Clinical trials: Change; Retina
Macular Edema
Investigation of the Change of Vision-related Quality of Life in Subjects Treated With Aflibercept According to EU Label for DME.
To evaluate the change in quality of life (NEI VFQ 25) in subjects with DME during the first year of treatment with aflibercept according to the EU Label.
- Trial name
- AQUA (NCT02581995)
- Testing
- Eylea (Aflibercept, VEGF Trap-Eye, BAY86-5321)
- Where
- 76 sites in Austria, Canada and 12 more
- Volunteers
- 560 people
- Sponsor
- Bayer
Diabetic Retinopathy
Changes of Macular Vasculature After Uncomplicated Phacoemulsification Surgery Using Optical Coherence Tomography Angiography
To record the vascular changes that may be present in the macular after uncomplicated phacoemulsification surgery by using OCTA, a comparative study between healthy and diabetic patients
- Trial name
- NCT04594603
- Testing
- Phacoemulsification for cataract
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Induced Defocus to the Retina
Defocus Induced Changes on Choroidal Thickness
The goals of this study are to assess the short-term (10-60 minutes) effects of different magnitudes of myopic and hyperopic optical defocus on the transient thickness of the choroid in children and adults, as well as to assess…
- Trial name
- NCT03954886
- Testing
- Plus powered optical lens
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Houston
Type 1 Diabetes Mellitus With Artificial Pancreas Device
OCT and OCT-A Deep Learning in Diabetic Patients Wiht Artificial Pancreas Device
This study evaluates the ability of deep learning to improve the knowledge about structural and vascular retinal changes in diabetic patients undergoing artificial pancreas device, using optical coherence tomography angiography.
- Trial name
- NCT05809843
- Testing
- hybrid artificial pancreas systems (CSII)
- Where
- Italy
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Federico II University
Healthy Participants, Retinal Oxygen Extraction
Age-related Changes in Retinal Oxygen Extraction in Healthy Subjects
It has been found that several systemic and ocular diseases are associated with impaired retinal oxygen extraction. In the present study, retinal oxygen extraction will be measured in different age groups in order to identify age…
- Trial name
- NCT06643403
- Testing
- Oxygen 100% Gas for Inhalation
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Twin Pregnancy, Antepartum Condition or Complication, Retinal Vascular
Comparison of Posterior Ocular Changes Between Singleton Pregnancy and Multifetal Pregnancy.
It has been known that a pregnant women undergoes significant anatomical and physiological changes that mainly caused by hormonal and hematologic changes during pregnancy.
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Retinal Vascular, Choroidal Effusion
- Trial name
- NCT04773561
- Testing
- Corneal tomography, optical coherence tomography and optical coherence tomography angiography
- Where
- Thailand
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Nerve Fiber Bundle Defect, Optic Nerve Diseases
Changes of the Peripapillary Retinal Nerve Fiber Layer After Filtration Surgery in Glaucoma Patients
At present, trabeculectomy is the most common performed and effective surgical method of filtration surgery for patients with medically uncontrolled glaucoma.
- Trial name
- NCT01422525
- Testing
- spectral domain optical coherence tomography
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Eye Hospital, Würzburg
All Comers
A-EYE: A Mixed Quantitative and Qualitative Study to Develop and Evaluate the Application of Artificial Intelligence (AI) Methods Using Retinal Imaging for the Identification of Adverse Retinal Changes Associated With Cancer Therapies.
This is a data collection study involving the gathering of clinical data and OCT (optical coherence tomography) scans from 350 patients.
- Trial name
- A-EYE (NCT04901468)
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Manchester
Electronic Cigarette Use, Retina; Change
Nicotine Influence on the Retina Following the Use of Electronic Cigarette
The marketing of electronic cigarettes (e-cigarettes) in 2003 was initially intended to present a healthier alternative to smokers.
- Trial name
- NCT05801419
- Testing
- RETI-port/scan 21, Zilia Ocular, OCT-A
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Christian Casanova
Retinitis Pigmentosa
A Phase 3 Study Of OCU400 Gene Therapy for the Treatment Of Retinitis Pigmentosa
This is a Phase 3 study to Assess the Efficacy, Safety and Tolerability of OCU400 in patients with retinitis pigmentosa (RP) associated with RHO mutations and patients with any other RP associated mutation with a clinical…
- Trial name
- liMeliGhT (NCT06388200)
- Testing
- Sub-Retinal Administration of OCU400-301
- Where
- 17 sites in United States, Canada
- Volunteers
- 140 people
- Sponsor
- Ocugen
Obesity, Obesity, Morbid
Effects of Differences in Body Composition on Retina and Choroid
The goal of this observational study is to examine the effects of body composition differences on retinal and choroidal structures.
- Conditions
- Obesity, Obesity, Morbid, Body Composition
- Trial name
- NCT06888765
- Testing
- Optical Coherence Tomography (OCT) and Body Composition Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Bayram Meydan
COVID-19
Retinal Vascular Changes in Patients After Coronavirus Disease 2019 (COVID-19)
The study examines changes in retinal oximetry in patients after COVID-19 disease. It aims to analyze and quantify possible retinal microvascular abnormalities that may result from possible post-inflammatory damage to the…
- Trial name
- NCT05747547
- Testing
- Central visual acuity, Intraocular pressure measurement, Slit lamp examination
- Where
- Czechia
- Volunteers
- 34 people
- Sponsor
- University Hospital Olomouc
Diabetic Retinopathy
Video-based Patient Education Intervention for Diabetic Eye Screening in Latinx Communities
An online survey (n=1,500) and 4 focus groups will be conducted with Latinx patients with diabetes (n=20) to obtain preliminary data regarding whether and how patient and clinician video testimonial interventions (n=6) increase…
- Trial name
- NCT06257082
- Testing
- Online Survey
- Where
- United States
- Volunteers
- 1,526 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Pseudoexfoliation Syndrome
The Correlation Between Pupil Size and Retinal Nerve Fibers Changes in Pseudoexfoliation Syndrome.
To study the possible correlation between pupillary diameter before and after dilation with intraocular pressure, lens stability and glaucomatous damage (represented by optic disc changes using cup to disc ratio and OCT changes…
- Trial name
- NCT06588816
- Testing
- optical coherence tomography
- Volunteers
- 33 people
- Sponsor
- Assiut University
Pregnancy Induced Hypertension, Pregnancy Related
SD-OCT Measurement of the Human Retina in Pregnancy With Pre-existing or De Novo Hypertension and Without Hypertension
The complications of long-standing severe and acute severe elevations in systemic blood pressure (hypertension) may involve large vessels as well as smaller vessels, these latter comprising what is known as the microcirculation.
- Trial name
- NCT04286217
- Volunteers
- 155 people
- Sponsor
- University of Calgary
Hypertension, Vascular Function
Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension.
This is a prospective, monocentric, randomized controlled trial to investigate the effect of anti-hypertensive treatment and/or individualized exercise training intervention on blood pressure and vascular health.
- Conditions
- Hypertension, Vascular Function, Fitness Testing, Metabolism Changes
- Trial name
- Antitension (NCT06823570)
- Testing
- Individualized exercise therapy, Lifestyle recommendations
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Cognitive Change
Yoga Training and Retinal Vasculature
This study will compare the impact of a novel high-speed, cued yoga program to a standard yoga program on retinal microvasculature, cognition and neuromuscular function.
- Trial name
- NCT06099405
- Testing
- High-speed, Cognitive Challenge Yoga, Traditional yoga
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Miami
Age Related Macular Degeneration, Diabetic Macular Edema
Change in Ocular Perfusion After Intravitreal Anti-VEGF in Patients with Age-related Maculopathy or Diabetic Macula Edema
This prospective study will include patients with neovascular age-related macular degeneration or diabetic macular edema, scheduled for intravitreal aflibercept.
- Trial name
- NCT06878573
- Testing
- Intravitreal Aflibercept Injection, Laser speckle flowgraphy
- Where
- Austria
- Volunteers
- 36 people
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Retinal Vascular
Physiologic Changes of Posterior Ocular Segment During the Menstrual Cycle
Changes of luteinizing hormone (LH), estrogen and progesterone during the menstrual cycle influence the ocular physiology in both anterior and posterior segments.
- Trial name
- NCT04731207
- Testing
- Optovue®
- Where
- Thailand
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Pregnancy, Retinal Nerve Fiber Layer Thickness
Retinal Nerve Fiber Layer and Macular Thickness Changes During Pregnancy
Purpose: Primary: to prospectively measure Retinal Nerve Fiber Layer (RNFL) and macular thickness changes during pregnancy by Optical coherence tomography Secondary: The effect of pregnancy abnormalities on RNFL and macular…
- Conditions
- Pregnancy, Retinal Nerve Fiber Layer Thickness, Macular Thickness
- Trial name
- NCT02154945
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya