Clinical trials: Childhood Leukemia, Acute Lymphoblastic
Acute Lymphoblastic Leukemia
Financial Distress During Treatment for Pediatric Acute Lymphoblastic Leukemia in the United States
The overall goals of this study are to measure parents' financial distress (worry or anxiety about money) during their child's/adolescent's treatment for acute lymphoblastic leukemia and whether it changes over time, and to learn…
- Trial name
- NCT04928599
- Testing
- Electronic Health Record Review, Interview, Survey Administration
- Where
- 40 sites in United States, Puerto Rico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Oncology Group
Pediatric Cancer, Pediatric ALL
Feasibility/Acceptability of Attentional-Control Training in Survivors
This is a multicenter pilot randomized controlled trial, with an active control condition, of the feasibility, acceptability, and preliminary efficacy of EndeavorRx in a cohort of survivors of acute lymphoblastic leukemia or…
- Conditions
- Pediatric Cancer, Pediatric ALL, Pediatric Brain Tumor, Attention Difficulties
- Trial name
- FAACTS (NCT05528939)
- Testing
- EndeavorRx, Control video game
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's National Research Institute
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Fludarabine Phosphate, Low-Dose Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer
This clinical trial studies fludarabine phosphate, low-dose total body irradiation, and donor stem cell transplant in treating patients with hematologic malignancies or kidney cancer.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT00005799
- Testing
- fludarabine phosphate, total-body irradiation, nonmyeloablative allogeneic hematopoietic stem cell transplantation
- Where
- 7 sites in United States, Germany
- Volunteers
- 55 people
- Sponsor
- Fred Hutchinson Cancer Center
Acute Lymphoblastic Leukemia, Transcranial Direct Current Stimulation
Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)
Brief Overview: Children and adolescents diagnosed with cancer will experience problems with learning, memory and attention during and after completing their cancer therapy.
- Conditions
- Acute Lymphoblastic Leukemia, Transcranial Direct Current Stimulation, Executive Dysfunction
- Trial name
- NCT04105530
- Testing
- Anodal tDCS treatment, Cathodal tDCS treatment, NIH Toolbox List Sorting Working Memory Test
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- St. Jude Children's Research Hospital
Anesthesia, Pediatric ALL
Topical Analgesia Before Inhalational Anaesthesia
Peripheral venous cannulation (insertion of a drip line into a vein) is a fundamental component of anaesthesia for both children and adults alike.
- Trial name
- NCT04959409
- Testing
- Topical analgesia (EMLA or AMETOP)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Childhood Cancer, Acute Lymphoblastic Leukemia
Quality of Life in Children With Cancer
Childhood cancers cover a wide range of diseases; leukemia, central nervous system cancers and lymphomas are the most common ones among them.
- Conditions
- Childhood Cancer, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
- Trial name
- sıcc (NCT03190499)
- Testing
- Family based assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Cumhuriyet University
Chronic Postoperative Pain, Pediatric ALL
Chronic Postsurgical Pediatric Pain. Evaluation Risk Factors to Develop Chronic Postsurgical Pain in Children and Adolescents Undergoing Surgery in a First Level Hospital
Chronic postsurgical pain had number of prevalence on 20%. Its derivates from risk factors, but recent research provide new potential risk factors to develop chronic postsurgical pediatric pain.
- Trial name
- NCT04735211
- Testing
- Surgery
- Where
- Spain
- Volunteers
- 260 people
- Sponsor
- Guillermo Ceniza Bordallo
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer
This phase I trial is studying how well ipilimumab works after allogeneic stem cell transplant in treating patients with persistent or progressive cancer.
- Conditions
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
- Trial name
- NCT00060372
- Testing
- ipilimumab, therapeutic allogeneic lymphocytes
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Acute Lymphoid Leukemia, Acute Myeloid Leukemia in Children
Study of the Medullary Microenvironment in Acute Childhood Leukemia
Acute leukemia (AL) is the most common cancer in children. Despite the optimization of chemotherapy treatments and the development of supportive care, a certain number of LAs relapse and/or progress to death of the child.
- Trial name
- MILA (NCT05792007)
- Testing
- Biological sampling in patients, Biological sampling in control patients
- Where
- 3 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Acute Lymphoblastic Leukemia
ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia Intermittent Versus Continuous PEG Asparaginase
The purpose of this study is to investigate if intramuscular PEG-asparaginase administered either at six or two week intervals from day 92 until 8 months from diagnosis for patients with non-HR ALL will result in equal…
- Trial name
- NCT00819351
- Testing
- PEG Asparaginase at six weeks interval, PEG Asparaginase at two weeks interval
- Where
- 6 sites in Denmark, Finland and 3 more
- Volunteers
- 650 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
B Lymphoblastic Leukemia
Ma-Spore ALL 2020 Study
The primary objective of this trial is to improve the overall survival rate of children and young adult with B-lineage acute lymphoblastic leukemia (B-ALL) in Singapore and Malaysia in the context of a multicenter cooperative…
- Trial name
- NCT06336395
- Testing
- Prednisolone, Dexamethasone, Vincristine
- Where
- 3 sites in Malaysia, Singapore
- Volunteers
- 500 people
- Sponsor
- National University Hospital, Singapore
Pediatric ALL, Cardiac Defect
Evaluating the Relationship Between Skin Color and Pulse Oximeter Accuracy in Children
This multisite study seeks to understand whether and how pulse oximeter accuracy varies across children with different skin colors in real world clinical settings.
- Trial name
- PACH (NCT06529575)
- Where
- 3 sites in United States
- Volunteers
- 650 people
- Sponsor
- University of Pennsylvania
Diabetes Mellitus, Type 1, Pediatric ALL
Intensive Versus Standard One Year Monitoring on Glycaemic Control After Initiating CSII in Children With DT1. DEEP Study
More than half of type 1 diabetes (DT1) children are under CSII (Continuous Subcutaneous Insulin Infusion). Several studies showed that despite a patients' follow-up mostly by hospital-based paediatricians, there are still some…
- Trial name
- DEEP (NCT04100070)
- Testing
- Monitoring of the patients
- Where
- France
- Volunteers
- 320 people
- Sponsor
- ISIS Diabete Service
Acute Lymphoblastic Leukemia, Cancer
PACE CALL: Weight Loss Study for Childhood Leukemia Survivors
UC San Diego researchers conducted a study to develop and evaluate an internet and text message based weight loss study for childhood acute lymphoblastic leukemia (ALL) survivors.
- Conditions
- Acute Lymphoblastic Leukemia, Cancer, Obesity
- Trial name
- NCT01253720
- Testing
- PACE CALL/Fit4Life
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Huang, Jeannie, M.D.
Cardiopulmonary Arrest, Pediatric ALL
Impact of a mHealth Supportive Tool on Cardiopulmonary Resuscitation' Situational Awareness
This study will be a prospective, single-center, randomized controlled trial in a tertiary pediatric emergency department with two parallel groups of voluntary pediatric physicians and nurses.
- Conditions
- Cardiopulmonary Arrest, Pediatric ALL, Resuscitation
- Trial name
- InterFACE (NCT04464603)
- Testing
- InterFACE (mHealth tool), Conventional methods
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform
Accelerated Phase Chronic Myelogenous Leukemia, Blastic Phase Chronic Myelogenous Leukemia
Dasatinib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Did Not Respond to Imatinib Mesylate
This phase I trial is studying the side effects and best dose of dasatinib in treating young patients with recurrent or refractory solid tumors or Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Blastic Phase Chronic Myelogenous Leukemia, Childhood Chronic Myelogenous Leukemia, Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Trial name
- NCT00316953
- Testing
- dasatinib, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer, Kidney Cancer
Combination Chemotherapy and Total-Body Irradiation Before Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer, Metastatic Breast Cancer, or Kidney Cancer
RATIONALE: Giving low doses of chemotherapy and radiation therapy before a donor umbilical cord blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Breast Cancer, Kidney Cancer, Leukemia, Lymphoma
- Trial name
- NCT00365287
- Testing
- anti-thymocyte globulin, cyclophosphamide, cyclosporine
- Volunteers
- 148 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Lymphoblastic Leukemia, Acute, Childhood, Myelogenous Leukemia, Acute, Childhood
AC220 for Children With Relapsed/Refractory ALL or AML
This is a phase I study of the investigational drug AC220 combined with cytarabine and etoposide in pediatric patients with relapsed acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML).
- Trial name
- NCT01411267
- Testing
- AC220, Cytarabine, Etoposide
- Where
- 11 sites in United States
- Volunteers
- 24 people
- Sponsor
- Therapeutic Advances in Childhood Leukemia Consortium
Acute Lymphoblastic Leukemia, Pediatric
The Individualized Treatment of 6-mercaptopurine in Children With Acute Lymphoblastic Leukemia in China
The purpose of this study was to assess the efficacy and safety of individualized treatment of 6-mercaptopurine (6-MP) in Chinese children with acute lymphoblastic leukemia, and to investigate the dose-concentration-response…
- Trial name
- NCT04228393
- Testing
- 6-mercaptopurine, Standard treatment, Individualized treatment
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Wei Zhao
Childhood Chronic Myelogenous Leukemia, Childhood Desmoplastic Small Round Cell Tumor
Tanespimycin in Treating Young Patients With Recurrent or Refractory Leukemia or Solid Tumors
This phase I trial is studying the side effects and best dose of tanespimycin in treating young patients with recurrent or refractory leukemia or selected solid tumors.
- Conditions
- Childhood Chronic Myelogenous Leukemia, Childhood Desmoplastic Small Round Cell Tumor, Disseminated Neuroblastoma, Metastatic Childhood Soft Tissue Sarcoma
- Trial name
- NCT00093821
- Testing
- tanespimycin, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)