Clinical trials: Chest Infection
Advanced Solid Tumor, MSI-H/dMMR Tumors
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors
The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, pharmacodynamics, and early clinical activity of INCB099280 in participants with select solid tumors
- Conditions
- Advanced Solid Tumor, MSI-H/dMMR Tumors, Cutaneous Squamous Cell Carcinoma, Urothelial Carcinoma
- Trial name
- NCT04242199
- Testing
- INCB099280
- Where
- 21 sites in United States, Australia and 3 more
- Volunteers
- 182 people
- Sponsor
- Incyte Corporation
Community Acquired Pneumonia
Epidemiological Study on Community Acquired Pneumonia
The main objective of this study is to investigate prevalence and risk factors for community-acquired pneumonia (CAP) and its interaction with comorbidities in an unselected group of adult patients receiving outpatient and…
- Trial name
- CAPNETZ (NCT02139163)
- Where
- Germany
- Volunteers
- 20,000 people
- Sponsor
- Capnetz Stiftung
COVID 19, SARS-Cov-2
Combination of Chest Scanography and Nasal Viral Detection Test to Detect COVID-19 Positive Patients Before Surgical Intervention in a University Hospital During Coronavirus Pandemia
This research aims to improve the screening for COVID-19 upon admission to the Montpellier University Hospital for an act under general anesthesia or at high risk of transmission of the virus.
- Trial name
- COVID-Scan (NCT04355715)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
COVID-19, Lung Cancer
Perioperative Outcomes of Anatomic Lung Resections in Patients Who Recovered From Coronavirus Disease 2019
This study will determine the outcomes of anatomic lung resections in patients who recovered from coronavirus disease 2019 (COVID-19) disease by describing the morbidity and mortality as well as the length of postoperative…
- Conditions
- COVID-19, Lung Cancer, Lung TB, Hemoptysis
- Trial name
- NCT05513248
- Testing
- anatomic lung resection
- Where
- Philippines
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lung Center of the Philippines
Coronary Artery Diseases, Myocardial Infarction
The Efficacy of Influenza Vaccine in Reducing Cardiovascular Events in Patients With Coronary Artery Diseases
Influenza vaccine reduces the cardiovascular events in post-myocardial infarction (MI) patients and in those with stable angina (SA).
- Conditions
- Coronary Artery Diseases, Myocardial Infarction, Stable Angina
- Trial name
- IVCAD (NCT00607178)
- Testing
- influenza vaccine
- Where
- Iran
- Volunteers
- 300 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial
This phase II trial studies how well low dose, reduced frequency nivolumab works in treating patients with cancer that cannot be removed by surgery (unresectable) or that has spread from where it first started (primary site) to…
- Conditions
- Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8, Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
- Trial name
- NCT07576725
- Testing
- Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging
- Where
- Uganda
- Volunteers
- 50 people
- Sponsor
- Fred Hutchinson Cancer Center
Covid19, Pneumonia, Viral
Vascular Abnormalities Detected With Chest CT in COVID-19
Chest computed tomography of patients having coronavirus disease (COVID-19) will be analyzed with regards to vascular abnormalities (pulmonary embolism and vascular thickening), and their association with lung inflammation.
- Conditions
- Covid19, Pneumonia, Viral, Pulmonary Embolism
- Trial name
- COVID-CAVA (NCT04824313)
- Testing
- Chest CT, Chest CTA
- Where
- Switzerland
- Volunteers
- 1,000 people
- Sponsor
- Salah D. Qanadli
Empyema, Pleural
Uniportal VATS Versus Chest Tube for Early Empyema
This randomized controlled study compared uniportal video-assisted thoracoscopic surgery (U-VATS) versus chest tube drainage for initial (first-line) treatment of stage I (exudative) and stage II (fibrinopurulent) empyema in…
- Trial name
- NCT06325904
- Testing
- Uniportal VATS, Tube thoracostomy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Minia University
Extensive Stage Small Cell Lung Cancer, Hereditary Paraganglioma
Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumors
RATIONALE: Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as vinorelbine ditartrate, work in different ways to stop the growth of tumor…
- Conditions
- Extensive Stage Small Cell Lung Cancer, Hereditary Paraganglioma, Male Breast Cancer, Malignant Paraganglioma
- Trial name
- NCT01155258
- Testing
- temsirolimus, vinorelbine ditartrate
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Southern California
Coronavirus Infections, Pneumonia
Magnetic Resonance Imaging to Detect Signs of Viral Pneumonia in Patients With Coronavirus Infection.
Since the onset of the COVID-19 pandemic, the importance of chest computed tomography (CT) in detecting signs of viral pneumonia has become clear from the literature.
- Trial name
- NCT04424355
- Testing
- Chest MRI
- Where
- Russia
- Volunteers
- 25 people
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Lung Neoplasm Malignant, Interstitial Lung Disease
Coorticosteroid Regimen in Patients With Anti-PD-1/PD-L1 Induced Pneumonitis
This is a prospective interventional open-label randomized trial. The patients treated with anti- PD-1 (programmed-death receptor type 1) or anti-PD-L1 (programmed-death ligand) antibodies in case of new acute onset interstitial…
- Trial name
- PROS-CONS (NCT04036721)
- Testing
- Prolonged glucocorticosteroid (prednisone) regimen, Short glucocorticosteroid (prednisone) regimen
- Where
- Poland
- Volunteers
- 85 people
- Sponsor
- National Institute for Tuberculosis and Lung Diseases, Poland
Lower Resp Tract Infection
TREATment of Lower Respiratory Tract Infection in Selected Hospitals in Southern Sri Lanka (TREAT-SL): a Stepped-Wedge Cluster Randomized Trial
This is a stepped-wedge, cluster-randomized, two-arm, open-label, clinical trial of an electronic clinical decision support tool (eCDST) for the diagnosis and treatment of lower respiratory tract infection (LRTI) among patients…
- Trial name
- TREAT-SL (NCT06331364)
- Testing
- electronic clinical decision support tool (eCDST) diagnostic plan
- Where
- 3 sites in Sri Lanka
- Volunteers
- 765 people
- Sponsor
- Duke University
Intestines Cancer, Pulmonary Cancer
Main Postoperative Complications After COVID-19
To explore the relationship between SARS-CoV-2 infection in different time before operation and postoperative main complications (mortality, main pulmonary and cardiovascular complications) 30 days after operation; To determine…
- Conditions
- Intestines Cancer, Pulmonary Cancer, Liver Cancer, Trauma
- Trial name
- NCT05694949
- Volunteers
- 100,000 people
- Sponsor
- RenJi Hospital
Influenza
Oseltamivir for Influenza Lower Respiratory Tract Infection in Children Under One
Currently, there is no treatment for children less than one year of age with influenza related lower respiratory tract infection that is either considered standard or registered in any country.
- Trial name
- NCT01546935
- Testing
- Oseltamivir
- Where
- 2 sites in Thailand
- Sponsor
- University of Oxford
Biofilms, Thoracic Surgery
Biofilm on Chest Drains After Thoracic Surgery: Clinical Impact and Antibiotic Resistance
This prospective observational study aims to investigate the frequency and clinical significance of biofilm formation on thoracic chest drains used after thoracic surgery.
- Conditions
- Biofilms, Thoracic Surgery, Postoperative Infection, Antibiotic Resistance, Bacterial
- Trial name
- NCT07228598
- Testing
- Chest Drain Tip Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 165 people
- Sponsor
- Caner İşevi, MD
COVID-19, Virus Diseases
suPAR-guided Anakinra Treatment for Validation of the Risk and Management of Respiratory Failure by COVID-19 (SAVE)
In the SAVE study patients with lower respiratory tract infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at high risk for progression to serious respiratory failure will be detected using the suPAR…
- Conditions
- COVID-19, Virus Diseases, Corona Virus Infection, Lower Respiratory Tract Infection Viral
- Trial name
- SAVE (NCT04357366)
- Testing
- Anakinra
- Where
- 28 sites in Greece
- Volunteers
- 1,000 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Covid19, Pneumonia
Coronavirus: Ventilator Outcomes Using Artificial Intelligence Chest Radiographs & Other Evidence-based Co-variates
We will determine ventilator outcomes to Coronavirus Infectious Disease 2019 (COVID-19) using artificial Intelligence with inputs of chest radiographs and other evidence-based co-variates.
- Trial name
- COVID VOICE (NCT04855539)
- Where
- 3 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- King's College Hospital NHS Trust
Lower Respiratory Tract Infections
Study Bronchoalveolar Lavage Fluid Driven Pathogenic Diagnosis of Lower Respiratory Tract Infections
Comparison of microbiological yield from Bronchoalveolar Lavage Fluid (BALF) for the two common-used volume bronchoalveolar lavages(60ml and 120ml)in patients with different types of lower respiratory tract infection.
- Trial name
- BALFinder (NCT02852070)
- Testing
- bronchoalveolar lavage 120ml, bronchoalveolar lavage 60ml
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Angina Pectoris, Acute Coronary Syndrome
Integrated Distance Management Strategy for Patients With Cardiovascular Diseases in the Context of COVID-19
Management of known patients with cardiovascular disease (in particular the whole spectrum of atherosclerotic ischaemic coronary artery disease, essential hypertension under treatment, and also patients with chronic heart failure…
- Conditions
- Angina Pectoris, Acute Coronary Syndrome, Coronary Syndrome, Coronary Artery Disease
- Trial name
- eCardioCovid19 (NCT04325867)
- Testing
- Tele-medicine platform
- Where
- 2 sites in Romania
- Volunteers
- 200 people
- Sponsor
- Professor Adrian Covic
COPD, Chronic Bronchitis
Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
The purpose of this study is to show that one form of mechanical airway clearance techniques, High Frequency Chest Wall Oscillation (HFCWO)using a pneumatic vest, will diminish exacerbations of COPD which will improve respiratory…
- Conditions
- COPD, Chronic Bronchitis, Emphysema
- Trial name
- NCT00181207
- Testing
- pneumatic vest
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University