Clinical trials: Chagas Cardiomyopathy
Chagas Cardiomyopathy, Heart Failure
Cardiac Contractility Modulation in Chagas Heart Disease
Chagas disease is an endemic problem in Latin America, where millions of people are chronically infected with T. cruzi. Recently, it was assumed to have clinical and epidemiological relevance in several other countries due to…
- Conditions
- Chagas Cardiomyopathy, Heart Failure, Systolic Dysfunction, Right Bundle Branch Block and Left Anterior Fascicular Block
- Trial name
- FIX-Chagas (NCT05519046)
- Testing
- Cardiac Contractility Modulation (CCM), CRT
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- InCor Heart Institute
Chagas Cardiomyopathy, Ventricular Arrythmia
Sympathetic Denervation by Video-assisted Thoracoscopy in Control of Cardiac Arrhythmias in Patients With Chagas Disease
Ventricular tachycardia (VT) is the main cause of sudden death in patients with structural heart diseases. The use of ICD (implantable cardio-defibrillator) could prevent sudden death, however, the occurrence of repetitive shock…
- Trial name
- NCT04239144
- Testing
- Bilateral sympathectomy, Catheter ablation
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo General Hospital
Chagas Cardiomyopathy, Speckle Tracking Echocardiography
Cardiac Mechanics by Speckle Tracking as a Prognostic Predictor in Patients With Chagas Cardiomyopathy
This study aims to evaluate the prognostic value of myocardial mechanics parameters, including global longitudinal strain (GLS) and mechanical dispersion (MD), assessed through speckle tracking echocardiography, in patients with…
- Conditions
- Chagas Cardiomyopathy, Speckle Tracking Echocardiography, Arrythmias, Sudden Death
- Trial name
- ST-Chagas (NCT06806722)
- Where
- Brazil
- Volunteers
- 153 people
- Sponsor
- University of Sao Paulo
Chagas Cardiomyopathy
Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF.
Chagas disease is considered by the World Health Organization (WHO) as one of the most neglected tropical diseases in the world, having relevance in many Latin America countries.
- Trial name
- ANSWER-HF (NCT04853758)
- Testing
- Sacubitril / Valsartan Oral Tablet [Entresto], Enalapril
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo General Hospital
Chagas Cardiomyopathy, Non-sustained Ventricular Tachycardia
Amiodarone Against ICD Therapy in Chagas Cardiomyopathy for Primary Prevention of Death
The primary objective is to compare the efficacy of the treatment using implantable cardioverter defibrillator (ICD) implantation to that of the treatment using amiodarone in the primary prevention of all-cause mortality in…
- Conditions
- Chagas Cardiomyopathy, Non-sustained Ventricular Tachycardia, At Least 10 Points in Rassi Risk Score for Death
- Trial name
- CHAGASICS (NCT01722942)
- Testing
- ICD implantation, amiodarone hydrochloride
- Where
- 20 sites in Brazil
- Volunteers
- 1,100 people
- Sponsor
- InCor Heart Institute
Chagas Cardiomyopathy
Microvascular Endothelial Function in a Cohort of Patients With the Cardiac Form of Chronic Chagas Disease.
The present study aims to evaluate the microvascular endothelial function of a single centre cohort of patients with the cardiac form of Chagas disease, and to search for associations with clinical and laboratory variables.
- Trial name
- NCT03524768
- Testing
- skin laser speckle contrast imaging and video-capillaroscopy
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Chagas Disease, Chagas Cardiomyopathy
Congenital Chagas Disease: Long Term Follow up of Treated Children. Preliminary Report or Cardiological Evaluation in Chagas Disease Treated Children
Chagas disease (CD) could be acquired by contact with the vector, transplacentally and by blood transfusion. The duration and clinical presentation of the initial acute phase of the infection may be variable, but the majority of…
- Trial name
- NCT04090489
- Where
- Argentina
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Chagas Disease, Chagas Cardiomyopathy
Physical Exercise Program in Chronic Chagas Heart Disease
The aim of this investigation is to evaluate the impact of exercise in a cardiac rehabilitation program on functional capacity, clinical markers, quality of life and biomarkers in patients with chronic chagasic cardiomyopathy.
- Trial name
- PEACH (NCT02517632)
- Testing
- Exercise, nutritional and pharmaceutical counceling, Nutritional and pharmaceutical counceling
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Evandro Chagas National Institute of Infectious Disease
Chagas Cardiomyopathy
A Trial Testing Amiodarone in Chagas Cardiomiopathy
Purpose: The ATTACH trial, as currently designed, will primarily test whether a treatment with Amiodarone for at least 6 months has a trypanocidal effect among individuals with mild-to-moderate Chronic Chagas Cardiomyopathy.
- Trial name
- ATTACH (NCT03193749)
- Testing
- Amiodarone Hydrochloride
- Where
- Colombia
- Volunteers
- 200 people
- Sponsor
- Fundación Cardioinfantil Instituto de Cardiología
Chagas Cardiomyopathy
Cell Therapy in Chagas Cardiomyopathy
The purpose of this study is to determine effect of cell therapy in patients with severe dilated cardiomyopathy
- Trial name
- NCT00349271
- Testing
- Stem cell, Filgrastime (G-CSF), Standart therapy
- Where
- Brazil
- Volunteers
- 182 people
- Sponsor
- Ministry of Health, Brazil
Chagas Cardiomyopathy
Effects of Omega-3 Supplementation on the Cytokine and Lipid Profiles in Patients With Chronic Chagas Cardiomyopathy
The objective of this trial is to study the effects of omega-3 PUFA supplementation on the inflammatory response and lipid profile in patients with chronic Chagas cardiomyopathy.
- Trial name
- NCT01863576
- Testing
- Omega-3
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Evandro Chagas Institute of Clinical Research
Heart Diseases, Myocardial Diseases
Chagas Disease as an Undiagnosed Type of Cardiomyopathy in the United States
A detailed review was made of data pertinent to the occurrence of chronic Chagas disease in the United States.
- Conditions
- Heart Diseases, Myocardial Diseases, Chagas Disease
- Trial name
- NCT00005455
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chagas Disease
Longitudinal Study of Patients With Chronic Chagas Cardiomyopathy in Brazil (SaMi_Trop Project)
BACKGROUND: Chagas Disease (ChD) remains as one of the most neglected diseases in the world, with 8-10 million infected people and only one marginally effective therapeutic.
- Trial name
- SaMi-Trop (NCT02646943)
- Volunteers
- 1,959 people
- Sponsor
- University of Sao Paulo
Chagas Disease, Cardiomyopathy
Exercise Training in Chagas Cardiomyopathy
The benefits of exercise training in heart failure are well established. Its effects, however, have not been evaluated in Chagas cardiomyopathy (ChC).
- Conditions
- Chagas Disease, Cardiomyopathy, Exercise Training
- Trial name
- NCT01006473
- Testing
- Exercise training
- Where
- Brazil
- Volunteers
- 37 people
- Sponsor
- Federal University of Minas Gerais
Chagas Cardiomyopathy, Heart Failure
A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy
Chronic Chagas cardiomyopathy causes substantial morbidity and mortality in Latin America. Whether RAS inhibitors and beta-blockers are safe and beneficial has been challenged because of the lack of formal trials.
- Conditions
- Chagas Cardiomyopathy, Heart Failure, Dilated Cardiomyopathy
- Trial name
- NCT01557140
- Testing
- RASi plus carvedilol
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Federal University of Minas Gerais
Chagas Disease, Chagas Cardiomyopathy
Cardiac Rehabilitation in Chagas Heart Failure
Due to the lack of information in the literature about the role of cardiac rehabilitation on Chagas heart failure, the aim of the present study was to evaluate the effects of a cardiac exercise program on functional capacity…
- Trial name
- NCT02516293
- Testing
- Exercise, nutritional and pharmaceutical counseling
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Evandro Chagas National Institute of Infectious Disease
Heart Failure, Heart Failure, Systolic
Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease
It is a randomized prospective controlled study of transcatheter renal denervation in patients with systolic heart failure secondary to Chagas' disease.
- Conditions
- Heart Failure, Heart Failure, Systolic, Chagas Disease, Chagas Cardiomyopathy
- Trial name
- NCT02099903
- Testing
- transcatheter renal denervation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- InCor Heart Institute
Chagas Cardiomyopathy, Cardiac Arrhythmia
The Signal-averaged ElectrocArdiogram in Long Term Follow-up of Chronic CHagas Disease - RIO de Janeiro Cohort
The study investigated 100 subjects, both genders, with chronic Chagas disease, confirmed by at least two distinct serological tests, and classified according to Los Andes classification in a long term follow-up aiming at…
- Conditions
- Chagas Cardiomyopathy, Cardiac Arrhythmia, Stroke, Left Ventricular Function Systolic Dysfunction
- Trial name
- SEARCH-Rio (NCT01340963)
- Where
- 4 sites in United States, Brazil
- Volunteers
- 100 people
- Sponsor
- Universidade Gama Filho
Chagas Cardiomyopathy, Chronic Heart Failure
Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity
Chagas disease (CD) is the major cause of disability secondary to tropical diseases in young adults from Latin America. In this region 20 million people are currently infected by T. cruzi, the etiologic agent for CD.
- Trial name
- NCT00323973
- Testing
- Bisoprolol
- Where
- Colombia
- Volunteers
- 500 people
- Sponsor
- Fundación Cardiovascular de Colombia