Clinical trials: Chemotherapy-induced Neuropathy
Chemotherapy-induced Peripheral Neuropathy
Chemotherapy Induced Neuropathy in Cancer Patients
The purpose of this prospective study is to perform Nerve conduction test, Vitamin D, Vitamin B12 and NADPH oxidase 4(NOX4) expression to assess severity of chemotherapy induced Peripheral neuropathy (CIPN) in solid cancer (Head…
- Trial name
- CIN (NCT06491082)
- Testing
- Cisplatin, Carboplatin, Paclitaxel, Docetaxel
- Where
- India
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Swami Rama Himalayan University
Breast Cancer, Chemotherapy-induced Peripheral Neuropathy
Involvement of SK3 Calcium Channel in Taxane Neuropathy
Taxane neuropathy is a common and long-term side effect of long-term morbidity in patients surviving cancer. No preventive or symptomatic treatment has been shown to be effective.
- Conditions
- Breast Cancer, Chemotherapy-induced Peripheral Neuropathy, Prostate Cancer
- Trial name
- NEUROTAX (NCT03816904)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 97 people
- Sponsor
- University Hospital, Tours
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Safety, Tolerability, and PK of AH-008 Following Single Ascending Dose in Healthy Subjects
This is a Phase 1, first-in-human (FIH), randomized, double-blind, placebo-controlled, parallel-group, single ascending dose (SAD) study to evaluate the safety, tolerability, and pharmacokinetics of AH-008 administered as a…
- Trial name
- NCT07697560
- Testing
- AH-008 for Injection, 150 mg
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AnHorn Medicines Co. Ltd.
Chemotherapy-induced Neuropathy
Home-Based Exercise and Vagus Nerve Stimulation for Chemotherapy-Induced Neuropathy
Background: Studies highlight the potential benefits of home-based exercise for cancer survivors with chemotherapy-induced neuropathy (CIN); however, its effectiveness in alleviating CIN-related sensorimotor impairments and…
- Trial name
- CIN (NCT07877558)
- Testing
- Active non-invasive vagus nerve stimulation (nVNS), Home-based aerobic and resistance exercise program
- Where
- 3 sites in Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Chemotherapy-induced Peripheral Neuropathy, Quality of Life
International CIPN Assessment and Validation Study
This is an observational study of chemotherapy-induced peripheral neurotoxicity (CIPN) patients to be investigated prospectively in order to assess responsiveness of a set of outcome measures in an international multi-center…
- Trial name
- ICAVS (NCT04633655)
- Testing
- outcome measures for CIPN testing
- Where
- 30 sites in United States, Australia and 14 more
- Volunteers
- 1,000 people
- Sponsor
- University of Milano Bicocca
Malignant Solid Neoplasm
Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy
This phase III trial compares the effect of 3 study approaches in preventing chemotherapy-induced peripheral neuropathy: 1) cryocompression, 2) continuous compression, and 3) low cyclic compression.
- Trial name
- ICE COMPRESS (NCT05642611)
- Testing
- Biospecimen Collection, Cryocompression Therapy, Pneumatic Compression Therapy
- Where
- 36 sites in United States
- Volunteers
- 777 people
- Sponsor
- SWOG Cancer Research Network
Chemotherapy-induced Peripheral Neuropathy
A Trial Measuring ART-123 Ability to Prevent Sensory Neuropathy in Unresectable mCRC Subjects w/Oxaliplatin-based Chemo
To evaluate the efficacy and safety of ART-123 on sensory symptoms of oxaliplatin-induced peripheral neuropathy (OIPN) in patients with unresectable metastatic colorectal cancer who receive oxaliplatin-containing chemotherapy
- Trial name
- NCT04492436
- Testing
- thrombomodulin alfa
- Sponsor
- Veloxis Pharmaceuticals
Chemotherapy-induced Peripheral Neuropathy, Electrical Stimulation
High Tone Therapy for Chemotherapy Induced Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN), a side effect of antineoplastic medication, was reported to occur in about 68% of the patients receiving chemotherapy.
- Trial name
- NCT06048471
- Testing
- HiTop
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Vienna Hospital Association
Peripheral Neuropathy Due to Chemotherapy
Compression Therapy of Hands and Feet for the Prevention of Taxane- or Oxaliplatin-induced Peripheral Neuropathy
Population Cohort 1 Taxane: Breast cancer patients; (neo-)adjuvant treatment Cohort 2 Oxaliplatin: Colorectal cancer patients; (neo-)adjuvant treatment Study design Multicentre, unblinded randomised controlled study Study…
- Trial name
- KompXX (NCT07464769)
- Testing
- Compression therapy
- Where
- Sweden
- Volunteers
- 358 people
- Sponsor
- Region Jönköping County
Chemotherapy Induced Peripheral Neuropathy
Self-applied taVNS for CIPN
The purpose of this study is to determine the feasibility of using a portable device at home to self-administer transcutaneous auricular vagus nerve stimulation (taVNS).
- Trial name
- NCT07596030
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Miami
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Assessing Functional Impairments in Patients With Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe side effect of several anti-cancer agents. Typical symptoms include tingling and hypoesthesia in the fingertips and/or toes, which substantially impair patients'…
- Trial name
- Assess CIPN (NCT07315334)
- Testing
- Questionnaire and Physical Exam
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Paracelsus Medical University
Chemotherapy-induced Peripheral Neuropathy
Dextromethorphan in Chemotherapy-induced Peripheral Neuropathy Management
The aim of this study is to assess if dextromethorphan administered during 4 weeks induces a decrease of pain intensity in breast cancer patients suffering from chemotherapy-induced peripheral neuropathy compared to placebo group.
- Trial name
- CHEMODEX (NCT02271893)
- Testing
- Dextromethorphan
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Clermont-Ferrand
Neurotoxicity Syndromes
To Study the Individual Variants of Chemotherapy-Induced Neurotoxicity
To study the risk prediction of chemotherapy-induced peripheral neuropathy (CIPN) by the clinical bioinformatics and genomic profile.
- Trial name
- NCT02481336
- Testing
- Questionnaires, Peripheral nervous system examination, Whole Genome Sequence
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Cheng-Kung University Hospital
Chemotherapy-induced Peripheral Neuropathy
Diagnostic of Chemotherapy Induced Neuropathy in Children
The purpose of this study is to determine the diagnostic accuracy of a newly developed tool (Electrochemical Skin Conductances (ESC) measurement) easy-to-perform, non-invasive, highly reproductible and not requiring specific…
- Trial name
- SUDOPED (NCT04262778)
- Testing
- electrochemical skin conductance measurement
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer
Efficacy of Cryotherapy in Managing Chemotherapy-Induced Peripheral Neuropathy in Children With Leukemia
This study aimed to assess the efficacy of cryotherapy in controlling Peripheral Neuropathy in cancer children
- Trial name
- NCT06543264
- Testing
- Cryotherapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Delta University for Science and Technology
Neuropathic Pain, Chemotherapy Induced Pain Neuropathy
The Effect of Foot Massage With a Massage Roller on Chemotherapy-Related Neuropathic Pain
Chemotherapy-related neuropathic pain is experienced by 30-40% of cancer patients. This pain significantly reduces the quality of life and overall well-being of patients battling cancer.
- Trial name
- NCT07650864
- Testing
- Roller Massage, Ice therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ataturk University
Breast Cancer
Effectiveness of Cryotherapy Combined With Compression Therapy for Preventing Chemotherapy-induced Peripheral Neuropathy
This is a prospective, multi-center, randomized study designed to evaluate the clinical efficacy of cryotherapy combined with compression therapy in preventing albumin-paclitaxel induced peripheral neuropathy.
- Trial name
- NCT05341141
- Testing
- Frozen glove and sock, ddEC-ddT
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Peking University
Peripheral Nervous System Diseases, Chemotherapy-Induced Peripheral Neuropathy
Neotrofin for Treatment of Chemotherapy-Induced Peripheral Neuropathy
This study will assess the safety and efficacy of Neotrofin in treating the peripheral neuropathy that results from chemotherapy for cancer.
- Trial name
- NCT00041795
- Testing
- leteprinim potassium (Neotrofin)
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- NeoTherapeutics
Cancer, Chemotherapy-induced Peripheral Neuropathy (CIPN)
Electroacupuncture and Exercise for Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment that causes numbness, pain, and balance issues in a patient's hands and feet.
- Trial name
- EA-EX CIPN (NCT07700901)
- Testing
- Electroacupuncture, Exercise Training, Structured Home-Based Health Education and Dose-Controlled Exercise Program
- Where
- 2 sites in Taiwan
- Volunteers
- 82 people
- Sponsor
- Show Chwan Memorial Hospital
Chronic Myeloproliferative Disorders, Leukemia
Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
RATIONALE: Baclofen-amitriptyline-ketamine (BAK) gel may lessen peripheral neuropathy caused by chemotherapy. It is not yet known whether BAK gel is more effective than a placebo in treating peripheral neuropathy caused by…
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT00516503
- Testing
- baclofen/amitriptyline/ketamine gel
- Where
- 165 sites in United States
- Volunteers
- 208 people
- Sponsor
- Alliance for Clinical Trials in Oncology