Clinical trials: Chemotherapy-induced Peripheral Neuropathy
Neuropathic Pain
Tolerability and Analgesic Efficacy of Loxapine in Patients With Refractory, Chemotherapy-induced Neuropathic Pain
Loxapine is an antipsychotic drug approved for the treatment of schizophrenia in several countries including the United States. In animal studies in mice, loxapine reduced neuropathic pain.
- Trial name
- LOX2015PILOT (NCT02820519)
- Testing
- Loxapine
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- University of Witten/Herdecke
Neurotoxicity, Pain
Topical Amitriptyline and Ketamine Cream in Treating Peripheral Neuropathy Caused by Chemotherapy in Cancer Patients
RATIONALE: Topical cream containing amitriptyline and ketamine may help relieve pain, numbness, tingling, and other symptoms of peripheral neuropathy.
- Conditions
- Neurotoxicity, Pain, Peripheral Neuropathy, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00471445
- Testing
- ketamine/amitriptyline NP-H cream
- Where
- 17 sites in United States
- Volunteers
- 462 people
- Sponsor
- Gary Morrow
Osteoarthritis, Pain
A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers
A First-in-Human, Double-blind, Randomized, Placebo-controlled, Single Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics/Pharmacodynamics of iN1011-N17 after Oral Administration in Healthy Volunteers.
- Conditions
- Osteoarthritis, Pain, Post Herpetic Neuralgia, Neuropathic Pain
- Trial name
- NCT05496205
- Testing
- iN1011-N17
- Where
- Australia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- iN Therapeutics Co., Ltd.
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Auricular Point Acupressure: Examining the Scientific Underpinnings of Pain Relief
Chemotherapy-induced peripheral neuropathy (CIPN)-numbness, burning and stunning pain distributed in hands and feet-is a major challenge among cancer patients.
- Trial name
- NCT03634527
- Testing
- Auricular Point Acupressure, Control Auricular Point Acupressure-
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Topical Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy
The goal of this clinical trial is to learn if menthol works to relieve chronic neuropathic pain and chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NCT07693387
- Testing
- menthol-based hand and foot gloves
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taiwan Municipal An-Nan Hospital-China Medical University
Nasopharyngeal Carcinoma, CIPN - Chemotherapy-Induced Peripheral Neuropathy
Compression Therapy as a Prophylactic Method Against CIPN: a Prospective Self-controlled Trial
This is a single-center, self-controlled, evaluator-blinded prospective study, which applies pressurized gloves and foot caps to prevent paclitaxel-induced peripheral neuropathy in patients with nasopharyngeal carcinoma.
- Trial name
- CIPN (NCT05531916)
- Testing
- Pressurized gloves and foot caps
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Sun Yat-sen University
Neuropathy, Peripheral Neuropathy
Study of Nicotine for Pain Associated With Chemotherapy-Induced Peripheral Neuropathy
Assess the efficacy of short-term nicotine transdermal patch administration for the treatment of chemotherapy-induced peripheral neuropathy (CIPN) in cancer stable patients or patients in remission.
- Conditions
- Neuropathy, Peripheral Neuropathy, Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy
- Trial name
- NCT04468230
- Testing
- Nicotine Transdermal Patch
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Adenocarcinoma of Pancreas
Hand Therapy Intervention Versus Traditional Occupational Therapy to Prevent Chemotherapy Induced Peripheral Neuropathy
A pilot randomized feasibility trial with a blinded evaluator.
- Trial name
- NCT05374876
- Testing
- Hand Therapy Until CIPN, Traditional Occupational Therapy (TOT)
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- HonorHealth Research Institute
Chemotherapy-induced Peripheral Neuropathy
CIPN and it's Impact on Quality of Life in Patients Receiving Platinum and Taxanes
Neuropathies are a major cause of moderate to severe impairments in cancer patients. Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by antineoplastic agents, with a prevalence…
- Trial name
- NCT05829967
- Volunteers
- 60 people
- Sponsor
- Assiut University
Cancer Patients, Chemotherapy-Induced Peripheral Neuropathy
Exercise and Mindfulness Intervention for Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer
The goal of this clinical trial is to learn whether an exercise- and mindfulness-based cognitive therapy intervention can improve physical and psychological symptoms in cancer patients with chemotherapy-induced peripheral…
- Conditions
- Cancer Patients, Chemotherapy-Induced Peripheral Neuropathy, Exercise Intervention
- Trial name
- NCT07556965
- Testing
- Exercise and Mindfulness
- Where
- 2 sites in China
- Volunteers
- 41 people
- Sponsor
- Nanjing Medical University
Cancer, Lung, Colon Neoplasm
Exploration of Circulating microRNAs as Biomarkers of Chemo-induced Peripheral Neuropathy: a Study in Cancer Patients
This study aims to find out whether certain molecules in the blood, called microRNAs, are linked to how often and how severely people develop nerve damage from chemotherapy.
- Conditions
- Cancer, Lung, Colon Neoplasm, Neuropathy;Peripheral
- Trial name
- miR-CIPN#1 (NCT07427537)
- Testing
- Assessment of blood concentrations of microRNAs, Chemotherapy-induced peripheral neuropathy (CIPN) - grade, Pain assessement
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
CIPN - Chemotherapy-Induced Peripheral Neuropathy
The CONTRoL Trial: Cryotherapy vs. cOmpression Neuropathy TRiaL
The primary objective of this study is to select the best intervention from cold therapy, compression therapy and placebo at reducing neuropathic pain as measured by the change in the Neurotoxicity (NTX) component of the…
- Trial name
- CONTRoL (NCT03873272)
- Testing
- Cryotherapy, Compression Therapy, Loose glove/sock
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Columbia University
Breast Cancer, Peripheral Neuropathies
Chemotherapy-Induced Peripheral Neuropathy-Essential Oil Intervention
This study will evaluate an oil blend with active ingredients for the reduction in chemotherapy-induced peripheral neuropathy in people with breast cancer.
- Trial name
- CIPN-EOI (NCT03449303)
- Testing
- EOI
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Augusta University
Cancer
Efficacy of Cryotherapy in Managing Chemotherapy-Induced Peripheral Neuropathy in Children With Leukemia
This study aimed to assess the efficacy of cryotherapy in controlling Peripheral Neuropathy in cancer children
- Trial name
- NCT06543264
- Testing
- Cryotherapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Delta University for Science and Technology
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Trial of a Virtual Exercise-based Rehabilitation Program to Treat Persistent Chemotherapy-Induced Peripheral Neuropathy (CIPN)
The purpose of this study is to determine the effectiveness of the EX-CIPN program in reducing the strength of CIPN symptoms and CIPN-related disability and improving the ability to complete everyday activities.
- Trial name
- EX-CIPN (NCT07481149)
- Testing
- EX-CIPN
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- University Health Network, Toronto
Peripheral Neuropathy, Chemotherapy-induced Peripheral Neuropathy
Lidocaine Versus Duloxetine for the Prevention of Taxane-Induced Peripheral Neuropathy In Breast Cancer Patients
The aim of the study is to evaluate the effect of intravenous (IV) lidocaine versus oral duloxetine on the onset and severity of TIPN in patient with breast cancer as well as evaluation of Patients' quality of life and estimation…
- Conditions
- Peripheral Neuropathy, Chemotherapy-induced Peripheral Neuropathy, Breast Cancer
- Trial name
- TIPN (NCT04732455)
- Testing
- Lidocaine in Saline, Duloxetine 30 MG, Normal saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Gamal Mohamed Taha Abouelmagd
Breast Cancer Female, Chemotherapy-induced Peripheral Neuropathy
Home-Based Physical Activity Intervention for Taxane-Induced CIPN
This two-group, randomized control trial (RCT) will test the effects of a home-based, 16 week gait/balance training plus resistance (exercise bands) exercise program as compared to an educational cancer survivorship attention…
- Conditions
- Breast Cancer Female, Chemotherapy-induced Peripheral Neuropathy, Gait Disorders, Neurologic, Balance; Distorted
- Trial name
- B-HAPI (NCT04621721)
- Testing
- Gait/balance & resistive exercise
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- University of South Florida
Breast Cancer, Ovarian Neoplasm
Omega-3 Fatty Acid in Treating Pain in Patients With Breast or Ovarian Cancer Receiving Paclitaxel
Paclitaxel, a widely used chemotherapeutic agent, is associated with several well-known side effects including neuropathy (weakness, numbness and pain) and generalized body aches.
- Conditions
- Breast Cancer, Ovarian Neoplasm, Pain
- Trial name
- NCT01821833
- Testing
- Omega-3 fatty acid, Paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- New Mexico Cancer Research Alliance
Chemotherapy-Induced Peripheral Neuropathy, Malignant Neoplasm
Transcranial Direct Current Stimulation in Reducing Pain in Cancer Patients With Chemotherapy Induced Peripheral Neuropathy
This early phase I trial studies how well transcranial direct current stimulation works in reducing pain in cancer patients with chemotherapy induced peripheral neuropathy.
- Trial name
- NCT04135326
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Transcranial Direct Current Stimulation
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Chemotherapy-induced Peripheral Neuropathy, Pain, Neuropathic
Ozone Therapy in Chemotherapy-induced Peripheral Neuropathy: RCT (O3NPIQ)
The main objective of this clinical trial is to evaluate the effectiveness and cost-effectiveness of adding ozone therapy to the clinical management of patients with pain secondary to chemotherapy-induced peripheral neuropathy
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Pain, Neuropathic, Pain Syndrome
- Trial name
- O3NPIQ (NCT04299893)
- Testing
- Ozone, Oxygen
- Where
- 2 sites in Spain
- Volunteers
- 42 people
- Sponsor
- Bernardino Clavo, MD, PhD