Clinical trials: Change; Mental
Prevention, Well Being
Troubled-Desire & Therapeutic Chat for Reduction of CSAM Use (TD-CHAT)
The goal of this prospective multicentred, stratified, parallel-group superiority study is to prevent and reduce the usage of Child Sexual Abuse Material (CSAM) by a Therapist Chat Service (TCS) and Selfhelp Platform for…
- Conditions
- Prevention, Well Being, Sexual Behavior, Behavior Change
- Trial name
- TD-CHAT (NCT06852443)
- Testing
- Selfhelp modules, Therapist Chat Service
- Where
- 2 sites in Germany, Spain
- Volunteers
- 180 people
- Sponsor
- Charite University, Berlin, Germany
Cognitive Decline, Mild
Cognition, Flavonoids, Exercise, Gut Microbiome
This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants…
- Trial name
- NCT06495190
- Testing
- Blueberry, Walking, Stretching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Major Depressive Disorder
Behavioral Activation for Depression and Habitual Rumination
Depressive rumination, a negative thinking style characterized by repetitive and passive thoughts about the causes, meanings, and consequences of one's feelings and distress, is often described as being a habitual response…
- Trial name
- MoodHab (NCT06322420)
- Testing
- Behavioural Activation (BA)
- Where
- Iceland
- Volunteers
- 120 people
- Sponsor
- University of Iceland
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Pregnancy Related, Weight Gain
HealthyPregnancy - Digital Support for Pregnant Women with a BMI At 25 or Above (BMI≥25)
The study aims to examine the effectiveness of a digital care guide offering support and information on diet, physical exercise and mental well-being on pregnancy weight gain among pregnant women with a BMI at 25 or above in a…
- Trial name
- NCT06734910
- Testing
- HealthyPregnancy
- Where
- 2 sites in Denmark
- Volunteers
- 450 people
- Sponsor
- Center for Clinical Research and Prevention
Amphetamine-related Disorders
Long-term Behavior Change - 1
The purpose of this study is to determine if different reinforcement procedures (i.e., schedules) produce different patterns of long-term abstinence from methamphetamine.
- Trial name
- NCT00158197
- Testing
- contingency management voucher
- Where
- 2 sites in United States
- Volunteers
- 119 people
- Sponsor
- Friends Research Institute, Inc.
Tobacco Dependence
Tobacco Treatment for Employable Californians, Total IMPACT Study
Previous findings indicate elevated risk for tobacco use among adults in California who are unemployed and seeking work. In a pilot study, tobacco use was associated with a longer duration of time out of work.
- Trial name
- TTEC (NCT02478697)
- Testing
- ProChange ExpertSystem
- Where
- 3 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Stanford University
Depressive Disorder
Meditation Based Lifestyle Modification in Depression
To evaluate effectiveness of a 8-week behavioral Mind-Body-Intervention based on Yoga and Meditation in depressive outpatients.
- Trial name
- MBLM-D (NCT03652220)
- Testing
- Meditation Based Lifestyle Modification, Minimal treatment, Multimodal specific treatment:
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Diakonie Kliniken Zschadraß
Obesity, Appetite Disorders
Impact of a Satiating Diet in Obese Men With a Low Satiety Phenotype
The global research project was organized as a clinical process starting with an evaluation aiming at the determination of a diagnosis pertaining to the degree of satiety signal capacity.
- Trial name
- NCT03128697
- Testing
- Satiating diet, Control diet
- Where
- 2 sites in Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Laval University
Kidney Transplant Recipients, Old Age
Neurocognitive Function Changes With Extended-Release Tacrolimus Among Older Kidney Transplant Recipients
The objective of this randomized controlled study is to assess the neurocognitive outcomes between individuals using immediate-release (IR) tacrolimus (Prograf®) and those who were converted to extended-release tacrolimus…
- Trial name
- Neuro-KTR (NCT06751992)
- Testing
- Conversion to extended-release tacrolimus, Maintenance of immediate-release tacrolimus
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Massachusetts General Hospital
Alcohol Abuse, Drug Use
The Weaving Healthy Families Program
Alcohol and other drug (AOD) abuse and violence in families are co-occurring risk factors that drive health disparities and mortality among Native Americans (NA), making the long-term goal of this research is to promote health…
- Conditions
- Alcohol Abuse, Drug Use, Violence, Domestic, Child Abuse
- Trial name
- NCT03924167
- Testing
- Weaving Healthy Families Program
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tulane University
The Association of Postoperative Cognitive Dysfunction With Glymphatic Function and Neuroinflammation, The Association of Postoperative Cognitive Dysfunction With CSF Metabolomic Change
CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.
In this randomized control study, the investigators intended to evaluate the influence of different anesthetics on postoperative cognitive dysfunction, neuroinflammation, CSF metabolomics, and glymphatic function in patients with…
- Trial name
- NCT06005363
- Testing
- Dexmedetomidine, anesthesia depth monitoring
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Chang Gung Memorial Hospital
Addiction, Substance
Gamified Adaptive Approach Bias Modification on Individuals With Methamphetamine Use History
A randomized controlled trial will be conducted to investigate whether a proposed algorithm that adjusts the congruency ratio based on the user's performance and difficulty can enhance the effectiveness of approach bias…
- Trial name
- NCT05794438
- Testing
- Static Approach Bias Modification, Adaptive Approach Bias Modification
- Where
- 12 sites in China
- Volunteers
- 139 people
- Sponsor
- Adai Technology (Beijing) Co., Ltd.
Cannabis Abuse, Cannabis Dependence
The Teen Marijuana Check-Up
This behavioral research is an efficacy trial evaluating an intervention called "The Teen Marijuana Check-Up" with non-treatment seeking adolescent marijuana users.
- Trial name
- TMCU3 (NCT00350285)
- Testing
- Motivational enhancement therapy, Marijuana education
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- University of Washington
Chronic Sinusitis
Assessing Improvement in Cognitive Deficit in CRS in Patients Treated With Medical Vs Surgical Management
Chronic rhinosinusitis presents with a plethora of symptoms including non-rhinologic symptoms such as depression, sleep disturbances \& the more recently recognized cognitive dysfunction.
- Trial name
- NCT04291118
- Testing
- Private system endoscopic sinus surgery, Public system endoscopic sinus surgery, Budesonide
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- St. Paul's Hospital, Canada
Mental Disorder, Stress
Exploring Effectiveness and Mechanism of Change of an Implementation Strategy on Guideline Implementation in Schools
This project is a two-armed randomized-controlled trial exploring the effectiveness and mechanisms of change of two different implementation strategies for implementing the Guideline for the prevention of mental ill-health at the…
- Trial name
- NCT05019937
- Testing
- Educational meeting, Implementation team, Workshops
- Where
- Sweden
- Volunteers
- 2,276 people, healthy volunteers welcome
- Sponsor
- Lydia Kwak
Elderly, Alzheimer Disease
Effects of 3-Month Melatonin Treatment on Regional Cerebellar Structure and Blood Biomarkers in Alzheimer's Disease Spectrum
The goal of this clinical trial is to explore and verify the preventive effects of melatonin on the progression of Alzheimer's disease.
- Conditions
- Elderly, Alzheimer Disease, Melatonin, Cognitive Decline
- Trial name
- NCT06756828
- Testing
- Melatonin, Cognitive behavioral therapy group for insomnia
- Volunteers
- 40 people
- Sponsor
- Saint Vincent's Hospital, Korea
Insomnia
Electrophysiologic Changes in Blacks Treated With CBT for Insomnia
Insomnia is a highly prevalent, often debilitating, and economically burdensome condition. Reviews of the literature indicate that there are ethnic differences in sleep behavior, with African Americans objectively and…
- Trial name
- NCT02741336
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Self-Monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- State University of New York - Downstate Medical Center
Weight Loss, Mental Health Issue
Effects of Competitive Exergame on Weight Loss, Mental Health, and Social-emotional
Overweight and obesity are prevalent, especially among adolescents. By 2016, over 124 million children and adolescents, comprising 6% of girls and 8% of boys, were classified as obese.
- Conditions
- Weight Loss, Mental Health Issue, Overweight and Obesity
- Trial name
- NCT06579495
- Testing
- Peer involvement in Two player mode(peer involvement) in Competitive Exergame play, Single player mode in Competitive Exergame play, Children did not engage in any Competitive Exergame play
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Schizophrenia, Schizoaffective
Does tDCS Change Synaptic Density in the Brains of Patients With Schizophrenia
This study will examine changes in synaptic density with transcranial direct current stimulation (tDCS) in the brains of patients with schizophrenia.
- Trial name
- NCT05435300
- Testing
- PET Scan
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
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