Clinical trials: Cesarean Section
Postcesarean Analgesia
Transversus Abdominis Plane Block Versus Wound Infiltration for Postcesarean Analgesia
The study will compare the analgesic efficacy of transversus abdominis plane block and wound infiltration in parturients undergoing cesarean delivery under spinal anesthesia.
- Trial name
- NCT02691572
- Testing
- Spinal anesthesia, Intrathecal bupivacaine, Intrathecal fentanyl
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Anesthesia
Comparison of Intratechal Levobupivacaine and Adding With Sufetanil and Fentanyl in Ceserean Section
45 pregnant women undergoing cesarean section were enrolled in the study in november 2006 to march 2007. 2 ml of 0.5% levobupivacaine was added to 1 ml of saline in group I, 1 ml of 15 µcg of fentanyl in group II and 1 ml of 1,5…
- Trial name
- NCT02430090
- Testing
- Levobupivacaine, Fentanyl, Sufentanil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Pre-Eclampsia
Restrictive Fluid Therapy in Severe Preeclampsia
Introduction: Pre-eclampsia is a multifactorial syndrome which occurs in hypertension and proteinuria in pregnant women over 20 weeks gestation.
- Trial name
- NCT02214186
- Testing
- Restrictive Fluid Therapy
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
Pruritus, Pregnancy Related
Treatment of Pruritus With Intramuscular Promethazine
Neuraxial narcotics are commonly used in obstetric patients for cesarean delivery to help with pain control over the first 24 hours after the surgery.
- Trial name
- NCT04805073
- Testing
- Promethazine
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Florida
Other Chronic Postoperative Pain
High Pain Intervention in Cesarean Sections
In previous studies the investigators have seen that the severity of pain one day after cesarean delivery can predict the presence of pain and depression 2 months later.
- Trial name
- NCT01298778
- Testing
- Duramorph 150, Acetaminophen, Duramorph 300
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Wake Forest University Health Sciences
Obstetric Pain, Postpartum Depression
Ketamine to Improve Recovery After Cesarean Delivery - Part 1
The objective of this study is evaluate the breastmilk transfer and pharmacokinetics (Part 1) and effectiveness (Part 2) of a post-cesarean delivery intravenous ketamine bolus-and-infusion strategy, as a preventive analgesic…
- Conditions
- Obstetric Pain, Postpartum Depression, Breastfeeding, Pain, Acute
- Trial name
- KINETIC (NCT04037085)
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Pain, Postoperative
Liposomal Bupivacaine at Cesarean Delivery to Decrease Post-operative Pain
This is a randomized controlled trial to test whether the use of liposomal bupivacaine at the time of cesarean delivery may decrease post-operative pain scores.
- Trial name
- NCT02959996
- Testing
- Liposomal bupivacaine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Pain, Postoperative, Caesarean Section
Infiltration Analgesia After Caesarean Section
Infiltration of a local anesthetic into the surgical wound is a simple method to strive to control postoperative pain after surgery. In the investigators institution, this method is used quite often.
- Trial name
- NCT01094106
- Testing
- Ropivacaine 0,75%, NaCl 0,9%
- Where
- Finland
- Volunteers
- 70 people
- Sponsor
- North Karelia Central Hospital
Pain
Pain Study of Rectus Muscle Closure at Cesarean Delivery
Suture reapproximation of the rectus muscles at primary cesarean delivery is a common practice about which there are no data. Some Obstetricians believe that suture reapproximation of the rectus muscles increases post-operative…
- Trial name
- NCT00505362
- Testing
- Rectus closure
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Stanford University
Pain, Postoperative
Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery
This study will compare IV (intravenous) versus oral (PO) acetaminophen for postoperative pain after scheduled, elective Cesarean delivery.
- Trial name
- NCT02487303
- Testing
- Acetaminophen Intravenous, Acetaminophen Oral
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cesarean Section, Pain, Postoperative
RCT (Randomized Controlled Trial) of IV Acetaminophen for Post Cesarean Pain Relief
This study is being done to evaluate the scheduled use of intravenous (IV) acetaminophen among cesarean section patients. The study hopes to find out if patients who receive scheduled IV acetaminophen for 48 hours following…
- Trial name
- NCT02046382
- Testing
- IV Acetaminophen
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- TriHealth Inc.
Obese Patients Undergoing Cesarean Section
The Effect of a Self-Retaining Pannus Retractor in Obese Patients Undergoing Cesarean Section
The purpose of this study is to investigate the effects of the Traxi Pannus retractor in obese patients (BMI ≥30 kg/m2) who undergo Cesarean sections compared to routine pannus retraction techniques.
- Trial name
- Traxi (NCT02865083)
- Testing
- Traxi Pannus Retractor
- Volunteers
- 4 people
- Sponsor
- St. Louis University
Pain Levels
Dural Puncture Epidural Versus Epidural Anesthesia for Cesarean Delivery
This study will compare two anesthetics techniques called Dural Puncture Epidural (DPE) and Standard Epidural as to which of the two can provide faster and potentially better at providing pain relief for cesarean sections.
- Trial name
- NCT03915574
- Testing
- 25G Dural Puncture Epidural, Standard Epidural
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Arkansas
Surgical Wound
A Clinical Trial of Subcuticular Staples Versus Subcuticular Suture for Cesarean Section Skin Closure
Currently, the way doctors close the skin during cesarean section is different between surgeons and there is little evidence to support the use of one kind of closure over the other.
- Trial name
- NCT01753518
- Testing
- Subcuticular suture, Subcuticular staple
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Margaret L. Dow, M.D.
Hemorrhage, Cesarean Section
Continuous Non-Invasive Measurement of Hemoglobin During Parturition
A non-invasive hemoglobin monitor will be used during cesarean delivery and the values obtained will be compared to values obtained from traditional blood draw.
- Trial name
- NCT03150043
- Testing
- Masimo Rainbow Pulse CO-oximeter
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Operative Time, Wound Heal
Subcuticular Absorbable Staples Versus Conventional Skin Closure in Women Undergoing Cesarean Delivery
Despite the high numbers of cesareans being performed, scientific evidence behind which surgical techniques are best remains uncertain.
- Trial name
- NCT05112640
- Testing
- INSORB: subcuticular stapling device, Subcuticular monocryl suture manufactured by Ethicon
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cesarean Section
Ripening Interventions: Prostaglandins vs EASI Catheter
The primary aim of this randomized clinical trial is to compare the effect of misoprostol vs extra amniotic saline infusion via a catheter (EASI) for cervical ripening on the proportion of patients delivered by cesarean section…
- Trial name
- RIPE (NCT00383942)
- Testing
- Misoprostol, Catheter
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Loyola University
Endometritis, Wound Infection
Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
The Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) study is a large pragmatic multi-center randomized clinical trial designed to evaluate the comparative effectiveness and safety of azithromycin-based extended-spectrum…
- Conditions
- Endometritis, Wound Infection, Abscess, Surgical Site Infection
- Trial name
- C/SOAP (NCT01235546)
- Testing
- Azithromycin and standard of care
- Where
- 9 sites in United States
- Volunteers
- 2,013 people
- Sponsor
- Alan Tita
Obstetrical Complications, Hemorrhage
Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean
A randomized placebo-controlled trial of 11,000 women to assess whether tranexamic acid as prophylaxis lowers the risk of postpartum hemorrhage in women undergoing a cesarean delivery.
- Conditions
- Obstetrical Complications, Hemorrhage, Labor and Delivery
- Trial name
- TXA (NCT03364491)
- Testing
- Tranexamic Acid
- Where
- 12 sites in United States
- Volunteers
- 11,000 people
- Sponsor
- The George Washington University Biostatistics Center
Pain, Postoperative, Postoperative Nausea and Vomiting
Dexamethasone for Post-cesarean Delivery Pain
The purpose of this study is to compare post-cesarean section consumption of pain medication between two groups of patients undergoing scheduled cesarean section at term gestation who receive a single-dose of intraoperative…
- Trial name
- NCT01812057
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Duke University