Clinical trials: Childhood Autism
Autism Spectrum Disorder
GABA Pathways in Autism Spectrum Disorder (ASD)
This study investigates the brain response to a single acute dose of a GABAa receptor acting drug (Benzodiazepine or positive allosteric modulator) compared to a single dose of placebo in adults with and without autism spectrum…
- Trial name
- NCT03678129
- Testing
- AZD7325_10, AZD7325_20, Clobazam
- Where
- United Kingdom
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- King's College London
Epilepsy, Autism Spectrum Disorder
Biomarkers for Epilepsy Development and the Effect of Physical Exercise in Children With Autism
This study aims to identify novel biomarkers for epilepsy development in children with autism and to evaluate the effects of physical exercise on these biomarkers and clinical outcomes.
- Trial name
- ASD/EP (NCT07373431)
- Testing
- Physical activity program
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Skane
Autism Spectrum Disorders
Evaluating the Validity of an Eye Gaze Paradigm in Predicting Autism Spectrum Disorder
The primary purpose of the present study is to evaluate the diagnostic validity of eye tracking measurements acquired during viewing of socially-relevant stimuli in predicting ASD diagnosis.
- Trial name
- EYE (NCT02573428)
- Where
- United States
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
PTEN Hamartoma Tumor Syndrome
Development and Validation of an Online Neurobehavioral Evaluation Tool for PTEN Patients
The purpose of this study is to develop a survey completed by parents, caregivers, or other informants that evaluates several important domains of functioning relevant to individuals with neurodevelopmental disorders, including…
- Trial name
- NCT05671107
- Testing
- NET
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 300 people
- Sponsor
- John Carroll University
Autism Spectrum Disorder
Omega-3 Fatty Acids For Treatment Of Young Children With Autism (OMG)
This is a pilot, randomized, placebo-controlled trial of omega-3 fatty acids in autism. Autism, originally described by Kanner in 1943, is among the most severe of neurodevelopmental disorders.
- Trial name
- NCT01248728
- Testing
- Omega-3 Fatty Acids
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Autism Spectrum Disorder
Esketamine and Propofol for Children With Autism Spectrum Disorder Undergoing Colonoscopy
The purpose of this study is to examine the dose-response relationship of esketamine in combination with propofol for children with Autism Spectrum Disorder undering colonoscopy.
- Trial name
- NCT05951465
- Testing
- Esketamine, Propofol
- Where
- China
- Volunteers
- 46 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Autism Spectrum Disorder
CASCADE: CAnnabidiol Study in Children With Autism Spectrum DisordEr
This is a randomized, placebo-controlled study but all study participants will receive the active study medication at some point during the study for at least 12 weeks, and some children with receive CBD for the entire study.
- Trial name
- CASCADE (NCT04520685)
- Testing
- Oral cannabidiol 100mg/mL
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Colorado, Denver
Autism Sibling
Sibwatch: Optimizing Intervention Options for Infants and Toddler Siblings of Autistic Children
This rigorous randomized controlled trial will evaluate the efficacy and acceptability of a preemptive, telehealth intervention (tele-ImPACT) in a large, representative sample of infant siblings of autistic children, who are…
- Trial name
- Sibwatch (NCT07069413)
- Testing
- tele-ImPACT
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Texas at Austin
Autism Spectrum Disorder, Child Autism
Assessment of the Benefit of Teleconsultations for Children With Autism Spectrum Disorders
The purpose of this study is to determine whether Teleconsultation would a)be effective and cost-effective by increasing the proportion of patients with Autism Spectrum Disorders having a correct follow-up, and less…
- Trial name
- NCT02996708
- Where
- 6 sites in France
- Volunteers
- 102 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autism Spectrum Disorder
Non-invasive Auricular Fiber Vagus Nerve Stimulation (afVNS) for Treatment of Autism Spectrum Disorder
Non-invasive vagus nerve stimulation for the symptomatic improvements in Autism Spectrum Disorder
- Trial name
- NCT06473623
- Testing
- vagus nerve stimulation
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Neuropix
Attention Deficit Disorder With Hyperactivity, Autistic Disorder
Methylphenidate in Children and Adolescents With Pervasive Developmental Disorders
This study will evaluate the efficacy and safety of methylphenidate for treating hyperactivity, impulsiveness, and distractibility in 60 children and adolescents with Pervasive Developmental Disorders (PDD).
- Conditions
- Attention Deficit Disorder With Hyperactivity, Autistic Disorder, Pervasive Development Disorders
- Trial name
- NCT00025779
- Testing
- methylphenidate, guanfacine
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
Autism
Testing Swim Instruction for Autistic Children
The goal of this clinical trial is to compare the effects of a specialized swimming and water-safety program (Sensory Enhanced Aquatics) and standard swimming lessons for autistic children.
- Trial name
- NCT06216613
- Testing
- Sensory Enhanced Aquatics, Standard Swim Lessons
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Kansas Medical Center
Autistic Disorder, Autism
School- and Home-Based Early Intervention for Toddlers With Autism
This study will determine the impact of early intervention on the communication and social development of toddlers with autism.
- Trial name
- NCT00106210
- Testing
- Early intervention blending several tx approaches, w/ focus, Early intervention blending several treatment approaches
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Autism Spectrum Disorder, Irritability
Behavior Therapy for Irritability in Autism
This is a clinical trial of a novel intervention, Behavioral Therapy for Irritability and Aggression (BTIA), for adolescents on the autism spectrum.
- Conditions
- Autism Spectrum Disorder, Irritability, Disruptive Behavior, Anger
- Trial name
- BTIA (NCT04654260)
- Testing
- Behavioral Therapy for Irritability in Autism, Psychoeducation and Supportive Therapy (PST)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Yale University
Cowden's Disease, Cowden's Syndrome
Double-Blind Trial of Everolimus for Improving Social Abilities in PTEN Germline Mutations
The goal of this study is to examine the safety and treatment effects of everolimus in adults and children with PTEN Hamartoma Tumor Syndrome (PHTS) who experience social difficulties.
- Conditions
- Cowden's Disease, Cowden's Syndrome, Lhermitte-Duclos Disease, Cerebellum Dysplastic Gangliocytoma
- Trial name
- NCT07218575
- Testing
- Everolimus blinded oral capsules
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston Children's Hospital
Autism Spectrum Disorder (ASD)
Guided ACT and for Adults With ASD
This study aims to investigate the efficacy of guided self-help Acceptance Commitment Therapy (ACT) for adults who have a diagnosis for Autistic Spectrum Disorder (ASD) and are experiencing psychological distress (stress, anxiety…
- Trial name
- NCT04376151
- Testing
- Acceptance and Commiment Therapy (ACT) bibliotherapy 'Get Out of Your Mind and Into Your Life'
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Lincoln
Autism Spectrum Disorder
Enabling Parents of Children With Autism Spectrum Disorders - a Randomized Controlled Trial of Parenting Programs
Autism spectrum disorders (ASD) are disabling and impairing conditions affecting 1% of children in Norway. ASD is hallmarked by severe social deficit and lack of independence causing reliance on supportive systems throughout…
- Trial name
- ENACT (NCT05750095)
- Testing
- Incredible Years Autism Spectrum and Language Delay Programme, First Aid for Parents
- Where
- 3 sites in Norway
- Volunteers
- 240 people
- Sponsor
- Haukeland University Hospital
Autism Spectrum Disorder
Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome. Researchers think brain development may be controlled by gamma-aminobutyric acid (GABA).
- Trial name
- NCT04798274
- Testing
- Continuous Theta Burst Stimulation
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Autism Spectrum Disorder
Individualized Parent-Based Nutrition Education in Preschool Children With Autism Spectrum Disorder
Feeding difficulties, such as food selectivity and refusal to try new foods, are common among preschool children with autism spectrum disorder (ASD).
- Trial name
- NCT07884097
- Testing
- Individualized Parent-Based Nutrition Education Programme
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Firat University
Autism Spectrum Disorder, Disruptive Behaviours
Feasibility Study on Parents Skill Training Program for Reducing Parental Distress and Disruptive Behavior of Their Children With Autism Spectrum Disorder (ASD)
Children with Autism Spectrum Disorder (ASD) usually exhibt problematic behavioral issues such as hitting, non-compliance, tantrums, spitting, headbanging and aggression, this not only cause distress for the child but also has a…
- Trial name
- NCT04339153
- Testing
- Parent Training for Disruptive Behaviours
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
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