Clinical trials: Childhood and Adolescent Cancer
Lymphoma
Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00433459
- Testing
- cyclophosphamide, dacarbazine, prednisolone
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 2,134 people
- Sponsor
- Christine Mauz-Körholz
Brain Tumors, Solid Tumor
Understanding Communication in Healthcare to Achieve Trust (U-CHAT)
Honest, clear, and empathetic communication between pediatric oncologists (POs) and parents of children with cancer (POCCs) is imperative to facilitating therapeutic alliance and ensuring that medical management aligns with the…
- Trial name
- NCT02846038
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- St. Jude Children's Research Hospital
Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract
Data Collection Study of Pediatric and Adolescent Gynecology Conditions
Background: Gynecologic conditions are those that are related to the reproductive system. They can be reproductive gland disorders or reproductive system tumors. They can also be inborn anomalies of the reproductive tract.
- Conditions
- Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract, Reproductive Endocrine Conditions in Puberty, Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions
- Trial name
- NCT04717349
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Childhood Cancer
Examining a Training Program for for Acute Lymphoblastic Leukemia Childhood Cancer Survivors
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, with the peak incidences occurring in children two to five years of age.
- Trial name
- JUMP (NCT05086354)
- Testing
- JUMP
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific
Cancer Occurrence and Outcome in Young Patients Undergoing Cancer Treatment at the Vanderbilt-Ingram Cancer Center
RATIONALE: Gathering information about the number of young patients with cancer and the outcome of these patients may help doctors learn more about cancer.
- Trial name
- NCT00670605
- Testing
- medical chart review, study of socioeconomic and demographic variables
- Where
- 3 sites in United States
- Sponsor
- Vanderbilt University
Childhood Cancer, Late Effects
Young Survivors at Kantonsspital Aarau, Switzerland
The Young Survivors at Kantonsspital Aarau project assesses the prevalence and severity of late effects in survivors of childhood and adolescent cancer according to the modified CTCAE criteria prospectively.
- Trial name
- NCT04811794
- Testing
- Physical examination, diagnostic tests, laboratory tests, Personal history
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Kantonsspital Aarau
Positron-Emission Tomography, Brain Neoplasms, Childhood
The Diagnostic Value of 18F-FET PET/MRI for CNS Tumors in Children and Adolescents
To investigate the diagnostic value of 18F-FET PET/MRI instead of MRI alone, children and adolescents with tumor in brain or spinal cord are included and scanned primarily at our hybrid PET/MRI using the amino acid analog…
- Trial name
- BUF (NCT03402425)
- Testing
- 18F-FET PET
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Lymphoblastic Leukemia, Pediatric
Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017
The understanding of acute lymphoblastic leukemia (ALL) in childhood and adolescence has largely changed due to extensive genetic research in recent years: ALL is now considered to be a very heterogeneous disease group.
- Trial name
- NCT03643276
- Testing
- Blinatumomab, Bortezomib, Cyclophosphamide
- Where
- 115 sites in Australia, Austria and 6 more
- Volunteers
- 5,000 people
- Sponsor
- Martin Schrappe
Lymphoblastic Lymphoma, Childhood
International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma
Primary objectives: Randomization R1, all patients eligible: To examine, whether the cumulative incidence of relapses with involvement of the CNS (CNS relapse, pCICR) can be decreased by a modified induction therapy including…
- Trial name
- LBL 2018 (NCT04043494)
- Testing
- Cyclophosphamide, Cytarabine, Dexamethasone
- Where
- 228 sites in Austria, Belgium and 19 more
- Volunteers
- 683 people
- Sponsor
- University Hospital Muenster
Diffuse Intrinsic Pontine Glioma, Medulloblastoma, Childhood, Recurrent
Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy
The aim of this study is to assess the safety and efficacy of AloCELYVIR, which consist in bone marrow-derived allogenic mesenchymal stem cells infected with an oncolytic Adenovirus, ICOVIR-5.
- Trial name
- AloCELYVIR (NCT04758533)
- Testing
- AloCELYVIR
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Hospital Infantil Universitario Niño Jesús, Madrid, Spain
Anthracycline Related Cardiotoxicity in Childhood Cancers, Chemotherapeutic Toxicity
Evaluation of Cardiac and Endothelial Function in Children and Adolescents Treated With Anthracycline
In recent decades, the survival rate of children with cancer has increased significantly thanks to personalized treatments and the adoption of international therapeutic protocols.
- Conditions
- Anthracycline Related Cardiotoxicity in Childhood Cancers, Chemotherapeutic Toxicity, Childhood Cancer Survivors
- Trial name
- CARDIO-PED (NCT07253077)
- Testing
- Biomarker detection
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Brain and Central Nervous System Tumors, Long-term Effects Secondary to Cancer Therapy in Children
Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma
RATIONALE: Collecting information on how craniopharyngioma is diagnosed and treated may help doctors predict a patient's response to treatment and help plan the best treatment.
- Conditions
- Brain and Central Nervous System Tumors, Long-term Effects Secondary to Cancer Therapy in Children, Perioperative/Postoperative Complications, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00258453
- Testing
- metabolic assessment, physiologic testing, biopsy
- Where
- 109 sites in Austria, Germany and 2 more
- Volunteers
- 120 people
- Sponsor
- German Society for Pediatric Oncology and Hematology GPOH gGmbH
Pediatric Cancer, Survivorship
Development and Evaluation of a Screening Approach for Sexual Dysfunction in AYA Patients With and Surviving Childhood Cancer
Prior research determined adolescent and young adult-aged childhood cancer survivor (AYA-CCS) and medical provider acceptability of the SexFS Brief in a controlled research setting.
- Trial name
- NCT05524610
- Testing
- Sexual Function Screening Approach
- Where
- 2 sites in United States
- Volunteers
- 205 people
- Sponsor
- University of Colorado, Denver
Cardiac Toxicity, Unspecified Childhood Solid Tumor, Protocol Specific
Oblimersen Plus Combination Chemotherapy and Dexrazoxane in Treating Children and Adolescents With Relapsed or Refractory Solid Tumors
Phase I trial to study the effectiveness of oblimersen plus combination chemotherapy and dexrazoxane in treating children and adolescents who have relapsed or refractory solid tumors.
- Trial name
- NCT00039481
- Testing
- oblimersen sodium, dexrazoxane hydrochloride, doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Lymphoma
Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00025064
- Testing
- bleomycin sulfate, chlorambucil, cisplatin
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 260 people
- Sponsor
- Children's Cancer and Leukaemia Group
Unspecified Childhood Solid Tumor, Protocol Specific
Temsirolimus, Irinotecan Hydrochloride, and Temozolomide in Treating Younger Patients With Relapsed or Refractory Solid Tumors
This phase I trial studies the side effects and the best dose of temsirolimus when given together with irinotecan hydrochloride and temozolomide in treating younger patients with recurrent or refractory solid tumors.
- Trial name
- NCT01141244
- Testing
- temsirolimus, temozolomide, irinotecan hydrochloride
- Where
- 25 sites in United States, Canada
- Volunteers
- 72 people
- Sponsor
- National Cancer Institute (NCI)
ALL, Childhood, Lymphoblastic Leukemia, Acute, Childhood
Vincristine Sulfate Liposome Injection (Marqibo®) in Combination With UK ALL R3 Induction Chemotherapy
This is a pilot study utilizing Marqibo® (vincristine sulfate liposome injection) combined with dexamethasone, mitoxantrone and asparaginase (UK ALL R3) for relapsed acute lymphoblastic leukemia (ALL).
- Conditions
- ALL, Childhood, Lymphoblastic Leukemia, Acute, Childhood, Lymphoblastic Leukemia, Acute
- Trial name
- NCT02879643
- Testing
- Marqibo
- Where
- 35 sites in United States, Australia and 1 more
- Volunteers
- 29 people
- Sponsor
- Therapeutic Advances in Childhood Leukemia Consortium
Childhood Burkitt Lymphoma, Childhood Lymphoblastic Lymphoma
Studying Genes Associated With Non-Hodgkin Lymphoma in Young Patients
This research studies genes associated with non-Hodgkin lymphoma in young patients. Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and…
- Trial name
- NCT01623856
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 483 people, healthy volunteers welcome
- Sponsor
- Children's Oncology Group
Cardiovascular Diseases, Pediatric Cancer
Cardiac Impairments Following Pediatric Cardiotoxic Anti-cancer Treatment
This study aims at investigating the feasibility of recruitment and application of a method regarding early detection of subclinical changes in cardiac health after completion of acute cancer treatment during childhood and…
- Trial name
- NCT05261256
- Testing
- Exercise stress echocardiography
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Influenza, Human
A Pilot Study of Influenza Viruses Isolated From Immunocompromised Children and Adolescents
The purpose of the proposed study is to gather critical information that may be useful in designing effective prevention and treatment strategies for control of seasonal influenza and an influenza pandemic.
- Trial name
- NCT02352389
- Testing
- Blood sample, Nasal swab, Oropharyngeal swab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- St. Jude Children's Research Hospital