Clinical trials: Chest Pain Rule Out Myocardial Infarction
Acute Chest Pain, NSTEMI - Non-ST Segment Elevation MI
Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)
The PRESC1SE-MI study compares two algorithms for triage of patients presenting with chest pain and symptoms of heart attack (myocardial infarction) to the emergency department.
- Trial name
- PRESC1SE-MI (NCT05649384)
- Testing
- European Society of Cardiology hs-cTnT/I 0 h/1 h algorithm, European Society of Cardiology hs-cTnT/I 0 h/3 h algorithm
- Where
- 20 sites in United States, Australia and 9 more
- Volunteers
- 64,374 people
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Syndrome, Acute, Coronary Artery Disease
A Study of Population and Sex-specific Troponin Cutoffs for Ruling Out Acute Myocardial Infarction
Acute myocardial infarction (MI) is defined as a rise and/or fall in cardiac troponins (cTn) with at least one value above the 99th percentile upper reference limit (URL) in the context of symptoms or clinical evidence of…
- Conditions
- Coronary Syndrome, Acute, Coronary Artery Disease, Myocardial Infarction
- Trial name
- DANSPOT (NCT05336435)
- Testing
- Implementation of the new population and sex-specific 99th percentile URL for cardiac troponin
- Where
- 22 sites in Denmark
- Volunteers
- 5,175 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Chest Pain, Myocardial Infarction
Rule Out of ACS in Primary Care Using a Decision Rule for Chest Pain Including Hs-troponin I POCT
The goal of this clustered, diagnostic randomized controlled trial is to study a clinical decision rule including a high-sensitive troponin I point of care test in patients with chest pain in primary care.
- Conditions
- Chest Pain, Myocardial Infarction, Acute Coronary Syndrome
- Trial name
- POB HELP (NCT05827237)
- Testing
- Clinical decision rule
- Where
- Netherlands
- Volunteers
- 946 people
- Sponsor
- Leiden University Medical Center
Chest Pain, Acute Coronary Syndrome
HEART Pathway Implementation
The purpose of this study is to determine the effectiveness of the HEART Pathway, a clinical decision aid for the care of patients with chest pain, in a "real-world" clinical setting.
- Conditions
- Chest Pain, Acute Coronary Syndrome, Chest Pain Atypical Syndrome, Chest Pain Rule Out Myocardial Infarction
- Trial name
- NCT02056964
- Where
- United States
- Volunteers
- 14,717 people
- Sponsor
- Wake Forest University Health Sciences
Acute Coronary Syndrome, NSTEMI - Non-ST Segment Elevation MI
Safety of Accelerated Rule-out Protocols in Patients Admitted With Chest Pain to a Crowded Chest Pain Unit (CPU)
The aim of this observational study registry is to assess the safety of a Non-ST-elevation myocardial infarction (STEMI) rapid rule-out strategy as proposed by European Guidelines in patients presenting with suspected acute…
- Trial name
- NCT03111862
- Testing
- NSTEMI Rule-Out according to hs-TnT
- Where
- Germany
- Volunteers
- 3,567 people
- Sponsor
- University Hospital Heidelberg
Emergency Medicine, Artificial Intelligence (AI)
Diagnostic Accuracy of GPT-4o and Claude for HEART Score Calculation in Chest Pain
This prospective observational diagnostic accuracy study evaluates whether large language models (LLMs) - GPT-4o (OpenAI, gpt-4o-2024-11-20) and Claude (Anthropic, claude-sonnet-4-6) - can accurately calculate HEART scores from…
- Conditions
- Emergency Medicine, Artificial Intelligence (AI), Artificial Intelligence (AI) in Diagnosis, Chest Pain Rule Out Myocardial Infarction
- Trial name
- LLM-HEART (NCT07626060)
- Testing
- GPT-4o HEART Score Calculator, Claude HEART Score Calculator, Three-Expert Consensus HEART Score
- Where
- Turkey (Türkiye)
- Volunteers
- 690 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Myocardial Infarction (MI), Chest Pain Rule Out Myocardial Infarction
The Rule-Out Acute Myocardial Infarction Using Aritifical Intelligence Electrocardiogram (ROMIAE) 2 Trial
This study is to see whether the AI ECG assisted protocol is as safe and efficacious as conventional protocol in early triage of suspected myocardial infarction.
- Trial name
- ROMIAE 2 (NCT07027891)
- Testing
- AI-ECG
- Where
- 12 sites in South Korea
- Volunteers
- 4,670 people
- Sponsor
- CHA University
Chest Pain Rule Out Myocardial Infarction
PPI's and SSRI's Therapy for the Management of NCCP
Non cardiac chest pain (NCCP) is defined as recurring, angina-like, retrosternal chest pain of non cardiac origin. Annual prevalence of NCCP in the general population of the western world ranges from 25-35%.
- Trial name
- NCCP (NCT02825342)
- Testing
- Citalopram
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Evangelismos Hospital
Acute Coronary Syndrome
VitalScan MCG Rule-out Multi-centre Pivotal Study - UK
The study is a prospective multi-centre observational study to evaluate a portable magnetocardiograph device for the rule-out of acute coronary syndrome (ACS) in patients who present to the emergency department with chest pain…
- Trial name
- MAGNET-ACS (NCT02921438)
- Testing
- VitalScan Magnetocardiograph
- Where
- 5 sites in United Kingdom
- Volunteers
- 756 people
- Sponsor
- Creavo Medical Technologies Ltd
Chest Pain, Acute Coronary Syndrome
Effectiveness and Safety of a Clinical Assessment and 0h/1h Troponin Rule-Out Protocol
Chest pain is a common presenting complaint at the Emergency Department (ED). Many of these patients undergo lengthy assessments in the ED or are admitted which contributes to ED and hospital crowding as well as a substantial…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Myocardial Infarction, Unstable Angina
- Trial name
- ESC-TROP (NCT03421873)
- Testing
- 0h/1h hs-cTnT protocol
- Where
- 5 sites in Sweden
- Volunteers
- 16,000 people
- Sponsor
- Ulf Ekelund
Chest Pain, Acute Coronary Syndrome
Computed Tomography Coronary Angiogram (CTCA) Versus Traditional Care in Emergency Department Assessment of Potential Acute Coronary Syndromes (ACS)
This multi-center, randomized, controlled trial conducted in Emergency Departments (ED) compares computed tomography (CT) coronary angiography with the traditional approach (usual care) for low- to intermediate-risk chest pain…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Acute Myocardial Infarction, Coronary Artery Disease
- Trial name
- NCT00933400
- Testing
- CT Coronary Angiography (CTCA), Traditional Strategy
- Where
- 5 sites in United States
- Volunteers
- 1,392 people
- Sponsor
- American College of Radiology
Acute Coronary Syndrome, Angina Pectoris
Mersey Acute Coronary Syndrome Rule-Out Using High Sensitive Troponin
The aim of this observational study is twofold. The primary hypothesis being tested is that initial(first) high sensitivity Tn <5ng/l (limit of detection) combined with an ECG with no ischaemic changes is superior as an…
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Cardiovascular Diseases, Chest Pain
- Trial name
- MACROS (NCT02581540)
- Volunteers
- 3,054 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Myocardial Infarction (MI), Acute Coronary Syndromes (ACS)
Prehospital Point-of-Care Hs-Troponin I for Rule-Out of Acute Myocardial Infarction in Patients Without ST-Segment Elevation
People who call emergency medical services (EMS) with chest pain or other possible heart-related symptoms are often taken to hospital for further testing.
- Trial name
- Pre-POCT TnI (NCT07563998)
- Testing
- Prehospital high-sensitivity cardiac troponin I measurement
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Central Denmark Region
Acute Coronary Syndrome, Myocardial Infarction
Multicenter Study to Rule Out Myocardial Infarction by Cardiac Computed Tomography
The growing availability of cardiac computed tomography (CT)* in emergency departments (EDs) across the U.S. expands the opportunities for its clinical application, but also heightens the need to define its appropriate use in the…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Unstable Angina Pectoris
- Trial name
- ROMICAT-II (NCT01084239)
- Testing
- Cardiac Computed Tomography
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Massachusetts General Hospital
Myocardial Infarction or Chest Pain
ROMIAE (Rule-Out Acute Myocardial Infarction Using Artificial Intelligence Electrocardiogram Analysis) Trial
This study is a prospective multicenter observational study for external validation and model advancement of a deep learning based 12-lead electrocardiogram analysis algorithm targeting adult patients presenting to the emergency…
- Trial name
- ROMIAE (NCT05435391)
- Where
- South Korea
- Volunteers
- 8,814 people
- Sponsor
- CHA University
Acute Coronary Syndrome, Myocardial Infarction
Improving the Referral of Patients With Chest Pain
Rationale: This study aims to aid the general practitioner (GP) in the diagnostic dilemma of chest pain patients. Patients with acute coronary syndrome (ACS) should be referred to the hospital promptly, though referring all…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Chest Pain
- Trial name
- Urgent (NCT03115190)
- Testing
- General Practitioner diagnosis with Heart score
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- VieCuri Medical Centre
Acute Coronary Syndrome, Myocardial Infarction
Rule Out Myocardial Infarction by Computer Assisted Tomography
The goal of this research is to determine noninvasively whether detection of coronary stenosis and plaque by multidetector computed tomography (MDCT) in patients with acute chest pain suspected of acute coronary syndrome (ACS)…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Unstable Angina Pectoris
- Trial name
- ROMICAT (NCT00990262)
- Testing
- Cardiac Computed Tomography
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- Massachusetts General Hospital
Acute Myocardial Infarction
Copeptin Registry (proCORE) Biomarkers in Cardiology (BIC)-19
Registry of an interventional Study-proved Strategy (BIC-8) using Copeptin and Troponin for the Early Rule-Out of Acute Myocardial Infarction (AMI) in Patients with Suspected Acute Coronary Syndrome (ACS) and a low-to…
- Trial name
- proCORE (NCT02490969)
- Testing
- Routine management observation
- Where
- Germany
- Volunteers
- 2,256 people
- Sponsor
- Charite University, Berlin, Germany
Myocardial Infarction, Chest Pain
Rapid Use of High-sensitive Cardiac Troponin I for ruling-in and Ruling-out of Acute Myocardial Infarction
Early rule-in or rule-out of myocardial infarction (MI) is essential in patients presenting to the Emergency Department with chest pain.
- Trial name
- RACING-MI (NCT03634384)
- Where
- Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital