Clinical trials: Chest Pains
Non-Cardiac Chest Pain
The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients
Noncardiac chest pain (NCCP) is a common clinical problem worldwide. In Hong Kong, it has been estimated that about 20% of patients with chest pain are misdiagnosed to have coronary heart disease.
- Trial name
- NCT00164814
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Angina Pectoris
Absorption and Pharmacokinetics of Nitroglycerin to a New Formulation
The study evaluate the absorption rate of different sublingual formulation of nitroglycerine (NTG) either in the form of available tablets or a new rapid absorbable gelation capsule formulation "NTG1523" by determining T-max and…
- Trial name
- NCT03777605
- Testing
- Nitroglycerin 0.4 MG
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kolding Sygehus
Post Mastectomy Lymphedema
Effect of Resisted Deep Breathing and Myofascial Release in Postmastectomy
This study aims to determine the combined effect of resisted deep breathing and Myofascial release on pain, respiratory efficiency, chest mobility and lymph edema in Postmastectomy.
- Trial name
- NCT07576270
- Testing
- Resisted Deep Breathing, Myofascial release
- Where
- Pakistan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Coronary Artery Disease
Can CCTA Technicians Provide Accurate Interpretation of Findings in Patients Presenting to the ED in After Hours?
Coronary Computed Tomographic Angiography (CCTA) is emerging as the diagnostic test of choice in chest pain patients with low to intermediate probability of coronary artery disease (CAD).
- Trial name
- NCT03168269
- Testing
- Coronary Computed Tomographic Angiography (CCTA)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jordan Collaborating Cardiology Group
Coronary Artery Disease, Ischemic Heart Disease
Volatilome and Single-Lead Electrocardiogram Optimize Ischemic Heart Disease Diagnosis Using Machine Learning Models
This is a prospective, case-control, single-center, observational, non-randomized study. It is designed to evaluate the diagnostic accuracy of functional tests involving physical exertion monitored via a 12-lead ECG, combined…
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Chronic Coronary Disease, Angina Pectoris
- Trial name
- NCT06181799
- Testing
- Mass spectrometry using the PTR TOF-1000 (IONICON PTR-TOF-MS - Trace VOC Analyzer, Eduard-Bodem-Gasse 3, 6020 Innsbruck, Austria (Europe).
- Where
- Russia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Stable Angina Pectoris, Periodontitis
Effect of Periodontal Therapy on Asprosin in Stable Angina
This study aims to evaluate the effect of non-surgical periodontal therapy on serum asprosin levels in patients with stable angina and periodontitis.
- Trial name
- NCT07591844
- Testing
- Non-surgical periodontal therapy (scaling and root planing), Non-surgical periodontal therapy (Professional dental cleaning)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Heart Diseases, Cardiovascular Diseases
Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes
Cardiovascular disease (CVD) is an important public health problem that affects millions of people worldwide. Associations between risk factors, such as smoking, dyslipidaemia or hypertension, and prevalent CVD are well…
- Conditions
- Heart Diseases, Cardiovascular Diseases, Acute Myocardial Infarction, Unstable Angina
- Trial name
- NCT01804439
- Volunteers
- 2,240,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Thoracic Diseases, Postoperative Pain
Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial
The Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial is a single center, double-blind, randomized, active-comparator controlled clinical trial to assess the analgesic efficacy of intercostal nerve block by…
- Conditions
- Thoracic Diseases, Postoperative Pain, Opioid Use
- Trial name
- NCT03508830
- Testing
- Liposomal bupivacaine, Bupivacaine Injection
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hypertension, Chronic Stable Angina
Bioequivalency Study of Amlodipine Tablets Under Fed Conditions
The objective of this study was the bioequivalence of a Roxane Laboratories' Amlodipine Besylate tablets, 10 mg, to Norvasc® Tablets, 10 mg (Pfizer) under fed conditions using a single-dose, randomized, 2-treatment, 2-period…
- Conditions
- Hypertension, Chronic Stable Angina, Vasospastic Angina
- Trial name
- NCT00601302
- Testing
- Amlodipine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Postoperative Pain
Continuous Ultrasound Guided Erector Spinae Plane Block vs Thoracic Paravertebral Block
in this study the investigators will investigate and compare the analgesic efficacy of two techniques (continuous TPVB and continuous ESPB) in relieving thoracotomy pain
- Trial name
- NCT05898607
- Testing
- continuous Thoracic paravertebral block, continuous Erector spinae plane block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amal Gouda Elsayed Safan
Acute Myocardial Ischemia
Non Invasive dP/dt to Detect an Acute Ischemic Myocardial Dysfunction in Emergency Department
Most patients presenting to the emergency department with chest discomfort have a nonischemic ECG and biomarkers of myocardial necrosis within normal limits.
- Trial name
- dP/dtAMDED (NCT02138604)
- Where
- Tunisia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Shoulder Pain, Shoulder Impingement Syndrome
Thoracic Spine and Shoulder Kinematics and Muscle Activation in Rock Climbers With Shoulder Pain
Background and Purpose: Rock climbing has been a popular sport in recent years. Rock climbing includes various open-chain and closed-chain arm movements.
- Trial name
- NCT05950360
- Testing
- Electromagnetic tracking system, surface electromyography
- Where
- Taiwan
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Coronary Artery Disease, Acute Coronary Syndrome
A Registry Study on Genetics and Biomarkers of Acute Coronary Syndrome
This is a national registry study to determine genetics risk factors and serial biomarkers of Acute Coronary Syndrome.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Acute Myocardial Infarction, Unstable Angina
- Trial name
- ARSGB-ACS (NCT03752515)
- Where
- 6 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Mediastinal Neoplasms, Thoracic Neoplasm
Pain and Quality of Life After Mediastinal Tumor Resection by Subxiphoid and Intercostal VATS
Thoracoscopic assisted mediastinal thymectomy is currently one of the most commonly used surgical methods, but there are some deficiencies.Minimally invasive surgery through the subxiphoid approach can achieve a good surgical…
- Conditions
- Mediastinal Neoplasms, Thoracic Neoplasm, Thoracic Surgery
- Trial name
- NCT03521986
- Testing
- Subxiphoid uniportal VATS, Intercostal uniportal VATS
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lei Jiang
Analgesia
Ultrasound Guided : Retrolaminar Block Versus Thoracic Epidural Analgesia Following Laparoscopic Cholecystectomy
The aim of this study is to evaluate analgesic effect of ultrasound-guided retrolaminar block vs ultrasound-guided thoracic epidural analgesia in pain control following laparoscopic cholecystectomy.
- Trial name
- NCT04835415
- Testing
- Bilateral retrolaminar block, Thoracic epidural analgesia
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Lung Diseases
The Feasibility and Safety of Avoiding Chest Tube Placement After Video-assisted Thoracoscopic Surgery (VATS）of the Lung
This is a prospective randomized controlled trial.The main study content is the feasibility and safety of avoiding chest tube placement after Video-Assisted Thoracoscopic Surgery lung disease,participants were randomly divided…
- Trial name
- NCT04012554
- Testing
- avoid chest drainage tube placement after video-assisted thoracoscopic wedge resection of lung, Indewlling chest drainage tube after video-assisted thoracoscopic wedge resection of lung
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xueying Yang
Coronary Artery Disease of Significant Bypass Graft, Coronary Syndrome
Implementation of Contemporary Coronary CT Angiography in Clinical Practice
Coronary CT angiography (CCTA) has been recognized as the first-line diagnostic test for most patients with suspected coronary syndrome, often acting as a gatekeeper for invasive coronary angiography.
- Conditions
- Coronary Artery Disease of Significant Bypass Graft, Coronary Syndrome, Coronary Arteriosclerosis
- Trial name
- CONCORDE (NCT06273033)
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Humanitas Hospital, Italy
Acute Coronary Syndrome, Myocardial Infarction (MI)
Clinical Echocardiography and S' Wave for Early Recognition of Acute Coronary Syndrome in the Emergency Department, A Prospective Study
The goal of this prospective observational study is to assess the diagnostic accuracy of the tissue Doppler imaging (TDI) S' wave in detecting acute coronary syndrome (ACS) in adult patients presenting to the emergency department…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction (MI), Non-ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- CLEAR_ECHO (NCT06860997)
- Testing
- Tissue Doppler Imaging (TDI) S' Wave Echocardiography
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chest Pain Atypical Syndrome
Is Non-Cardiac Chest Pain Caused by Sustained Longitudinal Smooth Muscle Contraction?
Non-cardiac chest pain (NCCP) is a common disorder whose pathophysiology is poorly understood. Some evidence suggests it may be related to sustained esophageal contractions (SECs) of longitudinal smooth muscle.
- Trial name
- NCT01839058
- Testing
- Esophageal Manometry
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Queen's University
Coronary Artery Diseases, Myocardial Infarction
The Efficacy of Influenza Vaccination in Patients With Coronary Artery Diseases
This study wishes to understand: 1. whether vaccination against influenza in coronary artery disease (myocardial infarction and stable angina) patients is as effective as it is in healthy subjects; 2.
- Conditions
- Coronary Artery Diseases, Myocardial Infarction, Stable Angina
- Trial name
- NCT00607217
- Testing
- influenza vaccine
- Where
- Iran
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences