Clinical trials: Cheyne Stokes Respiration
Cheyne-Stokes Respiration, Sleep Apnea, Central
Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients
Pilot study testing the Bipap autoSV Advanced Algorithm during full night, in-lab polysomnography (PSG) and 3 months at home on patients with Central Sleep Apnea, Hunter Cheyne Stokes Respiration, or Complex Sleep Apnea.
- Trial name
- NCT01199042
- Testing
- BiPAP autoSV Advanced
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Philips Respironics
Heart Failure, Sleep Disorder
Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation
The purpose of this study is to assess changes in left ventricular performance using echocardiography as well as ventricular remodelling, changes in sleep and changes in mood, anxiety and cognitive functions occurring as a result…
- Conditions
- Heart Failure, Sleep Disorder, Cheyne Stokes Respiration
- Trial name
- MS (NCT01164592)
- Testing
- adaptive servoventilation (ASV)
- Where
- 94 sites in Australia, Czechia and 6 more
- Volunteers
- 312 people
- Sponsor
- ResMed
Sleep Disordered Breathing, Cheyne-Stokes Respiration
Feasibility Study to Determine the Effects of Phrenic Nerve Stimulation in Patients With Periodic Breathing
The purpose of this feasibility study is to determine the effect of stimulating the phrenic nerve to treat periodic breathing (a pattern of breathing characterized by hyperpneas followed by hypopneas or apneas).
- Conditions
- Sleep Disordered Breathing, Cheyne-Stokes Respiration, Sleep Apnea
- Trial name
- NCT00909259
- Testing
- Phrenic stimulation device
- Where
- 5 sites in United States, China and 1 more
- Volunteers
- 50 people
- Sponsor
- Respicardia, Inc.
Obstructive Sleep Apnea, Central Sleep Apnea
Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing
The purpose of this study is to evaluate the accuracy of Somnarus diagnostic technology for diagnosis of sleep apnea in human subjects.
- Conditions
- Obstructive Sleep Apnea, Central Sleep Apnea, Mixed Sleep Apnea, Cheyne-Stokes Respiration
- Trial name
- NCT02034175
- Testing
- SomnaPatch, Polysomnography
- Where
- 3 sites in United States
- Volunteers
- 190 people
- Sponsor
- Somnarus Inc
Obstructive Sleep Apnoea
Morphine in Moderate Obstructive Sleep Apnoea
The aim of this study is to investigate the effects of morphine (a drug commonly used for the treatment of moderate to severe pain, particularly following surgery) on the number of pauses in breathing in patients with moderate…
- Trial name
- MIMOSA (NCT03127800)
- Testing
- Morphine sulphate
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Sleep Disordered Breathing, Cheyne Stokes Respiration
Chronic Evaluation of Respicardia Therapy
The purpose of this study is to determine the chronic safety and efficacy of phrenic nerve stimulation on central sleep apnea (CSA).
- Conditions
- Sleep Disordered Breathing, Cheyne Stokes Respiration, Periodic Breathing, Sleep Apnea
- Trial name
- NCT01124370
- Testing
- remedē (TM) system
- Where
- 13 sites in United States, Germany and 2 more
- Volunteers
- 57 people
- Sponsor
- Respicardia, Inc.
Congestive Heart Failure
Breathing Disorders in Patients With Congestive Heart Failure
The investigators prospectively evaluated 89 consecutive outpatients (29 female) with stable congestive heart failure. The presence of sleep disordered breathing (SDB) and Cheyne-Stokes respiration (CSR) while awake were…
- Trial name
- NCT01047787
- Testing
- Polysomnography
- Volunteers
- 89 people
- Sponsor
- University of Sao Paulo
Sleep Disordered Breathing, Able Bodied
Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment
Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive…
- Trial name
- CSA-HF (NCT07210606)
- Testing
- Trazodone + positive airway pressure (PAP) therapy, Oxygen + positive airway pressure (PAP) therapy
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnoea, Central Sleep Apnoea
Leg Fluid Shift in Patients With Chronic Heart Failure and Obstructive or Central Sleep Apnea
This study aims to investigate the influence of a potential leg fluid shift (LFS) in patients with chronic heart failure (CHF) and obstructive sleep apnea (OSA) or central sleep apnea (CSA).
- Conditions
- Obstructive Sleep Apnoea, Central Sleep Apnoea, Cheyne Stokes Respiration
- Trial name
- NCT03092388
- Testing
- Multi Frequency Bioimpedance Analysis (mfBIA), Polysomnography/Polygraphy (PSG/PG), Capillary Blood Gas Analysis (CBGA)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Heart Failure, Sleep Apnea Syndromes
Evaluation of the Effect of AVE0657 in Cheynes-Stokes Breathing Syndrome Patients
The primary objective of this study is to assess the activity on breathing parameters of 4 escalating doses of AVE0657 in comparison to placebo in patients with Cheynes-Stokes Breathing Syndrome.
- Conditions
- Heart Failure, Sleep Apnea Syndromes, Cheyne-Stokes Respiration
- Trial name
- NCT00694720
- Testing
- AVE0657
- Where
- 3 sites in France, Germany and 1 more
- Volunteers
- 8 people
- Sponsor
- Sanofi
Obstructive Sleep Apnea
Benefit of Cheyne-Stokes Respiration Remote Monitoring in CPAP-treated Patients With Obstructive Sleep Apnea to Detect Early Events of Heart Failure.
Obstructive sleep apnea (OSA) syndrome affects 40-60% of patients presenting with cardiovascular diseases. Cheyne-Stokes respiration is a type of central apnea characterised by the presence of at least three consecutive episodes…
- Trial name
- NCT03592108
- Testing
- CSR remote monitoring
- Where
- France
- Volunteers
- 555 people
- Sponsor
- Groupe Medical de Pneumologie, Polyclinique Saint-Laurent
Environmental Sleep Disorder, Cheyne-Stokes Respiration
Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude
One of the major challenges in adapting to high altitudes is that with increasing altitude sleeping quality declines rapidly. Thus, the night sleep can only provide limited to none regeneration.
- Conditions
- Environmental Sleep Disorder, Cheyne-Stokes Respiration, Altitude Sickness
- Trial name
- PerOxySleep (NCT01465971)
- Where
- Germany
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Goethe University
CHEYNE Stokes Respiration
Baclofen and Hypoxia-induced Periodic Ventilation
Periodic ventilation that includes CHEYNE Stokes ventilation is a pathological pattern characterized by alternating periods of hyperpneas and apnea-hypopneas.
- Trial name
- PERIODIBAC (NCT01095679)
- Testing
- Baclofen
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure, Congestive, Cheyne-Stokes Respiration
Cardiovascular Responses in Congestive Heart Failure With Cheyne- Stokes Respiration
The purpose of the trial is to investigate the cardiovascular response to peripheral chemoreceptor stimulation in Congestive Heart Failure with Cheyne- Stokes Respiration
- Trial name
- NCT00495196
- Testing
- Experimental lung function test
- Where
- Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ResMed
Heart Failure
Nocturnal Oxygen Treatment in Heart Failure and Cheyne-Stokes Respiration
The purpose of this study is to determine whether oxygen therapy during sleep improves quality of life, exercise capacity and heart function among patients with chronic heart failure and central sleep apnea.
- Trial name
- NCT00338078
- Testing
- nocturnal oxygen treatment from oxygen concentrators
- Where
- Sweden
- Volunteers
- 62 people
- Sponsor
- Umeå University
Heart Failure，Congestive
High-Flow-Therapy for the Treatment of Cheyne-Stokes-Respiration in Chronic Heart Failure
To demonstrate the effectiveness and safety of nocturnal ventilation with oxygen (HFT - high-flow-therapy) for the treatment of CSA in patients with HFrEF compared to placebo (patient will breathe ambient air via nasal cannula…
- Trial name
- FLOAT-CS (NCT03102827)
- Testing
- Oxygen
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Congestive Heart Failure, Left Ventricular Systolic Dysfunction
Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry
Objective target of the registry is to investigate the prevalence of SDB as well as the clinical characteristics of patients with and without SDB as well as the predominant type of sdb.
- Trial name
- SchlaHF (NCT01500759)
- Where
- 199 sites in Australia, Germany
- Volunteers
- 6,876 people
- Sponsor
- ResMed
Heart Failure, Cheyne Stokes Respiration
Chronic Heart Failure - Cheyne Stokes Respiration - CS2 (3C-study)
An investigation where patients with chronic heart failure and cheyne stokes respiration, treated with adapitve servo ventilator, will improve their cardiac function and quality of life.
- Trial name
- 3C (NCT00563693)
- Testing
- ASV, without Autoset CS2
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- University of Oslo
Central Sleep Apnea, Cheyne-Stokes Respiration
Treatment of Central Sleep Apnoea in Patients With Heart Failure With Nasal High Flow Therapy (nHFT)
To investigate whether nHFT is an effective treatment for patients with Chronic Heart Failure (CHF) and central sleep apnea (CSA).
- Trial name
- RELAX (NCT03085641)
- Testing
- Nasal high flow oxygen therapy
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- University Medical Center Groningen
Periodic Breathing, Cheyne-Stokes Respiration
Comparison of Modified With Conventional Adaptive Servoventilation Processes
The objective of this study is to compare the modified adaptive servoventilation control algorithm of the with the standardised algorithms of routinely-used servoventilation processes (AutoSet CS2) in terms of the effect on…
- Trial name
- NCT01037439
- Testing
- Adaptive Servo-controlled Ventilation (ASV)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- ResMed