Clinical trials: Children, Adolescents
Acute Lymphoid Leukemia
The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents
The purpose of the trail is to study the pharmacokinetics of Pegylated Recombinant Human Granulocyte Stimulating Factor（PEG-rhG-CSF） in Children and Adolescents
- Trial name
- NCT02953730
- Testing
- PEG-rhG-CSF
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Chinese Academy of Medical Sciences
Weight Loss, Pediatric Obesity
Dyad Plus Effectiveness/Feasibility
The purpose of this research is to determine the effectiveness of a coordinated program (Dyad Plus) that would help to facilitate self-monitoring, positive communication, joint problem solving, and social support to increase…
- Conditions
- Weight Loss, Pediatric Obesity, Overweight Adolescents, Parent-Child Relations
- Trial name
- NCT04036331
- Testing
- Brenner FIT Standard, By Design Essentials, Dyad Plus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
Diffuse Large B-cell Lymphoma
DLBCL Treatment in Children and Adolescents
We compared the efficacy and safety of modified NHL-BFM-90 regimen and R-CHOP/CHOP regimen in pediatric (aged 0-14 years) and adolescent（aged 15-18 years）DLBCL patients in a single institution during a 20-year period.
- Trial name
- NCT04726995
- Testing
- CHOP and BFM regiments
- Volunteers
- 106 people
- Sponsor
- Sun Yat-sen University
Ulcerative Colitis, Crohn Disease
Influence of Aerobic Exercise Training (AET) on Inflammatory Bowel Disease (IBD) in Children and Adolescents
The purpose of this study is to determine if aerobic exercise training can serve as comprehensive palliative care, whereby enhancing cardiovascular fitness, mitigating depressive symptoms and augmenting sleep while bolstering…
- Conditions
- Ulcerative Colitis, Crohn Disease, Depression, Sleep
- Trial name
- Ex-CED (NCT02264275)
- Testing
- Aerobic Exercise Training
- Where
- 3 sites in Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Basel
Suspected CSF Shunt Obstruction
ShuntCheck-Micro-Pumper Pediatric Clinical Outcomes Study
Primary objective is to demonstrate that data collected from ShuntCheck-Micro-Pumper (SCMP) testing results can be used in conjunction with imaging to diagnose shunt patency or obstruction in pediatric/adolescent subjects…
- Trial name
- NCT01881711
- Testing
- ShuntCheck-Micro-Pumper (SCMP), Imaging
- Where
- 11 sites in United States
- Volunteers
- 400 people
- Sponsor
- NeuroDx Development
Orbital Lymphatic Malformation
Systematic Approach for Children With Orbital Malformation With Sirolimus Use
The goal of this interventional study is to Set a systematic management approach for orbital lymphatic malformation and to study the safety and efficacy of sirolimus in children and adolescents with orbital lymphatic…
- Trial name
- sirolimus (NCT07378657)
- Testing
- Injection Sclerotherapy, Sirolimus (Rapamune®), both injection sclerotherapy and sirolimus
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Attention Deficit Hyperactivity Disorder, Sleep Disorder
Melatonin in ADHD and Sleep Problems
Treatment with melatonin is often initiated on an insufficient basis as it has not been established prior to starting the treatment whether or not the child had delayed release of endogenous melatonin.
- Trial name
- MELAS (NCT04318067)
- Testing
- Melatonin 3 mg
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Allan Hvolby
Duchenne Muscular Dystrophy
Phase 2 Study of EDG-5506 in Children and Adolescents With Duchenne Muscular Dystrophy Previously Treated With Gene Therapy
The FOX study is a 2-part, multicenter, Phase 2 study of safety, pharmacokinetics, and biomarkers in children and adolescents with Duchenne muscular dystrophy previously treated with gene therapy including a randomized…
- Trial name
- FOX (NCT06100887)
- Testing
- Sevasemten Dose 1, Sevasemten Dose 2, Sevasemten Dose 3
- Where
- 7 sites in United States
- Volunteers
- 43 people
- Sponsor
- Edgewise Therapeutics, Inc.
Lupus Erythematosus, Systemic
Study to Evaluate the Natural History of Osteoporosis in Children and Adolescents With Systemic Lupus Erythematosus
This is a study to determine if people with Lupus have weak bones. Test which is a better method for detecting bone changes: Dual energy X-ray absorptiometry (DXA) Single energy quantitative computed tomography (SEQCT) Evaluate…
- Trial name
- BMD (NCT00582465)
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- University of California, San Francisco
Rare Diseases
FACE for Children With Rare Diseases
Children with ultra-rare or complex rare diseases are routinely excluded from research studies because of their conditions, creating a health disparity.
- Trial name
- FACE-Rare (NCT04855734)
- Testing
- FAmily CEntered (FACE) pACP Intervention
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's National Research Institute
FMF
Evaluation of Familial Mediterranean Fever Impact on Oral and Dental Health in Children and Adolescents
Aim: It is the clinical and radiological evaluation of oral hygiene, teeth and surrounding tissues in children and adolescents diagnosed with FMF and comparing the results with healthy individuals.
- Trial name
- NCT06934434
- Testing
- FMF Study Group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ozge Gungor
Childhood Obesity
Predictors of Success in an Intervention Program for the Treatment of Childhood Obesity
The child health and sports center, at the Meir Medical Center, runs for over 10 years an intervention program to treat obese children. The program includes physical activity, nutritional intervention and behavioral treatment.
- Trial name
- NCT01578863
- Testing
- Intervention program for obese children
- Where
- Israel
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Forward Head Posture, Neck Pain
Effects of Deep Cervical Flexors Training On Forward Head Posture, Neck Pain and Functional Status
Using computer for long hours is related to higher risk of computer related muscular disorders like forward head posture and neck pain.
- Trial name
- NCT04463199
- Testing
- Craniocervical flexion training
- Where
- Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- King Saud University
HIV-1-infection
Study of Bictegravir/Lenacapavir in Children and Adolescents With HIV-1
The goal of this clinical study is to learn about the safety and tolerability of bictegravir (BIC)/lenacapavir (LEN) and to learn how the study drug interacts with the body in virologically suppressed (VS) children and…
- Trial name
- NCT06532656
- Testing
- Lenacapavir, Bictegravir/Lenacapavir (BIC/LEN) FDC, Bictegravir/Lenacapavir
- Where
- 21 sites in United States, Argentina and 3 more
- Volunteers
- 75 people
- Sponsor
- Gilead Sciences
Epilepsy in Children, Executive Dysfunction
Epilepsy Journey-An Executive Functioning Intervention for Teens With Epilepsy
The goal of this multi-site clinical trial is to determine the effectiveness of two components of a web-based intervention (Epilepsy Journey) to improve executive functioning in adolescents with epilepsy.
- Trial name
- NCT06608966
- Testing
- Epilepsy Journey web-based modules, Telehealth with a therapist
- Where
- 3 sites in United States
- Volunteers
- 310 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pediatric Orthopedic Surgery
A Short Digital Intervention for Youth Undergoing Major Surgery and Their Parents
The perioperative time, i.e., the time before, during, and directly after surgery, can be stressful for families whose child needs to undergo major orthopedic surgery.
- Trial name
- POPI (NCT07812961)
- Testing
- Psychoeducational single-session intervention for families during the perioperative period
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Helen Koechlin
Persistent Asthma, Asthma in Children
Asthma Research in Children and Adolescents
The purpose of this study is to assess the evolution of disease control, health-related quality of life, and the risk of severe asthma exacerbations in children and adolescents with persistent asthma in Spain at short, mid and…
- Conditions
- Persistent Asthma, Asthma in Children, Asthma Exacerbation
- Trial name
- ARCA (NCT04480242)
- Testing
- Inhaled Corticosteroids (ICs), Fixed-Dose Combination of Inhaled Corticosteroids and Long- Acting Beta-agonist (ICs/LABA), Other treatments
- Where
- 15 sites in Spain
- Volunteers
- 525 people
- Sponsor
- Parc de Salut Mar
Safety Issues, Immunogenicity
Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine in Indonesian Adults, Adolescents, Children and Infants
This study is to assess the safety and immunogenicity of Vi-DT vaccine in adults, adolescent, children and infants.
- Trial name
- NCT03460405
- Testing
- Vi-DT Vaccine, Vi Polysaccharide Vaccine, IPV Vaccine
- Where
- 2 sites in Indonesia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- PT Bio Farma
Asthma, Asthma in Children
Prospective Multicentre Study on Symptoms in First-onset Bronchial Asthma in Children and Adolescents
Bronchial asthma may present with symptoms other than the commonly reported complaints (cough, chest tightness, shortness of breath and wheezing).
- Conditions
- Asthma, Asthma in Children, Dyspnea, Cough
- Trial name
- NCT06201494
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Charles University, Czech Republic
Cognitive Change
Executive Function Training for Children and Adolescents
The goal of this clinical trial is to evaluate how different approaches to executive function (like adding game-like features, varying the number of tasks, and providing coaching) can enhance executive function outcomes in…
- Trial name
- NCT07147894
- Testing
- Nongamified N-back training, Gamified N-back training, Multiple Domain Training
- Where
- United States
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- Northeastern University
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