Clinical trials: Cessation, Smoking
Smoking
Study of TA-NIC to Assess the Efficacy and Safety of the Vaccine as an Aid to Smoking Cessation
Over 1 billion people worldwide smoke, resulting in an estimated 4 million deaths annually from smoking-related disease.1 Persistent and long-term smoking leads to an increased risk of cardiovascular damage, respiratory disease…
- Trial name
- NCT00633321
- Testing
- TA-NIC
- Where
- 9 sites in United States
- Volunteers
- 522 people, healthy volunteers welcome
- Sponsor
- Celtic Pharma Development Services
Smoking Cessation
Smoking Cessation Study In Healthy Adolescent Smokers
The study is designed to see if varenicline combined with age appropriate (adolescent) smoking cessation counseling will help teens quit smoking.
- Trial name
- NCT01312909
- Testing
- Varenicline 1mg BID, Varenicline 0.5mg BID
- Where
- 80 sites in United States, Canada and 4 more
- Volunteers
- 312 people
- Sponsor
- Pfizer
Tobacco Dependence
Nicotine Pharmacodynamics With a New Oral Nicotine Replacement Therapy and Nicotine Gum
A comparison of two products for oral nicotine replacement with respect to relief of urges to smoke after single doses of nicotine.
- Trial name
- NCT01368016
- Testing
- Nicotine
- Where
- 2 sites in Sweden
- Volunteers
- 346 people
- Sponsor
- McNeil AB
Smoking Cessation, Nicotine Dependence
Study Assessing Efficacy and Safety of NFL-101 as a Tobacco Cessation Therapy
CESTO 2 is a 318 participants, 3-arm, multicentric, randomized, double-blind, placebo-controlled Phase II clinical trial. The main objectives are to select the most efficient dose and to assess long-term efficacy of NFL-101…
- Trial name
- CESTO2 (NCT04571216)
- Testing
- NFL-101 dose 1, NFL-101 dose 2
- Where
- 9 sites in France
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- NFL Biosciences SAS
Smoking
In It To Quit: Commitment Contracts for Smoking Cessation
This study aims to examine whether a combination of positive and negative commitment devices is effective at inducing long-term smoking cessation in smokers from a low-to-moderate income background.
- Trial name
- I2Q (NCT02596061)
- Testing
- Deposit Contract, Incentives
- Where
- United States
- Volunteers
- 311 people, healthy volunteers welcome
- Sponsor
- Community Health Center, Inc.
Smoking Cessation
Safety and Efficacy Study of the NRT CQSS2 System for Smoking Cessation in Treatment-Seeking Subjects
Transdermal nicotine delivery systems are a cigarette smoking cessation aid designed to deliver nicotine into the systemic circulation via the skin.
- Trial name
- NCT03178422
- Testing
- CQSS2, NicoDerm CQ Patch
- Where
- 5 sites in United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Chrono Therapeutics, Inc.
Smoking Cessation
A First-in-Human Study of SBP-9330 in Healthy Subjects
This is a single center, first-in-human, randomized, double-blind, placebo-controlled, Single-Ascending Dose (SAD) / Multiple-Ascending Dose (MAD) study incorporating a food-effect cohort.
- Trial name
- NCT04948827
- Testing
- SBP-9330
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Camino Pharma, LLC
Smoking Cessation
Pharmacoeconomic Assessment in Nabi-4514 and Nabi-4515 Phase 3 Studies
The purpose of this study is to look at pharmacoeconomic data for subjects that have received either NicVAX or placebo in the Nabi-4514 or Nabi-4515 studies.
- Trial name
- NCT01178346
- Testing
- NicVAX vaccine
- Where
- 25 sites in United States
- Volunteers
- 500 people
- Sponsor
- Nabi Biopharmaceuticals
Tobacco Smoking Cessation, Motivation
Pro-Change Smoking Cessation Intervention
The purpose of this study is to determine whether a behavioral economics solution impacts smoking cessation program engagement and quit rates.
- Trial name
- NCT02299076
- Testing
- Behavioral economics incentives, Minimal incentives
- Where
- United States
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- VAL Health, LLC
Smoking Cessation
Effects of EVT 302 With or Without NRT on Craving and Withdrawal in Healthy Male Smokers Deprived of Cigarettes
This randomised, placebo-controlled study is designed to explore the effects of EVT 302 both with and without concomitant nicotine replacement therapy (NRT) on craving and withdrawal in smokers after short term deprivation of…
- Trial name
- NCT00622752
- Testing
- EVT 302, 10 mg, Nicotine replacement therapy (NRT)
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Evotec Neurosciences GmbH
Lung Neoplasms, Pulmonary Disease, Chronic Obstructive
A Study of Smoking Cessation Patterns in Participants Undergoing Lung Surgery
The purpose of this study is to assess the current smoking status and smoking cessation attempts among smokers or recent smoking quitters during the perioperative period, to describe postoperative pulmonary complications (PPCs)…
- Trial name
- CHAMPION (NCT04313361)
- Testing
- No intervention
- Where
- 3 sites in China
- Volunteers
- 290 people
- Sponsor
- Johnson & Johnson (China) Investment Ltd.
Smoking Cessation
Phase II Study to Evaluate the Effectiveness of EVT 302 in Smoking Cessation.
This study will investigate the efficacy of EVT 302, a potent and selective inhibitor of Monoamine Oxidase - B, in improving quit rates in chronic cigarette smokers who are motivated to quit smoking.
- Trial name
- NCT00738595
- Testing
- EVT 302, EVT 302 plus open label Nicotine replacement
- Where
- 9 sites in Germany
- Volunteers
- 400 people
- Sponsor
- Evotec Neurosciences GmbH
Smoking Cessation, Smoking, Tobacco
Pivot Breath Sensor Performance Study
A clinical study enrolling 70 subjects to: evaluate the user performance of the Pivot Breath Sensor compare measurements from the Pivot Breath Sensor to a similar device assess user documentation comprehension obtain feedback on…
- Trial name
- NCT03870022
- Testing
- Pivot Breath Sensor System, Similar Carbon Monoxide breath sensor system
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Jennifer Marler, MD
Smoking Cessation
Comparison of Efficacy and Safety of Rimonabant 20mg/Day Versus Placebo in Smoking Cessation
The primary objective is to assess the efficacy a 20mg/day fixed dose of rimonabant versus placebo on abstinence from tobacco use in cigarette smoker.
- Trial name
- STRATUS-META (NCT00464256)
- Testing
- rimonabant
- Where
- United States
- Volunteers
- 533 people
- Sponsor
- Sanofi
Smoking Cessation
A Study To Evaluate The Efficacy And Safety Of Varenicline Compared To Placebo For Smoking Cessation Through Reduction
This study will determine whether varenicline is safe and helps people to quit smoking through reduction when they are not willing/able to make an abrupt quit attempt.
- Trial name
- NCT01370356
- Testing
- Varenicline Tartrate
- Where
- 65 sites in United States, Australia and 8 more
- Volunteers
- 1,510 people
- Sponsor
- Pfizer
Smoking Cessation
A Pharmacokinetic and Pharmacodynamic Evaluation of Cytisine in Healthy Smokers
The primary objectives of this study are: To evaluate the pharmacokinetic (PK) parameters during repeat dosing of 1.5 mg or 3.0 mg cytisine when administered as the commercial 25-day schedule.
- Trial name
- NCT03303911
- Testing
- Cytisine
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Achieve Life Sciences
Tobacco Dependence
Pharmacokinetics With Two New Oral Nicotine Replacement Products and Nicorette® Gum
Single-dose pharmacokinetics with two new oral nicotine replacement products and Nicorette® gum.
- Trial name
- NCT01152723
- Testing
- Nicotine
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- McNeil AB
Smoking Cessation, Nicotine Dependence
A Follow-up Study to Assess Long-term Immunogenicity and Safety of NicVAX/Placebo as an Aid to Smoking Cessation
The purpose of the study is to obtain two year follow up data for subjects that received six vaccinations of NicVAX in prior phase III studies. No treatment will be administered.
- Trial name
- NCT01304810
- Testing
- NicVAX vaccine
- Where
- 12 sites in United States
- Volunteers
- 300 people
- Sponsor
- Nabi Biopharmaceuticals
Healthy Smokers
Nicotine Patch - Multidose Bioequivalence Study
The purpose of this study is to compare the relative bioavailability of nicotine following repeated applications of a new transdermal formulation to that of a reference formulation. Up to day 7
- Trial name
- NCT01658215
- Testing
- V0116 transdermal patch (Test treatment ), Nicotine transdermal patch (Reference treatment )
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Smoking Cessation
Safety and Pharmacodynamcis of SELA-070 Nicotine Vaccine in Smokers
The purpose of this study is to evaluate the safety and pharmacodynamics of SELA-070. Increasing subcutaneous doses of SELA-070 will be administered to healthy smoker volunteers.
- Trial name
- NCT03148925
- Testing
- SELA-070, Saline
- Where
- Belgium
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Selecta Biosciences, Inc.