Clinical trials: Change; Mental
ICU Delirium
Modified Hospital Elder Life Program at Intensive Care Unit
Delirium, a form of acute brain dysfunction, occurs in up to 81% of patients receiving mechanical ventilation in the intensive care unit (ICU).
- Trial name
- mHelp@ICU (NCT06054828)
- Testing
- mHELP@ICU
- Where
- Taiwan
- Volunteers
- 266 people
- Sponsor
- National Taiwan University Hospital
Depression, Depressive Disorder
Behavioral Activation Teletherapy to Increase Physical Activity
This is a pilot study of acceptability, feasibility, and preliminary efficacy of a brief, 10-session Behavioral Activation intervention delivered via teletherapy to increase physical activity and treat depressive symptoms.
- Conditions
- Depression, Depressive Disorder, Depressive Symptoms, Depressive Episode
- Trial name
- BAT (NCT04990401)
- Testing
- Behavioral Activation Teletherapy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Texas Southwestern Medical Center
ADHD, Time Perception Altered
Working Memory and Social-emotional Training for Preschoolers at Risk of ADHD
The study aims to explore the effectiveness of working memory training and social emotional training for young children with ADHD in Hong Kong.
- Conditions
- ADHD, Time Perception Altered, Working Memory, Social Skills
- Trial name
- NCT05162729
- Testing
- Game-like online working memory training, Game-like online social emotional training
- Where
- Hong Kong
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Anxiety
Attention Bias Modification for Reducing Health Anxiety During the Coronavirus Pandemic
The outbreak of the 2019 Coronavirus (COVID-19) pandemic is a major stressor leading to increased levels of anxiety, and specifically, an excessive fear of being infected and affected by the disease among major parts of the…
- Trial name
- NCT04365972
- Testing
- Attention Bias Modification (ABM)
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Affective Disorder
Brief Group Psychotherapy for Anxiety and Depression
The present work aims to develop a randomized clinical trial with a sample of 100 patients diagnosed with anxiety and depression in primary care.
- Trial name
- NCT04489641
- Testing
- Psychological treatment, Medication
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad de Córdoba
Attention Deficit Hyperactivity Disorder
The Efficacy of Computerized Cognitive Training in Adults With ADHD: Change in ADHD Symptoms, Executive Functions and Quality of Life Following Three Months of Training.
The study group of Adults with ADHD who will receive cognitive (executive attention) computerized training will show significant improvement in ADHD symptomatology,neuropsychological measures,daily functioning and quality of…
- Trial name
- NCT00843141
- Testing
- cognitive computerized training, simple cognitive computerized training
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Social Anxiety Disorder
Attention Bias Modification Training for Social Phobia (ABMSP)
Attentional bias has primarily been investigated as a primary cognitive etiology of social anxiety symptoms. Previous research has found that individuals with high social anxiety showed facilitated attentional engagement to…
- Trial name
- NCT06054386
- Testing
- Attentional Bias Modification Training (ABMT), General Attention Control Training
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Wisconsin, Milwaukee
Dementia Prevention, Mild Cognitive Impairment
Brain Health Support Program
The Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP, or CTU) is a comprehensive and innovative program aimed to develop, implement and evaluate an interactive and compelling…
- Conditions
- Dementia Prevention, Mild Cognitive Impairment, Subjective Cognitive Impairment, Cognitive Change
- Trial name
- CTU: BHSP (NCT05347966)
- Testing
- Brain Health PRO
- Where
- 7 sites in Canada
- Volunteers
- 354 people
- Sponsor
- Baycrest
Social Phobia
Treatment of Social Phobia With Cognitive Bias Modification
The purpose of this study is to determine whether different internet-based treatment programs, consisting of cognitive bias modification, reduce symptoms of social phobia among a population diagnosed with this disorder.
- Trial name
- NCT01577303
- Testing
- Cognitive bias modification training program variant 1, Cognitive bias modification training program variant 2, CBM training program variant 3
- Where
- Sweden
- Volunteers
- 129 people
- Sponsor
- Umeå University
Attention-Deficit Hyperactivity Disorder
A Phase II, Adaptive Trial Design Examining the Pharmacokinetic and Pharmacodynamic Effects of Modified Release Amphetamine (HLD100, Formulations B, C and E)) in Adolescents and Children With Attention-Deficit Hyperactivity Disorder (ADHD)
The main purpose of this study is to determine the rate and extent of absorption of one or more modified release formulations of amphetamine (HLD100) in both adolescents and children with ADHD.
- Trial name
- NCT01886469
- Testing
- HLD100-B, HLD100-C, HLD100-E
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Ironshore Pharmaceuticals and Development, Inc
Tobacco Dependence
Changing Thought and Action in Tobacco Dependence With Transcranial Magnetic Stimulation
This study will examine the effects of high frequency, repetitive Transcranial Magnetic Stimulation (rTMS) on decision-making and smoking behavior.
- Trial name
- rTMS (NCT00973622)
- Testing
- repetitive transcranial magnetic stimulation (rTMS) 10 Hertz (Hz), repetitive transcranial magnetic stimulation (rTMS) 20Hz
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Anorexia Nervosa
Metreleptin in Anorexia Nervosa
The treatment of anorexia nervosa often proves to be difficult. There are no drugs that work specifically for the treatment of anorexia nervosa.
- Trial name
- METRAN (NCT06305182)
- Testing
- Metreleptin, Sodium chloride
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Gabriella Milos
Major Depressive Disorder
Epigenetic Regulation of BDNF in Major Depression
The investigators will (1) detect the associations between brain-derived neurotrophic factor (BDNF) DNA methylation, histone modification, depressive symptoms, suicidal behavior and antidepressant responses in major depressive…
- Trial name
- NCT01182103
- Where
- Taiwan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Erectile Dysfunction (ED)
Sano V First In Human Study to Treat ED
A Prospective, First in Human Study to Evaluate the Safety and Performance of a Flow Modification System
- Trial name
- FMS (NCT03651024)
- Testing
- ED surgery
- Volunteers
- 10 people
- Sponsor
- Sano V Pte Ltd
Aging, Brain Metabolic Disorder
Monitoring of Brain Metabolites Using Proton and Deuterium MR Techniques
MR pulse for whole brain optimal Deuterium (2H) Metabolic Imaging and EPSI (echo planar spectroscopic imaging) based SLOW-edited 1H-MRSI will be developed and optimized for use at an UHF scanner at 7 Tesla.
- Conditions
- Aging, Brain Metabolic Disorder, Carotid Stenosis, Alzheimer Disease
- Trial name
- SIGNATURES2023 (NCT06705010)
- Testing
- Application of new pulse sequence package SIGNATURES2023 to healthy controls, Application of new pulse sequence package SIGNATURES2023 to 4 groups of patients (pilot)
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Binge Drinking, Liver Injury
Metabolic Changes in Healthy Subjects with Acute Binge Drink
The goal of this double-blinded, randomized trial is to investigate the effects of acute binge drinking on liver function, liver fat content, and lipid metabolism in healthy young subjects.
- Conditions
- Binge Drinking, Liver Injury, Hepatic Steatosis
- Trial name
- MeABD (NCT06298318)
- Testing
- Vodka, water
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhejiang Chinese Medical University
Implementation, Behavioral Symptoms
Working to Implement and Sustain Digital Outcome Measures
This study will investigate the effects of an organizational implementation strategy called Leadership and Organizational Change for Implementation (LOCI), relative to training and technical assistance only, on fidelity to, and…
- Trial name
- WISDOM (NCT04096274)
- Testing
- Leadership for Organization Change and Implementation (LOCI), Training and Technical Assistance Only
- Where
- 4 sites in United States
- Volunteers
- 686 people, healthy volunteers welcome
- Sponsor
- Boise State University
Alcohol Use Disorder
Emotional Attention Bias Modification and Targeted Memory Reactivation in Alcohol Use Disorder
Through this protocol, researchers examine whether Targeted Memory Reactivation (TMR), a technique used to enhance memory, can augment the control of craving levels in patients with Alcohol Use Disorder by enhancing positive…
- Trial name
- NCT06457113
- Testing
- Emotional Attention Bias Modification and Targeted memory reactivation during REM sleep, Emotional Attention Bias Modification
- Volunteers
- 74 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Metabolic Syndrome
Association of Multiple Genetic Polymorphisms With Clozapine-Associated Metabolic Change in Schizophrenia
We are going to investigate the association of multiple genetic polymorphisms with the metabolic side effects in patients with schizophrenia taking clozapine.
- Conditions
- Schizophrenia, Metabolic Syndrome, Genetic Polymorphism
- Trial name
- NCT00717509
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National Hospital
Fibromyalgia (FM)
Between Paws and Affections - Impact of Dog-Assisted Therapy in Fibromyalgia Patients
The purpose of this study is to evaluate the effectiveness and medium-term maintenance of a structured dog-assisted therapy (DAT) protocol, "Entre Patas e Afetos" (Between Paws and Affections), in reducing pain, anxiety and…
- Trial name
- IDAT26 (NCT07356206)
- Testing
- Behavioral: Dog Assisted Therapy (DAT - "Between Paws and Affections"), Behavioral: Psychoeducation and Relaxation without Dogs (Control)
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- University of Minho
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