Clinical trials: Children Development
Developmental Language Disorder and Language Impairment, Specific Language Impairment
Retrieval-Based Word Learning in Developmental Language Disorder During Book Reading II
Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and…
- Conditions
- Developmental Language Disorder and Language Impairment, Specific Language Impairment, Language Development
- Trial name
- NCT07048392
- Testing
- Retrieval-based word learning: Repeated Spaced Retrieval condition, Retrieval-based word learning: Repeated Study condition
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Purdue University
Autism Spectrum Disorder
Comparative Efficacy of Self-directed & Therapist-assisted Telehealth Parent Training Intervention for Children With ASD
The specific objectives of this project are to conduct a randomized control trial to examine the effect of a novel, telehealth parent training intervention for children with autism spectrum disorder (ASD), ImPACT Online, on…
- Trial name
- NCT02721381
- Testing
- ImPACT Online
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Michigan State University
Autism Spectrum Disorder, EEG With Periodic Abnormalities
Safety and Efficacy of tPBM for Epileptiform Activity in Autism
For this study, the proposed intervention will be noninvasively delivered near infra-red (NIR) light - transcranial Photobiomodulation (tPBM) - to the brains of autistic children with abnormal EEGs with epileptiform discharges or…
- Conditions
- Autism Spectrum Disorder, EEG With Periodic Abnormalities, Epilepsy, Neurodevelopmental Disorders
- Trial name
- tPBM (NCT06352372)
- Testing
- noninvasively delivered near infra-red (NIR) light - transcranial Photobiomodulation (tPBM)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Richard Frye
Autism, Autism Spectrum Disorders
Treatment of Sleep Disturbances in Young Children With Autism
This study will compare the efficacy of a behavioral parent training program (PT) aimed specifically at common sleep disturbances compared to parent education (PE) program focusing on general issues related to autism.
- Trial name
- NCT01322022
- Testing
- ParentTraining, Parent Education
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Growth Hormone Deficiency, Panhypopituitarism
Growth Hormone and Endothelial Function in Children
Objective: This study is designed to determine whether growth hormone treatment in children 8 to 18 years of age alters function of the lining of the arteries.
- Conditions
- Growth Hormone Deficiency, Panhypopituitarism, Short Stature
- Trial name
- NCT00373386
- Testing
- growth hormone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Ohio State University
Growth Hormone Insensitivity Syndrome
Long-Term Treatment With rhIGF-1 in GHIS
The objective of this study was to evaluate the long-term safety and effectiveness of mecasermin (the study drug) in children with growth failure due to severe Primary insulin-like growth factor-1 deficiency (Primary IGFD).
- Trial name
- NCT00571727
- Testing
- mecasermin
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Ipsen
Gastrointestinal Problems, Autism Spectrum Disorders
Beneficial Bacteria Treatment for Autism
This is an open-label clinical trial to investigate a combination therapy for treating gastrointestinal problems in children with autism spectrum disorders. The combination therapy includes beneficial bacteria.
- Trial name
- BBT (NCT02504554)
- Testing
- oral Vancomycin, MoviPrep, Prilosec
- Volunteers
- 18 people
- Sponsor
- Arizona State University
Autism Spectrum Disorder
A Study to Investigate the Efficacy, Safety, and Tolerability of JNJ-42165279 in Adolescent and Adult Participants With Autism Spectrum Disorder
The purpose of this study is to evaluate the efficacy of JNJ-42165279 compared with placebo in the improvement of symptoms of Autism Spectrum Disorder (ASD) during 12 weeks of treatment using the Autism Behavior Inventory (ABI).
- Trial name
- Envision (NCT03664232)
- Testing
- JNJ-42165279
- Where
- 9 sites in United States
- Volunteers
- 78 people
- Sponsor
- Janssen Research & Development, LLC
Autism Spectrum Disorders
A Study of Memantine Hydrochloride (Namenda®) for Cognitive and Behavioral Impairment in Adults With Autism Spectrum Disorders
The main objective of this study is to evaluate the safety and effectiveness of memantine (Namenda®) for cognitive and behavioral impairment in adults ages 18-50 years with autism spectrum disorders (ASD).
- Trial name
- NCT01333865
- Testing
- Memantine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder, Healthy
Effects of Drugs on Responses to Brain and Emotional Processes
To study the effects of a psychostimulant on responses to affective touch in individuals with a range of autistic traits
- Trial name
- MAT (NCT04053036)
- Testing
- MDMA
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Autism Spectrum Disorder, Typical Development
Improving Social Interaction for Adolescents With Autism During the Transition to Adulthood
This study compares the efficacy of two intervention strategies for improving social outcomes for autistic adolescents and young adults when interacting with unfamiliar non-autistic peers.
- Trial name
- NCT03785327
- Testing
- tDCS, Autism Training
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Autism Spectrum Disorder
CPI Training for Parents of Children With ASD
The purpose of this 24-week study is to determine whether the "Parent-based Crisis Prevention Institute (CPI) physical management training program" (i.e., P-CPI) is effective in increasing self-efficacy in parents of children…
- Trial name
- NCT03537261
- Testing
- Parent-based Crisis Prevention Institute (CPI) physical management training program (P-CPI)
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Chronic Toxic Stress, Developmental/ Behavioral Regression in Young Children
(YMP) Young Moms Program
Young Moms Program (YMP) is designed to address systemic barriers to the health and stability of young moms and their children such as the lack of coordination of service delivery or logistical barriers within the health system.
- Trial name
- YMP (NCT05082857)
- Testing
- "traditional" Parents as Teachers (PAT), "hybrid" PAT model
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b)
Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia
This phase II trial is studying the side effects and best dose of bortezomib and to see how well it works when given together with combination chemotherapy in treating younger patients with recurrent, refractory, or secondary…
- Conditions
- Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b), Adult Acute Myeloblastic Leukemia With Maturation (M2), Adult Acute Myeloblastic Leukemia Without Maturation (M1)
- Trial name
- NCT00666588
- Testing
- idarubicin, cytarabine, bortezomib
- Where
- 82 sites in United States, Australia and 1 more
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Autism Spectrum Disorder
Care Improving Cognition for ADolescents on the Autism Spectrum
This is a validation study to evaluate the acceptability, feasibility and impact of CICADAS (Care Improving Cognition for ADolescents on the Autism Spectrum), a clinician-assisted, digital application that aims to prime the brain…
- Trial name
- CICADAS (NCT04562688)
- Testing
- CICADAS only, PEERS + CICADAS and then no-contact, PEERS + Active Comparator and then no-contact
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Posit Science Corporation
Hypertrophic Cardiomyopathy, Sudden Cardiac Death
PRecIsion Medicine in CardiomyopathY
This is a retrospective cohort study of pediatric hypertrophic cardiomyopathy (HCM) patients using chart and registry review methodology.
- Trial name
- PRIMaCY (NCT04036799)
- Volunteers
- 572 people
- Sponsor
- The Hospital for Sick Children
Autism, Autism Spectrum Disorder
First CRUSH: Piloting the Preliminary Feasibility and Acceptability of the Competence in Romance and Understanding Sexual Health (CRUSH) Curriculum
The goal of this clinical trial is to learn about the feasibility and acceptability of a behavioral intervention in designed to provide sexual education and improve the behavioral skills of autistic adults for intimate…
- Trial name
- NCT05910658
- Testing
- Competence in Romance and Understanding Sexual Health (CRUSH)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Boston Children's Hospital
Autism Spectrum Disorder
The Impacts of Theta-burst Stimulation on Children and Adolescents With Autism Spectrum Disorder
The investigator would like to investigate the impact of theta-burst stimulation over posterior superior temporal sulcus in children and adolescents with autism spectrum disorder
- Trial name
- NCT03621189
- Testing
- intermittent theta burst stimulation
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Chang Gung Memorial Hospital
Early Child Development
Testing Means to Scale Early Childhood Development Interventions in Rural Kenya
This study aims to experimentally test the effectiveness and cost-effectiveness of competing models of delivery of an Early Childhood Development (ECD) intervention in rural Kenya to determine how to maximize their reach to…
- Trial name
- NCT03548558
- Testing
- Group sessions, Group+Home sessions, Booster sessions
- Where
- United States
- Volunteers
- 1,152 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Autism Spectrum Disorder
A Feasibility Study of N-acetylcysteine for Self-injurious Behavior in Children With Autism Spectrum Disorder
The purpose of this study is to demonstrate the feasibility of a 9-week, randomized trial of N-acetylcysteine (NAC) compared to placebo in 14 children (age 5 to 12 years) with Autism Spectrum Disorder (ASD) and a moderate level…
- Trial name
- NAC (NCT03008889)
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Emory University