Clinical trials: Chagas Disease
Chagas Cardiomyopathy
Cell Therapy in Chagas Cardiomyopathy
The purpose of this study is to determine effect of cell therapy in patients with severe dilated cardiomyopathy
- Trial name
- NCT00349271
- Testing
- Stem cell, Filgrastime (G-CSF), Standart therapy
- Where
- Brazil
- Volunteers
- 182 people
- Sponsor
- Ministry of Health, Brazil
Chagas Disease
CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY)
This randomized, blind, parallel-group trial will evaluate the efficacy and safety of Nifurtimox (NFX) and Benznidazole (BZN), the two usual interventions to treat the parasite Trypanosoma cruzi.
- Trial name
- CHICAMOCHA-3 (NCT02369978)
- Testing
- Nifurtimox, Benznidazole
- Where
- Colombia
- Volunteers
- 500 people
- Sponsor
- Universidad Autónoma de Bucaramanga
Chagas Disease, Heart Failure
Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC
The purpose of this study was to evaluate the effect of sacubitril/valsartan 200 mg BID compared with enalapril 10 mg BID, in addition to conventional heart failure (HF) treatment, in improving a hierarchical composite of…
- Trial name
- PARACHUTE-HF (NCT04023227)
- Testing
- Sacubitril/valsartan, Enalapril
- Where
- 79 sites in Argentina, Brazil and 2 more
- Volunteers
- 922 people
- Sponsor
- Novartis Pharmaceuticals
Chagas Disease
Pharmacokinetic Drug-Drug Interaction Study
The purpose of this study is to determine whether benznidazole and E1224 should be administered concomitantly in patients with Chagas Disease as not enough data are available.
- Trial name
- NCT03892213
- Testing
- Benznidazole, E1224
- Where
- Argentina
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Drugs for Neglected Diseases
Chagas Cardiomyopathy, Cardiac Arrhythmia
The Signal-averaged ElectrocArdiogram in Long Term Follow-up of Chronic CHagas Disease - RIO de Janeiro Cohort
The study investigated 100 subjects, both genders, with chronic Chagas disease, confirmed by at least two distinct serological tests, and classified according to Los Andes classification in a long term follow-up aiming at…
- Conditions
- Chagas Cardiomyopathy, Cardiac Arrhythmia, Stroke, Left Ventricular Function Systolic Dysfunction
- Trial name
- SEARCH-Rio (NCT01340963)
- Where
- 4 sites in United States, Brazil
- Volunteers
- 100 people
- Sponsor
- Universidade Gama Filho
Infectious Diseases
Specificity Study of Diagnostic for Chagas Disease
This study assesses the specificity of Chagas Detect™ Plus (CDP) rapid test versus standard reference tests (e.g. RIPA or IFA) for Chagas diagnosis in the US.
- Trial name
- NCT02544139
- Testing
- Chagas Detect Plus
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- InBios International, Inc.
Chagas Disease
Syndecan-4 as a Biomarker in Patients With Chagas Disease
The purpose of this study is to analyze the efficacy of syndecan-4 as a biomarker on the Chagas Disease prognosis. This analysis will be done through the correlation between the plasmatic levels of this molecule with functional…
- Trial name
- NCT01842867
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital Sao Rafael
Chagas Disease
Galectin-3 as a Biomarker in Patients With Chagas Disease
The purpose of this study is to analyze the efficacy of Galectin-3 as a biomarker on the Chagas Disease prognosis. This analysis will be done through the correlation between the plasmatic levels of this molecule with functional…
- Trial name
- NCT01842854
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital Sao Rafael
Chagas Disease
Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Trial
The purpose of this study is: 1. -to determine whether benznidazole (BZN) will be able to modify the natural evolution of chronic Chagas disease in adult patients by means of a randomized, double-blind clinical trial (RCT).
- Trial name
- TRAENA (NCT02386358)
- Testing
- Benznidazole
- Where
- Argentina
- Volunteers
- 910 people
- Sponsor
- Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben
HIV, Herpes Simplex 2
Improving Blood Safety and HIV Testing in Brazil
Conduct a randomized controlled trial (RCT) to test the hypothesis that offering client-centered HIV counseling and testing (HCT) to blood donor candidates will reduce the risk of HIV contamination in the blood supply and also…
- Conditions
- HIV, Herpes Simplex 2, Hepatitis C, Hepatitis B
- Trial name
- NCT01681420
- Testing
- HIV Counseling and Testing, Blood Donation
- Where
- Brazil
- Volunteers
- 11,900 people, healthy volunteers welcome
- Sponsor
- Vitalant Research Institute
Chagas Disease
New Tools for the Diagnosis, Prognosis and Treatment Follow-up in Chagas Disease
Chagas disease is endemic to Latin America, and is of emerging importance in non-endemic countries because migration of people infected with T. cruzi. Current methods for diagnosis of T. cruzi infection are not ideal.
- Trial name
- BIOMARCHA (NCT01755377)
- Testing
- Benznidazole
- Where
- Spain
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Barcelona Centre for International Health Research
Chagas Disease
Selenium Treatment and Chagasic Cardiopathy (STCC)
Background: Chagasic myocardiopathy caused by the protozoa Trypanosoma cruzi has been the principal cause of cardiac death in Latin America.
- Trial name
- STCC (NCT00875173)
- Testing
- Selenium
- Where
- Brazil
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Chagas Cardiomyopathy
A Trial Testing Amiodarone in Chagas Cardiomiopathy
Purpose: The ATTACH trial, as currently designed, will primarily test whether a treatment with Amiodarone for at least 6 months has a trypanocidal effect among individuals with mild-to-moderate Chronic Chagas Cardiomyopathy.
- Trial name
- ATTACH (NCT03193749)
- Testing
- Amiodarone Hydrochloride
- Where
- Colombia
- Volunteers
- 200 people
- Sponsor
- Fundación Cardioinfantil Instituto de Cardiología
Chagas Disease
Clinical Trial For The Treatment Of Chronic Chagas Disease With Posaconazole And Benznidazole
The investigators propose the evaluation of posaconazole and benznidazole in humans for the treatment of Chagas disease chronical infection. Exploratory trial of posaconazole antiparasitic activity against Trypanosoma cruzi.
- Trial name
- CHAGASAZOL (NCT01162967)
- Testing
- Benznidazole, Posaconazole
- Where
- 3 sites in Spain
- Volunteers
- 78 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chagas Disease
A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease.
This study is to investigate the ability of LXE408 to clear or reduce the level of parasites in the blood of people with chronic Chagas disease. Participants must have chronic Chagas disease without severe organ dysfunction.
- Trial name
- NCT06632600
- Testing
- LXE408, Benznidazole
- Where
- 22 sites in United States, Argentina and 2 more
- Volunteers
- 130 people
- Sponsor
- Novartis Pharmaceuticals
Chagas Cardiomyopathy
Microvascular Endothelial Function in a Cohort of Patients With the Cardiac Form of Chronic Chagas Disease.
The present study aims to evaluate the microvascular endothelial function of a single centre cohort of patients with the cardiac form of Chagas disease, and to search for associations with clinical and laboratory variables.
- Trial name
- NCT03524768
- Testing
- skin laser speckle contrast imaging and video-capillaroscopy
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Heart Diseases, Myocardial Diseases
Chagas Disease as an Undiagnosed Type of Cardiomyopathy in the United States
A detailed review was made of data pertinent to the occurrence of chronic Chagas disease in the United States.
- Conditions
- Heart Diseases, Myocardial Diseases, Chagas Disease
- Trial name
- NCT00005455
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chagas Disease
Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients
This study will evaluate the effect of food on the absorption of the drug as well as safety and tolerability of the novel 30 mg tablet (administered as 120 mg dose) in adults suffering from chronic Chagas' disease when…
- Trial name
- NCT02606864
- Testing
- Nifurtimox (BAYa2502)
- Where
- Argentina
- Volunteers
- 36 people
- Sponsor
- Bayer
Chagas Disease, Trypanosoma Cruzi Infection
Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease.
A phase 2 clinical trial to evaluate the the efficacy of different benznidazole regimens (300mg/day for 60 days, 150mg/day for 60 days, and 400mg/day for 15 days) for the treatment of chronic Chagas disease in adult patients.
- Trial name
- MULTIBENZ (NCT03191162)
- Testing
- Benznidazole
- Where
- 7 sites in Argentina, Brazil and 2 more
- Volunteers
- 238 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chagas Disease, Syphilis
Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases
Chagas disease and syphilis are considered a mayor public health problem worldwide. Both pathologies affect socio-economic vulnerable population and they are both transmitted congenitally, causing an alarming increasing number of…
- Trial name
- NCT04084379
- Where
- Argentina
- Volunteers
- 560 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires