Clinical trials: Children, Adolescents
Rare Diseases
Psychosocial Situation of Children With Rare (Congenital) Pediatric Surgical Diseases and Their Families
Families of children with rare diseases (i.e., not more than 5 out of 10.000 people are affected) are often highly burdened with fears, insecurities and concerns regarding the affected child and his/her siblings.
- Trial name
- NCT04382820
- Where
- Germany
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Depression - Major Depressive Disorder, Depressive Episodes
TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children
Depression in childhood and adolescence is a serious and increasing public-health problem associated with profound short- and long-term consequences, including impaired social and educational functioning, increased risk of…
- Trial name
- NCT07478796
- Testing
- Fluoxetine, Escitalopram, Sertralin
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Poznan University of Medical Sciences
Osteogenesis Imperfecta
Efficacy and Safety of Alendronate in Chinese Children or Adolescents With Osteogenesis Imperfecta
Alendronate should be considered as an alternative therapy of osteogenesis imperfecta (OI) because it significantly increased areal bone mineral density (BMD) and its Z score, decreased fracture incidence, inhibited bone…
- Trial name
- NCT02303873
- Testing
- Alendronate
- Volunteers
- 99 people
- Sponsor
- Peking Union Medical College Hospital
Child/Adolescent Problems, Mental Disorders
Addressing Mental Health Disparities in Refugee Children: A Community-based Participatory Research (CBPR) Collaboration
This study will use CBPR mixed methods (qualitative and quantitative data collection) to conduct needs assessments and design and evaluate a core family-based intervention.
- Trial name
- NCT02562794
- Testing
- Family Strengthening Intervention-Refugees
- Where
- 2 sites in United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Boston College
Inflammatory Bowel Disease, Ulcerative Colitis
Web-based Monitoring in Children and Adolescents With Inflammatory Bowel Disease
The investigators hypothesize that E-health - web based monitoring of disease and treatment - in young patients with chronic inflammatory disease (IBD) can improve the disease course and quality of life.
- Conditions
- Inflammatory Bowel Disease, Ulcerative Colitis, Crohn´s Disease
- Trial name
- NCT01860651
- Testing
- Web-monitoring
- Where
- Denmark
- Volunteers
- 103 people
- Sponsor
- Hvidovre University Hospital
Migraine in Children, Migraine
A Study in Children and Young People With Migraine to Learn What the Body Does to Eptinezumab
The purpose of the study is to investigate how the body absorbs, distributes, and get rid of eptinezumab when given directly into a vein.
- Trial name
- NCT04537429
- Testing
- Eptinezumab
- Where
- 9 sites in United States
- Volunteers
- 28 people
- Sponsor
- H. Lundbeck A/S
Firearm Injury
Rise up! A Youth-Informed Video Program For Young Children To Stay Safe From Community Violence
Gun violence is the number one reason children die in the U.S. In big cities, most of these cases come from shootings related to assaults and homicides.
- Trial name
- NCT07548437
- Testing
- Rise Up! video-based program
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Acquired Immune Deficiency Syndrome (AIDS), HIV Infections
Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV
The goal of this clinical study is to learn more about the safety and dosing of study drugs, cobicistat-boosted Atazanavir (ATV/co), cobicistat-boosted darunavir (DRV/co) and emtricitabine/tenofovir alafenamide (F/TAF), in…
- Trial name
- NCT02016924
- Testing
- ATV, DRV, Cobicistat
- Where
- 23 sites in United States, Argentina and 5 more
- Volunteers
- 133 people
- Sponsor
- Gilead Sciences
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Total Exposure of NN5401 (Insulin Degludec/Insulin Aspart) in Children, Adolescents and Adult Subjects With Type 1 Diabetes
This trial was conducted in Europe. The aim of this study was to investigate the total exposure of NN5401 (insulin degludec/insulin aspart) in children, adolescents and adult subjects with type 1 diabetes.
- Trial name
- NCT01138488
- Testing
- insulin degludec/insulin aspart
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Novo Nordisk A/S
Fractures in Children, Apophysitis
Total Genotype Score, Growth, Maturation and Loading Exposure as Risk Factors for Injury in Elite Male Youth Football
A total genotype risk score was generated based on the findings of previous research for non-contact injury, non-contact muscle injury, tendon injury, ligament injury, fracture injury and apophysitis injury.
- Conditions
- Fractures in Children, Apophysitis, Muscle Strain, Ligament Injury
- Trial name
- NCT05220969
- Testing
- Total Genotype Risk Score
- Where
- 2 sites in United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
HIV Infections, Influenza
Safety of and Immune Response to Two Influenza Vaccines in HIV Infected Children and Adolescents
The purpose of this study is to compare two flu vaccines to determine their safety and ability to stimulate an immune response in HIV infected children and adolescents.
- Trial name
- NCT00091702
- Testing
- Cold-adapted live attenuated influenza vaccine (FluMist), Inactivated influenza vaccine (IAIV)
- Where
- 61 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pain, Postoperative, Surgery, Thoracic
Pain Control in Children and Adolescent After Thoracic Surgery: The Effect of Gabapentin
The study is performed in patients aged 5-18 years after thoracic surgery. The primary aim of this trial is to determine whether the use of gabapentin as a component of multimodal analgesic regiments reduces pain scores following…
- Trial name
- NCT03393702
- Testing
- Gabapentin
- Where
- Poland
- Volunteers
- 104 people
- Sponsor
- National Institute for Tuberculosis and Lung Diseases, Poland
Autism Spectrum Disorder
Telehealth Mindfulness-based Intervention for Adolescents With Autism Spectrum Disorder and Their Caregivers
The goal of this clinical trial is to learn whether a mindfulness-based intervention can reduce depression and anxiety in autistic adolescents.
- Trial name
- NCT07501286
- Testing
- MINDful TIME, Mindfulness Mobile App
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Nicole Matthews, Ph.D.
Hypothalamic Obesity
Energy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity
The proposed multicenter study will test the effect of glucagon-like peptide (GLP)-1 agonist exenatide once weekly extended-release (ExQW, Bydureon®) on clinical outcomes and metabolic parameters in a double-blind…
- Trial name
- ECHO (NCT02664441)
- Testing
- Exenatide
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Seattle Children's Hospital
Posttraumatic Stress Disorder, PTSD
D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents
The purpose of this study is to show whether D-cycloserine in combination with cognitive behavioral therapy (CBT) is more effective than CBT plus placebo to reduce symptoms of posttraumatic stress disorder (PTSD) in 13-18…
- Trial name
- NCT01157429
- Testing
- D-cycloserine, CBT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Tulane University School of Medicine
Obesity, Obese Adolescents
AKK Study in Improving Obesity and Metabolic Status in Children and Adolescents
The problem of obesity among children and adolescents is becoming increasingly serious and may affect their health in adulthood.
- Conditions
- Obesity, Obese Adolescents, Obese Children and Adolescents, Akkermansia Muciniphila
- Trial name
- NCT07593170
- Testing
- AKK
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Central South University
Diabetes Mellitus, Type 1, Hyperglycemia, Postprandial
Effect of Protein Intake on Post Prandial Hyperglycemia in Children and Adolescents With Type1 Diabetes Mellitus
In type 1 Diabetes Mellitus, patients receive insulin doses if they consume specific amounts of carbohydrates. Currently, insulin is not being administered for consumption of protein although studies in adults show that consuming…
- Trial name
- NCT04655131
- Testing
- Whey protein isolate
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University Hospitals Cleveland Medical Center
Chronic Postsurgical Pain, Chronic Post-surgical Pain
Prevention of Postsurgical Chronic Pain in Children and Adolescents (PREVENDOL)
Chronic postsurgical pain is a health problem with a great societal impact: approximately 20% of all children and adolescents undergoing surgery will develop chronic pain.
- Conditions
- Chronic Postsurgical Pain, Chronic Post-surgical Pain, Chronic Postoperative Pain, Chronic Post-operative Pain
- Trial name
- NCT06638437
- Testing
- Cognitive-behavioral therapy
- Where
- 3 sites in Spain
- Volunteers
- 125 people
- Sponsor
- University Rovira i Virgili
Autism, Asperger's Syndrome
Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety
Autism spectrum disorders affect as many as 1 out of 88 children and are related to significant impairment in social, adaptive, and school functioning.
- Conditions
- Autism, Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified, Generalized Anxiety Disorder
- Trial name
- NCT01919970
- Testing
- Cognitive Behavioral Therapy, Treatment as usual
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Autism Spectrum Disorder (ASD)
Efficacy and Safety of Bumetanide Oral Liquid Formulation in Children and Adolescents Aged From 7 to Less Than 18 Years Old With Autism Spectrum Disorder
The purpose of this study was to evaluate the efficacy and the safety of bumetanide/S95008 in the improvement of Autism Spectrum Disorder core symptoms.
- Trial name
- NCT03715166
- Testing
- Bumetanide Oral Solution
- Where
- 45 sites in Brazil, France and 8 more
- Volunteers
- 211 people
- Sponsor
- Institut de Recherches Internationales Servier
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