Clinical trials: Cervix Uteri-Diseases
Cancer of Cervix
Prevention and Control of Neoplasms Associated With HPV in High-risk Groups in Mexico City: The Condesa Study
Objective: To evaluate the effectiveness of a combined strategy of human papillomavirus virus (HPV) vaccination and high-risk HPV screening to reduce the occurrence of neoplasms in the anogenital region and oral cavity among men…
- Trial name
- CONDESA (NCT05149248)
- Testing
- Gardasil® [Quadrivalent Human Papillomavirus (Types 6,11,16,18) Recombinant vaccine], Two dose, Control group
- Where
- Mexico
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Endometrial Carcinoma, Cervix Cancer
Dosimetric Analysis of Vaginal Cuff Brachytherapy in Endometrial Carcinoma
The purpose of this study is to investigate the effect of certain variables such as the fullness of the patients bladder and the position of the treatment applicator on the dose of radiation that other organs such as the bladder…
- Conditions
- Endometrial Carcinoma, Cervix Cancer, Carcinoma of the Uterus
- Trial name
- NCT00165126
- Testing
- Radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Dana-Farber Cancer Institute
Uterine Cervical Dysplasia
A Study of Amolimogene (ZYC101a) in Patients With High Grade Cervical Intraepithelial Lesions of the Uterine Cervix
The purpose of this study is to evaluate the efficacy and safety of amolimogene, in the treatment of patients with high-grade cervical intraepithelial lesions of the uterine cervix.
- Trial name
- NCT00264732
- Testing
- Amolimogene
- Where
- 26 sites in United States
- Volunteers
- 251 people
- Sponsor
- Eisai Inc.
Neoplasms, Uterine Cervix, Metastatic Cervical Cancer
Pazopanib Plus Lapatinib Compared to Lapatinib Alone and Pazopanib Alone In Subjects With Metastatic Cervical Cancer
This study is being conducted to compare the efficacy and safety of pazopanib in combination with lapatinib with that of lapatinib alone or pazopanib alone in subjects with metastatic cervical cancer
- Trial name
- NCT00430781
- Testing
- pazopanib (GW786034), lapatinib (GW572016)
- Where
- 63 sites in United States, Argentina and 11 more
- Volunteers
- 228 people
- Sponsor
- GlaxoSmithKline
Cervical Intraepithelial Neoplasia Grade 2/3, High-risk HPV (Any Strain)
Intravaginal Artesunate for the Treatment of HPV+ High Grade Cervical Intraepithelial Neoplasia (CIN2/3)
This phase I research protocol is designed to assess immunogenicity and clinical endpoints in patients with human papillomavirus (HPV) 16 cervical intraepithelial neoplasia (CIN)2/3.
- Trial name
- NCT02354534
- Testing
- Artesunate Suppositories
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Cervix Cancer
Investigation of Cervix Tumor Oxygenation and Microvasculature Using Magnetic Resonance Techniques
In cervix cancer tumor oxygen levels and fluid pressure in the tumor have been shown to be related to patient outcome. Analysis of the way tumors enhance after intravenous contrast injection using MRI and CT can be used to…
- Trial name
- NCT00242034
- Testing
- CT and MRI with contrast
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Comparison of Four Combination Chemotherapy Regimens Using Cisplatin in Treating Patients With Stage IVB, Recurrent, or Persistent Cancer of the Cervix
This randomized phase III trial is studying four combination chemotherapy regimens using cisplatin to compare how well they work in treating women with stage IVB, recurrent, or persistent cancer of the cervix.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Recurrent Cervical Carcinoma
- Trial name
- NCT00064077
- Testing
- Cisplatin, Gemcitabine Hydrochloride, Paclitaxel
- Where
- United States
- Volunteers
- 513 people
- Sponsor
- Gynecologic Oncology Group
Cancer of Prostate, Cancer Head Neck
ARCHERY - Artificial Intelligence Based Radiotherapy Treatment Planning for Cervical, Head and Neck and Prostate Cancer
The aim of this study is to look at whether an Artificial Intelligence (AI) based computer program can automate two components of the radiotherapy treatment pathway to a sufficient quality standard to enable its routine clinical…
- Conditions
- Cancer of Prostate, Cancer Head Neck, Cancer Cervix
- Trial name
- NCT05653063
- Testing
- A web-based artificial intelligence (AI) auto-planning tool
- Where
- 6 sites in India, Jordan and 2 more
- Volunteers
- 1,029 people
- Sponsor
- University College, London
Cervical Cancer, Anemia
A Study to Evaluate the Impact of Maintaining Hemoglobin Levels in Anemic Patients With Carcinoma of the Cervix
The purpose of this study is to assess the feasibility, safety and short term effects on health related quality of life, of maintaining hemoglobin from 120 to 130 g/L versus from 100 to 110 g/L, with red cell concentrate (RCC)…
- Trial name
- HOSTT (NCT00921635)
- Testing
- Blood transfusion
- Volunteers
- 2 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Cancer of the Cervix, Cervical Intraepithelial Neoplasia
Compass - Randomised Controlled Trial of Primary HPV Testing for Cervical Screening in Australia
Compass is a randomised controlled trial of primary HPV testing for cervical cancer screening in Australia. A pilot study involving 5,000 women was carried out in 2013-2014.
- Trial name
- Compass (NCT02328872)
- Testing
- Molecular testing for HPV, Liquid Based Cytology
- Where
- Australia
- Volunteers
- 76,181 people, healthy volunteers welcome
- Sponsor
- VCS Foundation
HIV Infections, Cervix, Dysplasia
Safety and Effectiveness of Giving Isotretinoin to HIV-Infected Women to Treat Cervical Tumors
The purpose of this study is to see if it is safe and effective to give isotretinoin to HIV-infected women with cervical tumors to prevent these tumors from becoming cancerous.
- Trial name
- NCT00001073
- Testing
- Isotretinoin
- Where
- 40 sites in United States, Puerto Rico and 1 more
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cervical Cancer
Phase I Pilot Study to Evaluate the Prognostic Value of Perfusion CT for Primary Cervical Cancer
The investigators hope to learn whether perfusion CT is a useful way to assess primary cervical tumor microenvironment and whether there is a relationship between pretreatment perfusion CT measurements and primary cervical tumor…
- Trial name
- NCT01805141
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stanford University
Cervical Cancer
Safety Study of Nelfinavir + Cisplatin + Pelvic Radiation Therapy to Treat Cervical Cancer
Nelfinavir will increase the efficacy of Cisplatin based chemo- radiation therapy for locally advanced cervical cancer.
- Trial name
- NCT01485731
- Testing
- Nelfinavir, Cisplatin, Pelvic External Beam Radiation Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Miami
Cervical Cancer
Post Market Clinical Follow-up Study Venezia
The investigational device is the Advanced Gynecological Applicator (AGA) Venezia configuration, an applicator to treat locally advanced stage cervical cancer.
- Trial name
- NCT03958357
- Testing
- Advanced Gynecological Applicator configuration
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 41 people
- Sponsor
- Nucletron Operations BV
Cervical Intraepithelial Neoplasia, Cervical Neoplasms
Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies
Background: Gene therapy is closely followed by the U.S. Food and Drug Administration (FDA). The FDA requires researchers to conduct long-term follow-up of people who have had the treatment.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Neoplasms, Oropharyngeal Neoplasms, Squamous Intraepithelial Lesions of the Cervix
- Trial name
- NCT04266093
- Testing
- GeneTherapy
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Lesion, Vaginal Bleeding
RWE Study in the Treatment of Cervical Lesions of Various Etiology
The aim of the study was to assess the post-market performance and tolerability of Cerviron® ovules in the treatment and management of cervical lesions of different etiologies.
- Trial name
- NCT05668806
- Testing
- Cerviron
- Where
- 15 sites in Romania
- Volunteers
- 345 people
- Sponsor
- Perfect Care Distribution
Cervix Cancer, Screen HPV-positive
Uniting Trusted Community Messengers to Improve Access to Cervical Cancer Screening in Rural North Carolina
The purpose of this study is to test the feasibility and acceptability of a multi-level, community-engaged intervention to increase access to cervical cancer screening using human papillomavirus (HPV) self-collection (HPVSC)…
- Trial name
- NCT07294066
- Testing
- Human papilloma virus screening
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
CIN, Cervical Cancer
New Gentle Biopsy Method of Cervix Lesions Using Superficial Curettage/Protocol ID: CX-CUR
It is to investigate to what extent a gentle tissue extraction of CIN lesions of the cervix will bring the same conclusion than the conventional cervix biopsy, but with less pain and morbidity, after patients were undergoing a…
- Trial name
- NCT01836588
- Testing
- conventional cervix biopsy
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Cervix Cancer, Endometrial Cancer
2D vs 3D Planning for High-Dose Rate (HDR) Gynecological Brachytherapy
Demonstrate the limitations of conventional dosimetry (2D) for the adjuvant brachytherapy treatment and assess whether tridimensional dosimetry relates more faithfully with the occurrence of adverse effects.
- Trial name
- NCT02091050
- Testing
- 2D HDR planning, 3D HDR planning
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- AC Camargo Cancer Center
Cervical Squamous Cell Carcinoma, Recurrent Cervical Cancer
Bevacizumab in Treating Patients With Persistent or Recurrent Cancer of the Cervix
This phase II trial is to see if bevacizumab works in treating patients who have persistent or recurrent cancer of the cervix. Monoclonal antibodies, such as bevacizumab, can block cancer growth in different ways.
- Trial name
- NCT00025233
- Testing
- bevacizumab, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)