Clinical trials: Child Birth
Children Born Very Prematurely in Relation to Structural Brain Abnormalities
Magnetic Resonance Spectroscopy at Term-equivalent Age and Executive Functions at 5 Years of Age Corrected in Very Preterm Infants
EPIRMEX is a complementary study to the national cohort EPIPAGE 2 the INSERM Unit 953 is responsible. The objective of this study is to evaluate at the age of 5 years corrected executive functions in children born very…
- Trial name
- EPIRMEX (NCT02851537)
- Testing
- an advanced technique as magnetic resonance spectroscopy (MRS)
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Very Preterm Birth
EPIPAGE2 Cohort Study Follow up at Five and a Half Years
Epipage 2 (epidemiologic study on small-for-gestational-age children) is a nationwide study implemented to improve our knowledge of the outcome of preterm children in France.
- Trial name
- EPIPAGE2 (NCT03078439)
- Testing
- Medical and neuropsychological assessments
- Where
- 98 sites in France, French Guiana and 2 more
- Volunteers
- 3,404 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Neonatal Brachial Plexus Palsy
Does Wearing Tetra-Grip Improve Arm Function in Children Diagnosed With Neonatal Brachial Plexus Palsy?
This study evaluates the effect of wearing a tetra-grip on the affected arm of children with neonatal brachial plexus palsy. Half of the participants will have tetra-grip applied to the arm, while the other half will not have it…
- Trial name
- NCT03647761
- Testing
- Tetra-grip
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
Asthma in Children, Allergy
Childhood Allergy and the Neonatal Environment
The purpose of this research study is to study the relationship between childhood asthma, allergies, and early-life environmental factors that may cause childhood asthma and allergies.
- Trial name
- CANOE (NCT04215783)
- Where
- 4 sites in United States
- Volunteers
- 499 people
- Sponsor
- University of Wisconsin, Madison
Very Low Birthweight Infants, Mother Child Interaction
Delivery Room Skin-to-skin Study
The first hours after birth are a sensitive period for promotion of optimal mother-child-interaction and secure attachment. Maternal sensitivity and responsivness are high in the first hours after birth due to high oxytocin…
- Conditions
- Very Low Birthweight Infants, Mother Child Interaction, Preterm Infant
- Trial name
- deisy (NCT01959737)
- Testing
- skin-to.skin-contact
- Where
- Germany
- Volunteers
- 88 people
- Sponsor
- University of Cologne
To Compare 2 Models of Midwifery Care in Maternity Care
Support and Personalized Care in Alternative Midwifery Birth Units Versus Traditional Units in France: Effects on the Psychological Health of Couples and on the Health of the Mother and Child at the Age of 2 Years.
Majority of pregnancies and childbirths in France occur without complication. While the impact of care failure on maternal and neonatal morbi-mortality is now well- established, the literature reveals that an overmedicalization…
- Trial name
- PhysioCareTwo (NCT06630741)
- Testing
- alternative midwifery units (AMU)
- Where
- 3 sites in France
- Volunteers
- 793 people
- Sponsor
- Rennes University Hospital
Infant, Premature, Diseases
Evolution of Food Orality in Children Aged Between 24 and 36 Months: Comparison of the Severity and Specificities of Disorders Between Two Populations of Children, Born Very Prematurely and Born at Term
Oral disorders are currently widely described in the premature birth population, but few studies compare them to their prevalence in the full-term population.
- Trial name
- EvOral (NCT03860142)
- Testing
- Archet scale
- Where
- France
- Volunteers
- 79 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Premature Birth
The Use of an Age-linked App for Parents During and After a NICU Stay
The main purpose of the neonatal intensive care unit (NICU) is to optimize the development of the newborn. Preterm children are at greater risk for developmental disorders.
- Trial name
- NCT03232190
- Testing
- Web Application
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Ziekenhuis Oost-Limburg
Hepatitis B, Vertical Transmission of Infectious Disease
The COMBAT HBV Feasibility Trial
This is a double-blind, randomized placebo-controlled trial (RCT) of a prophylaxis-for-all approach to prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) in the Democratic Republic of Congo (DRC).
- Trial name
- COMBAT-HBV (NCT05705427)
- Testing
- Tenofovir Disoproxil Fumarate 300 MG, Hepatitis B monovalent vaccine
- Where
- Democratic Republic of the Congo
- Volunteers
- 317 people
- Sponsor
- University of North Carolina, Chapel Hill
Child, Hospitalized, Delivery of Health Care
Family-Centered Rounds Checklist Implementation
The goal of this study is to develop, implement, and evaluate the effectiveness of an intervention designed to facilitate family engagement during bedside rounds at a children's hospital.
- Conditions
- Child, Hospitalized, Delivery of Health Care, Morning Rounds
- Trial name
- NCT02625142
- Testing
- Family-centered rounds checklist tool
- Where
- United States
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Autism, Developmental Delay
Developmental Delay in Children Exposed During Pregnancy to Either Lamotrigine,Sodium Valproate, or Carbamazepine
This study is investigating the neurodevelopmental effects of prenatal exposure to lamotrigine (LTG), sodium valproate (VPA), or carbamazepine (CBZ) monotherapies. The hypotheses to be tested include: 1.
- Conditions
- Autism, Developmental Delay, Birth Defects
- Trial name
- NCT01097720
- Where
- United States
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Prematurity
Developmental Impact of NICU Exposures (DINE)
The DINE study will test the hypothesis that potentially avoidable NICU-based exposures contribute to the neuro-cognitive and somatic impairments prevalent among NICU graduates.
- Trial name
- DINE (NCT03061890)
- Where
- 11 sites in United States
- Volunteers
- 600 people
- Sponsor
- Albert Einstein College of Medicine
Type 1 Diabetes Mellitus
Closed-Loop Insulin Delivery in Children Less Than 7 Years of Age
The investigators are conducting this study to find out whether a new device can control blood sugar levels in children who have Type 1 diabetes.
- Trial name
- NCT01421225
- Testing
- Closed-loop Insulin Pump therapy, Standard Insulin Pump Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston Children's Hospital
Myelomeningocele, Bladder, Neurogenic
Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele
The purpose of this study is to examine how injection of botulinum toxin in the bladder affects bladder function. The trial is carried out in children born with malformation of the spinal cord and subsequent overactive bladders.
- Trial name
- NCT00175123
- Testing
- Botulinum A toxin
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Type 1 Diabetes
Closing the Loop in Young Children With Type 1 Diabetes
The incidence of type 1 diabetes (T1D) is increasing worldwide with evidence of most rapid increase in preschool children. Intensive control of blood glucose levels, although essential to protect against onset and progression of…
- Trial name
- NCT01557634
- Testing
- Overnight closed-loop insulin delivery
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Daniela Elleri
Short Stature Born Small for Gestational Age (SGA)
Long Term Study of Genotropin (Somatropin) for Short Children Born Small for Gestational Age (SGA)
To assess the long-term safety of Genotropin(somatropin) on Small for Gestational Age (SGA) without epiphyseal closing.
- Trial name
- NCT01859949
- Testing
- Genotropin (somatropin)
- Where
- 19 sites in Japan
- Volunteers
- 62 people
- Sponsor
- Pfizer
COVID-19 Pneumonia, COVID-19 Pandemic
Corona Virus Disease 2019 Cohort Study
The goal of this observational study is to learn about the influence of Corona Virus Disease 2019 on obstetric outcome and offspring development.
- Conditions
- COVID-19 Pneumonia, COVID-19 Pandemic, COVID-19
- Trial name
- NCT06927622
- Where
- 5 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shandong University
Bronchopulmonary Dysplasia, Prematurity
Post-hospitalization Nursing Effectiveness (PHONE) Study
Based on success with telephone follow up for other groups of medically fragile infants, we designed an innovative model of post-hospital comprehensive and coordinated follow-up for infants with chronic lung disease.
- Trial name
- NCT00314431
- Testing
- Care coordination by telephone contacts with a nurse
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Wake Forest University
COVID-19
This Study Investigate the Impact of Maternal COVID-19 Infection During Birth on the Childrens' Physical and Mental Development.
This study investigates the impact of the maternal COVID infection during birth on the children's development: physical and mental outcomes.
- Trial name
- Coronababies (NCT05430594)
- Where
- Hungary
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Gestational Hypertension, Prematurity
Effects of Exercise During Pregnancy on Maternal and Child Health: a Randomized Clinical Trial
The Pamela Study is a clinical trial carried out during pregnancy to assess the potential effects of physical activity during pregnancy among previously inactive women.
- Conditions
- Gestational Hypertension, Prematurity, Maternal Post-partum Depression, Maternal Post-partum Weight Retention
- Trial name
- PAMELA (NCT02148965)
- Testing
- Physical Exercise / Physical Activity
- Where
- Brazil
- Volunteers
- 639 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas