Clinical trials: Change; Mental
Depression Symptoms, Depression - Major Depressive Disorder
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes
This study aims to evaluate the efficacy of a specially developed internet-based Cognitive Behavioural Therapy (CBT) programme with human interaction-referred to as the 3D programme-tailored specifically for women experiencing…
- Conditions
- Depression Symptoms, Depression - Major Depressive Disorder, Depressive Disorder
- Trial name
- 3D01 (NCT07060690)
- Testing
- iCBT with human interaction, Psychoeducational videos
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Francesc Colom, PsyD, PhD
Schizophrenia
A 12-Month Observational Prospective Cohort Study to Analyze Cardiometabolic Profile Changes to Switch to Lurasidone in Patients With Schizophrenia. RESPECT Study.
A 12-Month Observational Prospective Multicentre Cohort Study based on existing and newly collected data of schizophrenia patients followed-up for one year in secondary care settings (psychiatric services).
- Trial name
- RESPECT (NCT04742413)
- Where
- 10 sites in Spain
- Volunteers
- 9 people
- Sponsor
- Angelini Farmacéutica
Brain Cancer, Brain Tumor
HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)
The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-CA, to improve the quality of life and cognitive function in Service Members, Veterans and civilians who are survivors of brain cancer…
- Conditions
- Brain Cancer, Brain Tumor, Brain Neoplasms, Primary Brain Tumor
- Trial name
- HOBSCOTCH-CA (NCT06930846)
- Testing
- HOBSCOTCH-CA
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Menopause, Menopausal Symptoms
A Clinical Trial to Evaluate the Effects of A Supplement on Symptoms of Menopause and Overall Well-being
This study evaluates the effects of Primal Harvest's Primal Meno+ supplement on symptoms of menopause and overall well-being in females aged 40-60 who are currently menopausal and experiencing at least two menopausal symptoms.
- Conditions
- Menopause, Menopausal Symptoms, Hot Flashes, Night Sweats
- Trial name
- NCT07903480
- Testing
- Primal Meno+ Supplement
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Primal Harvest, LLC
Depressive Symptoms, Anxiety
Culturally Adapted iCBT for Arabic-speaking Refugee and Migrant Youth With Common Mental Health Problems
The aim of the current study is to explore whether culturally adapted internet-based cognitive behavioral therapy is effective in reducing the symptoms of various common mental health problems among Arabic-speaking refugee and…
- Conditions
- Depressive Symptoms, Anxiety, Insomnia, Grief
- Trial name
- RAHA (NCT06102096)
- Testing
- Culturally Adapted iCBT
- Where
- Sweden
- Volunteers
- 125 people
- Sponsor
- Karolinska Institutet
Chemotherapy-related Cognitive Impairment
Evaluating Cognitive Changes on Patients in Chemotherapy (ECCPC)
This randomized clinical trial aims to evaluate the impact of a structured low-intensity exercise program on cognitive function in adult cancer patients undergoing chemotherapy.
- Trial name
- (ECCPC) (NCT06950190)
- Testing
- Low-Intensity Walking Intervention, Control Group Intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ellis Medicine
Alzheimer Disease
Can Lifestyle Changes Reverse Early-Stage Alzheimer's Disease
The objective of this study is to determine if comprehensive lifestyle changes may slow, stop, or reverse the progression of early-stage Alzheimer's disease.
- Trial name
- NCT04606420
- Testing
- Lifestyle medicine
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- Preventive Medicine Research Institute
Major Depressive Disorder, Anhedonia
Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia
Investigating whether delta-beta cross-frequency transcranial alternating current stimulation can increase goal-directed behavior in participants with major depressive disorder and elevated symptoms of anhedonia.
- Trial name
- DEBRA (NCT05084924)
- Testing
- Cross-frequency transcranial alternating current stimulation via the NeuroConn Direct Current Stimulator Plus
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of North Carolina, Chapel Hill
Obesity, Health Behavior
DEMETRA - ADVICE-002-2022
The purpose of this study is to evaluate the safety and performance of DTXO App in improving weight loss and weight-loss maintenance in obese patients exposed to an experimental non-pharmacological treatment program.
- Conditions
- Obesity, Health Behavior, Life Style, Dietary Habits
- Trial name
- NCT05394779
- Testing
- DTXO APP
- Where
- Italy
- Volunteers
- 246 people
- Sponsor
- Advice Pharma Group srl
Alzheimer Disease, Cognitive Change
Evaluation of the Contribution of Regular Cognitive Exercises to Treatment in Patients With Alzheimer's Disease
In this study, it is aimed to compare the effects of cognitive exercises applied on long-term internet environment to the cognitive level of patients who received donepezil, memantine or donepezil / memantin combination therapy.
- Trial name
- NCT03954613
- Testing
- Ebicomb
- Where
- Turkey (Türkiye)
- Volunteers
- 198 people
- Sponsor
- Neutec Ar-Ge San ve Tic A.Ş
Binge-Eating Disorder
Decision Making, Daily Experiences, and Brain Activity in Young Adult Women
The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities.
- Trial name
- NCT04125589
- Testing
- Speaking Activity, Talking Activity
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Recurrent Pregnancy Loss Without Current Pregnancy, Anxiety Disorder
Altered Interhemispheric DLPFC Coordination and Cardiac Hyperreactivity During Multisensory Aversive Challenge in Recurrent Pregnancy Loss With Comorbid Anxiety
This exploratory clinical study, NEURO-CARD-2, will use simultaneous functional near-infrared spectroscopy (fNIRS) and electrocardiography (ECG) to investigate interhemispheric dysfunction in the dorsolateral prefrontal cortex…
- Trial name
- NCT07045818
- Testing
- Multisensory aversive emotional challenge task
- Where
- 4 sites in China
- Volunteers
- 70 people
- Sponsor
- Shenyang Medical College
Attention Deficit Hyperactivity Disorder, Attention Deficit and Disruptive Behavior Disorders
Efficacy of a Brief Behavioral Intervention to Treat ADHD and Disruptive Behaviors In Preschoolers
The purpose of this study is to test the intervention using a more rigorous randomized controlled trial design in order to demonstrate its efficacy compared to a wait-list control, thus ensuring that change in behavior does not…
- Trial name
- NCT01919073
- Testing
- Immediate Treatment Group, Delayed Treatment Group
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Baylor College of Medicine
Pharmacokinetics
Biomarker Changes and Anxiolytic Effects-Phase 2
This study will examine the utility of plasma and urinary based biomarkers for the anxiolytic properties of kava. The investigators will conduct a one week, double blind, randomized placebo controlled trial of kava, dosed at…
- Trial name
- KavaPK (NCT04565145)
- Testing
- Kava Dietary Supplement
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Florida
Anorexia Nervosa
Virtual Reality-Based Attention Bias Modification Training for Adolescents With Anorexia Nervosa
Anorexia Nervosa (AN) is considered one of the most severe subtypes of eating disorders (EDs), characterized by significant medical complications, high mortality rates, and high comorbidity with other disorders, such as anxiety…
- Trial name
- AN-VR-ABMT (NCT04786951)
- Testing
- Attentional Bias Modification Training, VR-based body exposure, Usual Care for Eating Disorders
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- University of Barcelona
Long QT Syndrome, ADHD
Drug-induced Repolarization ECG Changes
Studies have shown that the risk of developing heart arrhythmias, is increased in patients receiving medication for Attention-deficit hyperactivity disorder (ADHD) and depression.
- Conditions
- Long QT Syndrome, ADHD, Depression, Death
- Trial name
- NCT03642405
- Testing
- Electrocardiogram examination, Echocardiography, Blood Samples
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital at Herlev
Stress Disorders, Post-Traumatic
Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy
Cognitive Processing Therapy (CPT) consists of discrete therapeutic components that are delivered across 12 sessions, but most Veterans never reach session 12, and those who drop out receive only 4 sessions on average.
- Trial name
- CPT MOST (NCT05220137)
- Testing
- Modified A-B-C: Working with Events, Thoughts, and Feelings, Challenging Questions, Patterns of Problematic Thinking
- Where
- 3 sites in United States
- Volunteers
- 271 people
- Sponsor
- VA Office of Research and Development
Sleep Quality
Mitigation of Health Effects in Pregnant Women by Reducing Exposure to Heat and Air Pollution
The goal of this clinical trial is to assess the effectiveness of an intervention (combination of behavioural recommendations and technical measures) in reducing personal exposure to heat and air pollution and related health…
- Trial name
- ISMED CLIM PW (NCT07609433)
- Testing
- Heat intervention, Heat and air pollution mitigation intervention
- Where
- 3 sites in Cyprus, Italy
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Cyprus
Sleep Disorder Circadian Rhythm, Delayed Sleep Phase Type
SleepHelsinki! CIRCADIAN SLEEP REGULATION IN ADOLESCENCE
Adolescence associates with alterations in sleep-wake organization, such as later circadian phase preference. Simultaneously external pressures, such as evening-driven social activities increase.
- Trial name
- SleepHel (NCT02964598)
- Testing
- Gamified intervention, Sleep coaching, Bright light
- Where
- Finland
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Behavior Problem
Changing the Culture of Disrespect and Abuse in Maternity Care in Kumasi, Ghana
Using a public health facility Komfo Anokye Teaching Hospital in Ghana the overall goal of the research is to examine: 1) the feasibility of implementing respectful care modules (RMC-M) in Kumasi, Ghana; 2) whether exposure to…
- Trial name
- NCT04288947
- Testing
- Disrespect and Abuse in Maternity Care
- Where
- Ghana
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Kwame Nkrumah University of Science and Technology
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