Clinical trials: Chlorhexidine
Dental Plaque
A Protocol for the Use of Chlorhexidine Gluconate Saturation for the Reduction of Dental Biofilm Formation on Polymethylmethacrylate Restoration
Chlorhexidine gluconate (CHX), as an anti plaque agent, is commonly used with a variety of products. In this study we, the investigators at Hadassah Medical Organization, intend to examine the efficacy of a single dip in CHX of…
- Trial name
- NCT00259181
- Testing
- saturation of polymethylmethacrylate with chlorhexidine gluconate to reduce in vivo plaque formation
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Age Problem
Gingivitis Treated With Chlorhexidine 0.12% Mouthwash in Young Adults
The aim of this study will evaluate the effectiveness of 0.12% chlorhexidine solution as an anti-inflammatory agent and reducing the presence of biofilm in young adults.
- Trial name
- NCT04658225
- Testing
- 0.12% chlorhexidine
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal Fluminense
Ventilation Acquired Pneumonia, Mechanical Ventilation
Comparison of Green Tea, White Tea, and Chlorhexidine Oral Care for Prevention of Ventilator-Associated Pneumonia
This study was conducted to compare the effects of oral care performed using chlorhexidine (CHX), green tea, and white tea solutions on oral health, functional status, and the development of ventilator-associated pneumonia (VAP)…
- Conditions
- Ventilation Acquired Pneumonia, Mechanical Ventilation, Oral Care
- Trial name
- TEA-VAP (NCT07688057)
- Testing
- Clorhexidine group, Green Tea group, white tea group
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Gingivitis, Periodontitis
A Clinical Trial to Study the Effects of Two Home Made Mouthwashes in Patients With Gum Diseases
Periodontal Disease is a ubiquitous in nature affecting about 80% population of India. The Periodontal Disease is a multifactorial but the dental plaque is considered as main etiological agent.The dental plaque, a adhesive…
- Trial name
- NCT02546804
- Testing
- HOT SALT WATER, POTASSIUM PERMANGANATE, CHLORHEXIDINE
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government College of Dentistry, Indore
Peri-Implantitis
Clinical Efficacy of Hybenix vs Chlosite Gels in Peri-implantitis
The present study is a randomized clinical trial (RCT). Patients responding to the inclusion criteria will be included. The following peri-implant indexes will be collected: Bleeding On Probing, Gingival Bleeding Index, Marginal…
- Trial name
- NCT06083246
- Testing
- Hybenix gel, Chlosite gel
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Ventilator Associated Pneumonia
Reducing the Incidence of VAP in Critically Ill Children and Assessment of Oral Care With CHX
This was a single-centered, randomized, placebo-controlled double-blind clinical trial conducted in the pediatric intensive care unit (PICU), in patients who were aged 1 month to 18 years, needing MV for at least 48 hours, to…
- Trial name
- NCT04527276
- Testing
- Oral care with 0,12% Chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Istanbul Medeniyet University
Periodontal Diseases, Periodontitis
Clinical Effect of Chlorhexidine Mouthwash After Periodontal Surgery
Chlorhexidine is the gold standard of dental plaque prevention. Recent research have demonstrated that 0.2% Chlorhexidine solutions are more effective than 0.12% and 0.06% Chlorhexidine solutions.
- Conditions
- Periodontal Diseases, Periodontitis, Dental Plaque
- Trial name
- NCT04223076
- Testing
- Chlorhexidine 0.2%, Corsodyl, Chlorhexidine 0.2%, Curasept
- Where
- Norway
- Volunteers
- 31 people
- Sponsor
- University of Oslo
Chlorhexidine, Gingivitis
Clinical and Microbiological Comparison of 0.12% CHX and 0.05% CHX+0.05%CPC Mouthwashes in TPS Patients
The present study compares the effectiveness of two mouthwash formulations (0.12% CHX and 0.05% CHX+0.05%CPC) in reducing gingival inflammation and microbial colonization in individuals with gingivitis and in preventing…
- Conditions
- Chlorhexidine, Gingivitis, Periodontitis, Cetylpyridinium Chloride
- Trial name
- NCT06411522
- Testing
- Mouthwash containing 0.12% CHX (Chlorhexidine), Mouthwash containing 0.05% CHX (Chlorhexidine) and 0.05% CPC (Cetylpyridinium Chloride)
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- University of Siena
Periodontal and Endodontic Lesion
Chlorhexidine-Metronidazole Combination as an Intracanal Medicament on Periodontal Healing
Considering the beneficiary properties of both Chlorhexidine (CHX) and Metronidazole (MTZ) such as property of substantivity and diffusion of these drugs on the external surfaces through the anatomical communication channels in…
- Trial name
- NCT03169946
- Testing
- RCT with CHX-MTZ,OFD, RCT with CHX,OFD
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Preterm Birth
Preterm Labor Prevention Using Vaginal Antiseptics Prior to 16 Weeks of Gestation
The aim of this prospective observational study was to evaluate the efficacy of a universal strategy of primary prevention of preterm birth using intravaginal chlorhexidine (CLX) applied before 16 weeks.
- Trial name
- PLUVA (NCT05944094)
- Testing
- Clorhexidine
- Where
- Spain
- Volunteers
- 1,117 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Lentigines
A Single-Center 2-Arm Study for Lentigines on the Hands
The purpose of this study is to evaluate the effectiveness and safety of two laser systems for improvement of lentigines on the hands.
- Trial name
- NCT02763072
- Testing
- Enlighten Laser, Excel V Laser
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cutera Inc.
Skin Diseases, Infectious
Effect of Chlorhexidine Skin Cleansing on Skin Flora
Given the potential of skin cleansing with chlorhexidine as a safe, feasible, and cost-effective intervention for reducing neonatal death in developing country settings, this study follows a trial already underway in Nepal to…
- Trial name
- NCT00198679
- Testing
- Chlorhexidine
- Where
- Bangladesh
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Ventilator-Associated Pneumonia
The Effect of Solutions Used in Oral Care on Preventing Ventilator-Associated Pneumonia.
The goal of this clinical trial is to learn about effects of chlorhexidine gluconate, sodium bicarbonate, ozonated water and hypochlorous acid solutions used in oral care of patients on mechanical ventilation support on…
- Trial name
- NCT06118242
- Testing
- Use of oral care solutions
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Aydin Adnan Menderes University
Gingivitis and Periodontal Diseases, Dental Plaque
0.2% Chlorhexidine vs MicroRepair ABX in Gingivitis
Gingivitis is the most common form of reversible gum disease, caused by the accumulation of dental plaque. It leads to inflammation of the gums, bleeding, and discomfort, but it can be managed and reversed with professional…
- Conditions
- Gingivitis and Periodontal Diseases, Dental Plaque, Oral Hygiene
- Trial name
- GEM-CHX02 (NCT07088666)
- Testing
- MicroRepair ABX mouthwash, Chlorhexidine 0.2% mouthwash
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Endobronchial Ultrasound
Chlorhexidine Mouthrinse Before EBUS-TBNA
The purpose of this study is to investigate whether chlorhexidine mouthrinse is effective in preventing microbial contamination during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA).
- Trial name
- CHX_EBUS (NCT04718922)
- Testing
- Chlorhexidine Gluconate 0.12 % Mouthwash
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Seoul National University Hospital
Nosocomial Bacteremia, Nosocomial Fungemia
The Impact of Chlorhexidine-Based Bathing on Nosocomial Infections
The purpose of this study was to determine if the use of daily chlorhexidine bathing would decrease the incidence of MRSA and VRE colonization and healthcare associated Bloodstream Infections (BSI) among Intensive Care Unit (ICU)…
- Conditions
- Nosocomial Bacteremia, Nosocomial Fungemia, MRSA Colonization, MRSA Infection
- Trial name
- NCT00448942
- Testing
- Daily bathing with Chlorhexidine based product
- Where
- 4 sites in United States
- Volunteers
- 5,300 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Oral Squamous Cell Carcinoma, Oral Cancer
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
The goal of this phase II single arm clinical study is to evaluate the effect of antibiotics (metronidazole) and oral chlorhexidine (CHX) in reducing the bacteria load within tumors of patients undergoing surgery for oral cancer.
- Conditions
- Oral Squamous Cell Carcinoma, Oral Cancer, Head and Neck Cancer, Head and Neck Carcinoma
- Trial name
- NCT06627270
- Testing
- Metronidazole, Chlorhexidine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center
Ventilator Associated Pneumonia, Oral Hygiene
Implementation and Evaluation of Revised Protocols for Oral Hygiene for Mechanically Ventilated Patients
The primary objective of this study is to evaluate the effectiveness and feasibility of the implementation of revised standards of care for oral hygiene (SAGE Q-care q2 Oral Cleansing and Suctioning System with and without…
- Trial name
- NCT01657396
- Testing
- Standard Oral Hygiene, SAGE Q-care q2, SAGE Q-care q2 with Chlorhexidine
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of Calgary
Dental Plaque and Gingivitis
The Comparative Effects of Using 0.12% Chlorhexidine and Silver Nanoparticles Mouthwashes in Medical Students
This double-blind, randomized intervention study aims to evaluate and compare the efficacy of 0.12% Chlorhexidine (CHX) mouthwash and Nano Silver (AgNPs) mouthwash.
- Trial name
- mouthwash (NCT06963788)
- Testing
- Chlorhexidine 0,12%, 0,9% Chloride Sodium, Silver nanoparticles mouthwash
- Where
- Vietnam
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Neurodevelopment, Neonatal Mortality
Newborn Kit to Save Lives and Brains in Kenya
Each year, more than 3 million neonatal deaths occur worldwide and greater than 200 million children under the age of 5, almost all in low- and middle-income countries, are not fulfilling their developmental potential.
- Trial name
- NCT02208960
- Testing
- Neonatal Kit, Neonatal Stimulation
- Where
- Kenya
- Volunteers
- 2,294 people
- Sponsor
- The Hospital for Sick Children