Clinical trials: Chemoradiotherapy
Rectal Cancer
Capecitabine in the Perioperative Treatment of Rectal Cancer
This study compares capecitabine with standard 5-FU in the perioperative treatment of locally advanced rectal cancer.
- Trial name
- Rektum-III (NCT01500993)
- Testing
- Capecitabine, 5-FU
- Where
- 14 sites in Germany
- Volunteers
- 401 people
- Sponsor
- Universitätsmedizin Mannheim
Cervical Cancer
FDG-PET and Circulating HPV in Patients With Cervical Cancer
The addition of concurrent chemotherapy to definitive radiation has improved the 5-year survival of women with locally advanced cervical cancer to 58%.
- Trial name
- NCT02388698
- Testing
- Cervical swab, PET-CT, Plasma HPV
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Sunnybrook Health Sciences Centre
Rectal Cancer, Organ Preservation
Treatment Strategy for Rectal Cancer Patients With Complete Clinical Response
This was a propensity-score matched observational analysis, comparing the oncological outcome of surgical resection vs watch and wait apporach for rectal cancer patients with a cCR.
- Trial name
- NCT03846726
- Testing
- standard TME surgery
- Where
- China
- Volunteers
- 513 people
- Sponsor
- Yuan-hong Gao
Rectal Cancer, Lymph Node Cancer Metastatic
Indocyanine Green-guided Lymphadenectomy in Laparoscopic Total Mesorectal Excision for Low Rectal Cancer After Neoadjuvant Chemoradiotherapy
The goal of this clinical trial is to assess the number of harvested locoregional lymph nodes in rectal cancer patients undergoing laparoscopic total mesorectal excision and indocyanine green (ICG)-guided lymphoadenectomy after…
- Trial name
- (GreenEye-CRC) (NCT05873621)
- Testing
- ICG-guided lymphadenectomy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Infiltrating Bladder Urothelial Carcinoma
A Phase II Trial Evaluating an Organ-conserving Strategy by Radiochemotherapy for Muscle-infiltrative Bladder Cancer
If radical cystectomy remains the standard of care for muscle invasive bladder cancer, consequences of this surgical procedure are often harsh.
- Trial name
- GETUGV04 (NCT01495676)
- Testing
- Radiation + cisplatin, Radiation + cisplatin + gemcitabine
- Where
- 12 sites in France
- Volunteers
- 69 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Head and Neck Squamous Cell Carcinoma, HNSCC
Phase 2 Trial of Maintenance Cemiplimab for Head and Neck Squamous Cell Carcinoma (HNSCC)
The purpose of this study is to evaluate the experimental immunotherapy agent cemiplimab-rwlc when given after completion of chemotherapy and radiation treatment and determine if it will improve progression free survival and cure…
- Conditions
- Head and Neck Squamous Cell Carcinoma, HNSCC, Squamous Cell Carcinoma of the Larynx, Squamous Cell Carcinoma of the Oral Cavity
- Trial name
- NCT04831450
- Testing
- Cemiplimab-Rwlc
- Sponsor
- University of Miami
Head and Neck Neoplasms
Induction Chemotherapy With ACF Followed by Chemoradiation Therapy for Adv. Head & Neck Cancer
This phase II trial studies the safety and effectiveness of an induction chemotherapy (ACF) consisting of paclitaxel albumin-stabilized nanoparticle formulation (nab-paclitaxel), cisplatin and fluorouracil followed by…
- Trial name
- NCT01566435
- Testing
- paclitaxel albumin-stabilized nanoparticle formulation, Cisplatin, Fluorouracil
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Chemoradiotherapy
A Study for Short Preoperative Chemoradiotherapy for Resectable Rectal Carcinoma
Intensity modulated radiotherapy (IMRT)-based radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Trial name
- IMRT (NCT00973778)
- Testing
- Preoperative Chemoradiotherapy
- Where
- 2 sites in China
- Volunteers
- 62 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Squamous Cell Carcinoma of the Head and Neck
A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)
The primary objective of the study was to demonstrate superior efficacy of Xevinapant (Debio 1143) vs placebo when added to chemoradiotherapy (CRT) in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN).
- Trial name
- NCT04459715
- Testing
- Xevinapant (Debio 1143), Cisplatin, Intensity Modulation Radiation Therapy (IMRT)
- Where
- 288 sites in United States, Argentina and 24 more
- Volunteers
- 730 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Cancer
Assessment of Fitness After Neoadjuvant Chemoradiotherapy in Rectal Cancer Patients
Neoadjuvant chemoradiotherapy (NACRT) prior to surgery for lower gastrointestinal (colon and rectal) cancer is associated with improved survival, but also adversely affects physical fitness, potentially rendering patients unfit…
- Trial name
- NCT01334593
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Michelle Mossa
Gastroesophageal Junction Adenocarcinoma
Apatinib Plus Concurrent Neoadjuvant Chemoradiotherapy for Gastroesophageal Junction
The purpose of this study is to assess the efficacy and safety of patients who receive concurrent neoadjuvant chemoradiotherapy for Siewert II ，III of locally advanced HER-2 negative adenocarcinoma at gastroesophageal junction.
- Trial name
- NCT03986385
- Testing
- Apatinib Capecitabine Oxaliplatin, Capecitabine Oxaliplatin
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Hebei Medical University
Pancreatic Cancer
GI-4000 With Adoptive Transfer in Pancreatic Cancer
The purpose of this study is to determine if it is safe to add multiple immunotherapies to standard chemotherapy and radiation for treating pancreatic cancer tumors that cannot be completely removed by surgery. 1.
- Trial name
- NCT00837135
- Testing
- Screening, GI-4000 Vaccine, GI-4000 Vaccine + Activated T Cells
- Sponsor
- University of Pennsylvania
Rectal Cancer
Genotype-driven Phase I Study of Irinotecan Administered in Neoadjuvant Chemoradiotherapy in Patients With Stage II/III Rectal Cancer
Irinotecan is one of effective drugs for colorectal cancer. In neoadjuvant chemoradiotherapy (CRT), Irinotecan is prescribed in a low dose of 50mg/m2/week because of toxicity.
- Trial name
- NCT01474187
- Testing
- Irinotecan, Capecitabine, Radiotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fudan University
Lung Cancer, Non-small Cell Carcinoma
Durvalumab Followed by Chemoradiation and Consolidation Durvalumab for Stage III Non-small Cell Lung Cancer
Single arm study of induction durvalumab (1500 mg IV) for 1 cycle (every 4 weeks), administered prior to starting concurrent definitive chemoradiation, followed by consolidation durvalumab (1500 mg IV every 4 weeks) for up to 12…
- Trial name
- NCT04364048
- Testing
- Induction Durvalumab, Chemotherapy, Radiation
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Rachel Sanborn
Colorectal Cancer
Phase II RCT of LCRT vs SCRT + CAPOX/PD-1i/COX-2i in MSS Locally Advanced Rectal Cancer
This randomized phase II trial evaluates the efficacy of long-course chemoradiotherapy (50Gy/25Fx + capecitabine) versus short-course radiotherapy (25Gy/5Fx) combined with CAPOX（Capecitabine and Oxaliplatin）, PD-1 inhibitor…
- Trial name
- NCT07154316
- Testing
- LCRT, SCRT, CAPOX
- Where
- 5 sites in China
- Volunteers
- 138 people
- Sponsor
- Fudan University
Head and Neck Squamous Cell Carcinoma (HNSCC), Locally Advanced Head and Neck Squamous Cell Carcinoma
[18F]-AraG PET Imaging in LA HNSCC
This study will use [18F]-AraG PET/CT scans to monitor patients who have been diagnosed with locally advanced Head and Neck Squamous Cell carcinoma (LA-HNSCC), and are planning to undergo standard of care chemoradiotherapy for…
- Trial name
- NCT07168785
- Testing
- [18F]-AraG radiotracer, Chemotherapy, Radiotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Indiana University
Esophagus Cancer, Esophagogastric Junction Cancer
Phase II/III Study Comparing Chemoradiotherapy With Radiotherapy in Elderly Patients With Esophageal or Esophagogastric Cancer - 3JECROG P-01
Ratiotherapy alone is the current standard treatment for elderly esophageal or esophagogastric cancer in China. And Little is known about chemoradiotherapy (CRT) in elderly patients.
- Conditions
- Esophagus Cancer, Esophagogastric Junction Cancer, Radiotherapy; Complications, Chemoradiation
- Trial name
- NCT02979691
- Testing
- SIB-IMRT, S-1
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Chinese Academy of Medical Sciences
Non Small Cell Lung Carcinoma
Chemoradiotherapy in Patients With Localised Lung Cancer
The study compares 2 different methods of combined chemotherapy and radiotherapy for the treatment of localised lung cancer in patients not suitable for surgery. Hypothesis(es) to be tested: 1.
- Trial name
- NCT00193921
- Testing
- Vinorelbine, High dose Radiotherapy, Gemcitabine
- Where
- 8 sites in Australia
- Volunteers
- 82 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Esophageal Carcinoma
Diffusion-weighted Magnetic Resonance Imaging (DW-MRI )for Early Response Assessment in Patients With Esophageal Cancer
Esophageal carcinoma is a lethal disease, causing more than 400,000 deaths annually worldwide. Primary surgery results in microscopically positive resection margins (R1) in 25% patients, and the 5-year overall survival(OS) for…
- Trial name
- NCT02527057
- Testing
- DW-MRI
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Hunan Province Tumor Hospital
Colorectal Cancer, Colorectal Carcinoma
Nelfinavir, a Phase I/Phase II Rectal Cancer Study
The aim is to study safety and activity of nelfinavir , added to standard chemoradiotherapy in patients with locally advanced rectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Carcinoma, Colorectal Tumors, Neoplasms, Colorectal
- Trial name
- Nelfinavir (NCT00704600)
- Testing
- nelfinavir
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Maastricht Radiation Oncology
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