, Cervical Intraepithelial Neoplasia
Participation in Screening for Cervical Cancer: Interest of a Self-sampling Device Provided by the General Practitioner
This study evaluates the benefit in women aged from 30 to 65 years, who do not participate to the French opportunistic cervical cancer screening program, of an organized screening with the proposition by the family physician of a…
- Trial name
- PaCUDAHL-Gé (NCT02749110)
- Testing
- Vaginal self-sampling brush
- Where
- France
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Cervical Cancer
MR- PET Guided Biologically Optimised Interstitial Brachytherapy
The proposed two stage study will evaluate patterns of local recurrence after EBRT and brachytherapy in spatial reference to baseline functional MRI and FLT/F-Miso PET scan in patients undergoing chemoradiotherapy for…
- Trial name
- MR-PET Brachy (NCT01391065)
- Testing
- MR PET Guided Brachytherapy
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Tata Memorial Hospital
Uterine Cervical Neoplasms
A Trial of Comparing the Pathology Status of Lymphoseek®-Identified Sentinel Lymph Nodes Relative to the Pathological Pathology Status of Nonsentinel Lymph Nodes in Nodal Staging of Subjects With Known Cancer of the Cervix Who Are Undergoing Lymph Node Dissection
Prospective, open-label, within-patient, multi-center study of Lymphoseek in the detection of lymph nodes in subjects with known cancer of the cervix.
- Trial name
- NCT02509585
- Testing
- Tc99m tilmanocept
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Cardinal Health 414, LLC
Uterine Cancer, Rectal Cancer
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
Female patients with early onset (<50 years old) pelvic malignancies such as uterine and rectal cancers are rising in incidence, which often requires pelvic radiation; many of these patients are premenopausal and at a high risk…
- Conditions
- Uterine Cancer, Rectal Cancer, Colon Cancer, Breast Cancer
- Trial name
- OvAR-Y (NCT06904365)
- Testing
- HyperSight cone beam computed tomography (CBCT) scan, ETHOS 2.0
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Washington University School of Medicine
Cervical Cancer
Cetuximab and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00101192
- Testing
- cetuximab, cisplatin
- Where
- 18 sites in United States
- Volunteers
- 76 people
- Sponsor
- Gynecologic Oncology Group
Cervical Cancer
Belotecan (CKD-602) in Recurrent or Progressive Carcinoma of Uterine Cervix
-list item one, The purpose of this study is to evaluate the overall response rate of belotecan (CKD-602) in recurrent or progressive carcinoma of uterine cervix
- Trial name
- NCT00430144
- Testing
- Belotecan(CKD-602)
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Sokbom Kang
Cervical Dysplasia, Cervical High Grade Squamous Intraepithelial Lesion
REVEAL 1 (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)
HPV-301 is a prospective, randomized, double-blind, placebo controlled Phase 3 study to determine the efficacy, safety, and tolerability of VGX-3100 administered by intramuscular (IM) injection followed by electroporation (EP)…
- Conditions
- Cervical Dysplasia, Cervical High Grade Squamous Intraepithelial Lesion, HSIL
- Trial name
- REVEAL 1 (NCT03185013)
- Testing
- VGX-3100, Electroporation (EP)
- Where
- 60 sites in United States, Argentina and 17 more
- Volunteers
- 201 people
- Sponsor
- Inovio Pharmaceuticals
Cervix Diseases
The Potential for HPV Self-testing to Promote Participation in Cervical Screening
To explore the potential for vaginal self-sampling to increase participation in cervical screening, we offer the option of self-sampling to a group of non-participants in cervical screening (intervention), in addition to the…
- Trial name
- PROMOTER (NCT02779621)
- Testing
- Self-collecting a vaginal sample with a swab for HPV testing, Collection of cervical sample for routine cervical screening
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
CIN2, Therapy
Expectancy as Alternative to Treatment for Cervical Intraepithelial Neoplasia Grade 2 Among Women 25 - 30 Years of Age
In the Swedish organised cervical screening program precursors of cervical cancer are detected and treated. Most precursor lesions detected by screening heal spontaneously. Those who progress do it slowly.
- Trial name
- EXCIN2 (NCT03177863)
- Testing
- Expectancy
- Where
- 5 sites in Sweden
- Volunteers
- 125 people
- Sponsor
- Sahlgrenska University Hospital
Anatomy, Laparoscopy
Closure of the Uterine Artery at Its Origin vs at the Cervix: a Randomized Trial
One of the fundamental surgical steps in patients undergoing laparoscopic hysterectomy is the closure of the uterine artery, this vessel provides the greatest blood supply to the uterus.
- Conditions
- Anatomy, Laparoscopy, Uterine Artery, Hysterectomy
- Trial name
- NCT04156932
- Testing
- uterine artery closure
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Ospedale degli Infermi di Biella
Healthy
Non-Invasive Non-Ionizing Polarized Imaging System to Assess Structure of Cervix
Background: The uterine cervix is composed of muscle and collagen, which change as women age and under hormonal influences like puberty, pregnancy, and menopause.
- Trial name
- NCT00955864
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)