Clinical trials: Chemically-Induced Disorders
Alcohol Use Disorder
In Hospital IM Naltrexone: A Pilot Study
This is a study in-hospital administration of injectable naltrexone vs. oral naltrexone. This is a pilot study to assess provider's and patient's acceptability to be randomized to oral vs.
- Trial name
- IM-NTX (NCT05087771)
- Testing
- injectable naltrexone, oral naltrexone
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alcohol Use Disorder
Clinical Trial of Rybelsus (Semaglutide) Among Adults With Alcohol Use Disorder (AUD)
This study is a randomized controlled trial of oral semaglutide among treatment-seeking individuals with AUD. The investigators will randomly assign 50 participants to receive semaglutide (titrated to 7 milligrams (mg) per day)…
- Trial name
- NCT05892432
- Testing
- Semaglutide 3 MG [Rybelsus], Semaglutide 7 MG [Rybelsus]
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Opioid Use Disorder
Neuroplasticity in Maternal Opioid Use Disorder (OUD)
Opioid use disorder (OUD) remains a major public health problem particularly for mothers in the perinatal period, for whom stress, relapse rates, and risk for overdose are elevated.
- Trial name
- NCT05495984
- Testing
- ERPs with electroencephalography (EEG), MIO
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Substance Use Disorders
Online Cognitive Behavioural Therapy for Substance Use Disorder: The Impact of Peer Support
The purpose of this study is to evaluate the efficacy and cost-effectiveness of Breaking Free Online, in a comparison of outpatients seeking treatment for substance use disorder who receive standard care with group peer support…
- Trial name
- NCT05127733
- Testing
- Online Cognitive Behavioural Therapy, Individual Peer Support, Group Peer Support
- Where
- Canada
- Volunteers
- 198 people
- Sponsor
- Centre for Addiction and Mental Health
Alcohol Use Disorder, Alcohol Dependence
Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders
The purpose of this study is to examine the effects of rapamycin (sirolimus) versus a placebo, an inactive substance, on responses to alcohol cues in individuals with alcohol use disorder.
- Trial name
- NCT03732248
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Alcoholism
Dietary Fiber Intake in Alcohol-dependent Patients
The alcohol problem affects 7.5% of the population in Europe and represents a major public health problem. Alcoholism is also a major cause of undernutrition.
- Trial name
- NCT03803709
- Testing
- inulin
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Université Catholique de Louvain
Alcohol Use Disorder
A First in Human Study of CMND-100 in Healthy and Alcohol Use Disorder (AUD) Subjects
The primary objective of this study is to find the tolerable dose and characterize the safety and pharmacokinetics/ pharmacodynamics (PK/PD) of single and repeated dose of CMND-100 in Healthy Volunteers (HV) and Subjects with…
- Trial name
- NCT05913752
- Testing
- CMND-100
- Where
- 4 sites in United States, Israel
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Clearmind Medicine Inc.
Domestic Violence, Substance Abuse
Treatment of Intimate Partner Violence and Substance Abuse in a Forensic Setting
Intimate partner violence is a significant societal problem. However, treatment of IPV perpetrators is far from effective, which may be partly due to the fact that the role of substance abuse is not taken into account.
- Trial name
- NCT00847548
- Testing
- substance abuse/domestic violence treatment, CBT addressing partner violence
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- VU University of Amsterdam
Substance Abuse
A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements (CDEs) Into the Electronic Health Record (EHR) in Large Primary Care Settings ("CDE-EHR-PC" Study), Phase 3
This is a 4-phase study to implement the NIDA CDEs in primary care settings. Collecting and utilizing the CDEs in clinical practice requires a strategy for implementing screening to collect substance use information that…
- Trial name
- NCT02963948
- Testing
- Meetings with implementation leader(s), the SAAS survey, Patient surveys
- Where
- 2 sites in United States
- Volunteers
- 113,123 people
- Sponsor
- NYU Langone Health
Healthy Subject, Tobacco Use Disorder
Effect of Black Raspberry Phytochemicals on Oral Microbiome in Current Smokers and Non-smokers
This randomized clinical trial studies the effects of black raspberry compounds (phytochemicals) on the bacteria in the mouth (oral microbiome) of current smokers and non-smokers.
- Trial name
- NCT02439255
- Testing
- Laboratory Biomarker Analysis, Phytochemical, Screening Questionnaire Administration
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Substance Abuse
Adolescent Involvement in Parental Substance Abuse Treatment
Given the reciprocal nature of parent-child interaction, involvement of the adolescent in their mother's substance abuse treatment plan might be associated with reductions in adult relapse and improvements in child functioning.
- Trial name
- NCT01576393
- Testing
- Home-based Family Therapy, office-based family therapy, WHE
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Substance Abuse, Tobacco Use Disorder
Registration of Tobacco, Coffee and Substance Use Among Acutely Admitted Psychiatric Patients
This is a study of the registration of tobacco, coffee and substance abuse among acutely admitted psychiatric patients.
- Trial name
- NCT00184184
- Where
- Norway
- Volunteers
- 262 people
- Sponsor
- Norwegian University of Science and Technology
Substance Use, Substance Use Disorders
Peer-Delivered Behavioral Activation for Methadone Adherence - Pilot Phase
The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) among low-income, minoritized individuals…
- Conditions
- Substance Use, Substance Use Disorders, Opioid-use Disorder, Peer Delivered
- Trial name
- HEAL Together (NCT04248933)
- Testing
- Peer-Delivered Behavioral Activation (Peer Activate)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Maryland, College Park
Alcoholism, Alcohol Dependence
Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine)
This study will examine the effects of combing naltrexone and fluoxetine (Prozac) versus fluoxetine and placebo in alcoholics with co-occurring major depression.
- Conditions
- Alcoholism, Alcohol Dependence, Depression
- Trial name
- NCT00006204
- Testing
- naltrexone (Revia), fluoxetine (Prozac)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Breast Neoplasms
The Impact of Chronic Mitochondrial Antioxidant Supplementation on CardiovascularToxicity in Breast Cancer Patients
Investigate the protective effect of chronic MitoQ supplementation on cardiovascular toxicity induced by doxorubicin-based adjuvant chemotherapy in breast cancer patients.
- Trial name
- NCT05146843
- Testing
- Mitoquinone
- Volunteers
- 44 people
- Sponsor
- D'Or Institute for Research and Education
Bipolar Disorder, Alcohol Abuse/Dependence
Quetiapine in Patients With Bipolar and Alcohol Abuse/Dependence
The abuse of alcohol is especially common in people with bipolar disorder. However, very little is known about the pharmacotherapy of people with both bipolar disorder and alcohol abuse/dependence.
- Trial name
- NCT00223249
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Texas Southwestern Medical Center
Opioid Dependence, Methadone Toxicity
KCNH2 Polymorphisms on the QTc Interval in Kelantanese Malays Patients Receiving Methadone Maintenance Therapy (MMT)
Methadone maintenance therapy (MMT) is one of the modalities to prevent HIV transmission among injected drug users, particularly in opioid-dependent users.
- Conditions
- Opioid Dependence, Methadone Toxicity, HERG Gene Mutation
- Trial name
- NCT03603158
- Where
- Malaysia
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Breast Cancer, Cardiotoxicity
Exercise Prescription Guided by Heart Rate Variability in Breast Cancer Patients
Breast cancer is a chronic disease that has seen a boom in research into its treatments, improvements and effects in recent decades.
- Conditions
- Breast Cancer, Cardiotoxicity, Autonomic Imbalance
- Trial name
- NCT05040867
- Testing
- Physical exercise program
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- GO fit Lab- Ingesport
Hand-Foot Syndrome
The Efficacy of Acupuncture and Laser Acupuncture in Treating Chemotherapy or Target Therapy-induced Hand-foot Syndrome
Chemotherapy or target therapy-induced hand-foot syndrome in cancer patients affects the quality of life. At present, there is no better treatment for this side effect of chemotherapy or target therapy.
- Trial name
- NCT05949307
- Testing
- acupuncture, laser acupuncture
- Volunteers
- 60 people
- Sponsor
- China Medical University Hospital
NAFLD, Alcohol-Related Disorder
Screening in Primary Care of Advanced Liver Fibrosis in NAFLD and/or Alcoholic Patients (IMPROVE Study)
The main objective is to determine the performance of the simple eLIFT blood test for advanced liver fibrosis screening in NAFLD and/or alcoholic patients in primary care.
- Conditions
- NAFLD, Alcohol-Related Disorder, Liver Fibrosis
- Trial name
- IMPROVE (NCT04146636)
- Testing
- e-LIFT
- Where
- France
- Volunteers
- 282 people
- Sponsor
- University Hospital, Angers