Clinical trials: Childhood Rheumatic Diseases
Glucocorticoid-Associated Osteopenia and Osteoporosis
Alendronate Osteoporosis Study
This trial will test the hypothesis that among 20 children and adolescents from Children's Hospital, Boston with Crohn's disease, ulcerative colitis, systemic-onset juvenile rheumatoid arthritis, juvenile dermatomyositis…
- Trial name
- NCT00277251
- Testing
- Alendronate
- Volunteers
- 20 people
- Sponsor
- Boston Children's Hospital
Septic Arthritis, Juvenile Idiopathic Arthritis
ARTEMIS Synovial Markers in Arthritis Childhood
The aim of this study is to find markers that could differentiate infectious and inflammatory arthritis. The investigators want to find markers by differential analysis by compare synovial fluids of septic and inflammatory…
- Trial name
- ARTEMIS (NCT02505828)
- Testing
- Articular punction, salivary samples, blood sample
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
Juvenile Idiopathic Arthritis, ALL
Understanding Methotrexate Induced Gastrointestinal Intolerance in Juvenile Idiopathic Arthritis and Childhood Leukemia
Methotrexate is a cornerstone in the treatment of childhood leukemia. When given in high-dose as part of the initial phase of treatment, gastrointestinal toxicity is a known problem.
- Trial name
- NCT02528435
- Volunteers
- 145 people
- Sponsor
- University of Aarhus
Systemic Lupus Erythematosus of Childhood (Disorder)
Transforming Care for Individuals With Childhood-onset Systemic Lupus Erythematosus
This study aims to investigate the feasibility and effectiveness of a cognitive behavioral coping skills program, Treatment and Education Approach for Childhood-onset Lupus (TEACH), for youth with cSLE when integrated into…
- Trial name
- cSLE (NCT06232304)
- Testing
- TEACH
- Where
- 7 sites in United States, Canada
- Volunteers
- 175 people
- Sponsor
- Michigan State University
Chronic Inflammatory Rheumatic Diseases of Childhood, Juvenile-Onset Chronic Inflammatory Rheumatic Diseases
Compassionate Care and Organization of Healthcare Services for a Successful Transition in Rheumatology
The transition from pediatric to adult care is a critical period for young people with chronic inflammatory rheumatic diseases (CIRD) and is associated with risks of poor self-management, loss to follow-up, and disease worsening.
- Conditions
- Chronic Inflammatory Rheumatic Diseases of Childhood, Juvenile-Onset Chronic Inflammatory Rheumatic Diseases, Transition of Care in Chronic Inflammatory Rheumatic Diseases
- Trial name
- BOOST-R (NCT07469787)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus of Childhood
Fitness Integrative Training for Pediatric Rheumatology Disorders
This study evaluates the feasibility of the Fitness Integrative Training program for Teens (FIT Teens 2), a combined cognitive behavioral therapy and neuromuscular exercise training program in patients with pediatric rheumatic…
- Conditions
- Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus of Childhood, Joint Hypermobility, Juvenile Dermatomyositis
- Trial name
- FIT Teens 2 (NCT06556992)
- Testing
- FIT Teens
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Oligoarthritis, Juvenile, Polyarthritis, Juvenile, Rheumatoid Factor Negative
STep-up and Step-down Therapeutic Strategies in Childhood ARthritiS
This study aims to compare the effectiveness of a conventional therapeutic regimen, based on treatment escalation (step-up strategy) and driven by the treat-to-target approach, with that of an early aggressive intervention based…
- Trial name
- STARS (NCT03728478)
- Testing
- Etanercept, Methotrexate, Intra-articular corticosteroid injections
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Istituto Giannina Gaslini
Arthritis, Juvenile Idiopathic
Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis
This study will evaluate the effect of etanercept on the clinical benefit, safety, and physical functioning (ability to function in daily life) in children and adolescent subjects with 3 subtypes of childhood arthritis.
- Trial name
- CLIPPER (NCT00962741)
- Testing
- Etanercept
- Where
- 42 sites in Australia, Belgium and 17 more
- Volunteers
- 127 people
- Sponsor
- Pfizer
Juvenile Idiopathic Arthritis
UCAN CAN-DU: Canada-Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic Disease
Childhood arthritis is a chronic disabling disease. New medications called biologic therapies are now available to treat arthritis that target key biologic molecules that cause inflammation.
- Trial name
- UCAN CAN-DU (NCT06560606)
- Where
- 19 sites in Canada, Netherlands
- Volunteers
- 4,100 people
- Sponsor
- The Hospital for Sick Children
Childhood Rheumatic Diseases
Evaluation of Dental Maturation and Mandibular Bone Morphology in Childhood Rheumatic Diseases
The aim of our study is to examine possible disease-related changes in dental age and mandibular bone morphology in childhood rheumatic diseases.
- Trial name
- NCT05832359
- Testing
- Panoramic rad.
- Where
- Turkey (Türkiye)
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Marmara University
Arthritis, Juvenile
Sleep & Pain in Juvenile Arthritis
Childhood arthritis is an important cause of pain for affected children and youth (adolescents). Many youth with arthritis also have trouble sleeping.
- Trial name
- NCT04133662
- Testing
- Sleep Manipulation Protocol
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- The Hospital for Sick Children
Juvenile Idiopathic Arthritis (JIA), Childhood Rheumatic Diseases
Investigation of Catastrophizing of Pain Reported by Parents in JIA Patients
Juvenile idiopathic arthritis (JIA) is the primary rheumatic disease reported to affect the pediatric population. Research suggests that parents' thoughts and feelings about their child's pain, specifically with JIA diagnosis…
- Trial name
- NCT07185750
- Testing
- Questionnaire application for JIA cases and their parents
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Juvenile Idiopathic Arthritis, Childhood Rheumatic Disease
Dynamic Gait Index as a Functional Gait Assessment Measure in Children With JIA
Juvenile idiopathic arthritis (JIA) is one of the most common chronic rheumatic diseases seen in childhood. Pain, joint swelling and loss of function caused by inflammation significantly reduce the patients' quality of life and…
- Trial name
- NCT06870045
- Testing
- Physical examination, Dynamic Gait Index
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Arthritis, Juvenile, Arthritis, Childhood
Feasibility of a Diet Intervention for Juvenile Arthritis
Families of children with arthritis are highly interested in the benefits of diet to improve their child's disease and future health outcomes.
- Conditions
- Arthritis, Juvenile, Arthritis, Childhood, Juvenile Idiopathic Arthritis
- Trial name
- DIGEST-JA (NCT06474546)
- Testing
- Diet intervention
- Where
- 7 sites in Canada
- Volunteers
- 54 people
- Sponsor
- The Hospital for Sick Children
Systemic Lupus Erythematosus
Telehealth CBT for Adolescents and Young Adults With Childhood-onset Systemic Lupus Erythematosus
This study aims to investigate the feasibility and effectiveness of a remotely delivered psychological intervention for youth with cSLE.
- Trial name
- cSLE (NCT04335643)
- Testing
- TEACH
- Where
- 2 sites in United States, Canada
- Volunteers
- 65 people
- Sponsor
- Michigan State University
Muscular Disease, Fibromyalgia
Qigong vs. Aerobic Exercise in the Treatment of Childhood Chronic Musculoskeletal Pain
This study is comparing two different exercise programs, Qi Gong (gentle stretching, and breathing) with an aerobics program (boxing and dancing) to see if children with chronic pain or fibromyalgia are able to take part in the…
- Trial name
- NCT00312234
- Testing
- Aerobic exercise, Qigong exercise
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Fibromyalgia, Chronic Migraine, Headache
Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and Vulvodynia
Chronic pain (CP) is a substantial healthcare challenge with considerable economic costs. Recently, the term Nociplastic Pain (NP) has been introduced as a third descriptor of mechanisms related to CP.
- Conditions
- Fibromyalgia, Chronic Migraine, Headache, Vulvodynia
- Trial name
- PSYCHOFIBRO (NCT06138171)
- Testing
- Psychological self-reported measures assesment (questionnaire)
- Where
- Italy
- Volunteers
- 1,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Physical Activity, Adolescent
Development of The Pediatric Physical Activity Tracking Platform (Pedi@Ctivity) and Smartwatch-based Big Data Analysis
Regular physical activity is extremely important for the protection and development of physical and psychosocial health. In addition, acquiring regular physical activity habits in the early years of life allows maintaining…
- Conditions
- Physical Activity, Adolescent, Childhood Rheumatic Disease
- Trial name
- NCT05509907
- Testing
- Pedi@ctivity Analysis and Tracking Mobile Applications and Web Platform
- Where
- Turkey (Türkiye)
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Juvenile Chronic Polyarthritis, Juvenile Idiopathic Arthritis
Trial of Early Aggressive Drug Therapy in Juvenile Idiopathic Arthritis
The purpose of this study is to compare two aggressive drug regimens for children with poly-juvenile idiopathic arthritis (JIA) and extended oligo JIA.
- Conditions
- Juvenile Chronic Polyarthritis, Juvenile Idiopathic Arthritis, Juvenile Rheumatoid Arthritis
- Trial name
- NCT00443430
- Testing
- methotrexate, methotrexate - etanercept - prednisolone arm
- Where
- 15 sites in United States
- Volunteers
- 85 people
- Sponsor
- Seattle Children's Hospital
Childhood Rheumatic Diseases, Juvenile Idiopathic Arthritis (JIA)
Cognitive Exercise Therapy Approach (BETY) in JIA
Cognitive Exercise Therapy Approach (*Bilişsel Egzersiz Terapi Yaklaşımı*-BETY), an innovative method developed for adults with rheumatism, aims to promote behavioral change and prevent social isolation by focusing on exercises…
- Conditions
- Childhood Rheumatic Diseases, Juvenile Idiopathic Arthritis (JIA), Exercise
- Trial name
- NCT06591949
- Testing
- BETY, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Hacettepe University