Clinical trials: Change; Mental
Unipolar Depression, Bipolar Depression
Voice Changes During ECT
Depressed patients talk differently when they are depressed compared to when they are well. But it is hard to actually measure what the differences are.
- Conditions
- Unipolar Depression, Bipolar Depression, Bipolar Disorder, Manic
- Trial name
- VAPRE (NCT04420793)
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Mild Cognitive Impairment
Neurofeedback Training for Older Adults With Mild Cognitive Impairment: a Protocol Study
This is a non-pharmacological study evaluating the effects of SMR/delta ratio and beta1/theta ratio neurofeedback trainings on cognitive performance and electrical brain activity in elderly with mild cognitive impairment.
- Trial name
- NCT03526692
- Testing
- Neurofeedback
- Volunteers
- 60 people
- Sponsor
- Fabienne Marlats
Psychosis
A Probiotic Strategy for Antipsychotic-induced Metabolic Dysfunction
Antipsychotic drugs are used to treat a range of psychiatric disorders including schizophrenia, bipolar disorders, and psychotic depression.
- Trial name
- MetaboMicrobe (NCT06729671)
- Testing
- Bifidobacterium longum APC1472 hydroxypropylmethylcellulose (HPMC) capsule, maltodextrin
- Where
- 2 sites in Ireland
- Volunteers
- 70 people
- Sponsor
- University College Cork
Stress, Psychological, Depression and/or Anxiety in the Mild-to-moderate Range
Testing Adapted Self-Help Plus (SH+) for Stress and Well-Being in International Students at a U.S. University
The goal of this clinical trial is to learn if an adapted version of Self-Help Plus (SH+), a stress management program developed by the World Health Organization, can reduce stress and improve well-being in international students…
- Conditions
- Stress, Psychological, Depression and/or Anxiety in the Mild-to-moderate Range, Loneliness, Adjustment, Psychological
- Trial name
- NCT07188467
- Testing
- Digitized SH+
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The New School
Excessive Worry
Imagery Enhanced Cognitive Bias Modification for Chronic Worry
People who experience high levels of worry often have mental habits that fuel their worry. One mental habit of interest to researchers is the tendency to assess situations and experiences in a very negative way even when it is…
- Trial name
- NCT03855488
- Testing
- Standard cognitive bias modification, Imagery enhanced cognitive bias modification, Neutral Control Condition
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Toronto Metropolitan University
Sleep Deprivation, Hippocampal Atrophy
Chronic Sleep Deprivation and Changes in Cortical and Hippocampal Volume
Sleep is a physiological state that is essential for human performance, including academic, occupational, interpersonal, and psychological aspects.
- Conditions
- Sleep Deprivation, Hippocampal Atrophy, Cortical Irregularity
- Trial name
- NCT06260280
- Testing
- Cerebral Nuclear Magnetic Resonance
- Where
- Mexico
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Overactive Bladder, Dementia
Higher Neural Changes Following Anticholinergic, Beta 3 Agonist, or Placebo in Patients With Overactive Bladder
Women presenting with overactive bladder symptoms will be randomized to one of 3 arms (anticholinergic, beta-3 agonist, placebo). They will undergo baseline cognitive testing, functional MRI of the brain.
- Conditions
- Overactive Bladder, Dementia, Lower Urinary Tract Symptoms, Incontinence, Urge
- Trial name
- NCT03817931
- Testing
- Anticholinergic, Beta-3 Agonists, Adrenergic, Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Delirium, Respiratory Failure
How Your Patients' Non-REM Sleep Changes On Sedatives in the Intensive Care Units
The purpose of this study is to study the effect of two standard of care sedative medications on sleep stages and total sleep time.
- Trial name
- HYPNOS (NCT00826553)
- Testing
- Dexmedetomidine, GABA agonist
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt University Medical Center
Borderline Personality Disorder
Mechanisms of Change in Brief Treatment for Borderline Personality Disorder
The present two-arm randomized controlled study aims at testing the effects (i.e., symptom reduction) and the underlying mechanisms of change associated with a brief psychiatric treatment (10 sessions over 4 months), compared…
- Trial name
- BPDCHANGE (NCT03717818)
- Testing
- Good Psychiatric Management - Brief, treatment as usual
- Where
- Switzerland
- Volunteers
- 76 people
- Sponsor
- University of Lausanne Hospitals
Back Pain Lower Back Chronic, Disability Physical
Project AdaPT: An Adaptive Physiotherapy Intervention Augmented With a Healthy Mind Training Program for People With Chronic Low Back Pain
In the proposed research, we will elucidate the comparative effectiveness of standalone physiotherapy (PT) vs. PT augmented with a self-guided, app-based Healthy Minds Innovation wellbeing program (PT+HMI) aimed at cultivating…
- Trial name
- AdaPT (NCT06351774)
- Testing
- Physical therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Ohio University
Stress Disorders, Post-Traumatic
Gene Expression Correlates of Post-Traumatic Stress Disorder (PTSD) Symptom Change After EFT (Emotional Freedom Techniques)
The purpose of the study is to measure the change in psychological symptoms and gene expression in war veterans after a series of 10 EFT coaching sessions.
- Trial name
- NCT01250431
- Testing
- EFT (Emotional Freedom Techniques)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Soul Medicine Institute
Depression, Unipolar, Anxiety Disorder Social
Trans-diagnostic Group CBT vs. Standard Group CBT for Depression, Social Anxiety and Agoraphobia/Panic Disorder
Transdiagnostic Cognitive Behavior Therapy (CBT) delivered in the individual format, have been proven just as effective as traditional diagnosis specific CBT manuals.
- Conditions
- Depression, Unipolar, Anxiety Disorder Social, Panic Disorder
- Trial name
- TRACT-RCT (NCT02954731)
- Testing
- UP-CBT, Standard-CBT
- Where
- 4 sites in Denmark
- Volunteers
- 292 people
- Sponsor
- Psychiatric Research Unit, Region Zealand, Denmark
Obsessive Compulsive Disorder
Attention Training for Childhood Obsessive Compulsive Disorder
Voluntary and involuntary attention processes are thought to play an important role in the development and maintenance of anxiety disorders including OCD.
- Trial name
- AMP-OCD (NCT02114918)
- Testing
- Attention Modification Program, Attention Control Condition
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of California, Los Angeles
Autism Spectrum Disorder, Social Communication Disorder
Virtual Group Social ABCs - Multi-site Randomized Controlled Trial
The goal of this randomized control trial is to test the efficacy of the Social ABCs 6 week, group-based model using a virtual delivery platform.
- Conditions
- Autism Spectrum Disorder, Social Communication Disorder, Autism or Autistic Traits, Autism Spectrum Disorder With Impaired Functional Language
- Trial name
- NCT05663970
- Testing
- VG Social ABCs
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Irritable Bowel Syndrome
Stress Reduction and Lifestyle Modification in Irritable Bowel Syndrome Patients
In the planned efficacy study, a prospective randomized controlled trial will be conducted to investigate the extent to which a multimodal stress reduction and lifestyle modification program can be reflected in patients with…
- Trial name
- NCT06145022
- Testing
- lifestyle modification, waitlist control group
- Where
- Germany
- Volunteers
- 118 people
- Sponsor
- Universität Duisburg-Essen
Autism Spectrum Disorder
Culturally Adapted Play-Based Behavioural Intervention for Autism
This study compared Culturally Adapted Play-Based Behavioural Intervention (PPBI) and Applied Behaviour Analysis (ABA) for children with Autism Spectrum Disorder (ASD) in semi-rural Tamil Nadu through a double-blinded randomized…
- Trial name
- NCT06859541
- Testing
- Culturally Adapted Play-Based Behavioural Intervention, Applied Behaviour Analysis
- Where
- India
- Volunteers
- 56 people
- Sponsor
- Saveetha University
Motor Skills Disorders
Taekwondo for Children With Developmental Coordination Disorder
Objectives: To evaluate the effects of a novel adapted Taekwondo (TKD) training programme on skeletal development and motor proficiency in pre-pubertal children with developmental coordination disorder (DCD).
- Trial name
- NCT02635711
- Testing
- Adapted Taekwondo training, Control
- Where
- Hong Kong
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Tobacco Smoking, Nicotine Dependence
Smoking Interventions in General Medical Practices
Primary care physicians can play an important role in reducing tobacco smoking in the population. The general practice is a suitable setting for implementing proactive smoking interventions, because a large proportion of the…
- Trial name
- PRO GP (NCT00679861)
- Testing
- Counselling Intervention, Expert-system intervention
- Volunteers
- 3,215 people
- Sponsor
- University Medicine Greifswald
Sleep, Diet Modification
Diet and Sleep Monitoring
This study will investigate the effect of two dietary patterns on sleep outcomes and measures of reported appetite. Participants will be given two different diets on two separate stays.
- Trial name
- NCT03257137
- Testing
- Diet Quality
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Behavior Problem
Effects of Esketamine on Postoperative Behavioral Changes in Children Undergoing Tonsillectomy and/or Adenoidectomy
The goal of this clinical trial is to learn the effect of intravenous esketamine in postoperative negative behavior changes in children compared to placebo (a look-alike substance that contains no drug).
- Trial name
- NCT06579937
- Testing
- Esketamine hydrochloride, normal saline
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Fujian Provincial Hospital
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