Clinical trials: Childbirth Process
Bronchopulmonary Dysplasia
Safety and Efficacy of PNEUMOSTEM® in Premature Infants at High Risk for Bronchopulmonary Dysplasia (BPD) - a US Study
PNEUMOSTEM® consists of ex vivo cultured allogeneic, unrelated, human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) and it is intended for use as a cellular therapy product for prevention of Bronchopulmonary…
- Trial name
- NCT02381366
- Testing
- Human Umbilical Cord Blood Derived-Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Medipost, Inc.
Pediatric Tumor of CNS, Pediatric Tumor of Brain
A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors
This is an open label, Phase 1b safety, dose-finding, brain tumor delivery, and pharmacokinetics study of intranasal NEO100 in patients with pediatric-type diffuse high grade gliomas.
- Conditions
- Pediatric Tumor of CNS, Pediatric Tumor of Brain, Diffuse Midline Glioma, H3 K27M-Mutant, Pediatric Tumor of Brain Stem
- Trial name
- NCT06357377
- Testing
- NEO100
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Neonc Technologies, Inc.
Person Centered Care, Patient Safety
TeamBirth-SWE - a Care Process to Improve Safe and Person-centered Intrapartum Care
The primary objective of this project is to enhance understanding of intrapartum patient safety and person-centered care through the evaluation of an intervention designed to improve team communication and patient involvement…
- Conditions
- Person Centered Care, Patient Safety, Patient Satisfaction
- Trial name
- NCT06926504
- Testing
- The care process S-TeamBirth, S-TeamBirth
- Where
- 7 sites in Sweden
- Volunteers
- 800,000 people
- Sponsor
- Karolinska Institutet
Chronic Ischemic Left Ventricular Dysfunction, Myocardial Infarction
The TRansendocardial Stem Cell Injection Delivery Effects on Neomyogenesis STudy (The TRIDENT Study)
Thirty (30) patients with chronic ischemic left ventricular dysfunction secondary to MI scheduled to undergo cardiac catheterization will be enrolled in the study.
- Trial name
- Trident (NCT02013674)
- Testing
- Allogeneic hMSCs
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Joshua M Hare
Diffuse Intrinsic Pontine Glioma
CED With Irinotecan Liposome Injection Using Real Time Imaging in Children With Diffuse Intrinsic Pontine Glioma (DIPG) (PNOC 009)
This is a Phase I and Early Efficacy Study of Convection Enhanced Delivery (CED) of irinotecan liposome injection (nal-IRI) Using Real Time Imaging with Gadolinium in Children with Diffuse Intrinsic Pontine Glioma who have…
- Trial name
- NCT03086616
- Testing
- Convection Enhanced Delivery (CED) of Nanoliposomal irinotecan (nal-IRI)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Sabine Mueller, MD, PhD
Mothers, Premature
Empowering Mothers Whose Babies Are Hospitalized in the Neonatal Intensive Care Unit
Family Integrated Care is designed to eliminate the barriers between parents and their infants in the NICU by involving parents of premature infants in their care.
- Conditions
- Mothers, Premature, Empowerment
- Trial name
- NCT06958458
- Testing
- Mother Integrated Care
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Acute Myocardial Infarction
Rapid Delivery of Autologous Bone Marrow Derived Stem Cells in Acute Myocardial Infarction Patients.
The primary objective of the study is to determine the feasibility and safety of intracoronary administration of autologous bone marrow derived mononuclear cell product in patients at risk for clinically significant cardiac…
- Trial name
- AMIRST (NCT01536106)
- Testing
- Autologous Bone marrow mononuclear cells
- Where
- 3 sites in India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TotipotentRX Cell Therapy Pvt. Ltd.
Birth, First, Labor Pain
Effects of Yoga and Meditation on The Birth Process
Introduction: Today it is seen that women lose their birthing strength, give the control to healthcare personnel during labour and the rate of c-section or interventional labour is increasing.
- Conditions
- Birth, First, Labor Pain, State Anxiety, Self Efficacy
- Trial name
- NCT04883541
- Testing
- yoga and meditation, Birth preparation training
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Brain Cancer, Brain Stem Glioma
Convection-Enhanced Delivery of 124I-Omburtamab for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy
The purpose of this study is to test the safety of a new method to treat Diffuse Intrinsic Pontine Glioma (DIPG). The researchers will use "convection-enhanced delivery" (CED) to deliver an agent called 124I-omburtamab.
- Trial name
- NCT01502917
- Testing
- Radioactive iodine-labeled monoclonal antibody omburtamab, External Beam Radiotherapy
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Y-mAbs Therapeutics
Osteogenesis Imperfecta
Boost Brittle Bones Before Birth
An exploratory, open label, multiple dose, multicentre phase I/II trial evaluating safety and efficacy of postnatal or prenatal and postnatal administration of allogeneic expanded fetal mesenchymal stem cells for the treatment of…
- Trial name
- BOOSTB4 (NCT03706482)
- Testing
- BOOST cells
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Karolinska Institutet
Childbirth Process
Changes in Pain Level With the Use of the Regulated Expiratory Method.
Historically, pain management during childbirth has been a primary concern in the obstetric community. In recent decades, childbirth care providers have been witnessing, especially in developed countries, a real revolution in…
- Trial name
- NCT04302090
- Testing
- Regulated expiratory method
- Where
- Tunisia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Hemophilia A
Gene Therapy Trial for Platelet Derived Factor VIII Production in Hemophilia A
This is a Phase I study. This research study is being conducted to find new ways to treat severe hemophilia A. This study is a gene therapy study.
- Trial name
- NCT03818763
- Testing
- Auto CD34+PBSC, transduced with a lentiviral vector encoding the B domain deleted from of human coagulation factor VIII
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical College of Wisconsin
Low Back Pain, Pregnancy
The Effect of Kinesio Taping During Labor on Low Back Pain, Vaginal Birth Self-Efficacy, Postpartum Comfort Perception, and Newborn Apgar Scores
The Kinesio Taping® technique and Kinesio Tex® tape were invented by Japanese chiropractor and acupuncturist Dr. in 1973. Developed by Kenzo Kase.
- Conditions
- Low Back Pain, Pregnancy, Midwifery, Birth Self-efficacy
- Trial name
- kinesio tape (NCT07459231)
- Testing
- Kinesio Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ege University
Schizophrenia Negative Type
Safety and Feasibility of Nasal Delivery of Human Dental Follicle Mesenchymal Stem Cell-Derived Exosomes for Negative Symptoms in Treatment-Resistant Schizophrenia: A Pilot Study
The goal of this clinical trial is to determine the safety and feasibility of nasal delivery of human dental follicle mesenchymal stem cell-derived exosomes in the treatment of negative symptoms of treatment-resistant…
- Trial name
- NCT07485751
- Testing
- hDFSCs-Exo
- Volunteers
- 15 people
- Sponsor
- Zigong Mental Health Center
Ischemia Reperfusion Injury
Feasibility and Safety of Allogeneic Adipose Mesenchymal Stem Cells (aMSCs) Delivery Into Kidney Allografts Procured From Deceased Donors With High Kidney Donor Profile Index (KDPI)
The purpose of this research is to test an investigational drug called Adipose Mesenchymal Stem Cells (aMSCs) for the treatment of ischemia re-perfusion injury (IRI) in patients that have had a kidney transplant.
- Trial name
- NCT04388761
- Testing
- Allogeneic adipose derived mesenchymal stem cells
- Sponsor
- Tambi Jarmi
Congestive Heart Failure
To Assess Safety and Efficacy of Myoblast Implantation Into Myocardium Post Myocardial Infarction
This study injects a person's own stem cells into heart muscle tissue after a person has one or more heart attacks. The purpose of the study is whether the stem cells will improve a patient's heart performance.
- Trial name
- MARVEL (NCT00526253)
- Testing
- MyoCell, Hypothermosol
- Where
- 33 sites in United States
- Volunteers
- 170 people
- Sponsor
- Bioheart, Inc.
Labor Duration, Labor Bain
The Effect Of The Labour Hopscotch On The Birth Process And Satisfaction
This study is designed to evaluate the effect of the Labor Hopscotch exercise on the birth process and maternal satisfaction. The study will be conducted as a randomized controlled trial at a tertiary-level maternity unit.
- Conditions
- Labor Duration, Labor Bain, and Birth Satisfaction During Physiologic Vaginal Birth
- Trial name
- Labor Hopscotc (NCT07330557)
- Testing
- Labor Hopscotch Exercise Program Group, Standard Intrapartum Care
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Aydin Adnan Menderes University
Reperfused Acute Myocardial Infarction
Trial of Hematopoietic Stem Cells in Acute Myocardial Infarction
The aim of this study is to compare the effectiveness of four different strategies for preventing the ventricular postinfarction remodelling: 1) Conventional treatment for reperfunded extensive acute myocardial infarction, 2)…
- Trial name
- TECAM2 (NCT00984178)
- Testing
- Granulocite Colony Stimulating Factor treatment (G-CSF), Bone marrow mononuclear cells
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- TECAM Group
Premature Infants
The Impact of Masseter Muscle Thickness on the Feeding Process in Preterm Infants in Ultrasound Assessment
The aim of this study is to assess masseter muscle thickness using ultrasounds during oral feeding process in premature infants with gestational age from 28+0/7 to 32+0/7 weeks, taking into account the qualitative and…
- Trial name
- NCT07656467
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Craniosynostosis
Network Of Clinical Research Studies On Craniosynostosis, Skull Malformations With Premature Fusion Of Skull Bones
Craniosynostosis (CS) is a common malformation occurring in ~4 per 10,000 live births in which the sutures between skull bones close too early, causing long-term problems with brain and skull growth.
- Trial name
- NCT03025763
- Testing
- Craniosynostosis Network Environmental Survey, 2D/3D Photography, Buccal Swab Cell Sampling
- Where
- 20 sites in United States, France and 3 more
- Volunteers
- 2,145 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai