Clinical trials: Chest Infection
Pulmonary Function
Comparative Study Between CPAP Mask and Stacked Breathing o Pneumonia
the study aimed to compare the effect of using NIV with using CPAP mask and stacked breathing exercise and its efficacy on chest expansion and pulmonary functions in pneumonic patients.
- Trial name
- CPAP (NCT04576221)
- Testing
- stacked breathing exercise, NIV by CPAP mask
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ahmed talaat ahmed aly
Ovarian Cancer, Merkel Cell Carcinoma
BB-10901 in Treating Patients With Relapsed or Refractory Solid Tumors
RATIONALE: Monoclonal antibodies, such as BB-10901, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Conditions
- Ovarian Cancer, Merkel Cell Carcinoma, SCLC
- Trial name
- NCT00346385
- Testing
- BB-10901
- Where
- 9 sites in United States, United Kingdom
- Volunteers
- 97 people
- Sponsor
- ImmunoGen, Inc.
Chronic Ventilator Dependency
HFCWO in Prolonged Mechanical Ventilation Patients
The effectiveness, safety and tolerance/comfort of high-frequency chest wall oscillation (HFCWO) in prolonged mechanical ventilation patients remain unknown.
- Trial name
- NCT02077738
- Testing
- HFCWO (Hill-Rom Vest™ Airway Clearance System)
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Taichung Veterans General Hospital
Lung Cancer, Non-Small Cell, Lung Infection
Radiolabelled Nectin-4 Targeted LMW Probe PET/CT in Patients With Lung Lesions
To evaluate the ability of [68Ga]N188 to detect nectin-4 overexpression in patients with lung lesions.
- Trial name
- NCT06648317
- Testing
- FDG-PET
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Cancer Hospital & Institute
Colorectal Cancer, Lung Cancer
The Effects of Preoperative Bevacizumab on Perioperative Complications
This is a nationwide multicenter,retrospective,observational real-world study. 1. To assess the risk of perioperative complications in patients with tumor who received bevacizumab prior to unexpected operation. 2.
- Conditions
- Colorectal Cancer, Lung Cancer, Operation Wound; Infection, Bevacizumab
- Trial name
- NCT04788381
- Testing
- Bevacizumab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Urinary Tract Infections
Early or Late Foley Removal After Thoracotomy
Is the early removal of Foley catheter safe in patients undergoing general thoracic surgery with an epidural catheter in place?
- Trial name
- NCT01611519
- Where
- United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pneumonia
Effect of Neurophysiological Facilitation of Respiration on Blood Gases and Hospital Stay in Children With Pneumonia
The goal of this clinical trial is to investigate the effect of respiratory neurophysiological facilitation techniques on arterial blood gases, the severity of respiratory distress and duration of hospital stay in hospitalized…
- Trial name
- NCT07070271
- Testing
- Respiratory neurophysiological facilitation techniques, conventional chest physical therapy
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Asmaa Ahmed Abd El-samad
Respiratory Syncytial Virus Infections, Antibiotic Stewardship in Community Hospitals
RSV Antibiotic Drivers And Resource-use
This study retrospectively evaluated the clinical, laboratory, and radiologic factors that influence the decision to prescribe antibiotics in children under 2 years of age hospitalized with RSV-positive acute lower respiratory…
- Trial name
- RADAR (NCT06977971)
- Where
- Turkey (Türkiye)
- Volunteers
- 209 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Lower Resp Tract Infection
Prospective Clinical Evaluation of the FilmArray® Lower Respiratory Tract Infection (LRTI) Panel
This is a performance study to test the sensitivity and specificity of the BioFire FilmArray Lower Respiratory Tract Infection (LRTI) Panel.
- Trial name
- LRTI (NCT03361670)
- Testing
- Observational Study
- Where
- 8 sites in United States
- Volunteers
- 1,689 people
- Sponsor
- BioFire Diagnostics, LLC
Covid19, COVID-19 Lower Respiratory Infection
In-patient COVID-19 Study of Intranasal Foralumab
This is a Phase 2, randomized, placebo-controlled, double-blind, proof-of-concept study of intranasal foralumab in hospitalized subjects with severe COVID-19 and pulmonary inflammation.
- Conditions
- Covid19, COVID-19 Lower Respiratory Infection, COVID-19 Respiratory Infection
- Trial name
- NCT04983446
- Testing
- Foralumab
- Sponsor
- Tiziana Life Sciences LTD
Chest Infection, Pulmonary Edema - Acute
Grasshopper: a Novel Clinical Dashboard for Radiologists
Does a radiology clinical dashboard increase radiologist use of specific reporting language for chest X-rays (CXRs) and thereby decrease rates of unnecessary Emergency Department (ED) prescriptions and follow-up imaging?
- Trial name
- Grasshopper (NCT06785246)
- Testing
- Grasshopper dashboard
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8
Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors
This phase I/II trial tests the safety and tolerability of an experimental personalized vaccine when given by itself and with pembrolizumab in treating patients with solid tumor cancers that have spread to other places in the…
- Conditions
- Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8
- Trial name
- PNeoVCA (NCT05269381)
- Testing
- Cyclophosphamide, Neoantigen Peptide Vaccine, Pembrolizumab
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Mayo Clinic
Severe COVID-19
COVID-19 and VA-LRTI: Second Versus First Wave of the Pandemic
Multicenter observational retrospective cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic.
- Trial name
- CoVAPid2 (NCT05256511)
- Where
- France
- Sponsor
- University Hospital, Lille
Lower Respiratory Tract Infection (LRTI), Recurrent Wheezing
Prevent Wheeze Trial
This trial investigates whether a single dose of dexamethasone will prevent recurrent wheezing in children at high-risk for asthma admitted to hospital with a lower respiratory tract infection (LRTI).
- Trial name
- PRE-WHEE (NCT07858773)
- Testing
- Dexamethasone 0.6 mg/kilogram body weight single dose
- Where
- 2 sites in Nepal, South Africa
- Volunteers
- 486 people
- Sponsor
- Norwegian University of Science and Technology
Biofire Filmarray
Diagnosis of Lower Respiratory Tract Infections Using Biofire Filmarray
Comparison of pathogens causing lower respiratory tract infections in ventilated versus non ventilated pediatric patients in intensive care unit using biofire filmarray and vitek2 Antibiotic sensitivity using vitek2 Comparison of…
- Trial name
- NCT04283422
- Testing
- Biofire filmarray
- Volunteers
- 60 people
- Sponsor
- Assiut University
Ventilator-Associated Pneumonia, Tracheobronchitis
CT Scan and Lung Ultrasonography to Improve Diagnostic of Ventilation Acquired Pneumonia in ICU
We aim to show that systematic ultrasonography performed in ventilated patients suspected of ventilation-acquired pneumonia could improve the accuracy of diagnostic of pneumonia, and helps defining the diagnostic of…
- Trial name
- ECTOPICUS (NCT03018431)
- Testing
- CT Scan
- Where
- 2 sites in France
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
RSV Infection, Bronchiolitis
Exhaled Nitric Oxide in Respiratory Syncytial Virus (RSV) Bronchiolitis: a Pilot Study
The fraction of exhaled nitric oxide (feNO) in expired air is a reliable measure of airway inflammation. Some research experiments have demonstrated stimulation of nitric oxide production in respiratory epithelial cells infected…
- Trial name
- NCT01090557
- Testing
- Collection of exhaled breath
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Winthrop University Hospital
Cough, Lower Respiratory Tract Infection (LRTI)
An Observational Study of Cough / Lower Respiratory Tract Infection (LRTI) in Primary Care
The overall objective of GRACE is to combat the resistance of drugs that kill bacteria and other germs (antimicrobial) through integrating centres of research excellence and using the study of the entire DNA in a cell (genomics)…
- Conditions
- Cough, Lower Respiratory Tract Infection (LRTI), Chest Infection
- Trial name
- NCT00353951
- Where
- United Kingdom
- Volunteers
- 3,402 people
- Sponsor
- Cardiff University
Advanced Differentiated Thyroid Gland Carcinoma, Advanced Head and Neck Carcinoma
Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV
This phase I trial investigates the side effects of cabozantinib and nivolumab in treating patients with cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body…
- Conditions
- Advanced Differentiated Thyroid Gland Carcinoma, Advanced Head and Neck Carcinoma, Advanced Hepatocellular Carcinoma, Advanced Kaposi Sarcoma
- Trial name
- NCT04514484
- Testing
- Biospecimen Collection, Cabozantinib S-malate, Computed Tomography
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- National Cancer Institute (NCI)
Pneumonia, Ventilator-Associated, Respiratory Tract Infections
Predicting Ventilator-associated Lower Respiratory Tract Infection Outcomes Using Sequenced-based Early Microbiological Response
We are using a tool called QtNGS (quantitative targeted amplicon-based next-generation sequencing ) to measure the abundance of local pathogens in patients with ventilator-associated lower respiratory tract infections.
- Conditions
- Pneumonia, Ventilator-Associated, Respiratory Tract Infections, Prognosis
- Trial name
- NCT06467864
- Testing
- bronchoscope
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University