Clinical trials: Children, Adolescents
Autism Spectrum Disorders, Anxiety
An Open-Label Trial of Buspirone for the Treatment of Anxiety in Youth With Autism Spectrum Disorders
The main objective of this exploratory 8-week pilot study is to evaluate the safety and efficacy of buspirone for the treatment of anxiety in youth (ages 6-17 years) with autism spectrum disorders.
- Trial name
- NCT01850355
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder, Catatonia
Management of Catatonic Features in Adolescents With Profound Autism
The goal of this clinical trial is to learn if benzodiazepines and ECT can treat Catatonic features in Adolescents with Autistic spectrum disorder, it will also learn about Safety and efficacy of benzodiazepines and ECT.
- Trial name
- MOCFAPA (NCT07498387)
- Testing
- Intranasal Midazolam (Benzodiazepine Challenge Test), Oral Clonazepam, Electroconvulsive Therapy (ECT)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
HIV-1
Study To Evaluate Emtricitabine/Tenofovir Alafenamide (F/TAF) in Human Immunodeficiency Virus 1 (HIV-1) Infected Children and Adolescents Virologically Suppressed on a 2-Nucleoside/Nucleotide Reverse Transcriptase Inhibitor (2-NRTI)-Containing Regimen
The primary objective of this study is to confirm the TAF dose and to evaluate the pharmacokinetics (PK) of TAF, safety, and tolerability of F/TAF in children and adolescents with HIV-1 who are virologically suppressed (defined…
- Trial name
- NCT02285114
- Testing
- F/TAF, 3rd ARV agent, Boosted PIs
- Where
- 8 sites in United States, Panama and 1 more
- Volunteers
- 41 people
- Sponsor
- Gilead Sciences
Obsessive Compulsive Disorder (OCD), Anxiety Disorder of Childhood or Adolescence
Comparative Effectiveness of Internet-based Versus Parent-Coached Cognitive-Behavioral Therapy For Children and Adolescents With Anxiety and OCD
Anxiety disorders in children and adolescents are common and confer significant disability. Cognitive behavioral therapy (CBT) is the recommended treatment for youth with anxiety, yet many families cannot access CBT due to cost…
- Conditions
- Obsessive Compulsive Disorder (OCD), Anxiety Disorder of Childhood or Adolescence, Social Anxiety Disorder of Childhood, Generalized Anxiety Disorder (GAD)
- Trial name
- ASTRO (NCT07024758)
- Testing
- Parent Coached Exposure Therapy, Family Based, Internet-Based Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Baylor College of Medicine
Child Abuse, Child Neglect
Cognitive Bias Modification Training in Adolescents Who Have Experienced Adversity
Adolescents who have experienced adversity (childhood maltreatment and other forms of broader victimisation experiences) will be randomly allocated to receive a 5-session cognitive bias modification training (with attention and…
- Conditions
- Child Abuse, Child Neglect, Victimization
- Trial name
- NCT03625206
- Testing
- Cognitive bias modification training, Control training
- Where
- 2 sites in India, Nepal
- Volunteers
- 50 people
- Sponsor
- Institute of Psychiatry, London
Asthma, Allergy
Comparing Allergenic Effects of 3 German Cockroach Extracts in Adults
The purpose of this study is to test and compare the allergenic effects of three commercially available German cockroach allergen extracts in adults.
- Trial name
- NCT00132847
- Testing
- German Cockroach Allergen extract
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Craniopharyngioma, Hypothalamic Obesity
Intranasal Oxytocin in Hypothalamic Obesity
This research study will test if oxytocin, delivered by nasal spray, will promote weight loss in children, adolescents, and adults with Hypothalamic Obesity as compared to a placebo. The study is divided into two parts.
- Trial name
- NCT02849743
- Testing
- Syntocinon
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Shana McCormack, MD
Functional Gastrointestinal Disorders, Irritable Bowel Syndrome
Hypnotherapy Through Self-exercises in Children With Functional Abdominal Pain in Primary Care
The goal of this randomised controlled trial is to study the (cost-)effectiveness of home-based hypnotherapy by self-exercises in children with functional abdominal pain (FAP) or irritable bowel syndrome (IBS) in primary care.
- Conditions
- Functional Gastrointestinal Disorders, Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome
- Trial name
- ZelfHy (NCT05636358)
- Testing
- Home-based hypnotherapy
- Where
- Netherlands
- Volunteers
- 152 people
- Sponsor
- University Medical Center Groningen
Overweight
Evaluation of Multiprofessional Group Programs for Paediatric Obesity Therapy
The aim of this pilot project is to disseminate multiprofessional group programs (*MGP*) for therapy of the estimated 119'140 overweight/obese children in Switzerland.
- Trial name
- KIDSSTEP (NCT03233425)
- Testing
- multiprofessional group therapy
- Where
- Switzerland
- Volunteers
- 1,152 people
- Sponsor
- Ostschweizer Kinderspital
Nutritional and Metabolic Diseases, Child Obesity
The FibreGum Study - Changing the Course of Obesity in Children
The aim of this study is thus to assess the effect of a chewing gum containing fibres on body weight, metabolism and the oral and intestinal microbiomes in a population of obese children.
- Conditions
- Nutritional and Metabolic Diseases, Child Obesity, Adolescent Obesity
- Trial name
- FibreGum (NCT05540678)
- Testing
- FibreGum
- Where
- 2 sites in Switzerland
- Volunteers
- 93 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Autism Spectrum Disorder
Psychometric Validation of the Camouflaging Autistic Traits Questionnaire
For many affected individuals, despite impairment and distress, autism spectrum disorder (ASD) is recognized and diagnosed late, in school age, adolescence, or even in adulthood, which could be due, among other things, to the use…
- Trial name
- CAT-Q/DE (NCT05989685)
- Where
- Germany
- Volunteers
- 622 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Classical Hodgkins Lymphoma in Children and Adolescents.
Treatment for Classical Hodgkin Lymphoma in Children and Adolescents
Reduction of the indication for radiotherapy (RT) in newly diagnosed patients with classical Hodgkins lymphoma without compromising cure rates.
- Trial name
- EuroNet-PHL-C2 (NCT02797717)
- Testing
- Radiotherapy:, Vincristine, Etoposide
- Where
- Israel
- Volunteers
- 2,200 people
- Sponsor
- GALIA AVRAHAMI
Secondary Traumatic Stress, Burnout, Professional
International Online Survey Assessing Secondary Traumatic Stress, Burnout, Compassion Satisfaction and Turnover Intentions Among Youth Care (Para)Professionals in Flanders, Wallonia, France and The Netherlands.
The goal of this observational study is to understand how work-related stress and personal characteristics affect the wellbeing of adults who work with children and young people in youth care services in Flanders, Wallonia…
- Conditions
- Secondary Traumatic Stress, Burnout, Professional, Compassion Fatigue, Compassion Satisfaction
- Trial name
- 2021_VUB_CFCSJ (NCT07384026)
- Where
- Belgium
- Volunteers
- 4,214 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD)
Stepped Care Treatment for Anxiety Resilience
Childhood anxiety disorders (CAD) are common and impairing. Family based cognitive behavioral therapy (CBT) is efficacious in treating CAD.
- Conditions
- Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD), Separation Anxiety Disorder, Specific Phobia
- Trial name
- STAR (NCT07228143)
- Testing
- Relaxation and Mentorship Training (RMT), Stepped Care Targeting Exposure and Parenting for Anxiety (STEP-A)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Andrew Wiese
Chronic Myeloid Leukemia
International Chronic Myeloid Leukemia Pediatric Study
The purpose of the study is to describe and characterize CML in a large pediatric cohort of patients.
- Trial name
- ICMLPed (NCT01281735)
- Where
- 20 sites in Australia, Austria and 18 more
- Volunteers
- 750 people
- Sponsor
- Poitiers University Hospital
Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
HEM-iSMART-A: Decitabine / Venetoclax and Navitoclax in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
HEM-iSMART is a master protocol which investigates multiple investigational medicinal products in children, adolescents and young adults (AYA) with relapsed/refractory (R/R) ALL and LBL.
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
- Trial name
- HEM-iSMART A (NCT05740449)
- Testing
- Decitabine, Venetoclax, Navitoclax
- Where
- Netherlands
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Type 1 Diabetes Mellitus
Effect of Splitting Mealtime Insulin Doses After Mixed Meals High in Fat and Protein
The current management of type 1 diabetes mellitus (T1DM) depends on the use of intensive insulin therapy - either by insulin pump therapy or multiple daily injection (MDI) therapy - and the use of carbohydrate counting to…
- Trial name
- NCT04783376
- Testing
- : Insulin, lispro and regular insulin
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Sohag University
Autism Spectrum Disorder, Oxytocin
Understanding Oxytocin's Neural and Behavioral Effects in Adolescents Diagnosed With Autism
The investigators explored the neural and behavioral effect of oxytocin on youth with Autism spectrum disorder using magnetoencephalography (MEG).
- Trial name
- NCT05096676
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Prof. Ilanit gordon
Type 1 Diabetes (T1D)
Effects of Bedtime Snack Composition on Overnight Glucose in Children and Adolescents With Type 1 Diabetes
This study compared four types of bedtime snacks in children and adolescents with type 1 diabetes treated with multiple daily insulin injections.
- Trial name
- NCT07778147
- Testing
- Carbohydrate-Only Bedtime Snack, Carbohydrate-Plus-Protein Bedtime Snack, Carbohydrate-Plus-Fat Bedtime Snack
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Didem Güneş Kaya
Diabetes Mellitus, Type 1
DIABGAD - Trial to Preserve Insulin Secretion in Type 1 Diabetes Using GAD-Alum (Diamyd) in Combination With Vitamin D and Ibuprofen
The objectives of this study is to evaluate the safety and influence of treatment with GAD-Alum (Diamyd) combined with Vitamin D and Ibuprofen on preservation of residual insulin secretion in recently diagnosed Type 1 Diabetes…
- Trial name
- NCT01785108
- Testing
- GAD-Alum (Diamyd) 20 µg, GAD-Alum (Diamyd) 20 µg X 2, Vitamin D
- Where
- 10 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Johnny Ludvigsson
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