Clinical trials: Chlorhexidine
Nosocomial Bacteremia, MRSA Colonization
Multicenter Trial of Daily Chlorhexidine Bathing to Reduce Nosocomial Infections
To determine if daily bathing with chlorhexidine impregnated washcloths will reduce the incidence of MRSA and VRE within an Intensive Care Unit (ICU) or ward setting.
- Conditions
- Nosocomial Bacteremia, MRSA Colonization, MRSA Infection, VRE Colonization
- Trial name
- CBET (NCT00502476)
- Testing
- Bathing with Chlorhexidine Impregnated Washcloths
- Where
- 7 sites in United States
- Volunteers
- 14,000 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Infection
Measures for the Prevention of Surgical Site Infection
Among the causes associated with infection of hospitalized patients, surgical site infection is a complication that is potentially associated with any type of surgical procedure, it also represents an expressive burden in terms…
- Trial name
- Orthopedics (NCT03551561)
- Testing
- CSAAC, CSAC
- Where
- Brazil
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai
Pulmonary Hypertension, Heart Failure With Normal Ejection Fraction
Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension
This is an open-label, single-center study to examine distinguishing features of the structure and function of the oral and gut microbiome in volunteers with PH in the breakdown of oral nitrate and effect on hemodynamics.
- Conditions
- Pulmonary Hypertension, Heart Failure With Normal Ejection Fraction, Pulmonary Heart Disease and Diseases of Pulmonary Circulation
- Trial name
- NCT03787082
- Testing
- Nitrates, Chlorhexidine Gluconate Mouthwash
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD
Bone Resorption, Bacteria Caused Disease
0.2% Chx Gel vs Implant Bacterial Contamination
The objective of this human randomized, double blind, placebo-control (RDBPC) study is to evaluate the efficacy of a 0.2% chlorhexidine (CHX) gel on reducing bacterial load and peri-implant inflammation at implant-abutment…
- Trial name
- NCT03431766
- Testing
- 0.20% chlorhexidine gel
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Gingivitis, Gingivitis and Periodontal Diseases
Evaluation of the Effect of a Toothpaste Containing 0.3% Chlorhexidine in Subjects With Established Dental Plaque and Gingivitis
This is a Phase III, one-center, parallel group, double blind, clinical study to evaluate the effect of a toothpaste containing 0.3% chlorhexidine in subjects with established dental plaque and gingivitis.
- Conditions
- Gingivitis, Gingivitis and Periodontal Diseases, Gingival Disease, Dental Plaque
- Trial name
- CHX TP (NCT06732466)
- Testing
- Chlorhexidine toothpaste, Toothbrush
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Colgate Palmolive
Periprosthetic Joint Infection
Microbial Growth in Operative Splash Basins During Total Joint Arthroplasty
The usage of splash basins in the setting of total knee arthroplasty and total hip arthroplasty presents a risk of contamination and subsequent periprosthetic joint infection.
- Trial name
- NCT04274517
- Testing
- Sterile Water, 3.5% Betadine, 0.05% Chlorhexidine Gluconate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Southern California
Reducing Gingivitis, Clinical Effect
Effectiveness of Coconut Oil Pulling and Moringa Mouthwash Versus Chlorhexidine in Reducing Gingivitis in Diabetic Children
Gingivitis is a common and reversible inflammatory condition, mainly caused by dental plaque, and is particularly prevalent among children.
- Trial name
- NCT07826390
- Testing
- Chlorhexidine mouthwash, Moringa olfera mouthwash, coconut oil pulling
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Amira Yehia Zakaria
Traumatic Oral Ulceration, Orthodontic Treatment
Comparison of Hyaluronic Acid and Chlorhexidine Gels for Traumatic Oral Ulcers During Fixed Orthodontic Treatment
This randomized controlled trial aims to compare the effectiveness of topical hyaluronic acid gel and chlorhexidine gel in the management of traumatic oral ulcers that develop following placement of fixed orthodontic appliances.
- Conditions
- Traumatic Oral Ulceration, Orthodontic Treatment, Orthodontic Appliances, Fixed, Oral Mucosal Ulceration
- Trial name
- HYCHO-TOU (NCT07709455)
- Testing
- Hyaluronic Acid gel, Chlorhexidine gel
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Dow University of Health Sciences
Periodontitis, Subgingival Plaque
The Effect of Post-surgical Chlorhexidine Mouth Washing on the Sub-gingival Periodontal Microbiome A Pilot Study
Prospective applicants who conform with inclusion and exclusion criteria will be accepted into the study and sign a consent form.
- Trial name
- SUPEM1 (NCT05355740)
- Testing
- Corsodyl
- Where
- 2 sites in Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Periodontal Diseases
A Comparison of Chlorhexidine and Green Tea Mouthwash in Patients With Gingivitis and Their Salivary Neutrophil and TAC Levels
A Comparison of Chlorhexidine and Green Tea Mouthwash in Patients With Gingivitis and Their Salivary Neutrophil and TAC Levels.
- Trial name
- (1346) (NCT06875440)
- Testing
- CHX mouthwash
- Where
- Iran
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Covid19, Coronavirus
Efficacy of Mouthwashes in Reducing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load in the Saliva
This is a single-blind, parallel-group, randomized pilot study designed to evaluate and compare the efficacy of 3 different mouthwashes containing 0.2% Chlorhexidine digluconate, 1.5% Hydroxide peroxide or Cetylpyridinium…
- Trial name
- COVID-19 (NCT04723446)
- Testing
- Corsodyl® Alcohol free -0.2 % Chlorhexidine digluconate, Colgate Peroxyl® -1.5% Hydrogen peroxide, Oral-B® Gum & Enamel Care -Cetylpyridinium chloride
- Where
- 2 sites in United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Plaque Accumulation, Gingival Inflammation
Triphila Mouthwash Effect as Anti-plaque and Anti-gingivitis in Children
The study aim to to assess the antiplaque and antigingivitis efficacy of Triphala mouthwash versus chlorhexidine mouthwash among children.
- Trial name
- NCT07016659
- Testing
- 0.12% Chlorhexidine Mouthwash ( Hexitol ), Triphila mouthwash
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Unrecognized Condition
Effect of TCFA on Neointimal Coverage After PCI at 9 Months Follow-up
Although drug-eluting stents have reduced rates of restenosis and late lumen loss compared with bare metal stents, late stent thrombosis (LST), a life-threatening complication of this technology, has emerged as a major concern.
- Trial name
- NCT02384837
- Testing
- EXCEL biodegradable polymer-coated sirolimus-eluting stent
- Where
- China
- Volunteers
- 33 people
- Sponsor
- General Hospital of Chinese Armed Police Forces
Stage II, Grade B Periodontitis, Chronic Periodontitis
Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B Periodontitis
This clinical trial is designed to evaluate two locally delivered gels, metformin and chlorhexidine, as adjunctive therapies to scaling and root planing (SRP) in patients with Stage II, Grade B periodontitis.
- Trial name
- MET-CHX Perio (NCT07215156)
- Testing
- Arm 1 Scaling and Root Planing (SRP), Arm 2 Metformin Gel 1% (locally delivered), Arm 3 Chlorhexidine Gel 0.2% (locally delivered)
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Surgical Site Infections, Post Operative Complication
2% Chlorhexidine Gluconate Skin Cloths to Prevent SSI in Spine Surgery Patients
Surgical site infection (SSI) following spinal surgery is a frequent complication and results in higher morbidity, mortality and healthcare costs.
- Trial name
- DeSSI (NCT02490631)
- Testing
- 2% chlorhexidine gluconate cloths
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Vanderbilt University
Infections Associated With Mechanical Ventilation, Pneumonia Associated With Mechanical Ventilation
Efficacy of Mouth-rinse With Chlorhexidine for the Prevention of Ventilator-associated Infections in Intensive Care Unit
Background: Infections associated with mechanical ventilation are associated with high rates of morbidity and mortality, which results not only in an increase in hospitalization days and care costs, but also in an increase in…
- Trial name
- NCT04165356
- Testing
- Mouth-rinse with 0.12% clorhexidine, Mouth-rinse with isotonic solution with 1.5% sodium bicarbonate
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Universidad Autónoma de Yucatán
Hospital Infection
4% Chlorhexidine Gluconate Daily Bathing for Prevention of Hospital-acquired Infections in Intensive Care Settings
The study will assess the utility of 4% chlorhexidine gluconate (CHG) daily bathing to reduce hospital acquired infections in patients admitted to intensive care units.
- Trial name
- Duclorexint (NCT03639363)
- Testing
- 4% chlorhexidine gluconate soap-like solution, standard soap
- Volunteers
- 449 people
- Sponsor
- University Of Perugia
Infection Secondary to Surgical Procedure
Effect of Chlorhexidine Gluconate Hair Bath on the Development of Surgical Site Infection and Time to Discharge
One of the most important preventable complications occurring in the postoperative period is surgical site infections. Surgical site infections (SSI) are infections that occur in incisions, organs or organ spaces that occur after…
- Trial name
- NCT06763211
- Testing
- Chlorhexidine Hair Bath
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- HAVVA ÇOŞKUN
Satisfaction, Product Quality
Surgeons' Satisfaction With Two Types of Tinted Chlorhexidine Applicators (Chloraprep® and Nex Clorex 2%)
The development of surgical site infections (SSI) in clean-contaminated surgery is regarded as being preventable. Known to be effective in the prevention of surgical site infection are the adequate sterilization of the surgical…
- Trial name
- NCT03508492
- Testing
- Surgical tinted Chloraprep® applicators, Surgical tinted Nex Clorex 2% applicators
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cristina Fernandez Perez
Cesarean Section, Surgical Site Infection
Preoperative Application of Chlorhexidine to Reduce Infection With Cesarean Section After Labor
Surgical site infections (SSI) are the second most common cause of nosocomial infections accounting for 15% of all nosocomial infections among hospitalized patients and 38% of nosocomial infections in surgical patients.
- Conditions
- Cesarean Section, Surgical Site Infection, Nosocomial Infection
- Trial name
- PRACTICAL (NCT03423147)
- Testing
- 2% chlorhexidine gluconate cloth, 4% Chlorhexidine gluconate vaginal scrub
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Angela Bianco