Clinical trials: Chemotherapy Induced Pain Neuropathy
Neuropathy, Pain
Pregabalin in CIPN
The investigators seek to investigate certain patient characteristics that would predict the response to a currently approved analgesic, pregabalin, in patients with chronic pain due to nerve damage caused by chemotherapy.
- Trial name
- NCT02394951
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Washington University School of Medicine
Chemotherapy-induced Peripheral Neuropathy
A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN)
The investigators propose that using the Diode Laser fiber type Selective Stimulator (DLss) in patients with chemotherapy-induced peripheral neuropathy (CIPN) will allow for the assessment of changes in small-fiber pain…
- Trial name
- NCT03687970
- Testing
- Brief Pain Inventory, Hospital Anxiety and Depression Scale, Neuropathic Pain Symptom Inventory
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Patients With Taxane-induced Chronic Neuropathic Pain
Chemotherapy Induced Peripheral Neuropathy by Taxanes and Capsaicin 8%.
The goal of this study is to compare the evolution of the density of small nerve fibers assessed with skin biopsies at the foot between two groups of patients with taxane-induced chronic neuropathic pain matched for sex and age…
- Trial name
- capsaNeP (NCT07602387)
- Testing
- Capsaicin 8% Patch, antidepressants (tricyclics and serotonin reuptake inhibitor SRIs), antiepiletics, lidocaine patches, and neurostimulation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospital Ambroise Paré Paris
Chronic Myeloproliferative Disorders, Leukemia
Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
RATIONALE: Baclofen-amitriptyline-ketamine (BAK) gel may lessen peripheral neuropathy caused by chemotherapy. It is not yet known whether BAK gel is more effective than a placebo in treating peripheral neuropathy caused by…
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT00516503
- Testing
- baclofen/amitriptyline/ketamine gel
- Where
- 165 sites in United States
- Volunteers
- 208 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Neurotoxicity, Pain
Topical Amitriptyline and Ketamine Cream in Treating Peripheral Neuropathy Caused by Chemotherapy in Cancer Patients
RATIONALE: Topical cream containing amitriptyline and ketamine may help relieve pain, numbness, tingling, and other symptoms of peripheral neuropathy.
- Conditions
- Neurotoxicity, Pain, Peripheral Neuropathy, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00471445
- Testing
- ketamine/amitriptyline NP-H cream
- Where
- 17 sites in United States
- Volunteers
- 462 people
- Sponsor
- Gary Morrow
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Auricular Point Acupressure: Examining the Scientific Underpinnings of Pain Relief
Chemotherapy-induced peripheral neuropathy (CIPN)-numbness, burning and stunning pain distributed in hands and feet-is a major challenge among cancer patients.
- Trial name
- NCT03634527
- Testing
- Auricular Point Acupressure, Control Auricular Point Acupressure-
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Topical Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy
The goal of this clinical trial is to learn if menthol works to relieve chronic neuropathic pain and chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NCT07693387
- Testing
- menthol-based hand and foot gloves
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taiwan Municipal An-Nan Hospital-China Medical University
Neuropathy, Peripheral Neuropathy
Study of Nicotine for Pain Associated With Chemotherapy-Induced Peripheral Neuropathy
Assess the efficacy of short-term nicotine transdermal patch administration for the treatment of chemotherapy-induced peripheral neuropathy (CIPN) in cancer stable patients or patients in remission.
- Conditions
- Neuropathy, Peripheral Neuropathy, Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy
- Trial name
- NCT04468230
- Testing
- Nicotine Transdermal Patch
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Breast Cancer, Peripheral Neuropathies
Chemotherapy-Induced Peripheral Neuropathy-Essential Oil Intervention
This study will evaluate an oil blend with active ingredients for the reduction in chemotherapy-induced peripheral neuropathy in people with breast cancer.
- Trial name
- CIPN-EOI (NCT03449303)
- Testing
- EOI
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Augusta University
Breast Cancer, Ovarian Neoplasm
Omega-3 Fatty Acid in Treating Pain in Patients With Breast or Ovarian Cancer Receiving Paclitaxel
Paclitaxel, a widely used chemotherapeutic agent, is associated with several well-known side effects including neuropathy (weakness, numbness and pain) and generalized body aches.
- Conditions
- Breast Cancer, Ovarian Neoplasm, Pain
- Trial name
- NCT01821833
- Testing
- Omega-3 fatty acid, Paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- New Mexico Cancer Research Alliance
Chemotherapy-Induced Peripheral Neuropathy, Malignant Neoplasm
Transcranial Direct Current Stimulation in Reducing Pain in Cancer Patients With Chemotherapy Induced Peripheral Neuropathy
This early phase I trial studies how well transcranial direct current stimulation works in reducing pain in cancer patients with chemotherapy induced peripheral neuropathy.
- Trial name
- NCT04135326
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Transcranial Direct Current Stimulation
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Chemotherapy-induced Peripheral Neuropathy, Pain, Neuropathic
Ozone Therapy in Chemotherapy-induced Peripheral Neuropathy: RCT (O3NPIQ)
The main objective of this clinical trial is to evaluate the effectiveness and cost-effectiveness of adding ozone therapy to the clinical management of patients with pain secondary to chemotherapy-induced peripheral neuropathy
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Pain, Neuropathic, Pain Syndrome
- Trial name
- O3NPIQ (NCT04299893)
- Testing
- Ozone, Oxygen
- Where
- 2 sites in Spain
- Volunteers
- 42 people
- Sponsor
- Bernardino Clavo, MD, PhD
Cancer, Breast, Cancer, Colorectal
Exercise Effect on Chemotherapy-Induced Neuropathic Pain
Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a serious healthcare concern. It is painful, persistent, resistant to conventional pain therapies, and results in long-term suffering and decreased quality of life…
- Conditions
- Cancer, Breast, Cancer, Colorectal, Cancer, Lung, Cancer, Ovarian
- Trial name
- NCT02991677
- Testing
- aerobic exercise intervention, control group, resistive training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baltimore VA Medical Center
Diabetic Peripheral Neuropathic Pain (DPN), Postherpetic Neuralgia (PHN)
Pregabalin Treatment Of Peripheral Neuropathic Pain Associated With Diabetic Peripheral NeP (DPN), Postherpetic Neuralgia (PHN), HIV-related NeP (HIV), and Chemotherapy Induced NeP
Management of neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, human immunodeficiency virus-related peripheral neuropathy, and chemotherapy induced peripheral neuropathy.
- Conditions
- Diabetic Peripheral Neuropathic Pain (DPN), Postherpetic Neuralgia (PHN), HIV-related Neuropathic Pain (HIV), Chemotherapy Induced Neuropathic Pain
- Trial name
- NCT00407511
- Testing
- Pregabalin
- Where
- 11 sites in Colombia, Ecuador and 3 more
- Volunteers
- 121 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Chemotherapeutic Agent Toxicity, Neurotoxicity
Electrical Stimulation Therapy Using the MC5-A Scrambler in Reducing Peripheral Neuropathy Caused by Chemotherapy
RATIONALE: Electronic stimulation using a MC5-A Scrambler may help relieve pain in patients who develop peripheral neuropathy while undergoing chemotherapy treatments for cancer.
- Conditions
- Chemotherapeutic Agent Toxicity, Neurotoxicity, Pain, Peripheral Neuropathy
- Trial name
- NCT00952848
- Testing
- questionnaire administration, Sensory Neuropathy Scale instrument, Quality of Life instrument
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Chemotherapy-induced Peripheral Neuropathy, Pain
Efficacy and Safety of Duloxetine in Chinese Solid Tumor Patients With Taxanes-induced Painful Peripheral Neuropathy
The study is to evaluate the efficacy and safety of duloxetine in Chinese solid tumor patients with taxanes-induced painful peripheral neuropathy.
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Pain, Solid Tumor
- Trial name
- NCT04970121
- Testing
- Duloxetine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yan Yang, MD, Ph.D
Chemotherapy Induced Peripheral Neuropathy
Effects of Telerehabilitation Versus Clinical Rehabilitation on Chemotherapy Induced Peripheral Neuropathy
The aim of this study is to determine the comparative effects of telerehabilitation versus clinical rehabilitation on neuropathic pain, physical function and quality of life in Chemotherapy induced peripheral neuropathy patients.
- Trial name
- NCT06696976
- Testing
- Telerehabilitation, Clinical rehabilitation
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Riphah International University
Chemotherapy-Induced Peripheral Neuropathy, Numbness
Fingolimod in Treating Patients With Chemotherapy-Induced Neuropathy
This early phase I trial studies how well fingolimod works in treating patients with chemotherapy-induced nerve pain (neuropathy). Fingolimod acts by suppressing immune reactions in the brain.
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Numbness, Pain, Tingling
- Trial name
- NCT03943498
- Testing
- Fingolimod, Fingolimod Hydrochloride, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Breast Cancer, Neuropathic Pain in Cancer
Effect of Aromatherapy on the Management of Chemotherapy-Induced Neuropathy (CIN)
The main objective of this study is to describe the effect of an essential oil-based blend applied topically in the management of painful symptoms, sensory disturbances, or functional impairment caused by Chemotherapy-Induced…
- Trial name
- AROMA NEUROTAX (NCT07779135)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier de Colmar
Chronic Neuropathic Pain, Postoperative, Chronic Pain, Postoperative
Neuropathic Pain After Lung Surgery
To understand pain pathophysiology in terms of risk factors and protective mechanisms ranging from molecular pathways to societal impacts.
- Conditions
- Chronic Neuropathic Pain, Postoperative, Chronic Pain, Postoperative, Chronic Chemotherapy-induced Neuropathic Pain, Chronic Chemotherapy-induced Pain
- Trial name
- NCT02960971
- Testing
- Thoracic surgery for lung cancer
- Where
- 2 sites in Denmark
- Volunteers
- 78 people
- Sponsor
- Danish Pain Research Center