Clinical trials: Cervix Uteri-Diseases
Cervix Carcinoma
Radiotherapy + Metronidazole vs Radiotherapy Alone In Improving Treatment Outcomes in Advanced Cervical Cancer in Uganda
The objective of the study was to determine whether there was a difference in the effectiveness of Radiotherapy alone compared with Radiotherapy plus Metronidazole in the treatment of women with advanced cancer of the cervix in…
- Trial name
- NCT01937650
- Testing
- Radiotherapy plus metronidazole
- Volunteers
- 38 people
- Sponsor
- Makerere University
Cancer of the Cervix, Vulvar Cancer
Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers
This study expands on protocol (NCT01908504"PET adaptive RT") designed to evaluate the utility of adaptive PET-CT planning for radiation therapy (RT).
- Conditions
- Cancer of the Cervix, Vulvar Cancer, Esophageal Cancer, Anal Canal Cancer
- Trial name
- NCT03403465
- Testing
- FDG PET scan
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Duke University
Cervix Cancer, Vaginal Cancer
Impact of a Sexological Follow-up on the Sexual Function in Patients With Cervix or Vaginal Cancer Treated by Radiotherapy and Brachytherapy
Prospective, monocentric study evaluating the impact of a nurse-led sexological follow-up on sexual function in patients with cervix or vaginal cancer treated by radiotherapy and brachytherapy.
- Trial name
- FEMINICOL (NCT03956498)
- Testing
- Patients with cervix or vaginal cancer treated by radiotherapy and brachytherapy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut Claudius Regaud
Cervical Cancer
Predictive Assays In Cervix Cancer
The experiments outlined in this proposal will compare a number of currently available techniques for assessing hypoxia and interstitial fluid pressures in patients with cervix cancer.
- Trial name
- NCT01181375
- Testing
- Tumour Biopsies and Blood Sampling
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto
Pregnancy, High Risk, Preterm Birth
Prevention of Preterm Birth by Screening of the Consistency Index and Length of the Uterine Cervix in Women With a Single Pregnancy
Preterm birth (PTB) is the major cause of perinatal morbidity and mortality. Worldwide, about 15 million babies are born too soon every year, causing 1.1 million deaths, as well as short- and long-term disability in countless…
- Conditions
- Pregnancy, High Risk, Preterm Birth, Cervix; Pregnancy, Obstetric Labor, Premature
- Trial name
- PreBirthCerv (NCT04444206)
- Testing
- Transvaginal ultrasound cervical length screening
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Campania Luigi Vanvitelli
Cervical Intraepithelial Neoplasia Grade 2/3, Carcinoma Cervix
Extended VALidation of HUman Papillomavirus Assays and Collection DEvices for HPV Testing on Self-samples
The "Extended VALHUDES" study is a Clinical Performance / Diagnostic Test Accuracy Study that aims to extend validation, achieved as part of the "Belgian VALHUDES", of HPV testing using BD Onclarity on samples collected using…
- Trial name
- Ext-VALHUDES (NCT04788849)
- Testing
- BD Onclarity™ HPV assay
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Milano Bicocca
Cervix Lesion, Cervical Cancer
Application of Plasma Circulating HPV DNA Testing to Management of Cervical Intraepithelial Neoplasia
The purpose of this study is to see if circulating HPV DNA (cHPVDNA) can be used as a noninvasive biomarker for cervical intraepithelial neoplasia (CIN) 2-3 in hopes of reducing procedures and costs for patients, as well as…
- Trial name
- NCT04274465
- Testing
- digital PCR (dPCR) assay
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Diagnoses Disease, Screening
Strategies for Endocervical Canal Investigation in Women With Abnormal Screening Cytology and Negative Colposcopy
cervical cancer is the fourth most frequent cancer in women worldwide and in Brazil, it occupies the third position for the triennium 2020/2022, with a high mortality rate and maintained in the last 10 years.
- Conditions
- Diagnoses Disease, Screening, HSIL of Cervix, Cervical Cancer
- Trial name
- NCT05120167
- Testing
- Endocervical liquid-base cytology, Endocervical cell block, Endocervical curettage
- Where
- 4 sites in Brazil
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Cirbia Silva Campos Teixeira
Cervix; Intraepithelial Neoplasia
Depth of Necrosis in Normal Cervical Epithelium After 85% Trichloroacetic Acid (TCA) Application
Early detection and treatment of precancerous lesions are the pillars of cervical cancer prevention. Cervical Intraepithelial Neoplasia (CIN) is a precancerous lesion that histologically can be found in one of three stages of…
- Trial name
- NCT04911075
- Testing
- 85% TCA Solution
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Papillomavirus Infections, Dysplasia
Matrix Metalloproteinases and Human Papillomavirus in Dysplasias and Cancers of the Cervix
This study aims to compare the expression of matrix metalloproteinases and their tissue inhibitors between 4 groups of patients defined according to the severity of the cervical lesion.
- Conditions
- Papillomavirus Infections, Dysplasia, Cervix Cancer
- Trial name
- MMP-HPV (NCT04072913)
- Testing
- Vaginal samples (biopsies + vaginal smear)
- Where
- France
- Volunteers
- 216 people
- Sponsor
- University Hospital, Bordeaux
Cervical Cancer, Cervix Cancer
Investigating the Combination of VB10.16 and Atezolizumab in Patients With HPV 16-positive Cervical Cancer
This phase IIa study is designed to evaluate the safety and efficacy of multiple dosing with VB10.16 immunotherapy in combination with atezolizumab in patients with advanced or recurrent non-resectable HPV16-positive cervical…
- Trial name
- NCT04405349
- Testing
- VB10.16, Atezolizumab
- Where
- 21 sites in Belgium, Bulgaria and 4 more
- Volunteers
- 52 people
- Sponsor
- Nykode Therapeutics ASA
HPV Infections, Precancerous Disease of the Cervix
Primary and Secondary Prevention of Human Papillomavirus (HPV) Disease in China
In a hospital-based multi-center study in China, HPV 16 was found to be the predominant type (72.9%) in cervical cancer, followed by HPV 18(8.0%) which indicated that if the HPV prophylactic vaccine are wisely applied in China…
- Conditions
- HPV Infections, Precancerous Disease of the Cervix, Cervical Cancer, HPV Related Diseases
- Trial name
- NCT01021904
- Testing
- Gardasil (VLP, HPV Quadrivalent prophylactic vaccine)
- Volunteers
- 6,200 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Recurrent Cervical Carcinoma
Docetaxel in Treating Patients With Persistent or Recurrent Cervical Cancer
Phase II trial to study the effectiveness of docetaxel in treating patients who have persistent or recurrent cervical cancer. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or…
- Trial name
- NCT00041093
- Testing
- Docetaxel
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Gynecologic Oncology Group
Human Papilloma Virus Infection, Carcinoma in Situ of Uterine Cervix
Community-Driven Cervical Cancer Prevention in Western Kenya
There are many challenges to implementation of cervical cancer prevention in resource-limited countries, despite evidence based screening and treatment strategies.
- Trial name
- NCT02124252
- Testing
- Community-based testing with standard linkage to care, Community-based HPV testing with enhanced linkage to care
- Where
- Kenya
- Volunteers
- 7,200 people, healthy volunteers welcome
- Sponsor
- Duke University
Metastatic Tumor, Advanced Solid Tumor
A Clinical Research About CD70-positive Advanced/Metastatic Solid Tumors Treated by CD70-targeted CAR-T
As a phase I clinical research，this study plans to evaluate the safety and tolerability of CD70-targeting CAR-T cells in the treatment of CD70-positive advanced/metastatic solid tumors, and obtain recommended doses and infusion…
- Conditions
- Metastatic Tumor, Advanced Solid Tumor, Renal Cell Carcinoma, Ovarian Cancer
- Trial name
- NCT05468190
- Testing
- CD70 CAR-T cells
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Cervical Squamous Cell Carcinoma, Recurrent Cervical Carcinoma
Cetuximab in Treating Patients With Persistent or Recurrent Cervical Cancer
This phase II trial is studying cetuximab to see how well it works in treating patients with persistent or recurrent cervical cancer. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways.
- Trial name
- NCT00499031
- Testing
- Cetuximab
- Where
- 22 sites in United States
- Volunteers
- 38 people
- Sponsor
- Gynecologic Oncology Group
Breast Cancer, Cervix Cancer
Carboplatin-cyclophosphamide Combined With Atezolizumab
This is a single centre, 3+3, dose finding, open label, phase 1b clinical study of carboplatin and cyclophosphamide, in combination with atezolizumab.
- Conditions
- Breast Cancer, Cervix Cancer, Ovarian Cancer, Endometrial Cancer
- Trial name
- PROLOG (NCT02914470)
- Testing
- carbplatin, cyclophophamide, atezolizumab
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- The Netherlands Cancer Institute
Ovary Cancer, Cervix Cancer
Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors
The purpose of the trial is to establish the tolerability of HuMax-TF-ADC in a mixed population of patients with specified solid tumors.
- Conditions
- Ovary Cancer, Cervix Cancer, Endometrium Cancer, Bladder Cancer
- Trial name
- NCT02001623
- Testing
- Tisotumab Vedotin (HuMax-TF-ADC)
- Where
- 29 sites in United States, Belgium and 3 more
- Volunteers
- 195 people
- Sponsor
- Seagen Inc.
Uterine Cervical Neoplasms
ENGOT-cx1/BGOG-cx1: 3 Weekly Carboplatin/Paclitaxel With or Without Nintedanib in Cervix Cancer
Indication: Treatment of subjects with advanced (FIGO stage IVB) or recurrent cervical cancer, prior radiochemotherapy or neo-adjuvant chemotherapy is allowed.
- Trial name
- NCT02009579
- Testing
- Nintedanib
- Where
- 32 sites in Belgium, Germany and 2 more
- Volunteers
- 120 people
- Sponsor
- Belgian Gynaecological Oncology Group
Cervix Cancer
Prevalence of Abnormal Pap Smear
This study aims to evaluate prevalence of abnormal Pap smear among sexually active women of reproductive age attending sohag university hospital outpatient clinic.
- Trial name
- NCT06641531
- Testing
- Screening pap smear test
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sohag University