Clinical trials: Chlorhexidine, open to volunteers
Extraction Sites After Removal and Bone Replacement Grafting at Extraction Sockets of Dentally Hopeless Single-rooted Teeth
To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.
This study will compare commercially available, commonly used mouth rinses (0.12% chlorhexidine (CHX) vs. Ethylenediaminetetraacetic acid (EDTA)) for immediate post-operative and daily antiseptic use after tooth extraction and…
- Trial name
- NCT07191262
- Testing
- 0.12% CHX and Essential Oil mouthrinse, 2.6% EDTA and 0.2% EDTA mouth rinse
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Reducing Gingivitis, Clinical Effect
Effectiveness of Coconut Oil Pulling and Moringa Mouthwash Versus Chlorhexidine in Reducing Gingivitis in Diabetic Children
Gingivitis is a common and reversible inflammatory condition, mainly caused by dental plaque, and is particularly prevalent among children.
- Trial name
- NCT07826390
- Testing
- Chlorhexidine mouthwash, Moringa olfera mouthwash, coconut oil pulling
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Amira Yehia Zakaria
Dental Caries
Microbiome Changes After Laser and Chlorhexidine Disinfection in Caries Removal
The aim of this study was to investigate the effects of cavity disinfection with laser and chlorhexidine on the microbiome in cavities prepared using different caries removal methods.
- Trial name
- NCT06765330
- Testing
- CHX disinfection, Laser Disinfection, Tungsten carbide bur
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Mersin University
Surgical Site Infection
Novosyn® CHD vs Polyglactin 910 Suture to Close Wounds After Emergency or Elective Laparotomy or Laparoscopic Surgery
The aim of the study is to elucidate, if the colonization of bacteria is lower on the Novosyn® CHD suture compared to uncoated Polyglactin 910 suture, which will be assessed by the incidence of surgical site infections (SSI: A1…
- Trial name
- POLYNOVO-CHD (NCT05966961)
- Testing
- Novosyn® in emergency or elective laparotomy or laparoscopic surgery, Polyglactin 910 in emergency or elective laparotomy or laparoscopic surgery
- Where
- 4 sites in Italy, Spain
- Volunteers
- 2,998 people
- Sponsor
- Aesculap AG
Vaginal Dysbiosis
Effect of FB301 on Vaginal Bacterial Profile in Women With Asymptomatic Vaginal Dysbiosis Undergoing a Mock Frozen Embryo Transfer Cycle
The goal of this clinical trial is to evaluate FB301 during a mock frozen embryo transfer (FET) cycle in pre-menopausal women aged 18 to 45 years with a prior failed FET and a defined vaginal bacterial imbalance (dysbiosis).
- Trial name
- NCT07453069
- Testing
- FB-301, Chlorhexidine (0.5%) Vaginal Cleanse
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Freya Biosciences ApS
Plaque Induced Gingival Disease
Role of Herbal Based Mouthwashes in Plaque Control
Herbal medicine has been used for thousands of years. Traditional herbal medicine is used by an estimated 80% of the world's population for primary health care.
- Trial name
- mouthwash (NCT06711263)
- Testing
- Mouthwash Product
- Volunteers
- 80 people
- Sponsor
- Ajman University
Hand Washing
Optimization of Surgical Hand Preparation Using Sorbectol
Previous studies evaluated the efficacy of the hydroalcoholic solution of 3% digluconate of chlorhexidine, 0.3% potassium sorbate and 70% ethanol, "Sorbectol" (Spanish patent ES 2 784 275 B2) in the surgical hand preparation with…
- Trial name
- NCT06688890
- Testing
- Surgical hand rub with the reference product; n-propanol 60%., Surgical hand rub with the product P1; Sorbectol for 1 min., Surgical hand rub with the product P2; Sorbectol for 3 min.
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
HIV (Human Immunodeficiency Virus), HPV
Feasibility Study Comparing One vs Two Probes for Thermal Ablation Among Cervical Cancer Screen Positive WLWH in C1001P-CS9 South Africa
Cervical cancer disproportionately affects women in low- and middle-income countries (LMICs), particularly women living with HIV (WLWH) who have a 6-fold increased risk of cervical cancer compared to women in the general…
- Conditions
- HIV (Human Immunodeficiency Virus), HPV, Cervical Precancer, Cervical Neoplasia
- Trial name
- NCT07645378
- Testing
- Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes
- Where
- South Africa
- Volunteers
- 200 people
- Sponsor
- Fred Hutchinson Cancer Center
Bacterial Vaginosis (BV)
Chlorhexidine and/or Metronidazole Plus FB301 Pre-treatment Trial
The goal of this study is to evaluate how treatment with FB301 affects the balance of vaginal bacteria in women (aged 18-45) with bacterial vaginosis after pre-treatment with either a vaginal antiseptic wash (chlorhexidine), an…
- Trial name
- NCT07481955
- Testing
- FB 301, Chlorhexidine 0.5%, metronidazole 500 mg
- Where
- 2 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Freya Biosciences ApS
Vascular Access Complication, Device Related Infection
Chlorhexidine Caps for CLABSI Prevention in Hemodialysis: a Pilot Randomized Controlled Trial
The goal of this clinical trial is to compare a chlorhexidine antimicrobial barrier cap in patients requiring hemodialysis treatment to the standard hemodialysis caps currently used within the Metro North Kidney Health Service.
- Conditions
- Vascular Access Complication, Device Related Infection, Device Related Sepsis, Catheter Infection
- Trial name
- ECHO-HD (NCT07019610)
- Testing
- ClearGuard HD, B Braun Combi-stopper
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- The University of Queensland
Gingivitis
Effectiveness of Oil Pulling Using Oils in Comparison With Mouthwash for Gingivitis
The goal of this clinical trial is to learn if daily oil pulling with coconut oil or sesame oil works as effectively as a standard mouthwash to treat gum swelling and redness (gingivitis) in adults aged 18 to 55 years.
- Trial name
- NCT07892235
- Testing
- coconut oil, Sesame Oil, 0.2% Chlorhexidine Mouthwash
- Where
- Pakistan
- Volunteers
- 45 people
- Sponsor
- Bahria University
Surgical Wound Infection
The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal
The goal of this clinical trial is to learn if reducing bacterial load on the skin and nostrils with topical antibacterial soap and ointment, respectively, reduces rate of infection in surgical sites on lower leg wounds left open…
- Trial name
- NCT07142408
- Testing
- Chlorhexidine gluconate (4%), Mupirocin 2% Ointment
- Where
- United States
- Volunteers
- 848 people
- Sponsor
- Cooper Norcross Health
Gingivitis, Dental Plaque
Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices
This randomized crossover study will assess how three aligner-cleaning methods affect early supragingival oral microbial ecology and periodontal health in adults using clear aligners.
- Trial name
- NCT07307716
- Testing
- Mechanical toothbrushing (fluoride toothpaste), Chlorhexidine mouthwash (0.2%), Oxygen-based cleanser
- Where
- Saudi Arabia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Oral Squamous Cell Carcinoma, Oral Cancer
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
The goal of this phase II single arm clinical study is to evaluate the effect of antibiotics (metronidazole) and oral chlorhexidine (CHX) in reducing the bacteria load within tumors of patients undergoing surgery for oral cancer.
- Conditions
- Oral Squamous Cell Carcinoma, Oral Cancer, Head and Neck Cancer, Head and Neck Carcinoma
- Trial name
- NCT06627270
- Testing
- Metronidazole, Chlorhexidine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center
Periodontal Diseases
A Comparison of Chlorhexidine and Green Tea Mouthwash in Patients With Gingivitis and Their Salivary Neutrophil and TAC Levels
A Comparison of Chlorhexidine and Green Tea Mouthwash in Patients With Gingivitis and Their Salivary Neutrophil and TAC Levels.
- Trial name
- (1346) (NCT06875440)
- Testing
- CHX mouthwash
- Where
- Iran
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Impacted Third Molar Tooth, Surgical Wound Healing
Antibacterial Effect and Soft Tissue Healing of Chlorhexidine-Coated Polyglactin 910 Sutures After Impacted Lower Third Molar Surgery
This study evaluates whether coating Polyglactin 910 sutures with chlorhexidine diacetate (CHX-DA) improves outcomes after the surgical removal of impacted mandibular (lower) third molars (wisdom teeth).
- Trial name
- NCT07794280
- Testing
- Chlorhexidine Diacetate-Coated Polyglactin 910 Suture, Uncoated Polyglactin 910 Suture
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Postoperative Pain
Comparing Two Root Canal Cleaning Solutions (Chlorhexidine vs. Sodium Hypochlorite) for Pain After Treatment
Brief Summary (A short description for the lay public) This study aims to find out if the type of cleaning solution used during a root canal affects the pain a patient feels the next day.
- Trial name
- CHXvsNaOCl-Pai (NCT07453160)
- Testing
- Chlorhexidine gluconate 2%, Sodium hypochlorite 5.25%
- Volunteers
- 90 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Endodontic Issue, Periodontal Issues
Post-Extraction Healing: microRepair vs Chlorhexidine
This randomized clinical trial evaluates the efficacy of a microRepair ABX mouthwash mousse compared to 0.20% chlorhexidine in promoting wound healing following tooth extraction.
- Trial name
- NCT07555366
- Testing
- microRepair ABX Mousse, CHX mouthwash 0.20%
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Roma La Sapienza
Oral Mucosal Disorder
Effects of Chlorhexidine Gluconate, Ozonated Water and Hypochlorous Acid Solutions Used in the Oral Care of Patients Supported by Mechanical Ventilation on the Integrity of the Oral Mucosa
The purpose of this clinical trial is to learn whether ozonated water and hypochlorous acid solution can restore the integrity of the oral mucosa.
- Trial name
- NCT06942026
- Testing
- Control 1
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Dental Caries, Dental Caries in Children
The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries
This study aims to compare salivary IL-6, MMP-8, MMP-9, and TIMP-1 levels between healthy children and caries-active children, and to evaluate the effects of 5% sodium fluoride (NaF) varnish and 2% chlorhexidine (CHX) used in…
- Trial name
- DentalCaries (NCT07609797)
- Testing
- 5% Sodium Fluoride Varnish, 2% Chlorhexidine Pre-Treatment + 5% NaF Varnish, Standard Oral Hygiene Education
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gül Keskin