Clinical trials: Change; Mental
Depression
Confirmatory Efficacy Trial of Attention Bias Modification for Depression
The goal of this clinical trial is to compare the efficacy of two related, but different ABM (Attention Biased Modification) treatments for depression in adults with elevated symptoms of depression.
- Trial name
- NCT06361095
- Testing
- Traditional Attention Bias Modification, Gamified Attention Bias Modification
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of Texas at Austin
Addiction;Drug(S);LSD, Neuroprotective
Neuroprotective Effect of (Nano PSO), in Patients Who Used to Consume Psychoactive Substances
Addiction problems to psychoactive substances are becoming more frequent, which implies a serious health problem, with social, family and work repercussions.
- Trial name
- NCT06550167
- Testing
- Nano-PSO, Pomegranate seed oil (omega-5)
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Distribuidora Biolife SA de CV
Depressive Disorder
Combining Antidepressants and Attention Bias Modification in Depression
Background: Major depressive disorder (MDD) is a highly prevalent psychiatric condition associated with significant disability, mortality and economic burden.
- Trial name
- DEPTREAT (NCT05503966)
- Testing
- Attentional Bias Modification
- Where
- Norway
- Volunteers
- 246 people
- Sponsor
- University of Oslo
Anorexia Nervosa, Osteoporosis
Bone Mass Changes in Anorexia Nervosa Patient Followed During 4 Years
The mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism.
- Trial name
- AMOS (NCT02891356)
- Testing
- DEXA
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Lille
Obesity, Schizophrenia
Lifestyle Modification for Weight Loss in Schizophrenia
The purpose of this study is to find out how effective lifestyle modification group therapy is on reducing body weight when compared to usual care in individuals with schizophrenia and/or schizoaffective disorder.
- Conditions
- Obesity, Schizophrenia, Schizoaffective Disorder
- Trial name
- NCT00990925
- Testing
- Nutritional Lifestyle Modification Group, Usual Care
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Yale University
Bipolar Disorder, Schizophrenia
Life Goals Collaborative Care to Improve Health Outcomes in Mental Disorders
Persons with serious mental illness (SMI) are at increased risk of cardiovascular disease (CVD). The goals of this study are to test a treatment, Life Goals Collaborative Care to help promote health behavior change and improve…
- Conditions
- Bipolar Disorder, Schizophrenia, Major Depressive Disorder, Schizoaffective Disorder
- Trial name
- NCT01487668
- Testing
- Life Goals Collaborative Care
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- VA Office of Research and Development
Cardiovascular Disease Prevention
Effects of a Smartphone-Supported Daily Walking Intervention on Psychological Well-Being and Body Composition in Adults With Cardiometabolic Disease
This study evaluated whether a three-month smartphone-supported daily walking intervention could improve physical activity, psychological well-being, and body composition in adults with cardiometabolic disease.
- Trial name
- DAILY-WALK (NCT07674459)
- Testing
- Smartphone-Supported Daily Walking
- Where
- Lithuania
- Volunteers
- 419 people
- Sponsor
- Klaipėda University
Borderline Personality Disorder (BPD), Dialectical Behavior Therapy
CULTURALLY ADAPTED DIALECTICAL BEHAVIOR THERAPY FOR LOW-MIDDLE-INCOME COUNTRIES
The study aims to assess the efficacy of culturally adapted dialectical behaviour therapy (DBT) for addressing emotional dysregulation in a low- and middle-income country, as well as to evaluate the impact of DBT on secondary…
- Conditions
- Borderline Personality Disorder (BPD), Dialectical Behavior Therapy, Emotional Dysregulation, Self Harm
- Trial name
- NCT07239362
- Testing
- Culturally adapted DBT
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Pakistan Association of Cognitive Therapists
Depression, Adolescent Depression
"Culturally Adapted CBT for Depression in Arab and Asian Adolescents in the UAE (CA-CBT)"
This study evaluated the effectiveness of a culturally adapted form of Cognitive Behavioural Therapy (CA-CBT) for reducing depression among Arab and Asian adolescents in the United Arab Emirates (UAE).
- Conditions
- Depression, Adolescent Depression, Mental Health, Psychological Stress
- Trial name
- CA-CBT (NCT07109973)
- Testing
- Culturally Adapted Cognitive Behavioural Therapy (CA-CBT), Treatment-as-Usual (TAU)
- Where
- United Arab Emirates
- Volunteers
- 175 people
- Sponsor
- Bath Spa University Academic Centre RAK
Autism Spectrum Disorder
Acceptability and Efficacy of a Culturally Adapted, Low-Frequency Parent-Mediated Early Start Denver Model (ESDM) Versus Standard Care in Young Children With Autism
Early intervention is effective in improving developmental outcomes of children on the autism spectrum. However, cultural and contextual factors may influence parental acceptability of treatment models, highlighting a need for…
- Trial name
- NCT07840586
- Testing
- Early Start Denver Model
- Where
- Singapore
- Volunteers
- 58 people
- Sponsor
- National University Hospital, Singapore
Schizophrenia, Bipolar Disorder
Evaluation of A Statewide Program to Prevent Early Mortality and to Promote Fitness in Persons With SMI
The goal of this project, which has not changed, is to evaluate the statewide implementation of a two-component intervention (health promotion plus academic detailing) with respect to consumer outcomes and changes in provider…
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT02334280
- Testing
- In SHAPE
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Schizophrenia, Bipolar I Disorder
Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder
To compare changes in body mass index (BMI) Z-score following treatment with OLZ/SAM vs olanzapine
- Trial name
- NCT05303064
- Testing
- OLZ/SAM, Olanzapine
- Where
- 47 sites in United States, Argentina and 3 more
- Volunteers
- 220 people
- Sponsor
- Alkermes, Inc.
Opioid-Related Disorders, Parent-Child Relations
Modified ABC: A Home-based Parenting Program for Opioid-dependent Mothers and Their Infants
This study will assess the efficacy of the modified Attachment and Biobehavioral Catch-Up Intervention, adapted for use with peripartum mothers receiving medication-assisted treatment for opioid use disorder.
- Conditions
- Opioid-Related Disorders, Parent-Child Relations, Infant Development, Parenting
- Trial name
- mABC (NCT03891628)
- Testing
- Modified Attachment and Biobehavioral Catch-up, Modified Developmental Education for Families
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Delaware
Depression, Anxiety
Tracking Mood and Language Change Across a Phone-based Mindfulness Intervention
The objective of this study is to administer a brief, phone(voice)-based training program in mindfulness (or control task of active listening to narrated articles) to older adults who receive primary care services at NM.
- Trial name
- NCT04861844
- Testing
- mindfulness training, active listening
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Depression, PTSD
DDBT Adapted Problem Solving Treatment for Primary Care
Evidence-based psychosocial interventions are rarely used in part because of their design complexity. Although many implementation frameworks do address the importance of EBPI characteristics, adapting and modifying EBPIs to…
- Trial name
- PST-NA (NCT03514394)
- Testing
- Usual Care, Modified Behavioral Activation (Task Sharing)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Washington
Bipolar Disorder
Functional and Neurochemical Brain Changes in First-episode Bipolar Mania
The purpose of this study is to use magnetic resonance imaging (MRI) to examine brain structure, function and chemistry in people with bipolar disorder who are being treated with either quetiapine or lithium.
- Trial name
- NCT00609193
- Testing
- lithium, quetiapine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Cincinnati
Major Depressive Disorder
Continuation Ketamine in Major Depression
As of May 21st, 2012, the purpose of this study is to test the antidepressant effect of ketamine when given repeatedly over a period of 1 week, as well as the use of Lithium as a relapse-prevention strategy for patients with…
- Trial name
- NCT00548964
- Testing
- Lithium, Ketamine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- James Murrough
Alzheimer Disease
Effect of Acupuncture on the Gait Disturbance and Hemodynamic Changes in the Prefrontal Cortex
Background: Alzheimer's disease (AD) is characterized by cognitive impairment and behavioral impairment, and increasing attention is paid in the gait of AD patients.
- Trial name
- NCT06346275
- Testing
- Acupuncture
- Volunteers
- 108 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Major Depressive Disorder
Goal Achievement After a Change to Vortioxetine in Adults With Major Depressive Disorder
The purpose of this study is to determine the effectiveness of treatment with vortioxetine on participant goal achievement after a change in antidepressant medication for the treatment of major depressive disorder (MDD).
- Trial name
- NCT02972632
- Testing
- Vortioxetine
- Where
- 25 sites in United States
- Volunteers
- 123 people
- Sponsor
- Takeda
Cognitive Change
Impact of Challenging Engagement on Cognition in Older Adults
The study will enroll 90 participants in the "Impact of Challenging Engagement" study and assign them to one of three groups: high-demand photography, moderate-demand photography, and active placebo.
- Trial name
- engAGE (NCT03962439)
- Testing
- High-Demand Photography, Moderate-Demand Photography, At-Home Engagement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
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